ENSG00000055609

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262189 ENSG00000055609 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT2C protein_coding protein_coding 6.882747 7.244629 8.875849 0.790612 0.4048799 0.2926078 0.5146467 0.71548246 0.9995384 0.108665150 0.17434116 0.4766832 0.07024583 0.10053333 0.11180000 0.011266667 9.628832e-01 2.679012e-05 FALSE TRUE
ENST00000360104 ENSG00000055609 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT2C protein_coding protein_coding 6.882747 7.244629 8.875849 0.790612 0.4048799 0.2926078 0.5595282 0.42351174 0.7294331 0.291028888 0.47384436 0.7703486 0.08292083 0.06940000 0.07936667 0.009966667 9.389012e-01 2.679012e-05 FALSE TRUE
ENST00000418061 ENSG00000055609 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT2C protein_coding protein_coding 6.882747 7.244629 8.875849 0.790612 0.4048799 0.2926078 0.6200846 1.05849018 0.2891198 0.155379668 0.28911985 -1.8367781 0.09463333 0.15343333 0.03043333 -0.123000000 2.404689e-01 2.679012e-05 FALSE TRUE
ENST00000424877 ENSG00000055609 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT2C protein_coding protein_coding 6.882747 7.244629 8.875849 0.790612 0.4048799 0.2926078 0.7110402 1.68179473 0.9763748 0.574785366 0.23146922 -0.7783467 0.10080417 0.21870000 0.10940000 -0.109300000 5.695487e-01 2.679012e-05 FALSE TRUE
ENST00000682283 ENSG00000055609 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT2C protein_coding protein_coding 6.882747 7.244629 8.875849 0.790612 0.4048799 0.2926078 0.5306723 0.01752514 1.3517161 0.009016668 0.42137544 5.6285324 0.07336667 0.00220000 0.15643333 0.154233333 2.679012e-05 2.679012e-05 FALSE TRUE
ENST00000682824 ENSG00000055609 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT2C protein_coding retained_intron 6.882747 7.244629 8.875849 0.790612 0.4048799 0.2926078 0.3432124 0.32357538 0.2378540 0.071501713 0.04638186 -0.4285221 0.05641667 0.04833333 0.02690000 -0.021433333 7.042745e-01 2.679012e-05 FALSE FALSE
ENST00000684768 ENSG00000055609 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT2C protein_coding processed_transcript 6.882747 7.244629 8.875849 0.790612 0.4048799 0.2926078 0.5707229 0.69285483 0.0000000 0.573890192 0.00000000 -6.1351548 0.08807083 0.09216667 0.00000000 -0.092166667 3.901596e-01 2.679012e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000055609 E001 0.0000000       7 152134922 152134924 3 -      
ENSG00000055609 E002 0.0000000       7 152134925 152134927 3 -      
ENSG00000055609 E003 0.0000000       7 152134928 152134928 1 -      
ENSG00000055609 E004 0.0000000       7 152134929 152134932 4 -      
ENSG00000055609 E005 1.3345972 0.0136968632 2.476555e-02   7 152134933 152134935 3 - 0.106 0.560 3.244
ENSG00000055609 E006 1.5069716 0.0127578352 1.298578e-02 7.038682e-02 7 152134936 152134939 4 - 0.106 0.603 3.437
ENSG00000055609 E007 1.6378397 0.0116338459 6.894999e-03 4.415769e-02 7 152134940 152134944 5 - 0.106 0.641 3.606
ENSG00000055609 E008 1.6378397 0.0116338459 6.894999e-03 4.415769e-02 7 152134945 152134945 1 - 0.106 0.641 3.606
ENSG00000055609 E009 1.6378397 0.0116338459 6.894999e-03 4.415769e-02 7 152134946 152134947 2 - 0.106 0.641 3.606
ENSG00000055609 E010 7.2149586 0.0044547733 3.651262e-05 6.379304e-04 7 152134948 152134958 11 - 0.543 1.162 2.437
