ENSG00000048392

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251810 ENSG00000048392 HEK293_OSMI2_6hA HEK293_TMG_6hB RRM2B protein_coding protein_coding 8.216669 0.9996794 15.49123 0.2799036 0.6691681 3.940413 6.28219520 0.81312656 12.4883218 0.23223689 0.715196154 3.9244763 0.81782917 0.80646667 0.805666667 -0.00080000 1.000000000 0.004687935 FALSE TRUE
ENST00000395912 ENSG00000048392 HEK293_OSMI2_6hA HEK293_TMG_6hB RRM2B protein_coding protein_coding 8.216669 0.9996794 15.49123 0.2799036 0.6691681 3.940413 0.53258913 0.00000000 1.0352032 0.00000000 0.148443261 6.7076397 0.03498750 0.00000000 0.067133333 0.06713333 0.051600418 0.004687935 FALSE TRUE
ENST00000517517 ENSG00000048392 HEK293_OSMI2_6hA HEK293_TMG_6hB RRM2B protein_coding retained_intron 8.216669 0.9996794 15.49123 0.2799036 0.6691681 3.940413 0.11186466 0.14958045 0.1240323 0.09739331 0.004391652 -0.2517031 0.03750833 0.11320000 0.008033333 -0.10516667 0.011202148 0.004687935   FALSE
ENST00000522368 ENSG00000048392 HEK293_OSMI2_6hA HEK293_TMG_6hB RRM2B protein_coding protein_coding 8.216669 0.9996794 15.49123 0.2799036 0.6691681 3.940413 0.67723491 0.00000000 1.4947201 0.00000000 0.132599182 7.2333513 0.04887917 0.00000000 0.096166667 0.09616667 0.004687935 0.004687935 FALSE TRUE
ENST00000523957 ENSG00000048392 HEK293_OSMI2_6hA HEK293_TMG_6hB RRM2B protein_coding nonsense_mediated_decay 8.216669 0.9996794 15.49123 0.2799036 0.6691681 3.940413 0.05511921 0.03697237 0.0000000 0.03697237 0.000000000 -2.2318125 0.01747500 0.08033333 0.000000000 -0.08033333 0.519643491 0.004687935   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000048392 E001 106.8644966 1.4848598046 0.291169398 0.53174752 8 102204502 102205777 1276 - 1.658 2.141 1.629
ENSG00000048392 E002 24.7639590 0.7152026516 0.087190264 0.25859989 8 102205778 102205959 182 - 1.028 1.639 2.135
ENSG00000048392 E003 335.0094389 0.0003248196 0.206823739 0.43793262 8 102205960 102207744 1785 - 2.190 2.319 0.431
ENSG00000048392 E004 31.5469807 0.0015156195 0.503888586 0.70349620 8 102207745 102207775 31 - 1.186 1.345 0.558
ENSG00000048392 E005 76.0584447 0.0075103757 0.225142007 0.45954124 8 102207776 102208094 319 - 1.564 1.547 -0.058
ENSG00000048392 E006 31.2245493 0.0011477116 0.294503183 0.53505733 8 102208095 102208132 38 - 1.199 1.152 -0.167
ENSG00000048392 E007 57.8746249 0.0015200633 0.078168527 0.24115855 8 102208133 102208285 153 - 1.455 1.370 -0.292
ENSG00000048392 E008 56.7012733 0.0006977741 0.054751767 0.19077349 8 102212776 102212889 114 - 1.447 1.345 -0.355
ENSG00000048392 E009 56.7645725 0.0009592065 0.099031350 0.28007837 8 102214054 102214158 105 - 1.444 1.370 -0.255
ENSG00000048392 E010 0.2027342 0.0374243963 0.016010808   8 102214159 102214229 71 - 0.000 0.366 13.274
ENSG00000048392 E011 60.5601937 0.0040597496 0.009398445 0.05552525 8 102218814 102218947 134 - 1.475 1.289 -0.644
ENSG00000048392 E012 0.0000000       8 102218948 102219015 68 -      
ENSG00000048392 E013 44.1967938 0.0030554507 0.041229974 0.15793648 8 102224046 102224140 95 - 1.343 1.191 -0.536
ENSG00000048392 E014 32.7139527 0.0077069497 0.084027557 0.25283691 8 102224885 102224922 38 - 1.218 1.063 -0.556
ENSG00000048392 E015 54.4938071 0.0105122752 0.001274573 0.01197038 8 102224923 102225018 96 - 1.435 1.110 -1.141
ENSG00000048392 E016 39.7927585 0.0055854586 0.030872039 0.12996130 8 102225918 102225974 57 - 1.300 1.110 -0.674
ENSG00000048392 E017 43.2685145 0.0151024843 0.302202609 0.54283326 8 102225975 102226034 60 - 1.328 1.288 -0.140
ENSG00000048392 E018 43.8240286 0.0075818183 0.366625208 0.60123364 8 102232149 102232230 82 - 1.332 1.317 -0.049
ENSG00000048392 E019 38.0282840 0.0054508071 0.389367097 0.61996641 8 102232231 102232304 74 - 1.273 1.259 -0.051
ENSG00000048392 E020 0.5117739 0.0304034214 0.131737196   8 102234725 102234845 121 - 0.064 0.366 3.065
ENSG00000048392 E021 1.4119707 0.0127138766 0.019970821 0.09577005 8 102238441 102238558 118 - 0.168 0.695 3.065
ENSG00000048392 E022 5.3084651 0.0054642553 0.307435588 0.54804058 8 102238559 102238826 268 - 0.527 0.797 1.157
ENSG00000048392 E023 28.2245740 0.0030854458 0.005554329 0.03749315 8 102238827 102238961 135 - 1.166 0.798 -1.370