ENSG00000048991

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409478 ENSG00000048991 HEK293_OSMI2_6hA HEK293_TMG_6hB R3HDM1 protein_coding protein_coding 24.40389 31.48239 28.86781 7.581322 1.730026 -0.1250421 7.8388853 10.8236243 10.07839868 2.5297677 0.87042137 -0.1028188 0.31985417 0.34813333 0.35050000 0.002366667 1.000000e+00 1.078569e-12 FALSE TRUE
ENST00000429703 ENSG00000048991 HEK293_OSMI2_6hA HEK293_TMG_6hB R3HDM1 protein_coding protein_coding 24.40389 31.48239 28.86781 7.581322 1.730026 -0.1250421 2.7268125 4.5528612 0.07290315 1.5090678 0.03783361 -5.7823680 0.12348750 0.13643333 0.00260000 -0.133833333 1.078569e-12 1.078569e-12 FALSE TRUE
MSTRG.19284.11 ENSG00000048991 HEK293_OSMI2_6hA HEK293_TMG_6hB R3HDM1 protein_coding   24.40389 31.48239 28.86781 7.581322 1.730026 -0.1250421 1.0973336 0.7039223 4.26127692 0.7039223 0.77993258 2.5808285 0.03737917 0.01836667 0.14533333 0.126966667 1.356818e-01 1.078569e-12 FALSE TRUE
MSTRG.19284.3 ENSG00000048991 HEK293_OSMI2_6hA HEK293_TMG_6hB R3HDM1 protein_coding   24.40389 31.48239 28.86781 7.581322 1.730026 -0.1250421 2.3751835 1.3733891 1.99367805 0.6956858 1.77248850 0.5344437 0.10105417 0.03523333 0.07713333 0.041900000 9.908093e-01 1.078569e-12 FALSE TRUE
MSTRG.19284.7 ENSG00000048991 HEK293_OSMI2_6hA HEK293_TMG_6hB R3HDM1 protein_coding   24.40389 31.48239 28.86781 7.581322 1.730026 -0.1250421 1.3924392 2.6390120 1.61091074 0.7523032 0.87708217 -0.7086497 0.05404167 0.08233333 0.05243333 -0.029900000 8.164589e-01 1.078569e-12 FALSE TRUE
MSTRG.19284.8 ENSG00000048991 HEK293_OSMI2_6hA HEK293_TMG_6hB R3HDM1 protein_coding   24.40389 31.48239 28.86781 7.581322 1.730026 -0.1250421 0.8844783 0.0000000 1.49277506 0.0000000 1.49277506 7.2314853 0.03531250 0.00000000 0.05853333 0.058533333 9.097356e-01 1.078569e-12 FALSE TRUE
MSTRG.19284.9 ENSG00000048991 HEK293_OSMI2_6hA HEK293_TMG_6hB R3HDM1 protein_coding   24.40389 31.48239 28.86781 7.581322 1.730026 -0.1250421 3.0591202 5.3855731 3.80585659 1.3096460 1.90340685 -0.4997693 0.12310417 0.17176667 0.12463333 -0.047133333 8.793702e-01 1.078569e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000048991 E001 0.7664957 0.0178900528 5.236462e-01   2 135531291 135531454 164 + 0.311 0.203 -0.806
ENSG00000048991 E002 0.7962354 0.0594085713 7.944086e-01   2 135531455 135531472 18 + 0.230 0.278 0.363
ENSG00000048991 E003 0.9742192 0.1399928368 8.835881e-01   2 135531473 135531478 6 + 0.312 0.278 -0.230
ENSG00000048991 E004 0.9798287 0.1233098569 3.673009e-01   2 135531479 135531479 1 + 0.381 0.203 -1.240
ENSG00000048991 E005 1.6930516 0.2258339769 6.306576e-01 7.908293e-01 2 135531480 135531483 4 + 0.494 0.386 -0.561
ENSG00000048991 E006 7.6199494 0.0398455067 5.732633e-01 7.525144e-01 2 135531484 135531500 17 + 0.974 0.894 -0.303