ENSG00000055609 E011 12.4511214 0.0041316672 3.407289e-09 1.771696e-07 7 152134959 152134966 8 - 0.663 1.398 2.736
ENSG00000055609 E012 13.8269352 0.0106831147 1.373725e-07 4.948876e-06 7 152134967 152134976 10 - 0.756 1.429 2.458
ENSG00000055609 E013 25.4166622 0.1753110649 9.332372e-04 9.364520e-03 7 152134977 152135000 24 - 0.936 1.694 2.666
ENSG00000055609 E014 29.1040921 0.2114208008 1.729435e-03 1.522821e-02 7 152135001 152135018 18 - 0.973 1.755 2.735
ENSG00000055609 E015 41.2949311 0.3501074521 8.499613e-03 5.160266e-02 7 152135019 152135096 78 - 1.100 1.906 2.779
ENSG00000055609 E016 41.6619668 0.3203971203 3.725366e-03 2.761080e-02 7 152135097 152135172 76 - 1.040 1.922 3.053
ENSG00000055609 E017 33.5550796 0.3499206032 1.032982e-02 5.954045e-02 7 152135173 152135214 42 - 1.018 1.818 2.779
ENSG00000055609 E018 97.3133372 0.6497626324 4.194152e-02 1.597971e-01 7 152135215 152135451 237 - 1.470 2.272 2.706
ENSG00000055609 E019 105.4282439 0.7541637196 9.830025e-02 2.788036e-01 7 152135452 152135610 159 - 1.615 2.279 2.236
ENSG00000055609 E020 98.7711728 1.0596295302 2.609240e-01 4.999143e-01 7 152135611 152135979 369 - 1.720 2.204 1.628
ENSG00000055609 E021 62.3716878 0.6411346827 1.423328e-01 3.509202e-01 7 152135980 152136269 290 - 1.498 2.018 1.759
ENSG00000055609 E022 26.0625415 0.4153207502 1.961121e-01 4.246817e-01 7 152136270 152136281 12 - 1.222 1.607 1.333
ENSG00000055609 E023 29.9068990 0.4330051838 1.490936e-01 3.609443e-01 7 152136282 152136312 31 - 1.242 1.683 1.520
ENSG00000055609 E024 60.7437675 0.6153589549 1.239131e-01 3.219253e-01 7 152136313 152136583 271 - 1.475 2.011 1.819
ENSG00000055609 E025 26.9674253 0.2811367284 2.698003e-02 1.182468e-01 7 152136584 152136625 42 - 1.086 1.684 2.079
ENSG00000055609 E026 55.2343932 0.6464417838 1.953787e-01 4.238198e-01 7 152136626 152136801 176 - 1.500 1.943 1.502
ENSG00000055609 E027 58.7181374 0.7087301436 2.772443e-01 5.172647e-01 7 152136802 152136924 123 - 1.574 1.944 1.251
ENSG00000055609 E028 44.5682277 0.8526113689 7.052492e-01 8.388756e-01 7 152136925 152138795 1871 - 1.602 1.716 0.390
ENSG00000055609 E029 57.6469667 0.6824508342 2.335896e-01 4.693098e-01 7 152138796 152138904 109 - 1.536 1.952 1.411
ENSG00000055609 E030 0.0000000       7 152138980 152138982 3 -      
ENSG00000055609 E031 0.1426347 0.0315742038 5.057021e-01   7 152138983 152139185 203 - 0.106 0.000 -12.983
ENSG00000055609 E032 56.5588193 0.0723245392 1.359332e-01 3.412134e-01 7 152139186 152139259 74 - 1.611 1.899 0.974
ENSG00000055609 E033 0.9223018 0.0217931383 9.720179e-01   7 152139260 152139674 415 - 0.263 0.327 0.438
ENSG00000055609 E034 70.2677156 0.0193066314 1.429128e-01 3.518291e-01 7 152139675 152139791 117 - 1.744 1.965 0.746
ENSG00000055609 E035 7.6338512 0.2066400614 7.178441e-01 8.468700e-01 7 152139792 152141224 1433 - 0.887 0.979 0.345
ENSG00000055609 E036 86.3877903 0.0005219609 2.271654e-02 1.050211e-01 7 152144713 152144881 169 - 1.838 2.045 0.694
ENSG00000055609 E037 1.9380272 0.2568238179 9.159991e-01 9.601795e-01 7 152144882 152145152 271 - 0.424 0.515 0.457
ENSG00000055609 E038 17.4392053 0.0021097990 7.533997e-01 8.687639e-01 7 152145153 152145164 12 - 1.196 1.335 0.490
ENSG00000055609 E039 59.9906350 0.0007439314 1.994979e-02 9.571516e-02 7 152145165 152145295 131 - 1.670 1.896 0.763
