ENSG00000049883

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308077 ENSG00000049883 HEK293_OSMI2_6hA HEK293_TMG_6hB PTCD2 protein_coding nonsense_mediated_decay 3.494894 1.633347 4.758346 0.2200638 0.4836124 1.536852 1.0425276 0.6802448 1.4134411 0.01479068 0.1250347 1.04420276 0.2986417 0.43413333 0.30073333 -0.133400000 5.980535e-01 2.362201e-05 TRUE TRUE
ENST00000380639 ENSG00000049883 HEK293_OSMI2_6hA HEK293_TMG_6hB PTCD2 protein_coding protein_coding 3.494894 1.633347 4.758346 0.2200638 0.4836124 1.536852 0.3049681 0.1741801 0.1835961 0.08609955 0.1366204 0.07193289 0.1418667 0.09703333 0.04350000 -0.053533333 6.926621e-01 2.362201e-05 FALSE TRUE
ENST00000510676 ENSG00000049883 HEK293_OSMI2_6hA HEK293_TMG_6hB PTCD2 protein_coding protein_coding 3.494894 1.633347 4.758346 0.2200638 0.4836124 1.536852 0.2083605 0.0000000 0.7521166 0.00000000 0.0965993 6.25193993 0.0474250 0.00000000 0.15923333 0.159233333 2.362201e-05 2.362201e-05 FALSE TRUE
ENST00000511752 ENSG00000049883 HEK293_OSMI2_6hA HEK293_TMG_6hB PTCD2 protein_coding nonsense_mediated_decay 3.494894 1.633347 4.758346 0.2200638 0.4836124 1.536852 0.4186482 0.0000000 0.3886497 0.00000000 0.3886497 5.31704976 0.0827875 0.00000000 0.06793333 0.067933333 9.643501e-01 2.362201e-05 FALSE FALSE
ENST00000543322 ENSG00000049883 HEK293_OSMI2_6hA HEK293_TMG_6hB PTCD2 protein_coding protein_coding 3.494894 1.633347 4.758346 0.2200638 0.4836124 1.536852 1.2386682 0.6361434 1.7689146 0.13768097 0.1227495 1.46107102 0.3388375 0.38026667 0.37663333 -0.003633333 1.000000e+00 2.362201e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000049883 E001 0.1426347 0.030749077 0.682295009   5 72320367 72320367 1 + 0.088 0.000 -11.982
ENSG00000049883 E002 0.1426347 0.030749077 0.682295009   5 72320368 72320372 5 + 0.088 0.000 -11.981
ENSG00000049883 E003 0.1426347 0.030749077 0.682295009   5 72320373 72320375 3 + 0.088 0.000 -11.981
ENSG00000049883 E004 0.1426347 0.030749077 0.682295009   5 72320376 72320384 9 + 0.088 0.000 -11.981
ENSG00000049883 E005 0.7319543 0.078806091 0.064997961   5 72320385 72320387 3 + 0.325 0.000 -14.291
ENSG00000049883 E006 3.5300275 0.115991539 0.644226219 0.79961910 5 72320388 72320397 10 + 0.654 0.628 -0.113
ENSG00000049883 E007 3.5300275 0.115991539 0.644226219 0.79961910 5 72320398 72320398 1 + 0.654 0.628 -0.113
ENSG00000049883 E008 10.4598613 0.270799732 0.704356775 0.83836317 5 72320399 72320509 111 + 0.991 1.125 0.489
ENSG00000049883 E009 0.4756169 0.031321467 0.042374367   5 72320510 72321179 670 + 0.000 0.378 15.604
ENSG00000049883 E010 0.3336024 0.027442404 0.119213939   5 72321321 72321376 56 + 0.000 0.284 15.020
ENSG00000049883 E011 17.6744036 0.007372403 0.039790601 0.15419312 5 72322172 72322264 93 + 1.272 1.222 -0.177
ENSG00000049883 E012 25.0158337 0.015824300 0.216746885 0.44958724 5 72326612 72326741 130 + 1.379 1.414 0.123
ENSG00000049883 E013 23.0750142 0.022557431 0.040020539 0.15476984 5 72331258 72331375 118 + 1.378 1.325 -0.183
ENSG00000049883 E014 15.0065696 0.028578594 0.105880792 0.29213964 5 72335018 72335096 79 + 1.199 1.166 -0.118
ENSG00000049883 E015 0.1426347 0.030749077 0.682295009   5 72335559 72335793 235 + 0.088 0.000 -11.981
ENSG00000049883 E016 19.0013913 0.082041562 0.096235074 0.27514356 5 72335794 72335885 92 + 1.305 1.224 -0.283
ENSG00000049883 E017 21.1012213 0.069066600 0.044722571 0.16692501 5 72338622 72338735 114 + 1.357 1.247 -0.387
ENSG00000049883 E018 16.1805247 0.003460021 0.006602892 0.04271706 5 72342962 72343036 75 + 1.252 1.143 -0.386
ENSG00000049883 E019 22.9984251 0.034978042 0.029600466 0.12615818 5 72352641 72352754 114 + 1.387 1.309 -0.269
ENSG00000049883 E020 0.0000000       5 72352755 72352757 3 +      
ENSG00000049883 E021 38.4062776 0.065649147 0.452415926 0.66746874 5 72358203 72358470 268 + 1.546 1.622 0.258
ENSG00000049883 E022 33.6773276 0.079339532 0.589038873 0.76300579 5 72358471 72358725 255 + 1.482 1.573 0.311
ENSG00000049883 E023 19.4816170 0.001782144 0.929830898 0.96690184 5 72358726 72358823 98 + 1.247 1.373 0.442
ENSG00000049883 E024 25.3221126 0.048055072 0.383219438 0.61491449 5 72358824 72359603 780 + 1.376 1.445 0.240
ENSG00000049883 E025 209.4084255 1.074288454 0.292160169 0.53282984 5 72359604 72368395 8792 + 2.162 2.484 1.077