ENSG00000048707

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000011700 ENSG00000048707 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13D protein_coding protein_coding 5.223775 6.882191 4.831926 1.292403 0.1758156 -0.5093816 0.8538901 1.4145318 0.87083368 0.3287708 0.10485345 -0.6935463 0.16058333 0.20220000 0.18173333 -0.02046667 9.111703e-01 2.935511e-12 FALSE TRUE
ENST00000460333 ENSG00000048707 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13D protein_coding retained_intron 5.223775 6.882191 4.831926 1.292403 0.1758156 -0.5093816 0.1180720 0.0000000 0.31292506 0.0000000 0.18088309 5.0131275 0.02405417 0.00000000 0.06673333 0.06673333 2.766190e-01 2.935511e-12 TRUE TRUE
ENST00000613099 ENSG00000048707 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13D protein_coding protein_coding 5.223775 6.882191 4.831926 1.292403 0.1758156 -0.5093816 0.6414770 0.9109859 0.58450473 0.3456876 0.31770249 -0.6314908 0.12286667 0.12170000 0.11770000 -0.00400000 9.410141e-01 2.935511e-12 FALSE TRUE
ENST00000646411 ENSG00000048707 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13D protein_coding retained_intron 5.223775 6.882191 4.831926 1.292403 0.1758156 -0.5093816 1.1045719 1.9232516 0.00000000 0.5859732 0.00000000 -7.5948856 0.20169583 0.26700000 0.00000000 -0.26700000 2.935511e-12 2.935511e-12 FALSE TRUE
ENST00000647414 ENSG00000048707 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13D protein_coding retained_intron 5.223775 6.882191 4.831926 1.292403 0.1758156 -0.5093816 0.3494991 0.6183805 0.06381998 0.1757178 0.06381998 -3.0895552 0.06144583 0.08916667 0.01306667 -0.07610000 1.336664e-01 2.935511e-12 FALSE FALSE
MSTRG.334.1 ENSG00000048707 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13D protein_coding   5.223775 6.882191 4.831926 1.292403 0.1758156 -0.5093816 1.0991299 0.3830457 2.32176632 0.2084775 0.39252005 2.5686543 0.22932917 0.06446667 0.48260000 0.41813333 1.196463e-01 2.935511e-12 FALSE TRUE
MSTRG.334.11 ENSG00000048707 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13D protein_coding   5.223775 6.882191 4.831926 1.292403 0.1758156 -0.5093816 0.6240787 1.1748664 0.28201615 0.2883781 0.28201615 -2.0206043 0.11435417 0.16780000 0.05773333 -0.11006667 3.549173e-01 2.935511e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000048707 E001 0.1779838 0.0372142142 4.196782e-01   1 12230024 12230029 6 + 0.125 0.000 -16.604
ENSG00000048707 E002 0.1779838 0.0372142142 4.196782e-01   1 12230030 12230036 7 + 0.125 0.000 -16.614
ENSG00000048707 E003 0.8843097 0.9113166501 5.829141e-01   1 12230037 12230050 14 + 0.383 0.120 -2.153
ENSG00000048707 E004 2.2043457 0.2335060025 1.236473e-02 6.789091e-02 1 12230051 12230066 16 + 0.709 0.119 -3.708
ENSG00000048707 E005 4.8236298 0.0514992512 1.710418e-02 8.583993e-02 1 12230067 12230120 54 + 0.906 0.545 -1.491