ENSG00000055609 E040 0.1723744 0.0349502697 4.713186e-01   7 152145296 152145708 413 - 0.000 0.138 12.784
ENSG00000055609 E041 0.1308682 0.0326491905 4.745206e-01   7 152145709 152146598 890 - 0.000 0.138 12.796
ENSG00000055609 E042 49.4928900 0.0007877780 2.326690e-03 1.922670e-02 7 152146599 152146735 137 - 1.566 1.838 0.923
ENSG00000055609 E043 1.1625981 0.1546444034 6.471507e-01   7 152146736 152147679 944 - 0.263 0.400 0.859
ENSG00000055609 E044 131.6368613 0.0003399040 2.812508e-04 3.540874e-03 7 152148033 152148684 652 - 2.008 2.241 0.778
ENSG00000055609 E045 96.8852502 0.0010619023 1.133652e-01 3.047651e-01 7 152148685 152149152 468 - 1.904 2.085 0.607
ENSG00000055609 E046 3.0364464 0.0967308227 6.064152e-01 7.744965e-01 7 152149153 152150899 1747 - 0.506 0.686 0.807
ENSG00000055609 E047 43.1468866 0.0019938005 8.024400e-01 8.977291e-01 7 152150900 152151007 108 - 1.582 1.715 0.454
ENSG00000055609 E048 0.6370325 0.0323027221 3.054049e-01   7 152151008 152151441 434 - 0.106 0.327 2.020
ENSG00000055609 E049 40.0200649 0.0055616835 3.616082e-01 5.969959e-01 7 152151442 152151558 117 - 1.528 1.707 0.612
ENSG00000055609 E050 17.1814229 0.0049316738 5.517658e-01 7.375075e-01 7 152151559 152151581 23 - 1.180 1.349 0.592
ENSG00000055609 E051 0.0000000       7 152151582 152151677 96 -      
ENSG00000055609 E052 0.1308682 0.0326491905 4.745206e-01   7 152151678 152152389 712 - 0.000 0.138 12.796
ENSG00000055609 E053 0.1308682 0.0326491905 4.745206e-01   7 152152390 152152704 315 - 0.000 0.138 12.796
ENSG00000055609 E054 56.3757739 0.0145471773 6.992061e-01 8.350710e-01 7 152152705 152152954 250 - 1.684 1.839 0.524
ENSG00000055609 E055 0.3503582 0.0270170573 1.000000e+00   7 152152955 152154009 1055 - 0.106 0.138 0.436
ENSG00000055609 E056 42.1627623 0.0106112853 9.860478e-01 9.948527e-01 7 152154010 152154146 137 - 1.577 1.699 0.413
ENSG00000055609 E057 43.8916295 0.0010002728 6.517577e-01 8.046253e-01 7 152154267 152154445 179 - 1.585 1.728 0.487
ENSG00000055609 E058 0.5173834 0.0811009710 9.735232e-02   7 152154446 152154908 463 - 0.264 0.000 -14.270
ENSG00000055609 E059 1.1717919 0.0194235651 5.481497e-02   7 152154909 152155909 1001 - 0.426 0.138 -2.150
ENSG00000055609 E060 45.6493444 0.0008958825 5.696038e-01 7.499696e-01 7 152155910 152156057 148 - 1.603 1.752 0.504
ENSG00000055609 E061 33.6467664 0.0010873884 2.428961e-01 4.798459e-01 7 152156205 152156271 67 - 1.450 1.637 0.641
ENSG00000055609 E062 17.7959948 0.0056706216 1.396806e-01 3.470205e-01 7 152156272 152156274 3 - 1.147 1.386 0.840
ENSG00000055609 E063 26.1051927 0.0017163736 8.270060e-01 9.121026e-01 7 152156275 152156343 69 - 1.370 1.502 0.453
ENSG00000055609 E064 13.4164499 0.0031606732 2.865708e-01 5.272577e-01 7 152156344 152156346 3 - 1.156 1.172 0.058
ENSG00000055609 E065 0.1723744 0.0349502697 4.713186e-01   7 152156347 152156455 109 - 0.000 0.138 12.784
ENSG00000055609 E066 28.6556812 0.0156924022 1.434799e-01 3.526273e-01 7 152157761 152157854 94 - 1.472 1.470 -0.007
ENSG00000055609 E067 21.9690329 0.0015297782 2.000816e-01 4.298009e-01 7 152157855 152157922 68 - 1.349 1.371 0.075
ENSG00000055609 E068 9.4250766 0.0071334635 1.321648e-01 3.352195e-01 7 152157923 152157925 3 - 1.030 0.968 -0.230
ENSG00000055609 E069 1.3796150 0.6116555599 2.268356e-01   7 152157926 152158613 688 - 0.105 0.577 3.348
