ENSG00000055163

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000520424 ENSG00000055163 HEK293_OSMI2_6hA HEK293_TMG_6hB CYFIP2 protein_coding retained_intron 29.3456 38.33781 21.11199 3.147789 0.1975099 -0.8603981 8.677668 11.54386 5.536659 1.2343397 0.8576411 -1.058684 0.28755417 0.30006667 0.2615667 -0.03850000 0.8409648073 0.0008789351 FALSE FALSE
ENST00000522637 ENSG00000055163 HEK293_OSMI2_6hA HEK293_TMG_6hB CYFIP2 protein_coding nonsense_mediated_decay 29.3456 38.33781 21.11199 3.147789 0.1975099 -0.8603981 1.139110 0.62676 2.855956 0.2316619 0.3295210 2.170195 0.04622917 0.01703333 0.1353000 0.11826667 0.0008789351 0.0008789351 FALSE FALSE
ENST00000620254 ENSG00000055163 HEK293_OSMI2_6hA HEK293_TMG_6hB CYFIP2 protein_coding protein_coding 29.3456 38.33781 21.11199 3.147789 0.1975099 -0.8603981 14.712057 20.29359 9.745555 2.4289569 0.3013951 -1.057439 0.49583750 0.52593333 0.4617000 -0.06423333 0.6204582992 0.0008789351 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000055163 E001 0.2027342 0.0344131214 1.0000000000   5 157266079 157266095 17 + 0.000 0.079 8.983
ENSG00000055163 E002 7.2301666 0.0250790038 0.3931822476 0.622930703 5 157266096 157266122 27 + 0.758 0.901 0.556
ENSG00000055163 E003 9.4373772 0.0064820064 0.6814648228 0.823589122 5 157266123 157266127 5 + 0.923 0.987 0.241
ENSG00000055163 E004 10.6511550 0.0160201544 0.6990139439 0.835001068 5 157266128 157266135 8 + 0.974 1.037 0.233
ENSG00000055163 E005 12.1816072 0.0209537912 0.9849664059 0.994305050 5 157266136 157266138 3 + 1.062 1.080 0.068
ENSG00000055163 E006 32.6478276 0.0250225176 0.6105164579 0.777308476 5 157266139 157266173 35 + 1.500 1.471 -0.100
ENSG00000055163 E007 49.0322443 0.0428330500 0.5519359195 0.737657931 5 157266174 157266195 22 + 1.678 1.637 -0.139
ENSG00000055163 E008 6.4839820 0.0153996783 0.0558516761 0.193297177 5 157266196 157266383 188 + 0.560 0.880 1.321
ENSG00000055163 E009 8.8608562 0.0057761427 0.0013190020 0.012302397 5 157266384 157266584 201 + 0.560 1.044 1.936
ENSG00000055163 E010 0.0000000       5 157266711 157266946 236 +      
ENSG00000055163 E011 0.0000000       5 157269342 157269374 33 +      
ENSG00000055163 E012 1.1132696 0.0142050504 0.9070972188   5 157269375 157269583 209 + 0.312 0.299 -0.090
ENSG00000055163 E013 0.0000000       5 157271409 157271576 168 +      
ENSG00000055163 E014 0.1614157 0.0327859156 0.1698827994   5 157277059 157277173 115 + 0.184 0.000 -13.674
ENSG00000055163 E015 144.7215013 0.0201325034 0.1865249698 0.412477618 5 157285339 157285478 140 + 2.167 2.090 -0.259
ENSG00000055163 E016 138.6329409 0.0067611361 0.0565309719 0.194905352 5 157287019 157287074 56 + 2.150 2.071 -0.265
ENSG00000055163 E017 102.5119643 0.0005807229 0.0384483122 0.150745896 5 157287075 157287108 34 + 2.011 1.947 -0.215
ENSG00000055163 E018 0.2617363 0.1849690712 0.7286733844   5 157288612 157288659 48 + 0.000 0.142 11.409
ENSG00000055163 E019 129.1201477 0.0003993709 0.0011379630 0.010952835 5 157294783 157294860 78 + 2.131 2.036 -0.318
ENSG00000055163 E020 150.0780191 0.0002952513 0.0197231524 0.094973911 5 157296673 157296774 102 + 2.168 2.110 -0.194
ENSG00000055163 E021 146.6819738 0.0009784110 0.0125715446 0.068724849 5 157300715 157300817 103 + 2.167 2.098 -0.230
ENSG00000055163 E022 141.5203872 0.0019157290 0.0560535453 0.193773798 5 157300818 157300896 79 + 2.138 2.083 -0.185
ENSG00000055163 E023 180.4330063 0.0052031275 0.0014707960 0.013410738 5 157302794 157302890 97 + 2.291 2.168 -0.412
ENSG00000055163 E024 0.3336024 0.0244411696 0.6578927139   5 157302891 157303123 233 + 0.000 0.145 12.384
ENSG00000055163 E025 112.4905134 0.0040958046 0.0002520485 0.003241963 5 157304238 157304249 12 + 2.106 1.953 -0.513
ENSG00000055163 E026 179.5508173 0.0090174727 0.0021091101 0.017799304 5 157304250 157304366 117 + 2.305 2.158 -0.490
ENSG00000055163 E027 4.4004080 0.0082854006 0.6845425545 0.825640942 5 157304367 157304782 416 + 0.619 0.696 0.329
