ENSG00000050767

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000390654 ENSG00000050767 HEK293_OSMI2_6hA HEK293_TMG_6hB COL23A1 protein_coding protein_coding 1.11211 1.381517 1.027121 0.1244315 0.2333793 -0.4240733 0.5932932 0.7533786 0.1010381 0.1488570 0.04072637 -2.7813444 0.57363333 0.5612000 0.09206667 -0.46913333 0.03413137 0.03413137 FALSE TRUE
ENST00000679888 ENSG00000050767 HEK293_OSMI2_6hA HEK293_TMG_6hB COL23A1 protein_coding processed_transcript 1.11211 1.381517 1.027121 0.1244315 0.2333793 -0.4240733 0.1711998 0.0000000 0.2477096 0.0000000 0.14317736 4.6876744 0.12777083 0.0000000 0.20373333 0.20373333 0.14450875 0.03413137   FALSE
ENST00000679896 ENSG00000050767 HEK293_OSMI2_6hA HEK293_TMG_6hB COL23A1 protein_coding nonsense_mediated_decay 1.11211 1.381517 1.027121 0.1244315 0.2333793 -0.4240733 0.1312174 0.2198278 0.4121602 0.2198278 0.13508564 0.8772374 0.12837917 0.1348667 0.49883333 0.36396667 0.45104870 0.03413137 FALSE TRUE
ENST00000681261 ENSG00000050767 HEK293_OSMI2_6hA HEK293_TMG_6hB COL23A1 protein_coding nonsense_mediated_decay 1.11211 1.381517 1.027121 0.1244315 0.2333793 -0.4240733 0.0569878 0.0000000 0.0000000 0.0000000 0.00000000 0.0000000 0.05162917 0.0000000 0.00000000 0.00000000   0.03413137 FALSE TRUE
MSTRG.27418.8 ENSG00000050767 HEK293_OSMI2_6hA HEK293_TMG_6hB COL23A1 protein_coding   1.11211 1.381517 1.027121 0.1244315 0.2333793 -0.4240733 0.1397597 0.4083103 0.2662136 0.1279343 0.18628044 -0.5987889 0.10257083 0.3039333 0.20536667 -0.09856667 0.88242125 0.03413137 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000050767 E001 1.4638154 0.015868654 0.45029586 0.66593949 5 178237476 178237617 142 - 0.454 0.329 -0.703
ENSG00000050767 E002 0.4646582 0.022675639 1.00000000   5 178237618 178237633 16 - 0.164 0.162 -0.027
ENSG00000050767 E003 21.8123256 0.311378902 0.36969698 0.60376446 5 178237634 178238270 637 - 1.216 1.380 0.576
ENSG00000050767 E004 16.7997129 0.278128713 0.87409774 0.93826458 5 178238271 178238700 430 - 1.259 1.208 -0.179
ENSG00000050767 E005 3.2445298 0.130291070 0.89833768 0.95095214 5 178239141 178239179 39 - 0.571 0.609 0.169
ENSG00000050767 E006 6.8086302 0.005548756 0.66572212 0.81346184 5 178242042 178242128 87 - 0.814 0.879 0.253
ENSG00000050767 E007 5.9813700 0.005312290 0.71832700 0.84718905 5 178242341 178242394 54 - 0.782 0.838 0.219
ENSG00000050767 E008 0.3807181 0.027021939 0.58999898   5 178245771 178245875 105 - 0.165 0.089 -1.024
ENSG00000050767 E009 6.4206104 0.004772398 0.26579017 0.50523665 5 178245942 178245968 27 - 0.922 0.793 -0.499
ENSG00000050767 E010 6.5705671 0.004624332 0.56920991 0.74968048 5 178246254 178246307 54 - 0.898 0.837 -0.232
ENSG00000050767 E011 7.0660625 0.005281598 0.97456612 0.98912186 5 178246391 178246453 63 - 0.872 0.879 0.026
ENSG00000050767 E012 5.7392722 0.005447602 0.62684579 0.78842474 5 178247526 178247552 27 - 0.748 0.823 0.298