ENSG00000055609 E070 0.8286205 0.0205477509 1.650857e-01   7 152158857 152158862 6 - 0.106 0.398 2.436
ENSG00000055609 E071 52.1137301 0.0007253859 5.391670e-01 7.283965e-01 7 152158863 152159072 210 - 1.685 1.774 0.302
ENSG00000055609 E072 7.3527409 0.1786614829 2.117507e-01 4.438099e-01 7 152159073 152160550 1478 - 0.970 0.831 -0.527
ENSG00000055609 E073 0.3337900 0.0281355012 9.872869e-01   7 152160551 152160601 51 - 0.106 0.138 0.437
ENSG00000055609 E074 4.7934192 0.1118599273 6.413496e-01 7.977119e-01 7 152160602 152162116 1515 - 0.670 0.845 0.708
ENSG00000055609 E075 139.1534926 0.0091918809 3.226471e-02 1.340204e-01 7 152162117 152163177 1061 - 2.143 2.148 0.017
ENSG00000055609 E076 28.1738020 0.0035207408 1.935058e-01 4.214773e-01 7 152163178 152163273 96 - 1.450 1.475 0.085
ENSG00000055609 E077 61.7092798 0.0006680079 1.088674e-02 6.188982e-02 7 152163274 152163699 426 - 1.794 1.798 0.013
ENSG00000055609 E078 26.3242480 0.0013253892 9.416775e-02 2.714808e-01 7 152163700 152163826 127 - 1.437 1.441 0.015
ENSG00000055609 E079 36.7856906 0.0136579463 1.506813e-01 3.632726e-01 7 152167146 152167378 233 - 1.574 1.578 0.015
ENSG00000055609 E080 0.0000000       7 152168567 152168589 23 -      
ENSG00000055609 E081 26.3643166 0.0189665416 9.604520e-01 9.820744e-01 7 152169186 152169249 64 - 1.383 1.487 0.360
ENSG00000055609 E082 27.8302004 0.0021053094 7.206190e-01 8.486074e-01 7 152171264 152171342 79 - 1.419 1.511 0.318
ENSG00000055609 E083 31.0829896 0.0014216948 3.027982e-01 5.433730e-01 7 152174131 152174242 112 - 1.487 1.540 0.184
ENSG00000055609 E084 98.9661928 0.0047321386 6.831706e-04 7.297194e-03 7 152176191 152177075 885 - 2.018 1.975 -0.144
ENSG00000055609 E085 97.6605512 0.0052039198 2.397621e-07 8.088422e-06 7 152177076 152178010 935 - 2.047 1.912 -0.454
ENSG00000055609 E086 35.5716347 0.0037568621 1.149592e-05 2.362667e-04 7 152179834 152180126 293 - 1.627 1.458 -0.577
ENSG00000055609 E087 117.9686068 0.0212861589 1.477566e-05 2.943052e-04 7 152180711 152182156 1446 - 2.154 1.932 -0.745
ENSG00000055609 E088 38.2575752 0.0104176652 2.791132e-06 6.981064e-05 7 152182157 152182557 401 - 1.677 1.439 -0.814
ENSG00000055609 E089 13.3465293 0.0029545321 1.381393e-05 2.773287e-04 7 152182558 152182594 37 - 1.260 0.948 -1.128
ENSG00000055609 E090 24.2545195 0.0080072373 3.189406e-07 1.041204e-05 7 152182974 152183156 183 - 1.507 1.193 -1.095
ENSG00000055609 E091 0.0000000       7 152183157 152183163 7 -      
ENSG00000055609 E092 0.1779838 0.0364858254 5.044701e-01   7 152185466 152185557 92 - 0.106 0.000 -12.958
ENSG00000055609 E093 16.5103318 0.0035220291 1.356653e-07 4.892565e-06 7 152185558 152185631 74 - 1.366 0.999 -1.305
ENSG00000055609 E094 29.0061127 0.0157519114 3.061722e-07 1.003572e-05 7 152187262 152187476 215 - 1.593 1.247 -1.197
ENSG00000055609 E095 22.7169750 0.0038049894 4.934906e-07 1.529855e-05 7 152187715 152187847 133 - 1.475 1.193 -0.984
ENSG00000055609 E096 0.0000000       7 152193726 152193740 15 -      
ENSG00000055609 E097 0.1779838 0.0364858254 5.044701e-01   7 152193741 152194008 268 - 0.106 0.000 -12.958
ENSG00000055609 E098 18.7714352 0.0085344087 1.978562e-04 2.650929e-03 7 152194009 152194128 120 - 1.385 1.169 -0.757
ENSG00000055609 E099 0.0000000       7 152194129 152194228 100 -      
