ENSG00000058063

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323116 ENSG00000058063 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP11B protein_coding protein_coding 7.819964 1.896485 16.26435 0.3068724 0.7226709 3.093612 5.0999400 1.2782376 10.136849 0.1730419 0.1836438 2.977561 0.64726667 0.6871667 0.6260000 -0.06116667 8.517411e-01 5.434028e-06 FALSE TRUE
ENST00000482794 ENSG00000058063 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP11B protein_coding processed_transcript 7.819964 1.896485 16.26435 0.3068724 0.7226709 3.093612 0.5472034 0.0000000 2.044945 0.0000000 0.2079540 7.682956 0.03696667 0.0000000 0.1251333 0.12513333 5.434028e-06 5.434028e-06   FALSE
ENST00000490303 ENSG00000058063 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP11B protein_coding retained_intron 7.819964 1.896485 16.26435 0.3068724 0.7226709 3.093612 1.7614409 0.4307509 3.664565 0.1651996 0.3846497 3.059538 0.23457500 0.2163667 0.2241667 0.00780000 1.000000e+00 5.434028e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000058063 E001 0.3150090 0.0279691711 0.171244346   3 182793503 182793503 1 + 0.051 0.264 2.743
ENSG00000058063 E002 15.9274476 0.0021564536 0.792779987 0.89204754 3 182793504 182793786 283 + 1.065 1.103 0.138
ENSG00000058063 E003 27.6960059 0.0013695328 0.016773940 0.08463369 3 182820260 182820376 117 + 1.324 1.073 -0.890
ENSG00000058063 E004 32.1764442 0.0012485242 0.223813683 0.45799146 3 182828120 182828209 90 + 1.373 1.267 -0.368
ENSG00000058063 E005 43.1441416 0.0011351911 0.074537870 0.23389168 3 182829672 182829752 81 + 1.496 1.356 -0.485
ENSG00000058063 E006 0.3641499 0.0309545915 0.172078110   3 182833673 182833874 202 + 0.051 0.264 2.744
ENSG00000058063 E007 64.1811809 0.0006947013 0.008533331 0.05176296 3 182836035 182836142 108 + 1.668 1.492 -0.602
ENSG00000058063 E008 78.3791768 0.0030595106 0.589815549 0.76359832 3 182836342 182836470 129 + 1.739 1.714 -0.086
ENSG00000058063 E009 0.6260739 0.0698414890 0.084710042   3 182836471 182836624 154 + 0.097 0.425 2.735
ENSG00000058063 E010 49.6573457 0.0009065318 0.388724774 0.61944416 3 182837071 182837116 46 + 1.548 1.492 -0.193
ENSG00000058063 E011 51.3526644 0.0007626073 0.291982455 0.53264956 3 182837117 182837174 58 + 1.562 1.492 -0.239
ENSG00000058063 E012 49.4705640 0.0009657509 0.026850981 0.11784246 3 182842075 182842122 48 + 1.556 1.387 -0.580
ENSG00000058063 E013 46.3520266 0.0016334895 0.156944785 0.37218391 3 182845458 182845522 65 + 1.523 1.416 -0.367
ENSG00000058063 E014 46.5182270 0.0008066225 0.138565342 0.34533661 3 182848476 182848557 82 + 1.524 1.415 -0.375
ENSG00000058063 E015 60.2888296 0.0039545186 0.181267102 0.40562640 3 182857878 182858028 151 + 1.630 1.537 -0.320
ENSG00000058063 E016 73.9707299 0.0038410922 0.018723154 0.09146667 3 182859162 182859359 198 + 1.726 1.566 -0.543
ENSG00000058063 E017 57.6319044 0.0007812534 0.006230832 0.04086582 3 182865456 182865526 71 + 1.625 1.429 -0.672
