ENSG00000054118

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354618 ENSG00000054118 HEK293_OSMI2_6hA HEK293_TMG_6hB THRAP3 protein_coding protein_coding 71.49287 63.51207 89.61719 10.46744 4.678144 0.4966784 45.016345 48.8179286 49.301687 8.8607284 0.3483232 0.01422302 0.64999167 0.764533333 0.55286667 -0.2116667 9.733404e-05 1.970199e-07 FALSE TRUE
MSTRG.844.1 ENSG00000054118 HEK293_OSMI2_6hA HEK293_TMG_6hB THRAP3 protein_coding   71.49287 63.51207 89.61719 10.46744 4.678144 0.4966784 5.754061 1.6800001 13.563471 0.5031468 0.8573198 3.00569445 0.07031667 0.025466667 0.15116667 0.1257000 1.970199e-07 1.970199e-07 FALSE TRUE
MSTRG.844.6 ENSG00000054118 HEK293_OSMI2_6hA HEK293_TMG_6hB THRAP3 protein_coding   71.49287 63.51207 89.61719 10.46744 4.678144 0.4966784 6.522305 9.1708598 4.033537 1.3846329 1.6550424 -1.18301130 0.10047083 0.145000000 0.04333333 -0.1016667 1.164736e-01 1.970199e-07 FALSE TRUE
MSTRG.844.8 ENSG00000054118 HEK293_OSMI2_6hA HEK293_TMG_6hB THRAP3 protein_coding   71.49287 63.51207 89.61719 10.46744 4.678144 0.4966784 6.276168 0.2933285 12.479986 0.2933285 0.9269843 5.36374706 0.07570000 0.006433333 0.13890000 0.1324667 3.393037e-02 1.970199e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000054118 E001 1.1484311 1.436648e-02 2.849243e-02   1 36224329 36224401 73 + 0.110 0.500 2.909
ENSG00000054118 E002 1.1739893 1.563257e-02 1.701077e-01   1 36224402 36224404 3 + 0.198 0.448 1.650
ENSG00000054118 E003 1.6254760 1.182025e-02 3.625837e-01 5.978158e-01 1 36224405 36224407 3 + 0.333 0.501 0.911
ENSG00000054118 E004 3.7858263 6.526123e-03 8.065535e-01 9.000576e-01 1 36224408 36224423 16 + 0.649 0.697 0.202
ENSG00000054118 E005 5.0888462 5.606188e-03 7.287788e-01 8.534701e-01 1 36224424 36224431 8 + 0.749 0.808 0.235
ENSG00000054118 E006 5.0888462 5.606188e-03 7.287788e-01 8.534701e-01 1 36224432 36224432 1 + 0.749 0.808 0.235
ENSG00000054118 E007 19.1220633 2.547730e-03 5.037416e-01 7.034168e-01 1 36224433 36224442 10 + 1.319 1.280 -0.137
ENSG00000054118 E008 165.5589305 5.629317e-03 9.233045e-02 2.680601e-01 1 36224443 36224505 63 + 2.247 2.185 -0.207
ENSG00000054118 E009 6.2272234 2.131067e-02 1.737363e-02 8.682369e-02 1 36224844 36224928 85 + 0.677 1.015 1.318
ENSG00000054118 E010 5.5084636 7.597431e-03 2.923338e-02 1.250783e-01 1 36224929 36224970 42 + 0.649 0.951 1.198
ENSG00000054118 E011 13.9068290 4.370635e-03 9.832620e-02 2.788446e-01 1 36224971 36225102 132 + 1.078 1.247 0.603
ENSG00000054118 E012 7.0526808 1.810463e-02 9.818610e-01 9.927340e-01 1 36225412 36225463 52 + 0.897 0.915 0.068
ENSG00000054118 E013 0.1308682 3.085764e-02 4.075963e-01   1 36238021 36238110 90 + 0.000 0.134 9.685
ENSG00000054118 E014 284.5980700 2.768073e-03 2.591383e-02 1.150256e-01 1 36259382 36259484 103 + 2.479 2.421 -0.193
ENSG00000054118 E015 492.1374093 1.266966e-04 1.140586e-10 7.994129e-09 1 36282533 36282700 168 + 2.727 2.637 -0.302
ENSG00000054118 E016 1637.8714911 8.937655e-05 4.859926e-21 1.618289e-18 1 36286368 36287270 903 + 3.240 3.170 -0.231
ENSG00000054118 E017 1536.0738985 5.237388e-04 7.788992e-07 2.286122e-05 1 36289060 36289717 658 + 3.203 3.156 -0.155
ENSG00000054118 E018 381.1644763 1.805645e-04 4.332255e-02 1.633982e-01 1 36289718 36289764 47 + 2.586 2.563 -0.074
ENSG00000054118 E019 665.0635217 2.807569e-04 7.513132e-05 1.177618e-03 1 36291374 36291546 173 + 2.837 2.792 -0.150
ENSG00000054118 E020 553.2912951 4.682333e-04 3.321751e-04 4.059219e-03 1 36292598 36292709 112 + 2.759 2.712 -0.157
ENSG00000054118 E021 509.7658220 1.386009e-03 3.215908e-01 5.611112e-01 1 36293851 36293935 85 + 2.706 2.703 -0.009
ENSG00000054118 E022 12.1167172 7.708839e-02 1.149422e-01 3.073839e-01 1 36293936 36294049 114 + 1.205 0.970 -0.852
ENSG00000054118 E023 30.2645558 3.252879e-02 9.843546e-03 5.744933e-02 1 36294050 36294241 192 + 1.592 1.321 -0.934
ENSG00000054118 E024 826.0858930 3.922073e-04 2.632914e-02 1.162788e-01 1 36296583 36296770 188 + 2.921 2.905 -0.053
ENSG00000054118 E025 880.3216032 8.989400e-05 5.625146e-01 7.450668e-01 1 36300886 36301084 199 + 2.936 2.945 0.030
ENSG00000054118 E026 216.8407911 2.702888e-04 2.607137e-01 4.997095e-01 1 36301553 36301555 3 + 2.337 2.324 -0.041
ENSG00000054118 E027 685.8546182 9.616989e-05 3.323738e-01 5.711532e-01 1 36301556 36301696 141 + 2.818 2.848 0.098
ENSG00000054118 E028 388.5540920 2.325985e-04 5.096638e-03 3.514257e-02 1 36303796 36303831 36 + 2.554 2.623 0.230
ENSG00000054118 E029 1178.3216638 8.766592e-04 6.025659e-23 2.471728e-20 1 36303832 36304473 642 + 2.974 3.159 0.616
ENSG00000054118 E030 1338.4401147 1.318120e-03 1.123539e-22 4.437274e-20 1 36304474 36305357 884 + 3.018 3.223 0.683