ENSG00000050393

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379170 ENSG00000050393 HEK293_OSMI2_6hA HEK293_TMG_6hB MCUR1 protein_coding protein_coding 24.58082 17.17535 27.55412 3.579853 1.436041 0.6816121 5.855125 2.928104 7.472466 0.6924041 0.1854311 1.3486286 0.2265875 0.1676667 0.27210000 0.1044333 1.259684e-02 4.666077e-30 FALSE TRUE
ENST00000607303 ENSG00000050393 HEK293_OSMI2_6hA HEK293_TMG_6hB MCUR1 protein_coding protein_coding 24.58082 17.17535 27.55412 3.579853 1.436041 0.6816121 8.334632 4.295967 11.735860 1.0995080 1.2210135 1.4477432 0.3315625 0.2436333 0.42350000 0.1798667 4.735094e-03 4.666077e-30 FALSE TRUE
MSTRG.27669.11 ENSG00000050393 HEK293_OSMI2_6hA HEK293_TMG_6hB MCUR1 protein_coding   24.58082 17.17535 27.55412 3.579853 1.436041 0.6816121 5.204652 1.942097 5.706959 1.9420969 1.2798315 1.5502232 0.2065208 0.1071333 0.21040000 0.1032667 3.268957e-01 4.666077e-30 FALSE TRUE
MSTRG.27669.13 ENSG00000050393 HEK293_OSMI2_6hA HEK293_TMG_6hB MCUR1 protein_coding   24.58082 17.17535 27.55412 3.579853 1.436041 0.6816121 2.237087 3.648104 2.227878 2.1268290 0.9721250 -0.7089647 0.1018417 0.2204667 0.07943333 -0.1410333 9.209383e-01 4.666077e-30 FALSE TRUE
MSTRG.27669.4 ENSG00000050393 HEK293_OSMI2_6hA HEK293_TMG_6hB MCUR1 protein_coding   24.58082 17.17535 27.55412 3.579853 1.436041 0.6816121 2.675518 4.117683 0.000000 0.6946978 0.0000000 -8.6891885 0.1221167 0.2468000 0.00000000 -0.2468000 4.666077e-30 4.666077e-30 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000050393 E001 1.1894103 0.5858350426 8.669366e-01   6 13712421 13712541 121 - 0.409 0.245 -1.044
ENSG00000050393 E002 32.9314128 0.0029304522 6.967202e-01 8.334679e-01 6 13786557 13787049 493 - 1.508 1.548 0.138
ENSG00000050393 E003 31.5984449 0.0050609641 6.278336e-01 7.890924e-01 6 13787050 13787097 48 - 1.518 1.498 -0.069
ENSG00000050393 E004 36.9702656 0.0010334550 6.841373e-01 8.253741e-01 6 13787098 13787133 36 - 1.579 1.571 -0.029
ENSG00000050393 E005 32.7821613 0.0012485418 3.036117e-01 5.441716e-01 6 13787134 13787144 11 - 1.543 1.494 -0.168
ENSG00000050393 E006 45.9526080 0.0008391585 7.473115e-01 8.651026e-01 6 13787145 13787171 27 - 1.670 1.669 -0.004
ENSG00000050393 E007 86.9961455 0.0006328953 3.432558e-02 1.397472e-01 6 13787172 13787355 184 - 1.973 1.908 -0.219
ENSG00000050393 E008 173.8382744 0.0008162195 6.123880e-11 4.531264e-09 6 13787356 13788226 871 - 2.308 2.130 -0.594
ENSG00000050393 E009 69.2466813 0.0005743266 7.018719e-05 1.111988e-03 6 13788227 13788550 324 - 1.908 1.751 -0.529
ENSG00000050393 E010 30.5002895 0.0015291245 1.306789e-03 1.221325e-02 6 13788551 13788645 95 - 1.576 1.380 -0.674
ENSG00000050393 E011 25.4431092 0.0037831478 4.216394e-03 3.035357e-02 6 13788646 13788704 59 - 1.499 1.298 -0.697
ENSG00000050393 E012 155.7860401 0.0012303546 4.360005e-17 8.752117e-15 6 13788705 13789951 1247 - 2.289 2.025 -0.883
ENSG00000050393 E013 95.4604888 0.0007505695 9.335539e-18 2.056276e-15 6 13789952 13790571 620 - 2.094 1.768 -1.096
ENSG00000050393 E014 10.2409913 0.0036294702 1.011384e-01 2.838477e-01 6 13790572 13790640 69 - 1.109 0.950 -0.583
ENSG00000050393 E015 22.4549028 0.0018826015 1.378908e-03 1.275159e-02 6 13790641 13790787 147 - 1.448 1.217 -0.806
ENSG00000050393 E016 74.4292322 0.0006472639 3.562661e-02 1.432682e-01 6 13790788 13790864 77 - 1.831 1.933 0.345
ENSG00000050393 E017 172.8247027 0.0003071295 4.249469e-04 4.976263e-03 6 13791878 13791992 115 - 2.189 2.299 0.368
ENSG00000050393 E018 175.3488681 0.0003966891 1.121723e-01 3.027420e-01 6 13793894 13793947 54 - 2.221 2.280 0.196
ENSG00000050393 E019 230.5460619 0.0002278482 7.386612e-01 8.596606e-01 6 13798833 13798904 72 - 2.355 2.379 0.079
ENSG00000050393 E020 195.6004509 0.0002770256 2.586191e-01 4.974343e-01 6 13800341 13800382 42 - 2.275 2.319 0.147
ENSG00000050393 E021 242.6488087 0.0002680243 1.778956e-02 8.832414e-02 6 13801288 13801389 102 - 2.356 2.424 0.229
ENSG00000050393 E022 238.4987801 0.0012950501 5.482144e-03 3.711802e-02 6 13802243 13802346 104 - 2.337 2.423 0.288
ENSG00000050393 E023 0.3503582 0.0501337187 8.343754e-01   6 13803730 13804315 586 - 0.106 0.139 0.452
ENSG00000050393 E024 181.4574275 0.0041595017 1.303682e-03 1.219167e-02 6 13806925 13807044 120 - 2.197 2.328 0.440
ENSG00000050393 E025 2.4040457 0.0096734460 3.098219e-01 5.502843e-01 6 13810422 13810498 77 - 0.467 0.642 0.813
ENSG00000050393 E026 5.0978182 0.0057119521 1.322738e-02 7.136135e-02 6 13810499 13810600 102 - 0.606 0.950 1.384
ENSG00000050393 E027 0.6268817 0.1840937448 1.077907e-01   6 13810601 13810602 2 - 0.322 0.000 -10.715
ENSG00000050393 E028 124.5776587 0.0118740079 6.640860e-12 5.910749e-10 6 13814015 13815400 1386 - 1.863 2.289 1.427