ENSG00000048707 E006 10.0307609 0.0036358339 1.723289e-04 2.361066e-03 1 12234191 12234363 173 + 1.194 0.841 -1.300
ENSG00000048707 E007 7.0523550 0.0978570759 1.501102e-01 3.625114e-01 1 12242513 12242590 78 + 1.031 0.774 -0.977
ENSG00000048707 E008 13.7443515 0.5703832460 6.412454e-01 7.976496e-01 1 12244246 12244423 178 + 1.310 0.983 -1.172
ENSG00000048707 E009 6.7077077 0.2940638583 4.372233e-01 6.566155e-01 1 12244424 12244436 13 + 1.012 0.735 -1.068
ENSG00000048707 E010 9.3694257 0.1073090933 2.125524e-01 4.447382e-01 1 12244537 12244617 81 + 1.126 0.895 -0.850
ENSG00000048707 E011 10.9255672 0.0040814847 2.825063e-04 3.552628e-03 1 12249223 12249339 117 + 1.212 0.880 -1.218
ENSG00000048707 E012 0.0000000       1 12249340 12249603 264 +      
ENSG00000048707 E013 8.2126017 0.0073859926 1.069553e-03 1.044898e-02 1 12253722 12253733 12 + 1.102 0.756 -1.309
ENSG00000048707 E014 11.1057639 0.0119227327 6.217446e-04 6.765332e-03 1 12253734 12253826 93 + 1.221 0.880 -1.247
ENSG00000048707 E015 0.2922838 0.0259829832 8.970799e-01   1 12256276 12256332 57 + 0.125 0.118 -0.092
ENSG00000048707 E016 13.8158327 0.0216308124 6.360643e-03 4.150242e-02 1 12256333 12256503 171 + 1.293 1.026 -0.954
ENSG00000048707 E017 13.2063794 0.0025739092 8.031635e-04 8.307614e-03 1 12256987 12257087 101 + 1.270 1.003 -0.958
ENSG00000048707 E018 20.5387381 0.0019245377 7.802653e-08 2.974343e-06 1 12257935 12258103 169 + 1.491 1.120 -1.297
ENSG00000048707 E019 16.3677632 0.0100820617 3.657300e-03 2.724095e-02 1 12260693 12260794 102 + 1.349 1.127 -0.781
ENSG00000048707 E020 18.3987095 0.0208760645 4.168856e-03 3.010194e-02 1 12260948 12261149 202 + 1.399 1.156 -0.854
ENSG00000048707 E021 17.1712625 0.0028005255 7.082504e-05 1.120527e-03 1 12261901 12262080 180 + 1.386 1.099 -1.010
ENSG00000048707 E022 12.8236521 0.0027104443 1.312038e-04 1.875856e-03 1 12266881 12267011 131 + 1.278 0.960 -1.144
ENSG00000048707 E023 11.1498276 0.0033548503 1.839338e-04 2.493907e-03 1 12267845 12267920 76 + 1.230 0.896 -1.215
ENSG00000048707 E024 16.9515866 0.0037731209 2.149830e-03 1.807648e-02 1 12268706 12268876 171 + 1.355 1.140 -0.756
ENSG00000048707 E025 17.3075931 0.0022098413 8.610589e-04 8.780330e-03 1 12270994 12271124 131 + 1.361 1.131 -0.811
ENSG00000048707 E026 17.2645911 0.0022902923 3.459851e-02 1.404985e-01 1 12273003 12273135 133 + 1.322 1.196 -0.443
ENSG00000048707 E027 87.6030170 0.0022723527 7.038608e-10 4.221655e-08 1 12275825 12277120 1296 + 2.049 1.828 -0.742
ENSG00000048707 E028 48.1020907 0.0471056632 2.763259e-02 1.202103e-01 1 12277121 12277534 414 + 1.791 1.572 -0.743
ENSG00000048707 E029 44.1737098 0.0031074629 5.183858e-03 3.558217e-02 1 12277535 12277902 368 + 1.707 1.593 -0.389
