ENSG00000048342

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000506643 ENSG00000048342 HEK293_OSMI2_6hA HEK293_TMG_6hB CC2D2A protein_coding protein_coding 4.756097 4.749099 3.35959 1.065389 0.1073058 -0.4981153 1.3534816 1.0372836 1.5394777 0.3333245 0.10037946 0.5651299 0.3043208 0.20726667 0.45946667 0.25220000 0.03494961 0.03494961 FALSE TRUE
ENST00000514450 ENSG00000048342 HEK293_OSMI2_6hA HEK293_TMG_6hB CC2D2A protein_coding protein_coding 4.756097 4.749099 3.35959 1.065389 0.1073058 -0.4981153 0.5165145 0.4039173 0.3067289 0.1281299 0.04345696 -0.3860938 0.1030917 0.08223333 0.09163333 0.00940000 0.97615481 0.03494961 FALSE TRUE
ENST00000515124 ENSG00000048342 HEK293_OSMI2_6hA HEK293_TMG_6hB CC2D2A protein_coding protein_coding 4.756097 4.749099 3.35959 1.065389 0.1073058 -0.4981153 0.2950902 0.3977980 0.1047919 0.2283308 0.10479192 -1.8288337 0.0574750 0.07146667 0.03073333 -0.04073333 0.78680050 0.03494961 FALSE FALSE
ENST00000652443 ENSG00000048342 HEK293_OSMI2_6hA HEK293_TMG_6hB CC2D2A protein_coding protein_coding 4.756097 4.749099 3.35959 1.065389 0.1073058 -0.4981153 2.0206768 2.5354949 1.0091890 0.5783509 0.22074065 -1.3205246 0.4043958 0.53730000 0.29933333 -0.23796667 0.14095514 0.03494961   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000048342 E001 0.0000000       4 15469865 15469870 6 +      
ENSG00000048342 E002 0.0000000       4 15469871 15469881 11 +      
ENSG00000048342 E003 0.4762370 0.021768165 6.315876e-01   4 15469882 15469895 14 + 0.127 0.208 0.855
ENSG00000048342 E004 1.1849480 0.015378759 6.700229e-02   4 15469896 15469902 7 + 0.127 0.454 2.442
ENSG00000048342 E005 1.3158162 0.013683900 3.797628e-02   4 15469903 15469905 3 + 0.127 0.498 2.662
ENSG00000048342 E006 1.8217929 0.011376679 6.576008e-03 4.258857e-02 4 15469906 15469920 15 + 0.127 0.609 3.177
ENSG00000048342 E007 2.7073902 0.008349065 1.182693e-02 6.574478e-02 4 15469921 15470012 92 + 0.305 0.723 2.075
ENSG00000048342 E008 2.9297133 0.007826033 9.676215e-02 2.760522e-01 4 15470013 15470057 45 + 0.431 0.698 1.232
ENSG00000048342 E009 0.0000000       4 15473222 15473255 34 +      
ENSG00000048342 E010 3.1922574 0.007867777 2.804084e-01 5.205882e-01 4 15475915 15475971 57 + 0.528 0.698 0.746
ENSG00000048342 E011 3.9160453 0.152423650 2.363992e-01 4.724139e-01 4 15478723 15478806 84 + 0.527 0.784 1.102
ENSG00000048342 E012 0.3206185 0.027442404 1.804282e-01   4 15479204 15479215 12 + 0.225 0.000 -13.721
ENSG00000048342 E013 0.3206185 0.027442404 1.804282e-01   4 15479216 15479218 3 + 0.225 0.000 -13.721
ENSG00000048342 E014 0.4514866 0.021768165 5.114353e-01   4 15479219 15479222 4 + 0.225 0.116 -1.149
ENSG00000048342 E015 21.4243973 0.010024201 2.114844e-06 5.481519e-05 4 15479223 15479328 106 + 1.086 1.509 1.483
ENSG00000048342 E016 22.4246590 0.002038705 7.535702e-05 1.180677e-03 4 15480704 15480727 24 + 1.184 1.483 1.046
ENSG00000048342 E017 37.8045460 0.001279775 7.691333e-07 2.261366e-05 4 15480728 15480827 100 + 1.417 1.707 0.989