ENSG00000048991 E007 18.4145534 0.0668505944 4.626832e-01 6.749611e-01 2 135531501 135531512 12 + 1.345 1.227 -0.412
ENSG00000048991 E008 20.9585747 0.0551776307 4.411133e-01 6.595563e-01 2 135531513 135531516 4 + 1.396 1.284 -0.391
ENSG00000048991 E009 29.1201467 0.0403081388 4.155955e-01 6.402839e-01 2 135531517 135531526 10 + 1.527 1.425 -0.354
ENSG00000048991 E010 70.6939007 0.0042871424 3.877881e-02 1.515763e-01 2 135531527 135531633 107 + 1.905 1.803 -0.344
ENSG00000048991 E011 2.6070850 0.0962756546 8.160807e-01 9.058774e-01 2 135565737 135565925 189 + 0.581 0.530 -0.235
ENSG00000048991 E012 1.0351266 0.0153787590 3.054451e-01   2 135568758 135568809 52 + 0.379 0.204 -1.219
ENSG00000048991 E013 0.0000000       2 135586250 135586322 73 +      
ENSG00000048991 E014 0.0000000       2 135586323 135586351 29 +      
ENSG00000048991 E015 0.0000000       2 135586352 135586436 85 +      
ENSG00000048991 E016 0.1614157 0.0347183057 4.233559e-01   2 135586437 135586506 70 + 0.130 0.000 -9.404
ENSG00000048991 E017 166.7167922 0.0003538273 9.102256e-10 5.363540e-08 2 135602500 135602708 209 + 2.304 2.145 -0.533
ENSG00000048991 E018 102.2790673 0.0004536198 1.554193e-08 6.982479e-07 2 135604806 135604855 50 + 2.107 1.920 -0.630
ENSG00000048991 E019 182.1636530 0.0002842047 3.260130e-11 2.552536e-09 2 135604856 135605016 161 + 2.345 2.181 -0.545
ENSG00000048991 E020 5.7712001 0.0047328399 1.132351e-04 1.657324e-03 2 135605017 135606676 1660 + 1.032 0.530 -2.029
ENSG00000048991 E021 2.1953944 0.0146970003 7.539770e-01 8.691136e-01 2 135616152 135616193 42 + 0.536 0.490 -0.218
ENSG00000048991 E022 34.4183628 0.0012487914 2.325992e-01 4.681730e-01 2 135616668 135616757 90 + 1.575 1.514 -0.207
ENSG00000048991 E023 90.6540204 0.0042682797 6.017939e-04 6.593022e-03 2 135621494 135621511 18 + 2.035 1.880 -0.520
ENSG00000048991 E024 131.5742486 0.0004486369 5.884400e-06 1.327629e-04 2 135621512 135621608 97 + 2.185 2.054 -0.438
ENSG00000048991 E025 104.5930753 0.0004119737 1.892961e-03 1.635856e-02 2 135622654 135622732 79 + 2.071 1.974 -0.323
ENSG00000048991 E026 100.1621954 0.0005364313 9.357113e-05 1.414503e-03 2 135631718 135631777 60 + 2.068 1.939 -0.434
ENSG00000048991 E027 177.3348968 0.0003369631 3.415873e-04 4.155479e-03 2 135631861 135632001 141 + 2.292 2.207 -0.283
ENSG00000048991 E028 4.1965468 0.0067142962 7.713019e-01 8.794273e-01 2 135633712 135633828 117 + 0.742 0.714 -0.116
ENSG00000048991 E029 180.5962594 0.0002771896 1.497087e-04 2.094750e-03 2 135635890 135635998 109 + 2.304 2.215 -0.295
ENSG00000048991 E030 181.8904232 0.0003943598 3.841397e-04 4.579782e-03 2 135636088 135636183 96 + 2.304 2.221 -0.278
ENSG00000048991 E031 106.5295881 0.0003809790 1.049974e-01 2.906292e-01 2 135638618 135638640 23 + 2.055 2.012 -0.143