ENSG00000048707 E030 22.3873591 0.0082564224 1.154687e-01 3.082440e-01 1 12277903 12278038 136 + 1.409 1.334 -0.260
ENSG00000048707 E031 25.1309056 0.0013813243 1.041535e-04 1.547342e-03 1 12279499 12279650 152 + 1.518 1.296 -0.767
ENSG00000048707 E032 79.5523645 0.0053254348 1.389219e-02 7.391250e-02 1 12282705 12283434 730 + 1.942 1.865 -0.259
ENSG00000048707 E033 43.7050157 0.0008710824 7.692322e-05 1.200737e-03 1 12283435 12283736 302 + 1.723 1.561 -0.553
ENSG00000048707 E034 23.9744509 0.0181344986 8.166153e-03 5.009586e-02 1 12288223 12288313 91 + 1.487 1.279 -0.723
ENSG00000048707 E035 25.5369967 0.0089114531 1.351094e-02 7.241039e-02 1 12290998 12291124 127 + 1.495 1.342 -0.530
ENSG00000048707 E036 25.8446214 0.0179368283 5.689055e-01 7.494569e-01 1 12293524 12293704 181 + 1.436 1.427 -0.031
ENSG00000048707 E037 19.0505842 0.0090645622 8.478431e-01 9.237533e-01 1 12299202 12299280 79 + 1.287 1.320 0.117
ENSG00000048707 E038 22.7838641 0.0018774692 1.597678e-02 8.172610e-02 1 12299281 12299384 104 + 1.436 1.309 -0.440
ENSG00000048707 E039 38.6402816 0.0010022498 3.613785e-03 2.700587e-02 1 12304506 12304728 223 + 1.653 1.537 -0.392
ENSG00000048707 E040 37.8918902 0.0012082839 1.001236e-02 5.821452e-02 1 12308431 12308641 211 + 1.636 1.537 -0.337
ENSG00000048707 E041 13.0962550 0.0330271837 7.196766e-01 8.480279e-01 1 12311454 12311467 14 + 1.094 1.181 0.311
ENSG00000048707 E042 19.8296818 0.0369669448 8.556936e-01 9.280713e-01 1 12311468 12311525 58 + 1.282 1.342 0.208
ENSG00000048707 E043 21.5408669 0.0082134023 1.464129e-01 3.570298e-01 1 12311526 12311625 100 + 1.386 1.310 -0.265
ENSG00000048707 E044 23.6372577 0.0083287028 6.296104e-01 7.902611e-01 1 12311813 12311925 113 + 1.385 1.390 0.015
ENSG00000048707 E045 37.5914308 0.0095541652 2.850888e-01 5.257032e-01 1 12314115 12314327 213 + 1.602 1.566 -0.121
ENSG00000048707 E046 44.4377401 0.0009920510 2.286783e-03 1.896510e-02 1 12318072 12318337 266 + 1.710 1.597 -0.384
ENSG00000048707 E047 33.6336765 0.0011903295 1.377427e-03 1.274345e-02 1 12319497 12319630 134 + 1.609 1.465 -0.493
ENSG00000048707 E048 33.4383030 0.0011690051 1.991447e-02 9.557536e-02 1 12321809 12321964 156 + 1.586 1.496 -0.310
ENSG00000048707 E049 43.6592068 0.0038058830 2.229663e-01 4.569126e-01 1 12322536 12322746 211 + 1.662 1.644 -0.062
ENSG00000048707 E050 24.0141000 0.0017391529 2.287874e-01 4.637935e-01 1 12323706 12323780 75 + 1.414 1.377 -0.127
ENSG00000048707 E051 43.9030535 0.0010250643 2.290925e-01 4.640684e-01 1 12327648 12327854 207 + 1.659 1.645 -0.047
ENSG00000048707 E052 30.4719228 0.0343804755 1.165571e-01 3.100576e-01 1 12329829 12329918 90 + 1.544 1.446 -0.336
ENSG00000048707 E053 42.1444030 0.0094927964 6.450239e-02 2.127732e-01 1 12333226 12333366 141 + 1.670 1.593 -0.265
