ENSG00000055917

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338086 ENSG00000055917 HEK293_OSMI2_6hA HEK293_TMG_6hB PUM2 protein_coding protein_coding 17.29606 5.275709 35.42161 1.397633 1.155453 2.744868 5.4412637 3.0430405 9.396378 0.56621047 0.9603413 1.623393 0.48055417 0.6301667 0.26540000 -0.36476667 0.0762051148 0.0001611206 FALSE TRUE
ENST00000361078 ENSG00000055917 HEK293_OSMI2_6hA HEK293_TMG_6hB PUM2 protein_coding protein_coding 17.29606 5.275709 35.42161 1.397633 1.155453 2.744868 4.3117736 1.0208250 6.758618 0.52445943 1.9535868 2.715062 0.20874167 0.1526000 0.18753333 0.03493333 0.9147541427 0.0001611206 FALSE TRUE
ENST00000440577 ENSG00000055917 HEK293_OSMI2_6hA HEK293_TMG_6hB PUM2 protein_coding protein_coding 17.29606 5.275709 35.42161 1.397633 1.155453 2.744868 1.4448177 0.3920443 4.512120 0.20527811 0.1554827 3.491573 0.06175417 0.0585000 0.12786667 0.06936667 0.5750835836 0.0001611206 FALSE TRUE
ENST00000442400 ENSG00000055917 HEK293_OSMI2_6hA HEK293_TMG_6hB PUM2 protein_coding protein_coding 17.29606 5.275709 35.42161 1.397633 1.155453 2.744868 0.7496976 0.0000000 3.065017 0.00000000 0.9776830 8.264450 0.02441667 0.0000000 0.08856667 0.08856667 0.0001611206 0.0001611206 FALSE TRUE
MSTRG.18016.7 ENSG00000055917 HEK293_OSMI2_6hA HEK293_TMG_6hB PUM2 protein_coding   17.29606 5.275709 35.42161 1.397633 1.155453 2.744868 1.5424171 0.1548966 4.396101 0.03979964 0.7509192 4.739869 0.06169583 0.0384000 0.12576667 0.08736667 0.1674541347 0.0001611206 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000055917 E001 3.5100995 0.064707393 0.0003032591 0.003762171 2 20248691 20248736 46 - 0.326 1.073 3.278
ENSG00000055917 E002 25.3435894 0.552092115 0.0959016015 0.274577632 2 20248737 20248859 123 - 1.129 1.694 1.959
ENSG00000055917 E003 264.6359663 1.616610121 0.3127835118 0.553138904 2 20248860 20249863 1004 - 2.137 2.668 1.773
ENSG00000055917 E004 272.0021448 1.638633774 0.3591702895 0.595187167 2 20249864 20250633 770 - 2.165 2.646 1.604
ENSG00000055917 E005 231.2055991 1.603429690 0.4266184218 0.648506805 2 20250634 20251322 689 - 2.124 2.505 1.272
ENSG00000055917 E006 192.0179663 0.355517329 0.2701120944 0.510084953 2 20251323 20251716 394 - 2.064 2.367 1.012
ENSG00000055917 E007 178.2287118 0.011902480 0.9568395838 0.980281178 2 20253822 20254014 193 - 2.069 2.202 0.446
ENSG00000055917 E008 162.0205992 0.001136385 0.0310407301 0.130445421 2 20254863 20254984 122 - 2.041 2.100 0.197
ENSG00000055917 E009 163.6349145 0.016582523 0.2712176651 0.511211677 2 20255216 20255341 126 - 2.042 2.101 0.197
ENSG00000055917 E010 170.0539913 0.029364699 0.8057013248 0.899524134 2 20256033 20256170 138 - 2.050 2.160 0.369
ENSG00000055917 E011 13.5472201 0.065037654 0.7560941422 0.870279489 2 20258237 20258242 6 - 0.998 1.071 0.268
ENSG00000055917 E012 140.3551609 0.017754200 0.7079975124 0.840538502 2 20258243 20258371 129 - 1.956 2.126 0.569
ENSG00000055917 E013 136.0997480 0.014433334 0.1773529172 0.400241916 2 20260337 20260466 130 - 1.962 2.016 0.179
