ENSG00000049759

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382850 ENSG00000049759 HEK293_OSMI2_6hA HEK293_TMG_6hB NEDD4L protein_coding protein_coding 6.501935 5.356841 9.537318 1.302584 0.8111225 0.8310224 1.4982085 1.7000029 1.736339 0.4257093 0.062187662 0.03033467 0.2541292 0.3446667 0.18386667 -0.16080000 0.608621126 0.000669299 FALSE TRUE
ENST00000588066 ENSG00000049759 HEK293_OSMI2_6hA HEK293_TMG_6hB NEDD4L protein_coding processed_transcript 6.501935 5.356841 9.537318 1.302584 0.8111225 0.8310224 0.9100176 0.7345770 2.044556 0.4290593 0.368132869 1.46433346 0.1160833 0.1142000 0.21333333 0.09913333 0.746739576 0.000669299 FALSE FALSE
ENST00000590638 ENSG00000049759 HEK293_OSMI2_6hA HEK293_TMG_6hB NEDD4L protein_coding retained_intron 6.501935 5.356841 9.537318 1.302584 0.8111225 0.8310224 1.2750641 1.1574529 1.898243 0.6650336 0.129731341 0.70888047 0.1790917 0.1810333 0.20046667 0.01943333 0.922857932 0.000669299 FALSE FALSE
ENST00000592601 ENSG00000049759 HEK293_OSMI2_6hA HEK293_TMG_6hB NEDD4L protein_coding processed_transcript 6.501935 5.356841 9.537318 1.302584 0.8111225 0.8310224 1.2143602 0.6523374 2.879668 0.3762834 0.118550067 2.12526537 0.1604500 0.1208333 0.30480000 0.18396667 0.536446415 0.000669299 FALSE FALSE
ENST00000617539 ENSG00000049759 HEK293_OSMI2_6hA HEK293_TMG_6hB NEDD4L protein_coding protein_coding 6.501935 5.356841 9.537318 1.302584 0.8111225 0.8310224 0.7784083 0.8679062 0.153535 0.2062648 0.006409416 -2.42446753 0.1559542 0.1789000 0.01623333 -0.16266667 0.000669299 0.000669299 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000049759 E001 0.1308682 0.0307325401 4.940024e-01   18 58044226 58044366 141 + 0.000 0.121 11.540
ENSG00000049759 E002 0.1308682 0.0307325401 4.940024e-01   18 58044367 58044383 17 + 0.000 0.121 13.969
ENSG00000049759 E003 0.1308682 0.0307325401 4.940024e-01   18 58044384 58044386 3 + 0.000 0.121 13.969
ENSG00000049759 E004 0.9043783 0.0295469843 4.501365e-01   18 58044387 58044451 65 + 0.217 0.357 0.973
ENSG00000049759 E005 2.5537969 0.0086651836 1.320858e-02 0.0712871109 18 58044452 58044547 96 + 0.295 0.713 2.096
ENSG00000049759 E006 7.9400410 0.0358571250 1.031805e-01 0.2875120552 18 58044548 58044660 113 + 0.815 1.067 0.949
ENSG00000049759 E007 8.0084922 0.0287085002 8.744897e-01 0.9384627070 18 58044661 58044708 48 + 0.946 0.979 0.125
ENSG00000049759 E008 5.4465453 0.0051306333 5.424629e-06 0.0001237875 18 58045072 58045477 406 + 0.361 1.026 2.888
ENSG00000049759 E009 0.0000000       18 58045525 58045615 91 +      
ENSG00000049759 E010 0.0000000       18 58045657 58045665 9 +      
ENSG00000049759 E011 0.0000000       18 58045666 58045688 23 +      
ENSG00000049759 E012 0.0000000       18 58045689 58045690 2 +      
ENSG00000049759 E013 0.0000000       18 58045691 58045696 6 +      
ENSG00000049759 E014 0.1426347 0.0327828299 4.845185e-01   18 58045697 58045706 10 + 0.122 0.000 -14.801
ENSG00000049759 E015 0.1426347 0.0327828299 4.845185e-01   18 58045707 58045714 8 + 0.122 0.000 -14.801