ENSG00000048707 E054 38.9852029 0.0064263733 2.006251e-01 4.304962e-01 1 12335705 12335827 123 + 1.620 1.590 -0.101
ENSG00000048707 E055 0.1308682 0.0326491905 5.653531e-01   1 12335828 12337988 2161 + 0.000 0.118 16.396
ENSG00000048707 E056 5.7681411 0.0438831150 8.850621e-01 9.439540e-01 1 12338231 12338305 75 + 0.824 0.840 0.060
ENSG00000048707 E057 5.5339882 0.0050299441 6.140496e-01 7.795743e-01 1 12341780 12341782 3 + 0.823 0.801 -0.088
ENSG00000048707 E058 36.4619082 0.0127854732 9.565752e-01 9.801669e-01 1 12341783 12341885 103 + 1.552 1.603 0.174
ENSG00000048707 E059 0.6536007 0.1147541401 4.216966e-01   1 12342805 12342898 94 + 0.125 0.287 1.488
ENSG00000048707 E060 44.0892012 0.0123497242 5.239327e-01 7.177784e-01 1 12342899 12343051 153 + 1.602 1.704 0.349
ENSG00000048707 E061 0.0000000       1 12344865 12345010 146 +      
ENSG00000048707 E062 39.1327617 0.0011487071 2.988289e-02 1.269880e-01 1 12345374 12345509 136 + 1.509 1.683 0.593
ENSG00000048707 E063 25.0502086 0.0013264976 1.296220e-01 3.312336e-01 1 12346605 12346652 48 + 1.328 1.483 0.535
ENSG00000048707 E064 36.6936240 0.0010120304 2.760573e-01 5.160920e-01 1 12348823 12348973 151 + 1.513 1.626 0.385
ENSG00000048707 E065 2.5987853 0.0255611964 5.624842e-01 7.450668e-01 1 12348974 12349163 190 + 0.601 0.542 -0.267
ENSG00000048707 E066 43.6999338 0.0012616987 7.003781e-01 8.358713e-01 1 12349164 12349374 211 + 1.609 1.678 0.236
ENSG00000048707 E067 50.6549921 0.0007128457 4.695053e-01 6.796876e-01 1 12353974 12354221 248 + 1.665 1.751 0.291
ENSG00000048707 E068 43.6175972 0.0011358418 6.872832e-01 8.273639e-01 1 12355899 12356090 192 + 1.612 1.683 0.242
ENSG00000048707 E069 0.0000000       1 12356351 12356397 47 +      
ENSG00000048707 E070 35.7556390 0.0011870469 7.782415e-01 8.836454e-01 1 12356398 12356524 127 + 1.531 1.596 0.225
ENSG00000048707 E071 34.2873183 0.0010014405 2.815436e-01 5.218575e-01 1 12358459 12358601 143 + 1.486 1.600 0.389
ENSG00000048707 E072 34.4286517 0.0010289979 5.399708e-01 7.289724e-01 1 12362720 12362850 131 + 1.500 1.586 0.295
ENSG00000048707 E073 46.1835198 0.0012008563 7.377354e-01 8.590899e-01 1 12363072 12363247 176 + 1.656 1.689 0.113
ENSG00000048707 E074 0.1308682 0.0326491905 5.653531e-01   1 12367670 12367701 32 + 0.000 0.118 16.396
ENSG00000048707 E075 41.8688145 0.0009466665 3.893723e-01 6.199664e-01 1 12368468 12368591 124 + 1.629 1.633 0.011
ENSG00000048707 E076 59.7212932 0.0011380865 9.506794e-01 9.772953e-01 1 12369467 12369702 236 + 1.753 1.799 0.159
ENSG00000048707 E077 41.3265274 0.0137227955 8.476247e-01 9.236430e-01 1 12373750 12373858 109 + 1.582 1.654 0.245
ENSG00000048707 E078 55.7966208 0.0008000173 6.288949e-01 7.897483e-01 1 12378428 12378591 164 + 1.712 1.786 0.249
ENSG00000048707 E079 48.3615361 0.0229626326 9.806253e-01 9.920870e-01 1 12379488 12379596 109 + 1.667 1.711 0.151