ENSG00000050767 E013 6.1779243 0.004553107 0.02078524 0.09863115 5 178247775 178247831 57 - 0.575 0.916 1.390
ENSG00000050767 E014 7.4855085 0.004327768 0.20602170 0.43705075 5 178248192 178248254 63 - 0.782 0.950 0.647
ENSG00000050767 E015 9.8966913 0.035606136 0.89925729 0.95147693 5 178249117 178249206 90 - 1.008 0.999 -0.035
ENSG00000050767 E016 7.3085904 0.031571666 0.40319883 0.63087303 5 178250061 178250105 45 - 0.946 0.844 -0.388
ENSG00000050767 E017 7.2367243 0.007238777 0.33944006 0.57749256 5 178252544 178252597 54 - 0.946 0.839 -0.407
ENSG00000050767 E018 7.1414632 0.004994914 0.11176003 0.30201812 5 178254949 178255026 78 - 0.989 0.809 -0.684
ENSG00000050767 E019 0.0000000       5 178255787 178255889 103 -      
ENSG00000050767 E020 6.7457408 0.004932161 0.04319892 0.16307645 5 178256353 178256397 45 - 1.009 0.776 -0.888
ENSG00000050767 E021 5.2110842 0.005778439 0.33830984 0.57649955 5 178256866 178256928 63 - 0.844 0.724 -0.476
ENSG00000050767 E022 6.2902374 0.004606788 0.25934184 0.49827704 5 178257523 178257567 45 - 0.922 0.793 -0.501
ENSG00000050767 E023 4.5942377 0.005642283 0.71409484 0.84439087 5 178259721 178259747 27 - 0.748 0.705 -0.176
ENSG00000050767 E024 5.5151842 0.005564368 0.71861743 0.84735667 5 178261722 178261748 27 - 0.815 0.776 -0.151
ENSG00000050767 E025 4.1397304 0.007127698 0.36339278 0.59847316 5 178262217 178262252 36 - 0.575 0.724 0.640
ENSG00000050767 E026 6.0136461 0.005674448 0.42880591 0.65019860 5 178263208 178263324 117 - 0.748 0.865 0.458
ENSG00000050767 E027 0.0000000       5 178265655 178265834 180 -      
ENSG00000050767 E028 2.2479090 0.010419019 0.37280020 0.60630774 5 178267307 178267333 27 - 0.377 0.542 0.847
ENSG00000050767 E029 3.7595801 0.010980412 0.75470389 0.86950027 5 178268730 178268756 27 - 0.626 0.684 0.249
ENSG00000050767 E030 3.5026455 0.054657255 0.70619948 0.83948170 5 178270337 178270363 27 - 0.577 0.661 0.366
ENSG00000050767 E031 1.4578306 0.012240493 0.13862964 0.34543603 5 178288324 178288350 27 - 0.164 0.449 1.976
ENSG00000050767 E032 2.0169079 0.013741242 0.49908373 0.70016154 5 178290362 178290369 8 - 0.519 0.413 -0.538
ENSG00000050767 E033 3.5698976 0.007582767 0.68739497 0.82742997 5 178306875 178306919 45 - 0.671 0.620 -0.219
ENSG00000050767 E034 0.0000000       5 178523505 178523713 209 -      
ENSG00000050767 E035 2.7833357 0.010664583 0.68702206 0.82719112 5 178560682 178560748 67 - 0.519 0.595 0.349
ENSG00000050767 E036 0.1723744 0.030830806 1.00000000   5 178561844 178562006 163 - 0.000 0.089 9.371
ENSG00000050767 E037 0.1723744 0.030830806 1.00000000   5 178562026 178562238 213 - 0.000 0.089 9.371
ENSG00000050767 E038 0.0000000       5 178562598 178562726 129 -      
ENSG00000050767 E039 0.0000000       5 178577503 178577718 216 -      
ENSG00000050767 E040 3.3660952 0.048765722 0.10769577 0.29521117 5 178589904 178590393 490 - 0.377 0.704 1.556