ENSG00000049759 E016 1.0301373 0.0178385902 3.977014e-01   18 58045715 58045788 74 + 0.361 0.216 -1.013
ENSG00000049759 E017 0.0000000       18 58045922 58045933 12 +      
ENSG00000049759 E018 0.0000000       18 58045934 58045979 46 +      
ENSG00000049759 E019 0.0000000       18 58045980 58046018 39 +      
ENSG00000049759 E020 0.0000000       18 58046363 58047225 863 +      
ENSG00000049759 E021 0.0000000       18 58047226 58047510 285 +      
ENSG00000049759 E022 0.0000000       18 58054227 58054876 650 +      
ENSG00000049759 E023 0.1308682 0.0307325401 4.940024e-01   18 58061301 58061472 172 + 0.000 0.121 13.969
ENSG00000049759 E024 0.0000000       18 58088138 58088249 112 +      
ENSG00000049759 E025 0.0000000       18 58088250 58088301 52 +      
ENSG00000049759 E026 0.0000000       18 58089865 58089982 118 +      
ENSG00000049759 E027 0.0000000       18 58090791 58091227 437 +      
ENSG00000049759 E028 0.0000000       18 58091228 58091514 287 +      
ENSG00000049759 E029 0.0000000       18 58091515 58091627 113 +      
ENSG00000049759 E030 0.0000000       18 58099933 58100159 227 +      
ENSG00000049759 E031 0.0000000       18 58149333 58149336 4 +      
ENSG00000049759 E032 0.0000000       18 58149337 58149559 223 +      
ENSG00000049759 E033 0.0000000       18 58149560 58149569 10 +      
ENSG00000049759 E034 5.7113722 0.0706147108 4.938249e-01 0.6965813846 18 58165788 58165791 4 + 0.880 0.779 -0.394
ENSG00000049759 E035 11.8505148 0.0352183916 3.255567e-01 0.5647760443 18 58165792 58165861 70 + 1.166 1.066 -0.360
ENSG00000049759 E036 0.0000000       18 58165862 58169419 3558 +      
ENSG00000049759 E037 0.0000000       18 58195390 58195429 40 +      
ENSG00000049759 E038 0.0000000       18 58195430 58195436 7 +      
ENSG00000049759 E039 0.0000000       18 58195437 58195468 32 +      
ENSG00000049759 E040 0.0000000       18 58195469 58195652 184 +      
ENSG00000049759 E041 0.0000000       18 58195653 58195733 81 +      
ENSG00000049759 E042 0.0000000       18 58196872 58197024 153 +      
ENSG00000049759 E043 0.0000000       18 58197769 58197869 101 +      
ENSG00000049759 E044 0.0000000       18 58221535 58221567 33 +      
ENSG00000049759 E045 0.0000000       18 58221568 58221570 3 +      
ENSG00000049759 E046 0.1614157 0.0339398567 4.842299e-01   18 58221571 58221630 60 + 0.122 0.000 -14.795
ENSG00000049759 E047 0.2922838 0.0265922150 1.000000e+00   18 58221631 58221757 127 + 0.122 0.121 -0.020
ENSG00000049759 E048 0.0000000       18 58227830 58227888 59 +      
ENSG00000049759 E049 0.0000000       18 58227889 58227907 19 +      
ENSG00000049759 E050 18.1370280 0.0593081092 3.192641e-01 0.5589836904 18 58245427 58245508 82 + 1.346 1.226 -0.420
ENSG00000049759 E051 0.1614157 0.0339398567 4.842299e-01   18 58245886 58247280 1395 + 0.122 0.000 -14.795
ENSG00000049759 E052 0.0000000       18 58247281 58247571 291 +      
ENSG00000049759 E053 0.0000000       18 58247572 58247624 53 +      