ENSG00000055609 E100 9.7094587 0.0311297991 7.332209e-02 2.314457e-01 7 152194229 152194261 33 - 1.082 0.975 -0.393
ENSG00000055609 E101 0.0000000       7 152194262 152194397 136 -      
ENSG00000055609 E102 0.1308682 0.0326491905 4.745206e-01   7 152194398 152194439 42 - 0.000 0.138 12.796
ENSG00000055609 E103 20.4127230 0.0151742279 1.914229e-03 1.650237e-02 7 152194440 152194568 129 - 1.401 1.228 -0.605
ENSG00000055609 E104 0.1779838 0.0364858254 5.044701e-01   7 152194569 152195521 953 - 0.106 0.000 -12.958
ENSG00000055609 E105 0.1779838 0.0364858254 5.044701e-01   7 152195522 152195569 48 - 0.106 0.000 -12.958
ENSG00000055609 E106 0.0000000       7 152195570 152195906 337 -      
ENSG00000055609 E107 13.8689002 0.0051450932 4.790162e-04 5.486105e-03 7 152195907 152196011 105 - 1.254 1.031 -0.798
ENSG00000055609 E108 0.4812263 0.0226826331 5.573397e-01   7 152196012 152199278 3267 - 0.106 0.243 1.434
ENSG00000055609 E109 17.9635981 0.0065828900 6.878068e-05 1.092763e-03 7 152199279 152199459 181 - 1.366 1.125 -0.851
ENSG00000055609 E110 0.3337900 0.0281355012 9.872869e-01   7 152202860 152202933 74 - 0.106 0.138 0.437
ENSG00000055609 E111 16.8386307 0.0050580410 4.556667e-06 1.062365e-04 7 152202934 152203064 131 - 1.355 1.047 -1.093
ENSG00000055609 E112 0.9279113 0.0156565764 4.327506e-01   7 152203065 152203656 592 - 0.324 0.243 -0.564
ENSG00000055609 E113 0.9991572 0.2510944735 9.621155e-01   7 152203657 152204604 948 - 0.263 0.331 0.457
ENSG00000055609 E114 0.8158242 0.0172788180 1.812842e-01   7 152204605 152205105 501 - 0.324 0.138 -1.564
ENSG00000055609 E115 17.2807607 0.0029379508 1.004080e-06 2.851912e-05 7 152205106 152205225 120 - 1.375 1.061 -1.113
ENSG00000055609 E116 0.0000000       7 152207286 152207299 14 -      
ENSG00000055609 E117 21.2698821 0.0023017568 1.618889e-06 4.332250e-05 7 152207300 152207425 126 - 1.437 1.173 -0.925
ENSG00000055609 E118 9.5044054 0.0438753138 2.094612e-03 1.769806e-02 7 152207426 152207428 3 - 1.133 0.793 -1.274
ENSG00000055609 E119 0.0000000       7 152207429 152208963 1535 -      
ENSG00000055609 E120 0.0000000       7 152220052 152220522 471 -      
ENSG00000055609 E121 27.3990841 0.0220013976 2.155415e-03 1.810999e-02 7 152220523 152220735 213 - 1.517 1.328 -0.653
ENSG00000055609 E122 12.3024421 0.0037907433 5.220656e-03 3.578557e-02 7 152222001 152222066 66 - 1.181 1.016 -0.594
ENSG00000055609 E123 15.5615032 0.0326032835 1.973826e-03 1.689351e-02 7 152222573 152222682 110 - 1.309 1.032 -0.985
ENSG00000055609 E124 16.9113037 0.0052946724 7.169375e-08 2.757076e-06 7 152224015 152224179 165 - 1.376 0.983 -1.402
ENSG00000055609 E125 0.0000000       7 152224180 152224434 255 -      
ENSG00000055609 E126 12.6636816 0.0127738403 3.861967e-07 1.232571e-05 7 152224435 152224616 182 - 1.275 0.796 -1.762
ENSG00000055609 E127 0.0000000       7 152224617 152226215 1599 -      
ENSG00000055609 E128 11.7761772 0.0031954900 5.858876e-06 1.322925e-04 7 152229923 152230027 105 - 1.226 0.868 -1.311
ENSG00000055609 E129 13.2593484 0.0026855446 8.092638e-08 3.072471e-06 7 152230220 152230321 102 - 1.292 0.868 -1.544
ENSG00000055609 E130 6.5712640 0.0041206091 2.422531e-05 4.499141e-04 7 152235817 152235818 2 - 1.018 0.560 -1.844
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