ENSG00000049860

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261416 ENSG00000049860 HEK293_OSMI2_6hA HEK293_TMG_6hB HEXB protein_coding protein_coding 42.88272 19.76416 62.44485 2.220784 2.122886 1.659197 29.590202 12.531990 48.280458 1.4217373 0.8645138 1.9449719 0.66239167 0.6351667 0.77406667 0.13890000 0.017757244 0.002037215 FALSE TRUE
MSTRG.26397.2 ENSG00000049860 HEK293_OSMI2_6hA HEK293_TMG_6hB HEXB protein_coding   42.88272 19.76416 62.44485 2.220784 2.122886 1.659197 3.045282 1.657032 1.998853 0.2735615 0.3172908 0.2690903 0.06897083 0.0830000 0.03176667 -0.05123333 0.002037215 0.002037215 FALSE TRUE
MSTRG.26397.9 ENSG00000049860 HEK293_OSMI2_6hA HEK293_TMG_6hB HEXB protein_coding   42.88272 19.76416 62.44485 2.220784 2.122886 1.659197 6.366555 3.916080 6.360561 0.9336293 1.8472272 0.6983308 0.17084167 0.1950667 0.10006667 -0.09500000 0.421561058 0.002037215 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000049860 E001 0.2617363 0.1091607123 5.576494e-02   5 74640023 74640558 536 + 0.000 0.307 12.383
ENSG00000049860 E002 0.3040503 0.0274424043 6.273478e-01   5 74684962 74685162 201 + 0.146 0.000 -9.757
ENSG00000049860 E003 6.5652409 0.0041061752 1.347252e-02 0.0722706368 5 74685163 74685195 33 + 0.732 1.037 1.167
ENSG00000049860 E004 14.5204785 0.0022095522 1.336257e-03 0.0124324017 5 74685196 74685205 10 + 1.049 1.338 1.027
ENSG00000049860 E005 24.5248916 0.0014594083 5.737309e-06 0.0001299449 5 74685206 74685232 27 + 1.250 1.573 1.115
ENSG00000049860 E006 174.4388133 0.0010034803 1.986641e-04 0.0026607044 5 74685233 74685559 327 + 2.164 2.281 0.390
ENSG00000049860 E007 252.4228782 0.0023708579 8.597466e-01 0.9302154342 5 74689328 74689473 146 + 2.361 2.355 -0.021
ENSG00000049860 E008 0.5941213 0.0207856977 9.341161e-01   5 74689474 74689849 376 + 0.204 0.182 -0.208
ENSG00000049860 E009 0.0000000       5 74693475 74693638 164 +      
ENSG00000049860 E010 200.8147854 0.0002583794 3.146671e-01 0.5548222924 5 74693639 74693704 66 + 2.270 2.241 -0.097
ENSG00000049860 E011 184.2555585 0.0019243494 5.062855e-02 0.1811608225 5 74696693 74696739 47 + 2.244 2.175 -0.231
ENSG00000049860 E012 264.7577352 0.0004045958 1.465871e-04 0.0020575133 5 74696996 74697106 111 + 2.407 2.308 -0.331
ENSG00000049860 E013 1.9532966 0.0108089169 1.110625e-01 0.3007073500 5 74700753 74700797 45 + 0.343 0.615 1.377
ENSG00000049860 E014 2.0231375 0.0107681973 3.070965e-01 0.5477096188 5 74700798 74700850 53 + 0.380 0.557 0.894
ENSG00000049860 E015 0.3559677 0.5118545589 7.796824e-01   5 74702493 74702536 44 + 0.150 0.000 -9.800
ENSG00000049860 E016 272.3956796 0.0047038205 1.179297e-01 0.3124423877 5 74705219 74705320 102 + 2.409 2.344 -0.218
ENSG00000049860 E017 13.1391451 0.0157739024 1.433236e-01 0.3524369892 5 74705321 74706168 848 + 1.065 1.229 0.590
ENSG00000049860 E018 191.7139600 0.0015622373 7.812866e-02 0.2410837452 5 74713506 74713537 32 + 2.256 2.194 -0.208
ENSG00000049860 E019 266.4284651 0.0020671391 3.984942e-02 0.1543356837 5 74713538 74713635 98 + 2.401 2.332 -0.230
ENSG00000049860 E020 237.9774963 0.0002003152 4.764874e-01 0.6846245853 5 74715510 74715585 76 + 2.340 2.320 -0.065
ENSG00000049860 E021 217.5074904 0.0002510087 5.900661e-01 0.7638046750 5 74715586 74715645 60 + 2.299 2.283 -0.052
ENSG00000049860 E022 194.0867621 0.0008045360 9.498639e-01 0.9769904588 5 74715646 74715690 45 + 2.243 2.244 0.002
ENSG00000049860 E023 173.1175235 0.0023842348 9.520559e-01 0.9779664337 5 74716587 74716628 42 + 2.195 2.191 -0.015
ENSG00000049860 E024 199.0216032 0.0012794874 5.026468e-01 0.7026029390 5 74716629 74716673 45 + 2.248 2.268 0.065
ENSG00000049860 E025 1.0159857 0.1294139888 1.271971e-01   5 74716674 74716829 156 + 0.345 0.000 -11.361
ENSG00000049860 E026 218.6698980 0.0002547210 2.235605e-02 0.1037597937 5 74718291 74718363 73 + 2.281 2.339 0.194
ENSG00000049860 E027 265.5433544 0.0002228260 3.847884e-02 0.1508042017 5 74718797 74718908 112 + 2.368 2.416 0.160
ENSG00000049860 E028 220.3830761 0.0008605527 8.910921e-01 0.9472044476 5 74718909 74718971 63 + 2.301 2.304 0.012
ENSG00000049860 E029 18.2122380 0.0149880269 6.656951e-02 0.2173334547 5 74719989 74720427 439 + 1.182 1.360 0.626
ENSG00000049860 E030 255.1630424 0.0007371337 7.883953e-01 0.8895894464 5 74720428 74720487 60 + 2.361 2.367 0.020
ENSG00000049860 E031 215.2573741 0.0003541724 7.533150e-01 0.8687310694 5 74720488 74720518 31 + 2.292 2.282 -0.033
ENSG00000049860 E032 282.0976279 0.0016722955 4.795493e-01 0.6868273655 5 74720643 74720747 105 + 2.403 2.421 0.062
ENSG00000049860 E033 1.5351340 0.0511556510 3.136321e-01 0.5538484477 5 74720748 74720836 89 + 0.302 0.490 1.052
ENSG00000049860 E034 0.9340683 0.2987803045 7.624081e-01   5 74721057 74721117 61 + 0.251 0.313 0.429
ENSG00000049860 E035 157.5456072 0.0223038206 2.603780e-01 0.4993413413 5 74721118 74721317 200 + 2.133 2.210 0.256
ENSG00000049860 E036 1.6848037 0.4166016024 7.066766e-01 0.8397331953 5 74721318 74721436 119 + 0.437 0.314 -0.713
ENSG00000049860 E037 2.1101144 0.0805853213 7.227946e-01 0.8498199594 5 74722299 74722468 170 + 0.480 0.406 -0.386
ENSG00000049860 E038 0.4231520 0.0713711377 1.827554e-01   5 74722469 74722647 179 + 0.079 0.308 2.364