ENSG00000058063 E018 86.1391744 0.0017136433 0.026987071 0.11825941 3 182865527 182865698 172 + 1.791 1.663 -0.435
ENSG00000058063 E019 78.7702778 0.0004749403 0.100145898 0.28206914 3 182866268 182866443 176 + 1.746 1.655 -0.309
ENSG00000058063 E020 54.2601780 0.0067662862 0.203237448 0.43359790 3 182867376 182867444 69 + 1.591 1.492 -0.340
ENSG00000058063 E021 53.2971424 0.0012423511 0.040596018 0.15631344 3 182869078 182869151 74 + 1.590 1.442 -0.507
ENSG00000058063 E022 54.5530043 0.0007571104 0.133138208 0.33673289 3 182869228 182869331 104 + 1.593 1.492 -0.346
ENSG00000058063 E023 81.8596759 0.0007662910 0.779011886 0.88417756 3 182872356 182872537 182 + 1.757 1.748 -0.028
ENSG00000058063 E024 78.3871309 0.0006747911 0.668108002 0.81496987 3 182873812 182873965 154 + 1.730 1.761 0.107
ENSG00000058063 E025 59.2474945 0.0079693842 0.318305245 0.55820222 3 182873966 182874015 50 + 1.623 1.547 -0.260
ENSG00000058063 E026 54.6354653 0.0022685054 0.517023429 0.71302665 3 182879496 182879538 43 + 1.585 1.546 -0.134
ENSG00000058063 E027 67.6754337 0.0005555900 0.749556290 0.86649147 3 182879539 182879649 111 + 1.675 1.663 -0.040
ENSG00000058063 E028 48.3547623 0.0009430352 0.782179773 0.88595473 3 182880879 182880947 69 + 1.529 1.557 0.094
ENSG00000058063 E029 31.1134488 0.0071753120 0.105589340 0.29164455 3 182880948 182880981 34 + 1.326 1.479 0.529
ENSG00000058063 E030 55.5347018 0.0007167099 0.027168635 0.11879895 3 182884753 182884898 146 + 1.569 1.715 0.496
ENSG00000058063 E031 32.6902729 0.0011820364 0.002641868 0.02122179 3 182885951 182886010 60 + 1.327 1.566 0.826
ENSG00000058063 E032 59.1776744 0.0043771823 0.017058251 0.08567619 3 182887586 182887713 128 + 1.590 1.759 0.576
ENSG00000058063 E033 72.0935283 0.0006247800 0.040965725 0.15722569 3 182889410 182889548 139 + 1.681 1.803 0.414
ENSG00000058063 E034 48.7935325 0.0007752702 0.427185495 0.64885536 3 182896700 182896765 66 + 1.523 1.586 0.216
ENSG00000058063 E035 0.0000000       3 182897302 182897302 1 +      
ENSG00000058063 E036 63.1042362 0.0005686753 0.325532592 0.56476473 3 182897303 182897406 104 + 1.633 1.701 0.231
ENSG00000058063 E037 58.1460769 0.0006228699 0.237094517 0.47319660 3 182898607 182898684 78 + 1.596 1.678 0.281
ENSG00000058063 E038 73.7523776 0.0005136463 0.017043887 0.08562431 3 182898685 182898772 88 + 1.687 1.825 0.467
ENSG00000058063 E039 2.1618982 0.0095655331 0.035814394 0.14375817 3 182902481 182902566 86 + 0.327 0.713 1.892
ENSG00000058063 E040 0.6839606 0.0191002163 0.005145456   3 182905794 182905919 126 + 0.051 0.545 4.326
ENSG00000058063 E041 0.1779838 0.0348653917 0.844298483   3 182908459 182908505 47 + 0.051 0.000 -7.338
ENSG00000058063 E042 84.6955298 0.0018215112 0.041671265 0.15906359 3 182913861 182913994 134 + 1.749 1.867 0.399
ENSG00000058063 E043 42.9429734 0.0156250629 0.834395937 0.91624705 3 182913995 182915249 1255 + 1.478 1.519 0.138
ENSG00000058063 E044 380.8355649 0.0031292090 0.003194894 0.02457832 3 182918023 182921629 3607 + 2.399 2.500 0.335