ENSG00000048342 E018 48.4018189 0.002203926 3.985303e-15 6.163898e-13 4 15481197 15482259 1063 + 1.412 1.853 1.502
ENSG00000048342 E019 12.5588166 0.003384711 9.691482e-01 9.863932e-01 4 15502429 15502517 89 + 1.132 1.132 0.001
ENSG00000048342 E020 10.9631169 0.003168415 3.034139e-01 5.439709e-01 4 15502822 15502923 102 + 1.132 1.034 -0.356
ENSG00000048342 E021 13.8807397 0.002587790 5.071475e-02 1.813775e-01 4 15510139 15510240 102 + 1.262 1.091 -0.610
ENSG00000048342 E022 16.5021116 0.002998813 7.900631e-02 2.428497e-01 4 15511247 15511423 177 + 1.323 1.178 -0.508
ENSG00000048342 E023 3.1953414 0.011685583 9.581525e-02 2.744507e-01 4 15511424 15511672 249 + 0.482 0.746 1.168
ENSG00000048342 E024 10.9390722 0.003459903 1.078717e-02 6.147760e-02 4 15514707 15514869 163 + 1.202 0.952 -0.907
ENSG00000048342 E025 10.0153629 0.027958838 2.807671e-02 1.214919e-01 4 15515868 15516004 137 + 1.180 0.902 -1.018
ENSG00000048342 E026 8.0496660 0.019069540 2.226759e-02 1.034901e-01 4 15516625 15516756 132 + 1.096 0.812 -1.064
ENSG00000048342 E027 10.6758625 0.017934483 5.354943e-03 3.646614e-02 4 15527447 15527618 172 + 1.219 0.902 -1.154
ENSG00000048342 E028 6.4579235 0.006869051 6.834869e-02 2.214012e-01 4 15527619 15527656 38 + 0.992 0.770 -0.849
ENSG00000048342 E029 8.0982028 0.004391364 1.040886e-02 5.989754e-02 4 15528620 15528726 107 + 1.098 0.813 -1.066
ENSG00000048342 E030 11.8238611 0.003799243 4.049150e-04 4.777592e-03 4 15533193 15533333 141 + 1.255 0.906 -1.268
ENSG00000048342 E031 0.0000000       4 15533334 15533453 120 +      
ENSG00000048342 E032 13.2056264 0.010363046 8.855599e-03 5.316709e-02 4 15536920 15537076 157 + 1.263 0.997 -0.956
ENSG00000048342 E033 11.0278976 0.003493001 6.722808e-02 2.188818e-01 4 15537899 15538055 157 + 1.164 0.982 -0.659
ENSG00000048342 E034 8.8957391 0.004799475 2.513335e-01 4.894076e-01 4 15538056 15538137 82 + 1.049 0.923 -0.466
ENSG00000048342 E035 1.6764835 0.024163466 6.277179e-01 7.890092e-01 4 15538843 15540276 1434 + 0.483 0.402 -0.420
ENSG00000048342 E036 7.3391428 0.005603954 2.563347e-01 4.951079e-01 4 15540837 15540906 70 + 0.831 0.968 0.522
ENSG00000048342 E037 6.6185657 0.005611662 5.021348e-01 7.022897e-01 4 15540907 15541014 108 + 0.852 0.937 0.323
ENSG00000048342 E038 0.1308682 0.032649190 5.261807e-01   4 15543579 15543961 383 + 0.000 0.116 11.671
ENSG00000048342 E039 0.0000000       4 15550738 15550823 86 +      
ENSG00000048342 E040 8.7708064 0.004183536 4.996983e-01 7.005314e-01 4 15550824 15550980 157 + 1.035 0.967 -0.253
ENSG00000048342 E041 9.8520214 0.022478958 1.993378e-01 4.289003e-01 4 15553158 15553305 148 + 1.120 0.975 -0.530
ENSG00000048342 E042 10.1142916 0.003825636 2.958104e-01 5.363020e-01 4 15555072 15555210 139 + 1.110 1.008 -0.372
ENSG00000048342 E043 13.8378799 0.009689712 1.070446e-02 6.112781e-02 4 15557304 15557458 155 + 1.287 1.044 -0.865
ENSG00000048342 E044 8.5171479 0.003621052 1.626312e-02 8.276205e-02 4 15557459 15557507 49 + 1.098 0.834 -0.987
