ENSG00000048828

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000652239 ENSG00000048828 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM120A protein_coding protein_coding 50.1969 55.05915 54.37953 13.43489 1.220535 -0.01791534 2.255036 7.435584 0.000000 1.623876 0.0000000 -9.5402413 0.04320833 0.1383333 0.00000000 -0.13833333 9.529671e-36 9.529671e-36 FALSE TRUE
MSTRG.33016.10 ENSG00000048828 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM120A protein_coding   50.1969 55.05915 54.37953 13.43489 1.220535 -0.01791534 15.961659 16.840661 22.880991 2.994036 0.6505515 0.4419747 0.32015833 0.3263000 0.42066667 0.09436667 5.561738e-01 9.529671e-36 FALSE TRUE
MSTRG.33016.14 ENSG00000048828 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM120A protein_coding   50.1969 55.05915 54.37953 13.43489 1.220535 -0.01791534 7.615460 4.866356 0.762855 4.193419 0.5557343 -2.6575336 0.15316250 0.0706000 0.01453333 -0.05606667 9.281355e-01 9.529671e-36   FALSE
MSTRG.33016.2 ENSG00000048828 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM120A protein_coding   50.1969 55.05915 54.37953 13.43489 1.220535 -0.01791534 9.337433 7.577453 12.734042 2.296097 1.2703815 0.7481355 0.18421667 0.1389000 0.23366667 0.09476667 2.428815e-01 9.529671e-36 FALSE TRUE
MSTRG.33016.4 ENSG00000048828 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM120A protein_coding   50.1969 55.05915 54.37953 13.43489 1.220535 -0.01791534 9.269092 11.099073 13.085525 3.479877 0.4133646 0.2373355 0.18342500 0.1908667 0.24063333 0.04976667 6.110286e-01 9.529671e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000048828 E001 3.2911500 0.0072312807 1.237161e-03 1.169618e-02 9 93451685 93451890 206 + 0.294 0.832 2.577
ENSG00000048828 E002 14.3454777 0.0032113494 2.694914e-04 3.422232e-03 9 93451891 93451944 54 + 0.973 1.340 1.313
ENSG00000048828 E003 15.4229705 0.0155050661 9.878960e-04 9.820726e-03 9 93451945 93451951 7 + 0.988 1.377 1.386
ENSG00000048828 E004 17.3925750 0.0032008590 1.680694e-05 3.293947e-04 9 93451952 93451961 10 + 1.029 1.431 1.422
ENSG00000048828 E005 263.4675261 0.3784053518 3.829403e-01 6.146873e-01 9 93451962 93452383 422 + 2.348 2.484 0.455
ENSG00000048828 E006 108.7779814 1.2949437059 6.127853e-01 7.787783e-01 9 93452384 93452389 6 + 2.006 2.072 0.221
ENSG00000048828 E007 0.0000000       9 93459787 93459875 89 +      
ENSG00000048828 E008 1.1969022 0.1453164274 7.148270e-01   9 93470375 93470405 31 + 0.293 0.366 0.459
ENSG00000048828 E009 1.1859435 0.0647593879 7.072313e-01   9 93470406 93470430 25 + 0.359 0.296 -0.399
ENSG00000048828 E010 428.6796562 0.0089121182 1.961482e-01 4.247208e-01 9 93471141 93471387 247 + 2.660 2.609 -0.169
ENSG00000048828 E011 303.3367160 0.0001904933 1.199743e-07 4.370210e-06 9 93476256 93476338 83 + 2.529 2.444 -0.283
ENSG00000048828 E012 383.4877584 0.0003115484 3.125063e-08 1.308928e-06 9 93497471 93497599 129 + 2.629 2.545 -0.279
ENSG00000048828 E013 281.9409686 0.0002563238 1.679539e-03 1.487791e-02 9 93498790 93498886 97 + 2.477 2.433 -0.147
ENSG00000048828 E014 103.2170061 0.0022118227 1.386220e-01 3.454287e-01 9 93515667 93515669 3 + 2.043 2.002 -0.136
ENSG00000048828 E015 168.1459308 0.0020867669 9.910309e-01 9.972549e-01 9 93515670 93515767 98 + 2.222 2.241 0.062
ENSG00000048828 E016 440.1409598 0.0006184900 7.537892e-01 8.689974e-01 9 93515983 93516269 287 + 2.639 2.655 0.053
ENSG00000048828 E017 389.1773521 0.0012380522 1.804422e-02 8.918499e-02 9 93527155 93527242 88 + 2.611 2.574 -0.124
ENSG00000048828 E018 400.4479137 0.0001669858 4.674011e-05 7.851182e-04 9 93529353 93529469 117 + 2.633 2.584 -0.160
ENSG00000048828 E019 343.9757029 0.0011452227 3.713002e-05 6.472523e-04 9 93529470 93529580 111 + 2.581 2.503 -0.259
ENSG00000048828 E020 4.0656941 0.0068041452 8.895665e-02 2.618495e-01 9 93529581 93530710 1130 + 0.813 0.590 -0.926
ENSG00000048828 E021 0.9159572 0.0172671820 4.690349e-01   9 93530711 93530731 21 + 0.217 0.359 0.992
ENSG00000048828 E022 2.2525614 0.1024143963 1.421535e-01 3.506462e-01 9 93530732 93531406 675 + 0.630 0.357 -1.358
ENSG00000048828 E023 408.3232721 0.0021564799 8.248663e-04 8.480009e-03 9 93532155 93532329 175 + 2.649 2.582 -0.224
ENSG00000048828 E024 13.7315950 0.0059875095 4.448056e-02 1.663032e-01 9 93532330 93532589 260 + 1.042 1.257 0.771
ENSG00000048828 E025 461.7021458 0.0025269174 7.793682e-02 2.406886e-01 9 93543222 93543471 250 + 2.683 2.654 -0.098
ENSG00000048828 E026 299.1121936 0.0002466779 7.926494e-02 2.433294e-01 9 93550577 93550691 115 + 2.489 2.477 -0.040
ENSG00000048828 E027 270.1639024 0.0003575955 1.729282e-03 1.522799e-02 9 93556382 93556451 70 + 2.463 2.417 -0.153
ENSG00000048828 E028 363.3525187 0.0007579013 4.869776e-01 6.918535e-01 9 93556452 93556591 140 + 2.563 2.571 0.024
ENSG00000048828 E029 468.1005149 0.0001526843 5.229376e-05 8.646366e-04 9 93557827 93558010 184 + 2.627 2.720 0.310
ENSG00000048828 E030 397.0822336 0.0002255252 1.164172e-04 1.696037e-03 9 93558581 93558718 138 + 2.553 2.650 0.323
ENSG00000048828 E031 41.3045412 0.0859305334 7.150057e-02 2.278260e-01 9 93559002 93559061 60 + 1.742 1.476 -0.905
ENSG00000048828 E032 144.5748590 0.0015259849 4.429378e-02 1.658348e-01 9 93561109 93561111 3 + 2.114 2.208 0.315
ENSG00000048828 E033 373.1063795 0.0011541027 3.373061e-03 2.560333e-02 9 93561112 93561250 139 + 2.525 2.619 0.312
ENSG00000048828 E034 333.1390067 0.0036970118 5.970777e-01 7.684075e-01 9 93562208 93562304 97 + 2.506 2.542 0.121
ENSG00000048828 E035 2526.4774733 0.0073824872 4.141939e-02 1.584119e-01 9 93564229 93566112 1884 + 3.353 3.446 0.306