ENSG00000055917 E014 182.8535470 0.017200439 0.0369351944 0.146751334 2 20263193 20263460 268 - 2.098 2.095 -0.009
ENSG00000055917 E015 128.3035022 0.022964076 0.0394788295 0.153405026 2 20278583 20278819 237 - 1.949 1.920 -0.096
ENSG00000055917 E016 126.6708651 0.020819455 0.2039386675 0.434569819 2 20282947 20283231 285 - 1.931 1.990 0.200
ENSG00000055917 E017 64.5766694 0.024370893 0.1088361841 0.297123867 2 20283343 20283486 144 - 1.652 1.641 -0.035
ENSG00000055917 E018 70.6643254 0.031166161 0.0823403407 0.249376414 2 20290652 20290790 139 - 1.695 1.659 -0.122
ENSG00000055917 E019 74.9457822 0.016312669 0.0210919408 0.099649372 2 20294376 20294518 143 - 1.723 1.674 -0.166
ENSG00000055917 E020 70.7745483 0.010055210 0.0013152495 0.012271832 2 20297553 20297678 126 - 1.705 1.594 -0.376
ENSG00000055917 E021 28.3999819 0.018491679 0.0647935412 0.213451669 2 20307978 20307980 3 - 1.316 1.248 -0.238
ENSG00000055917 E022 73.2732609 0.018077868 0.0563739880 0.194509113 2 20307981 20308071 91 - 1.708 1.702 -0.021
ENSG00000055917 E023 90.2875381 0.020116695 0.0228108794 0.105346785 2 20308314 20308413 100 - 1.800 1.764 -0.121
ENSG00000055917 E024 102.3603745 0.013382814 0.0069738020 0.044521333 2 20308414 20308489 76 - 1.855 1.803 -0.175
ENSG00000055917 E025 103.3796476 0.007392753 0.0116931151 0.065200942 2 20308490 20308584 95 - 1.855 1.849 -0.018
ENSG00000055917 E026 126.8579617 0.013910519 0.0004357947 0.005088556 2 20311494 20311639 146 - 1.955 1.839 -0.390
ENSG00000055917 E027 69.5931959 0.017796726 0.0036102993 0.026989217 2 20311640 20311663 24 - 1.698 1.576 -0.413
ENSG00000055917 E028 89.9941443 0.019077967 0.0078776602 0.048757486 2 20312236 20312298 63 - 1.804 1.715 -0.299
ENSG00000055917 E029 129.4581900 0.012973800 0.0010129915 0.010008692 2 20312299 20312423 125 - 1.960 1.873 -0.291
ENSG00000055917 E030 95.3000924 0.020880827 0.0013236656 0.012337479 2 20318537 20318592 56 - 1.833 1.703 -0.440
ENSG00000055917 E031 87.1814428 0.015477296 0.0008451072 0.008655086 2 20318593 20318645 53 - 1.795 1.668 -0.431
ENSG00000055917 E032 10.4506267 0.003382827 0.2547941075 0.493338709 2 20326261 20326385 125 - 0.916 0.885 -0.118
ENSG00000055917 E033 74.8994033 0.011506352 0.0008496230 0.008685621 2 20327310 20327378 69 - 1.730 1.610 -0.406
ENSG00000055917 E034 0.1426347 0.032201956 1.0000000000   2 20327379 20327383 5 - 0.051 0.001 -6.518
ENSG00000055917 E035 11.0996294 0.013491345 0.1957353350 0.424276438 2 20331717 20331937 221 - 0.942 0.884 -0.220
ENSG00000055917 E036 5.8403052 0.014212060 0.3226559151 0.562045681 2 20332967 20333063 97 - 0.699 0.637 -0.260
ENSG00000055917 E037 0.9688700 0.088333040 1.0000000000   2 20333409 20333499 91 - 0.212 0.262 0.401
ENSG00000055917 E038 1.1002857 0.018654484 0.1172255070   2 20350205 20350301 97 - 0.176 0.544 2.326
ENSG00000055917 E039 38.6997929 0.010108341 0.1983342046 0.427503390 2 20350597 20350809 213 - 1.433 1.466 0.113
ENSG00000055917 E040 2.0258685 0.010772417 0.3267218293 0.565889313 2 20350810 20350844 35 - 0.397 0.263 -0.844
ENSG00000055917 E041 0.1426347 0.032201956 1.0000000000   2 20352166 20352234 69 - 0.051 0.001 -6.518