ENSG00000049759 E054 0.1426347 0.0327828299 4.845185e-01   18 58247625 58248898 1274 + 0.122 0.000 -14.801
ENSG00000049759 E055 18.6038948 0.0018889772 4.732957e-02 0.1733410240 18 58248899 58248937 39 + 1.363 1.214 -0.521
ENSG00000049759 E056 0.1308682 0.0307325401 4.940024e-01   18 58251894 58252000 107 + 0.000 0.121 13.969
ENSG00000049759 E057 23.8532647 0.0017571965 2.119364e-03 0.0178698536 18 58252001 58252054 54 + 1.490 1.278 -0.735
ENSG00000049759 E058 0.2852693 0.3391017860 2.851272e-01   18 58252055 58254537 2483 + 0.214 0.000 -14.872
ENSG00000049759 E059 0.2027342 0.0317689725 4.925867e-01   18 58255440 58256774 1335 + 0.000 0.121 13.968
ENSG00000049759 E060 0.0000000       18 58291202 58291414 213 +      
ENSG00000049759 E061 0.0000000       18 58314555 58314589 35 +      
ENSG00000049759 E062 27.2159366 0.0027965509 6.667429e-04 0.0071532171 18 58315982 58316032 51 + 1.546 1.314 -0.800
ENSG00000049759 E063 30.1625486 0.0013098081 9.628147e-04 0.0096107733 18 58322425 58322486 62 + 1.580 1.376 -0.701
ENSG00000049759 E064 26.0394906 0.0018229731 1.663391e-01 0.3856983182 18 58323232 58323304 73 + 1.471 1.382 -0.306
ENSG00000049759 E065 18.0143243 0.0223246748 6.672435e-01 0.8144594083 18 58323305 58323319 15 + 1.304 1.255 -0.170
ENSG00000049759 E066 17.5419157 0.0036467871 1.379658e-01 0.3443987382 18 58323320 58323334 15 + 1.325 1.206 -0.416
ENSG00000049759 E067 37.8426677 0.0011217337 2.819826e-03 0.0223155455 18 58324996 58325162 167 + 1.661 1.498 -0.557
ENSG00000049759 E068 31.8409193 0.0017157151 1.021041e-02 0.0590285007 18 58328995 58329127 133 + 1.584 1.431 -0.525
ENSG00000049759 E069 25.4816062 0.0016069135 2.254897e-01 0.4599216629 18 58330738 58330850 113 + 1.461 1.387 -0.255
ENSG00000049759 E070 19.8182551 0.0022724259 7.388115e-01 0.8596925032 18 58330851 58330914 64 + 1.304 1.339 0.121
ENSG00000049759 E071 20.7266003 0.0027765545 5.054476e-01 0.7045988215 18 58333818 58333892 75 + 1.304 1.364 0.210
ENSG00000049759 E072 1.6360748 0.0133137327 9.533348e-01 0.9786068486 18 58333893 58335477 1585 + 0.419 0.415 -0.020
ENSG00000049759 E073 0.5171231 1.1642764188 4.227760e-01   18 58335478 58335537 60 + 0.000 0.301 14.290
ENSG00000049759 E074 0.6785387 0.8678488944 6.598482e-01   18 58335538 58336494 957 + 0.123 0.300 1.610
ENSG00000049759 E075 0.2027342 0.0317689725 4.925867e-01   18 58340959 58341037 79 + 0.000 0.121 13.968
ENSG00000049759 E076 24.7464496 0.0111510882 4.917644e-01 0.6951877224 18 58341038 58341169 132 + 1.380 1.437 0.198
ENSG00000049759 E077 26.6814297 0.0074889756 5.836539e-01 0.7593725483 18 58341678 58341797 120 + 1.405 1.454 0.171
ENSG00000049759 E078 38.1189331 0.0035804056 8.499110e-01 0.9249361675 18 58342906 58343103 198 + 1.573 1.594 0.074
ENSG00000049759 E079 0.0000000       18 58348529 58349536 1008 +      
ENSG00000049759 E080 22.9475231 0.0018609544 2.223883e-01 0.4563449518 18 58349537 58349614 78 + 1.318 1.416 0.338
