ENSG00000048028

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000003302 ENSG00000048028 HEK293_OSMI2_6hA HEK293_TMG_6hB USP28 protein_coding protein_coding 13.78785 7.867169 21.99623 1.219725 2.026014 1.482163 1.6559084 1.37224035 1.4309069 0.46650935 0.63302041 0.05996864 0.15760417 0.17090000 0.06183333 -0.10906667 0.435141586 0.001905662 FALSE TRUE
ENST00000544967 ENSG00000048028 HEK293_OSMI2_6hA HEK293_TMG_6hB USP28 protein_coding protein_coding 13.78785 7.867169 21.99623 1.219725 2.026014 1.482163 1.4733030 1.68860272 0.4928103 0.28890661 0.27579402 -1.75626221 0.18080417 0.22810000 0.02120000 -0.20690000 0.082297925 0.001905662 FALSE TRUE
ENST00000545540 ENSG00000048028 HEK293_OSMI2_6hA HEK293_TMG_6hB USP28 protein_coding protein_coding 13.78785 7.867169 21.99623 1.219725 2.026014 1.482163 0.7525078 0.03129594 1.7807029 0.03129594 0.36405867 5.43838222 0.04101667 0.00370000 0.08293333 0.07923333 0.001905662 0.001905662 FALSE TRUE
MSTRG.6337.10 ENSG00000048028 HEK293_OSMI2_6hA HEK293_TMG_6hB USP28 protein_coding   13.78785 7.867169 21.99623 1.219725 2.026014 1.482163 0.9911689 0.39272993 1.5987528 0.04252196 0.09563879 1.99805810 0.06124167 0.05086667 0.07383333 0.02296667 0.589916463 0.001905662 FALSE TRUE
MSTRG.6337.2 ENSG00000048028 HEK293_OSMI2_6hA HEK293_TMG_6hB USP28 protein_coding   13.78785 7.867169 21.99623 1.219725 2.026014 1.482163 5.4161584 2.73535830 10.8197360 0.91779255 0.47481514 1.97993172 0.31949583 0.32433333 0.49700000 0.17266667 0.475848284 0.001905662 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000048028 E001 17.2729556 0.3715904415 0.077072396 0.23893070 11 113797874 113798091 218 - 1.019 1.505 1.713
ENSG00000048028 E002 159.7147476 1.4038509077 0.363765110 0.59886270 11 113798092 113798779 688 - 2.029 2.383 1.186
ENSG00000048028 E003 33.8340968 0.6438651902 0.267723647 0.50738051 11 113798780 113798804 25 - 1.395 1.686 0.995
ENSG00000048028 E004 78.1071291 0.9264742026 0.351087927 0.58821654 11 113798805 113798978 174 - 1.761 2.028 0.899
ENSG00000048028 E005 60.7302134 0.8581761516 0.358429682 0.59452920 11 113798979 113799061 83 - 1.663 1.907 0.823
ENSG00000048028 E006 59.4457510 0.8712228979 0.425515570 0.64769116 11 113799062 113799119 58 - 1.679 1.861 0.613
ENSG00000048028 E007 58.1510067 0.8453866487 0.357592258 0.59377154 11 113799120 113799171 52 - 1.647 1.886 0.807
ENSG00000048028 E008 103.2904570 1.2903789555 0.438703527 0.65778254 11 113799172 113799415 244 - 1.890 2.135 0.821
ENSG00000048028 E009 91.3229719 0.0141046547 0.129543147 0.33109661 11 113801483 113801678 196 - 1.875 2.034 0.535
ENSG00000048028 E010 0.8759238 0.0374274772 0.682369451   11 113801679 113801701 23 - 0.207 0.307 0.748
ENSG00000048028 E011 85.2213129 0.0093174860 0.776022441 0.88238752 11 113803158 113803281 124 - 1.866 1.954 0.297
ENSG00000048028 E012 75.8433945 0.0123108341 0.314585547 0.55478796 11 113803798 113803877 80 - 1.800 1.932 0.445
ENSG00000048028 E013 71.3790867 0.0035283705 0.059857795 0.20245720 11 113804673 113804751 79 - 1.766 1.923 0.528
ENSG00000048028 E014 62.4045230 0.0060804678 0.665705305 0.81345803 11 113804868 113804927 60 - 1.732 1.819 0.293
ENSG00000048028 E015 90.9774912 0.0020882857 0.653051733 0.80542585 11 113804928 113805046 119 - 1.898 1.980 0.274
ENSG00000048028 E016 2.2739151 0.0094853730 0.378996850 0.61140289 11 113806489 113806584 96 - 0.420 0.609 0.914
ENSG00000048028 E017 1.0654865 0.0644608408 0.925710948   11 113808023 113808136 114 - 0.259 0.308 0.340
ENSG00000048028 E018 98.5252022 0.0057098941 0.426932723 0.64868609 11 113808298 113808437 140 - 1.952 1.973 0.070
ENSG00000048028 E019 127.4596937 0.0121022549 0.552578765 0.73810423 11 113809063 113809254 192 - 2.062 2.081 0.063
ENSG00000048028 E020 44.0137029 0.0110771934 0.368554162 0.60287208 11 113812276 113812278 3 - 1.617 1.608 -0.028
ENSG00000048028 E021 94.3266602 0.0096283065 0.572798234 0.75224076 11 113812279 113812414 136 - 1.931 1.956 0.085
ENSG00000048028 E022 72.1854345 0.0040864474 0.890253839 0.94681264 11 113812415 113812504 90 - 1.808 1.860 0.177
ENSG00000048028 E023 2.7265849 0.0087900316 0.209613355 0.44143592 11 113813755 113813884 130 - 0.585 0.404 -0.893
