ENSG00000055483

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312010 ENSG00000055483 HEK293_OSMI2_6hA HEK293_TMG_6hB USP36 protein_coding protein_coding 31.0185 43.73422 20.47631 4.856076 0.6953081 -1.094432 0.4017838 0.000000 1.3976262 0.000000 0.1188182 7.137120 0.01859167 0.0000000 0.06816667 0.06816667 7.574655e-22 7.574655e-22 FALSE  
ENST00000449938 ENSG00000055483 HEK293_OSMI2_6hA HEK293_TMG_6hB USP36 protein_coding protein_coding 31.0185 43.73422 20.47631 4.856076 0.6953081 -1.094432 9.0550214 14.625890 5.1358518 1.936310 0.2545602 -1.508029 0.28488333 0.3326333 0.25070000 -0.08193333 9.982064e-02 7.574655e-22 FALSE  
ENST00000588130 ENSG00000055483 HEK293_OSMI2_6hA HEK293_TMG_6hB USP36 protein_coding protein_coding 31.0185 43.73422 20.47631 4.856076 0.6953081 -1.094432 3.3006642 3.980754 0.8497147 1.126157 0.4251106 -2.214732 0.09969583 0.0874000 0.04143333 -0.04596667 7.457627e-01 7.574655e-22 FALSE  
ENST00000592231 ENSG00000055483 HEK293_OSMI2_6hA HEK293_TMG_6hB USP36 protein_coding protein_coding 31.0185 43.73422 20.47631 4.856076 0.6953081 -1.094432 13.9187290 20.010652 9.9752108 2.880977 0.2637982 -1.003624 0.44180000 0.4537333 0.48740000 0.03366667 7.987973e-01 7.574655e-22 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000055483 E001 2.6431588 0.0337589425 4.151125e-01 6.398837e-01 17 78787381 78787465 85 - 0.411 0.574 0.798
ENSG00000055483 E002 2.1786883 0.0122447808 6.366662e-01 7.948087e-01 17 78787466 78787466 1 - 0.411 0.501 0.459
ENSG00000055483 E003 26.1709234 0.0015027337 6.027209e-02 2.034382e-01 17 78787467 78787658 192 - 1.264 1.417 0.534
ENSG00000055483 E004 4.3664226 0.0924061750 9.747203e-01 9.892364e-01 17 78791863 78791942 80 - 0.674 0.682 0.034
ENSG00000055483 E005 5.5978662 0.1252623003 7.699000e-01 8.785835e-01 17 78791943 78792040 98 - 0.722 0.782 0.242
ENSG00000055483 E006 4.5405147 0.1302870618 9.516508e-01 9.777424e-01 17 78792041 78792080 40 - 0.675 0.691 0.068
ENSG00000055483 E007 2.1530574 0.0572248294 9.661196e-03 5.666356e-02 17 78795652 78795652 1 - 0.000 0.573 14.014
ENSG00000055483 E008 2.3557917 0.0108415417 4.270152e-03 3.066258e-02 17 78795653 78795654 2 - 0.000 0.598 14.846
ENSG00000055483 E009 134.2585918 0.0027041979 3.806370e-05 6.606123e-04 17 78795655 78795842 188 - 1.936 2.123 0.627
ENSG00000055483 E010 640.8571890 0.0001269255 2.707033e-10 1.749968e-08 17 78795843 78796316 474 - 2.676 2.783 0.354
ENSG00000055483 E011 303.1033117 0.0010636899 1.518257e-05 3.012794e-04 17 78796317 78796494 178 - 2.340 2.462 0.408
ENSG00000055483 E012 407.3147595 0.0042887968 1.922380e-03 1.655331e-02 17 78796495 78796846 352 - 2.473 2.587 0.380
ENSG00000055483 E013 154.1654672 0.0004614742 1.225769e-01 3.198853e-01 17 78796847 78796882 36 - 2.099 2.153 0.179
ENSG00000055483 E014 132.2215489 0.0004866318 5.833646e-01 7.592404e-01 17 78796883 78796897 15 - 2.085 2.067 -0.058