ENSG00000048342 E045 8.5935105 0.003459209 8.423808e-02 2.532348e-01 4 15559165 15559257 93 + 1.074 0.889 -0.688
ENSG00000048342 E046 9.0063688 0.003306245 8.876474e-02 2.615150e-01 4 15560531 15560622 92 + 1.086 0.906 -0.668
ENSG00000048342 E047 0.1308682 0.032649190 5.261807e-01   4 15560623 15561587 965 + 0.000 0.116 11.671
ENSG00000048342 E048 0.1308682 0.032649190 5.261807e-01   4 15561588 15561602 15 + 0.000 0.116 11.671
ENSG00000048342 E049 3.5798991 0.105308468 4.528956e-01 6.678368e-01 4 15561603 15563309 1707 + 0.736 0.575 -0.688
ENSG00000048342 E050 0.7664957 0.017747760 5.782201e-01   4 15563310 15563354 45 + 0.305 0.208 -0.732
ENSG00000048342 E051 11.8761548 0.002628456 8.244439e-01 9.105601e-01 4 15563355 15563522 168 + 1.121 1.102 -0.068
ENSG00000048342 E052 9.1261885 0.041041040 9.130765e-01 9.586300e-01 4 15567377 15567482 106 + 1.008 0.986 -0.081
ENSG00000048342 E053 9.5846896 0.025086980 9.367467e-01 9.705928e-01 4 15567677 15567786 110 + 1.023 1.010 -0.045
ENSG00000048342 E054 9.7769107 0.003683115 3.729772e-01 6.064968e-01 4 15569293 15569389 97 + 1.074 0.982 -0.338
ENSG00000048342 E055 12.0009337 0.002697684 3.687968e-01 6.030425e-01 4 15570398 15570496 99 + 1.153 1.070 -0.302
ENSG00000048342 E056 14.0098727 0.007779340 7.073723e-01 8.401447e-01 4 15574150 15574326 177 + 1.153 1.189 0.130
ENSG00000048342 E057 0.0000000       4 15576604 15576624 21 +      
ENSG00000048342 E058 0.1779838 0.037535774 4.558915e-01   4 15576625 15577094 470 + 0.127 0.000 -12.770
ENSG00000048342 E059 14.8650966 0.016448902 7.045414e-01 8.384713e-01 4 15579968 15580171 204 + 1.173 1.215 0.151
ENSG00000048342 E060 0.1426347 0.032528454 4.567257e-01   4 15580172 15580534 363 + 0.127 0.000 -12.786
ENSG00000048342 E061 11.4564484 0.003439685 5.836793e-01 7.593823e-01 4 15586157 15586246 90 + 1.121 1.069 -0.188
ENSG00000048342 E062 12.4032092 0.002881260 3.705984e-01 6.044023e-01 4 15587816 15587929 114 + 1.164 1.081 -0.298
ENSG00000048342 E063 11.3640843 0.003441589 8.183153e-01 9.070772e-01 4 15589545 15589679 135 + 1.086 1.112 0.091
ENSG00000048342 E064 1.0835299 0.014876419 8.131424e-01   4 15590764 15591676 913 + 0.305 0.348 0.269
ENSG00000048342 E065 0.5117739 0.023179739 5.162949e-01   4 15595872 15596084 213 + 0.225 0.116 -1.147
ENSG00000048342 E066 6.1350066 0.005170934 8.610773e-01 9.309315e-01 4 15596085 15596143 59 + 0.872 0.853 -0.073
ENSG00000048342 E067 6.2482066 0.004374400 2.680570e-01 5.077086e-01 4 15596144 15596207 64 + 0.928 0.793 -0.519
ENSG00000048342 E068 7.1781254 0.013106063 4.776689e-01 6.855512e-01 4 15597407 15597465 59 + 0.945 0.855 -0.340
ENSG00000048342 E069 12.2685438 0.062553458 8.114161e-01 9.030800e-01 4 15599529 15599706 178 + 1.104 1.121 0.064
ENSG00000048342 E070 1.5823493 0.687310046 1.952050e-01 4.236294e-01 4 15599707 15600887 1181 + 0.125 0.560 2.983
ENSG00000048342 E071 13.0333447 0.014083154 4.141906e-01 6.391669e-01 4 15601237 15601552 316 + 1.184 1.093 -0.326