ENSG00000048028 E024 62.9683257 0.0015197760 0.469688908 0.67981776 11 113813885 113813955 71 - 1.760 1.784 0.081
ENSG00000048028 E025 83.5029127 0.0038235043 0.033567985 0.13767276 11 113815174 113815263 90 - 1.899 1.848 -0.171
ENSG00000048028 E026 80.9811316 0.0142770489 0.204622543 0.43542063 11 113815264 113815376 113 - 1.880 1.851 -0.098
ENSG00000048028 E027 33.9091458 0.0487071809 0.834907346 0.91645425 11 113815377 113815382 6 - 1.495 1.525 0.104
ENSG00000048028 E028 46.7560970 0.0518028667 0.411515943 0.63719871 11 113817658 113817694 37 - 1.652 1.602 -0.172
ENSG00000048028 E029 38.4077015 0.0602763495 0.883443948 0.94304546 11 113817695 113817705 11 - 1.545 1.578 0.115
ENSG00000048028 E030 64.5483462 0.0128934746 0.410579891 0.63647977 11 113817706 113817830 125 - 1.773 1.779 0.021
ENSG00000048028 E031 26.7431121 0.0013206040 0.297719548 0.53820618 11 113817831 113817837 7 - 1.408 1.390 -0.065
ENSG00000048028 E032 1.1176617 0.0144746458 0.308422075   11 113820292 113820358 67 - 0.346 0.180 -1.253
ENSG00000048028 E033 66.5270177 0.0007542767 0.043647409 0.16424769 11 113823605 113823700 96 - 1.800 1.762 -0.128
ENSG00000048028 E034 86.1421786 0.0023821208 0.016693010 0.08433059 11 113827233 113827360 128 - 1.917 1.866 -0.173
ENSG00000048028 E035 2.4498011 0.3951428156 0.667392829 0.81456258 11 113828844 113828920 77 - 0.421 0.666 1.155
ENSG00000048028 E036 59.0875959 0.0167405744 0.262417108 0.50160349 11 113829197 113829220 24 - 1.749 1.722 -0.092
ENSG00000048028 E037 83.6139994 0.0040442893 0.065670598 0.21543828 11 113829221 113829345 125 - 1.898 1.863 -0.118
ENSG00000048028 E038 1.4480551 0.6372070552 0.961619820 0.98283649 11 113829346 113829467 122 - 0.343 0.412 0.392
ENSG00000048028 E039 42.7012782 0.0027319630 0.087897476 0.25981193 11 113830867 113830882 16 - 1.613 1.566 -0.162
ENSG00000048028 E040 57.5028051 0.0009002552 0.087282981 0.25876189 11 113830883 113830943 61 - 1.736 1.708 -0.094
ENSG00000048028 E041 8.9315924 0.0070444527 0.057052844 0.19617035 11 113830944 113830946 3 - 1.007 0.821 -0.706
ENSG00000048028 E042 3.8045231 0.1885257381 0.068845819 0.22247685 11 113830947 113830976 30 - 0.731 0.304 -2.111
ENSG00000048028 E043 58.1985476 0.0008490269 0.038827521 0.15169334 11 113831920 113831989 70 - 1.746 1.700 -0.157
ENSG00000048028 E044 31.8409497 0.0014381030 0.020016712 0.09594406 11 113831990 113831993 4 - 1.504 1.399 -0.363
ENSG00000048028 E045 86.3477858 0.0094641922 0.003738806 0.02768291 11 113833420 113833557 138 - 1.931 1.821 -0.371
ENSG00000048028 E046 68.1793015 0.0107131551 0.001817457 0.01582026 11 113834249 113834335 87 - 1.838 1.692 -0.494
ENSG00000048028 E047 2.6752175 0.0372204613 0.100646683 0.28295242 11 113835207 113835327 121 - 0.586 0.307 -1.473
ENSG00000048028 E048 106.9717864 0.0013319388 0.001799096 0.01569466 11 113840598 113840757 160 - 2.012 1.946 -0.221
ENSG00000048028 E049 84.5853650 0.0006622577 0.051636325 0.18360196 11 113841663 113841765 103 - 1.901 1.879 -0.076
ENSG00000048028 E050 40.9952930 0.0060329752 0.446847741 0.66334223 11 113841766 113841768 3 - 1.584 1.593 0.034
ENSG00000048028 E051 45.7112659 0.0015960589 0.057934738 0.19815807 11 113852501 113852526 26 - 1.642 1.590 -0.180
ENSG00000048028 E052 54.6696024 0.0008955209 0.087678437 0.25941349 11 113852527 113852621 95 - 1.713 1.682 -0.105
ENSG00000048028 E053 26.3791516 0.0036814145 0.047056981 0.17266386 11 113852622 113852633 12 - 1.422 1.321 -0.350
ENSG00000048028 E054 35.4597043 0.0013921160 0.087579711 0.25922695 11 113854258 113854335 78 - 1.533 1.480 -0.185
ENSG00000048028 E055 8.5129533 0.0319320007 0.090728643 0.26510663 11 113874517 113874626 110 - 0.995 0.787 -0.792
ENSG00000048028 E056 10.8067240 0.0036992996 0.985067552 0.99435247 11 113874627 113874762 136 - 1.015 1.070 0.201
ENSG00000048028 E057 11.6134719 0.0290090149 0.641878752 0.79807894 11 113874763 113874800 38 - 1.024 1.128 0.377
ENSG00000048028 E058 12.0543597 0.0119742751 0.480220375 0.68726136 11 113874801 113874879 79 - 1.032 1.157 0.455
ENSG00000048028 E059 23.1188520 0.0194361994 0.769411711 0.87828655 11 113875445 113875570 126 - 1.312 1.413 0.352