ENSG00000048707 E080 32.3742768 0.0015945781 8.248898e-01 9.108630e-01 1 12382976 12382995 20 + 1.490 1.553 0.214
ENSG00000048707 E081 51.5788712 0.0006893716 2.144988e-01 4.469275e-01 1 12382996 12383155 160 + 1.659 1.770 0.377
ENSG00000048707 E082 44.8415384 0.0019508074 5.226360e-02 1.849808e-01 1 12385260 12385373 114 + 1.571 1.727 0.529
ENSG00000048707 E083 56.4931202 0.0008630300 2.274044e-01 4.622690e-01 1 12386185 12386334 150 + 1.701 1.807 0.360
ENSG00000048707 E084 49.3470660 0.0007570225 6.647475e-01 8.128382e-01 1 12400181 12400309 129 + 1.665 1.736 0.242
ENSG00000048707 E085 28.9183886 0.0014282770 4.996335e-01 7.005004e-01 1 12400310 12400330 21 + 1.476 1.482 0.021
ENSG00000048707 E086 42.4912167 0.0010541737 6.620629e-01 8.111325e-01 1 12401608 12401704 97 + 1.598 1.672 0.253
ENSG00000048707 E087 0.1723744 0.0511462844 5.620023e-01   1 12402568 12402702 135 + 0.000 0.118 16.402
ENSG00000048707 E088 65.4151758 0.0191993908 7.715984e-01 8.795522e-01 1 12403825 12403973 149 + 1.795 1.843 0.163
ENSG00000048707 E089 0.1723744 0.0511462844 5.620023e-01   1 12407254 12407330 77 + 0.000 0.118 16.402
ENSG00000048707 E090 0.0000000       1 12409838 12409894 57 +      
ENSG00000048707 E091 63.2869054 0.0206767319 2.176609e-01 4.506081e-01 1 12415087 12415221 135 + 1.706 1.881 0.594
ENSG00000048707 E092 74.8058748 0.0019653013 4.610979e-06 1.073554e-04 1 12416660 12416827 168 + 1.718 1.983 0.893
ENSG00000048707 E093 0.3751086 0.0279387380 2.493221e-01   1 12453839 12453899 61 + 0.000 0.212 17.404
ENSG00000048707 E094 62.3254888 0.0006994762 2.161909e-04 2.854026e-03 1 12455998 12456071 74 + 1.671 1.892 0.745
ENSG00000048707 E095 52.5144161 0.0009298517 1.904999e-02 9.264501e-02 1 12456072 12456130 59 + 1.633 1.799 0.563
ENSG00000048707 E096 45.1433050 0.0014672547 3.560863e-01 5.925926e-01 1 12460201 12460239 39 + 1.609 1.708 0.337
ENSG00000048707 E097 68.5855290 0.0008294338 1.656090e-02 8.383525e-02 1 12460240 12460396 157 + 1.753 1.907 0.522
ENSG00000048707 E098 0.0000000       1 12464940 12465249 310 +      
ENSG00000048707 E099 0.0000000       1 12478549 12478873 325 +      
ENSG00000048707 E100 0.3032425 0.0274424043 2.511711e-01   1 12497098 12497208 111 + 0.000 0.211 17.398
ENSG00000048707 E101 0.6894974 1.3461821822 4.826575e-01   1 12497226 12497499 274 + 0.000 0.363 18.460
ENSG00000048707 E102 53.1829231 0.0225733819 1.047905e-02 6.018114e-02 1 12497500 12497631 132 + 1.578 1.843 0.897
ENSG00000048707 E103 73.7938370 0.6925011408 1.836166e-01 4.086269e-01 1 12506853 12507093 241 + 1.595 2.030 1.469
ENSG00000048707 E104 3.2921979 0.0146401285 6.567330e-02 2.154388e-01 1 12507094 12507163 70 + 0.425 0.756 1.503
ENSG00000048707 E105 312.3870468 1.4052752359 2.476817e-01 4.854958e-01 1 12508893 12512047 3155 + 2.156 2.671 1.719