ENSG00000051523

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261623 ENSG00000051523 HEK293_OSMI2_6hA HEK293_TMG_6hB CYBA protein_coding protein_coding 320.0799 473.8498 142.54 70.62677 5.786773 -1.732993 287.98254 434.82814 104.93390 69.394020 1.279227 -2.050860 0.87545 0.91410000 0.7389 -0.1752000 0.000801353 0.000801353 FALSE TRUE
ENST00000565588 ENSG00000051523 HEK293_OSMI2_6hA HEK293_TMG_6hB CYBA protein_coding protein_coding 320.0799 473.8498 142.54 70.62677 5.786773 -1.732993 11.61267 12.05501 21.74708 3.352454 6.761293 0.850656 0.04640 0.02436667 0.1492 0.1248333 0.002670126 0.000801353 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000051523 E001 2.643534 8.425899e-03 3.137455e-01 5.539730e-01 16 88643275 88643288 14 - 0.635 0.459 -0.819
ENSG00000051523 E002 6.487777 4.504346e-03 6.536331e-01 8.058592e-01 16 88643289 88643289 1 - 0.843 0.779 -0.252
ENSG00000051523 E003 1145.689412 2.874670e-03 9.747599e-08 3.625419e-06 16 88643290 88643513 224 - 2.826 2.978 0.506
ENSG00000051523 E004 1042.967011 9.579572e-04 1.130591e-06 3.159460e-05 16 88643514 88643539 26 - 2.833 2.930 0.321
ENSG00000051523 E005 1193.680083 4.630713e-04 3.329090e-04 4.067018e-03 16 88643540 88643571 32 - 2.927 2.983 0.187
ENSG00000051523 E006 11.845784 9.463693e-02 6.743214e-01 8.190955e-01 16 88643572 88643581 10 - 0.976 1.029 0.195
ENSG00000051523 E007 114.204985 3.384220e-02 2.479332e-02 1.115860e-01 16 88643582 88644022 441 - 2.125 1.905 -0.736
ENSG00000051523 E008 68.933824 3.099127e-02 6.746732e-02 2.193789e-01 16 88644023 88644178 156 - 1.883 1.697 -0.626
ENSG00000051523 E009 53.185832 4.546092e-02 2.647334e-02 1.166892e-01 16 88644179 88644247 69 - 1.828 1.565 -0.892
ENSG00000051523 E010 43.163819 4.979436e-02 3.918736e-02 1.526602e-01 16 88644248 88644274 27 - 1.738 1.478 -0.887
ENSG00000051523 E011 33.663822 6.164135e-02 2.727173e-02 1.190950e-01 16 88644275 88644287 13 - 1.670 1.357 -1.074
ENSG00000051523 E012 121.458735 3.049538e-02 3.164216e-03 2.439684e-02 16 88644288 88644741 454 - 2.192 1.915 -0.928
ENSG00000051523 E013 30.465884 4.595262e-02 2.055895e-01 4.365597e-01 16 88644742 88644821 80 - 1.529 1.357 -0.594
ENSG00000051523 E014 85.920032 4.631455e-02 1.013787e-02 5.872908e-02 16 88644822 88645086 265 - 2.053 1.761 -0.980
ENSG00000051523 E015 101.861808 3.640964e-02 9.819415e-03 5.734988e-02 16 88645087 88645429 343 - 2.107 1.843 -0.886
ENSG00000051523 E016 130.962272 2.330663e-02 1.054779e-04 1.564442e-03 16 88645430 88645964 535 - 2.257 1.932 -1.088
ENSG00000051523 E017 56.955775 1.954640e-02 5.072766e-03 3.501066e-02 16 88645965 88646115 151 - 1.845 1.598 -0.838
ENSG00000051523 E018 1157.873220 1.724944e-04 2.268284e-02 1.049038e-01 16 88646116 88646131 16 - 2.935 2.966 0.103
ENSG00000051523 E019 1113.938085 1.402326e-04 1.135708e-01 3.050957e-01 16 88646132 88646140 9 - 2.927 2.948 0.070
ENSG00000051523 E020 1699.700202 4.889228e-04 2.736987e-02 1.193977e-01 16 88646141 88646197 57 - 3.102 3.131 0.095
ENSG00000051523 E021 20.318844 1.492235e-01 1.912010e-02 9.287164e-02 16 88646198 88646519 322 - 1.540 1.109 -1.504
ENSG00000051523 E022 10.351331 4.154511e-02 6.861318e-03 4.399674e-02 16 88646520 88646603 84 - 1.243 0.855 -1.421
ENSG00000051523 E023 17.384145 5.052217e-02 3.067773e-01 5.473980e-01 16 88646604 88646754 151 - 1.276 1.129 -0.522
ENSG00000051523 E024 1466.341439 1.954678e-03 4.962634e-01 6.983834e-01 16 88646755 88646787 33 - 3.052 3.062 0.034
ENSG00000051523 E025 2128.203949 5.358121e-05 3.702671e-02 1.469689e-01 16 88646788 88646838 51 - 3.242 3.221 -0.071
ENSG00000051523 E026 60.753807 7.605600e-04 1.989476e-01 4.283960e-01 16 88646839 88646968 130 - 1.743 1.670 -0.247
ENSG00000051523 E027 26.637957 1.925582e-02 9.296250e-01 9.668231e-01 16 88646969 88647100 132 - 1.349 1.330 -0.065
ENSG00000051523 E028 2183.112642 1.498029e-04 7.905947e-03 4.888446e-02 16 88647101 88647175 75 - 3.259 3.228 -0.102
ENSG00000051523 E029 1761.224928 7.667867e-04 5.065438e-02 1.812227e-01 16 88648045 88648114 70 - 3.169 3.133 -0.121
ENSG00000051523 E030 12.269731 1.103293e-01 7.412811e-03 4.662121e-02 16 88650253 88650314 62 - 1.365 0.882 -1.743
ENSG00000051523 E031 1614.950778 1.034768e-04 4.983293e-01 6.996863e-01 16 88650956 88651083 128 - 3.112 3.103 -0.031