ENSG00000055163 E028 121.2343834 0.0010014501 0.0007305340 0.007700898 5 157307761 157307865 105 + 2.109 1.999 -0.367
ENSG00000055163 E029 108.3418147 0.0014699739 0.0269586973 0.118189974 5 157309743 157309834 92 + 2.035 1.961 -0.249
ENSG00000055163 E030 4.2366698 0.1108688320 0.6734614541 0.818586253 5 157311038 157311663 626 + 0.720 0.659 -0.257
ENSG00000055163 E031 130.0318017 0.0017718699 0.4695641380 0.679704751 5 157311664 157311781 118 + 2.073 2.060 -0.044
ENSG00000055163 E032 149.2378491 0.0028007894 0.6370125433 0.795057349 5 157314344 157314463 120 + 2.124 2.120 -0.010
ENSG00000055163 E033 168.5773140 0.0009439419 0.2376458012 0.473849042 5 157314969 157315094 126 + 2.189 2.167 -0.076
ENSG00000055163 E034 206.1867542 0.0011971699 0.5078585637 0.706327053 5 157319762 157319928 167 + 2.263 2.259 -0.013
ENSG00000055163 E035 181.0551702 0.0003137651 0.2388027341 0.475257488 5 157320655 157320802 148 + 2.221 2.202 -0.063
ENSG00000055163 E036 0.0000000       5 157322942 157323016 75 +      
ENSG00000055163 E037 195.9343694 0.0002383882 0.0039677097 0.028969791 5 157323921 157324074 154 + 2.287 2.223 -0.214
ENSG00000055163 E038 0.2027342 0.0344131214 1.0000000000   5 157324771 157324900 130 + 0.000 0.079 11.246
ENSG00000055163 E039 224.6847792 0.0006169863 0.0040182740 0.029268512 5 157325482 157325599 118 + 2.343 2.280 -0.210
ENSG00000055163 E040 158.9649956 0.0018066541 0.2608004548 0.499805572 5 157325600 157325638 39 + 2.165 2.142 -0.077
ENSG00000055163 E041 9.0198182 0.0944547025 0.1328408882 0.336281406 5 157325639 157326170 532 + 1.115 0.884 -0.854
ENSG00000055163 E042 216.1114017 0.0003020381 0.8627425270 0.931877602 5 157326171 157326267 97 + 2.265 2.287 0.072
ENSG00000055163 E043 0.6368449 0.0189220009 0.2490197822   5 157327925 157327972 48 + 0.000 0.253 13.469
ENSG00000055163 E044 182.3312013 0.0100435988 0.7387677259 0.859682925 5 157327973 157328049 77 + 2.184 2.219 0.119
ENSG00000055163 E045 241.5756785 0.0062684243 0.6322459832 0.791832233 5 157330742 157330850 109 + 2.303 2.342 0.130
ENSG00000055163 E046 237.7985157 0.0021384004 0.5675294473 0.748439540 5 157333327 157333446 120 + 2.297 2.334 0.124
ENSG00000055163 E047 344.9611758 0.0004555712 0.6714409126 0.817206215 5 157339057 157339256 200 + 2.466 2.493 0.091
ENSG00000055163 E048 241.9131369 0.0002987314 0.4178071970 0.641985466 5 157341070 157341157 88 + 2.303 2.342 0.129
ENSG00000055163 E049 300.8324092 0.0015166716 0.0182949304 0.090008111 5 157359005 157359148 144 + 2.363 2.451 0.292
ENSG00000055163 E050 216.5398035 0.0595591122 0.0717344065 0.228283437 5 157360282 157360372 91 + 2.126 2.332 0.690
ENSG00000055163 E051 0.2922838 0.0265701914 0.4564069428   5 157361405 157361467 63 + 0.184 0.078 -1.416
ENSG00000055163 E052 251.8698520 1.2332045026 0.4181740283 0.642278549 5 157361468 157361598 131 + 2.154 2.405 0.837
ENSG00000055163 E053 173.3118226 0.0630781610 0.0919469851 0.267306563 5 157382590 157382662 73 + 2.033 2.235 0.675
ENSG00000055163 E054 0.0000000       5 157383232 157383237 6 +      
ENSG00000055163 E055 0.0000000       5 157383238 157383255 18 +      
ENSG00000055163 E056 0.4349185 0.0217681645 0.1504139830   5 157383256 157383264 9 + 0.312 0.078 -2.414
ENSG00000055163 E057 209.7685148 0.0192857662 0.1098732557 0.298802260 5 157383265 157383359 95 + 2.173 2.303 0.434
ENSG00000055163 E058 0.5177432 0.0221793634 0.7897890937   5 157383360 157383580 221 + 0.184 0.145 -0.408
ENSG00000055163 E059 1.2039167 0.0228891465 0.9115827066   5 157384306 157384530 225 + 0.312 0.299 -0.087
ENSG00000055163 E060 300.6475854 0.0022940444 0.0001333571 0.001902319 5 157389189 157389427 239 + 2.314 2.461 0.491
ENSG00000055163 E061 2.0585339 0.2593485348 0.9236186573 0.964179097 5 157389428 157389628 201 + 0.414 0.469 0.283
ENSG00000055163 E062 233.3395925 0.0012464855 0.0001056331 0.001566582 5 157390521 157390668 148 + 2.207 2.350 0.477
ENSG00000055163 E063 727.7064235 0.0005410403 0.0682345480 0.221094725 5 157392833 157395595 2763 + 2.771 2.821 0.168