ENSG00000049759 E081 20.5597038 0.0019495745 6.483654e-01 0.8024318719 18 58350991 58351045 55 + 1.304 1.346 0.146
ENSG00000049759 E082 0.0000000       18 58351146 58351199 54 +      
ENSG00000049759 E083 20.0648734 0.0021896551 8.348533e-01 0.9164333140 18 58357194 58357252 59 + 1.304 1.327 0.080
ENSG00000049759 E084 0.0000000       18 58359871 58360058 188 +      
ENSG00000049759 E085 0.0000000       18 58362479 58362768 290 +      
ENSG00000049759 E086 22.0445515 0.0021150722 3.255706e-01 0.5647815160 18 58364268 58364333 66 + 1.387 1.320 -0.231
ENSG00000049759 E087 46.8947386 0.0009380763 6.818033e-01 0.8238290415 18 58365999 58366228 230 + 1.685 1.671 -0.047
ENSG00000049759 E088 0.1426347 0.0327828299 4.845185e-01   18 58366229 58366231 3 + 0.122 0.000 -14.801
ENSG00000049759 E089 0.0000000       18 58366597 58366621 25 +      
ENSG00000049759 E090 0.0000000       18 58367121 58367226 106 +      
ENSG00000049759 E091 34.7936953 0.0012291245 9.769187e-01 0.9902342311 18 58367746 58367867 122 + 1.553 1.559 0.021
ENSG00000049759 E092 24.2070865 0.0065986973 7.194709e-01 0.8478904196 18 58370397 58370467 71 + 1.414 1.393 -0.073
ENSG00000049759 E093 0.0000000       18 58372875 58373169 295 +      
ENSG00000049759 E094 0.2027342 0.0317689725 4.925867e-01   18 58373170 58373173 4 + 0.000 0.121 13.968
ENSG00000049759 E095 32.1194102 0.0013786608 4.138918e-01 0.6389036679 18 58373174 58373269 96 + 1.537 1.494 -0.147
ENSG00000049759 E096 32.1727557 0.0012340402 4.514037e-01 0.6666492346 18 58383246 58383319 74 + 1.489 1.544 0.188
ENSG00000049759 E097 0.3032425 0.0274424043 2.061934e-01   18 58383320 58385525 2206 + 0.000 0.215 14.937
ENSG00000049759 E098 24.3381104 0.0024173431 1.687961e-01 0.3889848203 18 58385526 58385586 61 + 1.344 1.451 0.371
ENSG00000049759 E099 20.5660622 0.0017760147 3.880050e-03 0.0284748300 18 58387439 58387498 60 + 1.202 1.431 0.799
ENSG00000049759 E100 2.4401325 0.0098409684 7.500694e-01 0.8668299281 18 58387711 58389084 1374 + 0.556 0.511 -0.213
ENSG00000049759 E101 33.4730511 0.0068206226 2.306212e-02 0.1061519957 18 58389085 58389192 108 + 1.447 1.615 0.575
ENSG00000049759 E102 0.4646582 0.0220786574 5.834504e-01   18 58389193 58389519 327 + 0.122 0.215 0.981
ENSG00000049759 E103 0.4576437 0.2946830833 6.749005e-01   18 58390064 58390645 582 + 0.214 0.122 -0.981
ENSG00000049759 E104 37.1310874 0.0012867532 8.759210e-02 0.2592483884 18 58390646 58390742 97 + 1.520 1.627 0.365
ENSG00000049759 E105 0.1723744 0.0617585084 4.915860e-01   18 58391029 58391185 157 + 0.000 0.121 13.831
ENSG00000049759 E106 0.1723744 0.0617585084 4.915860e-01   18 58391186 58391239 54 + 0.000 0.121 13.831
ENSG00000049759 E107 0.1426347 0.0327828299 4.845185e-01   18 58391240 58391486 247 + 0.122 0.000 -14.801
ENSG00000049759 E108 34.2439335 0.0299752510 3.502884e-01 0.5875029520 18 58391487 58391559 73 + 1.473 1.596 0.421
ENSG00000049759 E109 158.4555009 0.0043816606 3.165711e-02 0.1322144962 18 58396167 58401540 5374 + 2.149 2.245 0.318