ENSG00000055483 E015 248.9061394 0.0011009640 2.779884e-02 1.207007e-01 17 78796898 78797061 164 - 2.297 2.364 0.223
ENSG00000055483 E016 364.7252047 0.0002865182 3.405308e-03 2.579277e-02 17 78797062 78797401 340 - 2.465 2.532 0.225
ENSG00000055483 E017 238.9202147 0.0001988921 1.845508e-04 2.500876e-03 17 78797402 78797536 135 - 2.254 2.357 0.344
ENSG00000055483 E018 368.1226790 0.0011057207 2.298780e-04 2.999967e-03 17 78797537 78797785 249 - 2.442 2.542 0.333
ENSG00000055483 E019 241.2555338 0.0003047968 3.197417e-01 5.594794e-01 17 78797786 78797879 94 - 2.312 2.341 0.097
ENSG00000055483 E020 102.9231342 0.0006194770 6.233533e-01 7.861435e-01 17 78797880 78797902 23 - 1.976 1.959 -0.058
ENSG00000055483 E021 57.0968149 0.1169508421 3.587253e-01 5.947732e-01 17 78797903 78798399 497 - 1.785 1.682 -0.349
ENSG00000055483 E022 280.8535555 0.0075456277 3.194172e-01 5.591839e-01 17 78798400 78798551 152 - 2.357 2.411 0.180
ENSG00000055483 E023 252.2246567 0.0013621412 7.875692e-01 8.891299e-01 17 78798908 78799023 116 - 2.344 2.355 0.036
ENSG00000055483 E024 234.4692499 0.0003545239 6.861471e-01 8.265958e-01 17 78799667 78799768 102 - 2.313 2.327 0.046
ENSG00000055483 E025 264.7219358 0.0005143972 2.023215e-03 1.721417e-02 17 78802324 78802535 212 - 2.312 2.398 0.287
ENSG00000055483 E026 375.8814767 0.0002123019 4.900911e-02 1.772559e-01 17 78803385 78803803 419 - 2.495 2.539 0.148
ENSG00000055483 E027 158.0984262 0.0002954960 1.591271e-01 3.754692e-01 17 78803804 78803978 175 - 2.182 2.140 -0.140
ENSG00000055483 E028 141.6224080 0.0011327411 8.234800e-02 2.493830e-01 17 78806156 78806286 131 - 2.149 2.090 -0.197
ENSG00000055483 E029 1.8836958 0.1541939512 3.210970e-01 5.606397e-01 17 78806287 78806320 34 - 0.558 0.347 -1.093
ENSG00000055483 E030 587.4214489 0.0001050053 1.961449e-02 9.459014e-02 17 78806959 78807612 654 - 2.745 2.710 -0.117
ENSG00000055483 E031 155.9734429 0.0013209696 2.223341e-02 1.033884e-01 17 78807613 78807636 24 - 2.201 2.124 -0.257
ENSG00000055483 E032 215.8917903 0.0002366819 5.582047e-02 1.932207e-01 17 78812860 78812971 112 - 2.322 2.273 -0.162
ENSG00000055483 E033 152.5890255 0.0003291608 5.638619e-02 1.945365e-01 17 78812972 78813001 30 - 2.177 2.119 -0.195
ENSG00000055483 E034 209.9385158 0.0002817094 8.554731e-05 1.312469e-03 17 78813773 78813873 101 - 2.347 2.244 -0.346
ENSG00000055483 E035 253.6952654 0.0023636315 4.123410e-03 2.985758e-02 17 78814412 78814552 141 - 2.423 2.327 -0.321
ENSG00000055483 E036 223.4093134 0.0031216774 1.197055e-02 6.633794e-02 17 78818667 78818778 112 - 2.367 2.274 -0.310
ENSG00000055483 E037 0.0000000       17 78818779 78818943 165 -      
ENSG00000055483 E038 0.0000000       17 78819029 78819097 69 -      
ENSG00000055483 E039 164.0651790 0.0036758014 3.424093e-02 1.395129e-01 17 78819930 78820012 83 - 2.229 2.143 -0.287
ENSG00000055483 E040 136.2098682 0.0042271215 1.861783e-01 4.120398e-01 17 78820991 78821061 71 - 2.132 2.071 -0.204