ENSG00000048991 E032 99.0748826 0.0005036631 2.466788e-01 4.843816e-01 2 135638641 135638655 15 + 2.017 1.989 -0.096
ENSG00000048991 E033 0.0000000       2 135638733 135638738 6 +      
ENSG00000048991 E034 126.0073908 0.0003987351 3.873416e-01 6.183845e-01 2 135638739 135638789 51 + 2.111 2.096 -0.051
ENSG00000048991 E035 71.4554379 0.0006331424 7.182704e-01 8.471378e-01 2 135638896 135638898 3 + 1.860 1.856 -0.012
ENSG00000048991 E036 204.1951094 0.0002557939 3.658532e-01 6.006504e-01 2 135638899 135639074 176 + 2.316 2.306 -0.034
ENSG00000048991 E037 112.3990780 0.0010284784 1.776846e-01 4.006983e-01 2 135639075 135639122 48 + 2.072 2.036 -0.119
ENSG00000048991 E038 51.4664756 0.0023035165 4.852377e-01 6.907162e-01 2 135641536 135641604 69 + 1.693 1.745 0.175
ENSG00000048991 E039 62.4805616 0.0016570029 6.934577e-01 8.313279e-01 2 135641605 135641790 186 + 1.784 1.818 0.113
ENSG00000048991 E040 0.9832093 0.0195412429 3.107524e-01   2 135645233 135645378 146 + 0.379 0.204 -1.216
ENSG00000048991 E041 184.4038664 0.0002527784 6.556375e-01 8.071267e-01 2 135645379 135645527 149 + 2.254 2.278 0.083
ENSG00000048991 E042 1.3155265 0.0777347654 9.897611e-01   2 135649087 135649331 245 + 0.377 0.393 0.091
ENSG00000048991 E043 0.9159572 0.0160778363 5.597314e-01   2 135649902 135650003 102 + 0.230 0.341 0.776
ENSG00000048991 E044 43.2196290 0.0009577467 9.501378e-01 9.771401e-01 2 135651730 135651732 3 + 1.638 1.655 0.056
ENSG00000048991 E045 234.7006591 0.0002311759 2.945882e-01 5.351587e-01 2 135651733 135652032 300 + 2.379 2.368 -0.038
ENSG00000048991 E046 180.0495259 0.0002932023 9.265401e-01 9.653536e-01 2 135661270 135661393 124 + 2.252 2.262 0.034
ENSG00000048991 E047 155.5057498 0.0003062282 2.570441e-01 4.958650e-01 2 135675332 135675397 66 + 2.167 2.213 0.153
ENSG00000048991 E048 203.3994970 0.0002809009 9.312187e-01 9.676617e-01 2 135675398 135675486 89 + 2.302 2.313 0.034
ENSG00000048991 E049 251.0214357 0.0002306890 1.107884e-02 6.269385e-02 2 135680173 135680324 152 + 2.362 2.433 0.237
ENSG00000048991 E050 213.3489402 0.0049523457 8.374094e-02 2.522574e-01 2 135709433 135709536 104 + 2.285 2.367 0.276
ENSG00000048991 E051 247.2215742 0.0015219059 9.898019e-04 9.833916e-03 2 135710059 135710231 173 + 2.334 2.441 0.357
ENSG00000048991 E052 242.6595431 0.0002784561 9.927165e-04 9.855954e-03 2 135715550 135715694 145 + 2.334 2.426 0.305
ENSG00000048991 E053 5.2159013 0.1618000565 7.851381e-01 8.876362e-01 2 135721509 135721923 415 + 0.821 0.763 -0.231
ENSG00000048991 E054 196.3676554 0.0002575695 3.856683e-02 1.510327e-01 2 135721924 135722006 83 + 2.257 2.324 0.222
ENSG00000048991 E055 169.3963892 0.0002633888 8.232415e-04 8.468432e-03 2 135722469 135722553 85 + 2.169 2.275 0.354
ENSG00000048991 E056 1076.0541851 0.0008338773 2.907691e-18 6.906192e-16 2 135723937 135725270 1334 + 2.942 3.093 0.502