ENSG00000055483 E041 1.6531178 0.3675044481 7.113195e-01 8.426346e-01 17 78821062 78821360 299 - 0.308 0.420 0.660
ENSG00000055483 E042 143.1212823 0.0003691367 2.714456e-02 1.187290e-01 17 78821937 78822004 68 - 2.160 2.090 -0.234
ENSG00000055483 E043 5.4633525 0.0719810347 4.173559e-02 1.592447e-01 17 78823113 78823121 9 - 0.996 0.655 -1.340
ENSG00000055483 E044 8.5877328 0.0680812704 1.357582e-01 3.409624e-01 17 78823122 78823183 62 - 1.097 0.863 -0.870
ENSG00000055483 E045 14.7310950 0.0958413899 5.166757e-02 1.836635e-01 17 78826473 78827244 772 - 1.345 1.043 -1.072
ENSG00000055483 E046 185.1246914 0.0006863000 1.061369e-01 2.925910e-01 17 78827245 78827347 103 - 2.253 2.205 -0.158
ENSG00000055483 E047 154.3849791 0.0005929291 3.681385e-02 1.464264e-01 17 78828897 78828945 49 - 2.187 2.121 -0.220
ENSG00000055483 E048 131.4152438 0.0003440192 2.417918e-01 4.785312e-01 17 78828946 78828991 46 - 2.098 2.060 -0.127
ENSG00000055483 E049 110.8961676 0.0004257893 3.449244e-01 5.824931e-01 17 78828992 78829003 12 - 2.022 1.989 -0.111
ENSG00000055483 E050 90.6245435 0.0004760481 2.399687e-01 4.766117e-01 17 78829004 78829007 4 - 1.946 1.900 -0.154
ENSG00000055483 E051 254.3201814 0.0002687900 2.888311e-04 3.616735e-03 17 78835280 78835501 222 - 2.421 2.334 -0.290
ENSG00000055483 E052 1.3651447 0.0382521844 8.861485e-01   17 78836025 78836110 86 - 0.312 0.341 0.179
ENSG00000055483 E053 112.8689472 0.0004850332 2.200977e-03 1.841192e-02 17 78836111 78836123 13 - 2.086 1.978 -0.364
ENSG00000055483 E054 128.5827072 0.0005070176 5.207320e-03 3.571722e-02 17 78836124 78836163 40 - 2.133 2.039 -0.313
ENSG00000055483 E055 129.2318994 0.0007312512 8.794537e-04 8.925570e-03 17 78836164 78836205 42 - 2.148 2.034 -0.380
ENSG00000055483 E056 133.0252429 0.0010584462 9.870056e-04 9.815969e-03 17 78836206 78836261 56 - 2.162 2.047 -0.383
ENSG00000055483 E057 188.0175062 0.0002531951 6.839464e-02 2.214782e-01 17 78836262 78836372 111 - 2.264 2.214 -0.166
ENSG00000055483 E058 168.7225502 0.0003453974 2.841818e-01 5.246859e-01 17 78838587 78838750 164 - 2.202 2.172 -0.103
ENSG00000055483 E059 3.0970460 0.0442654928 7.554099e-01 8.699130e-01 17 78838751 78838794 44 - 0.619 0.572 -0.209
ENSG00000055483 E060 0.9271035 0.0162732515 7.432074e-01   17 78840342 78840399 58 - 0.312 0.253 -0.413
ENSG00000055483 E061 2.5040358 0.0095064908 1.615882e-01 3.791138e-01 17 78840400 78840525 126 - 0.312 0.576 1.394
ENSG00000055483 E062 3.0102002 0.0121280651 2.506807e-01 4.887192e-01 17 78840526 78840735 210 - 0.411 0.619 1.001
ENSG00000055483 E063 71.8392944 0.0006231628 9.718802e-01 9.878544e-01 17 78840736 78840900 165 - 1.811 1.811 0.001
ENSG00000055483 E064 0.7119354 1.0608073709 1.625455e-01   17 78841011 78841260 250 - 0.512 0.000 -13.169
ENSG00000055483 E065 1.1404365 0.3716571073 5.957752e-01   17 78841261 78841441 181 - 0.420 0.249 -1.072