ENSG00000047849

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360240 ENSG00000047849 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP4 protein_coding protein_coding 84.30883 115.9816 75.30785 21.60755 4.108922 -0.6229563 5.093735 5.541779 8.041565 0.5038149 0.9392400 0.5363192 0.06412083 0.0501 0.1061000 0.05600000 0.005940942 1.500635e-08 FALSE TRUE
ENST00000395734 ENSG00000047849 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP4 protein_coding protein_coding 84.30883 115.9816 75.30785 21.60755 4.108922 -0.6229563 44.131378 64.429778 35.752130 13.1734092 1.3981752 -0.8495189 0.51839583 0.5506 0.4758667 -0.07473333 0.305527158 1.500635e-08 FALSE TRUE
MSTRG.22895.6 ENSG00000047849 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP4 protein_coding   84.30883 115.9816 75.30785 21.60755 4.108922 -0.6229563 15.412961 24.780433 9.704201 5.8378169 0.8369269 -1.3516163 0.17793750 0.2084 0.1306667 -0.07773333 0.226526686 1.500635e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000047849 E001 1.5323736 0.7217982139 5.846568e-01 7.601028e-01 3 47850328 47850689 362 - 0.589 0.225 -2.090
ENSG00000047849 E002 0.4702677 0.0217681645 2.522548e-01   3 47850690 47850694 5 - 0.279 0.090 -1.960
ENSG00000047849 E003 2.0343359 0.2306647911 3.135795e-01 5.537959e-01 3 47850695 47850695 1 - 0.280 0.557 1.521
ENSG00000047849 E004 851.6724647 0.0014012058 6.944194e-18 1.561965e-15 3 47850696 47851093 398 - 2.766 2.964 0.658
ENSG00000047849 E005 2118.1956946 0.0011493717 7.390469e-18 1.655767e-15 3 47851094 47851867 774 - 3.192 3.348 0.519
ENSG00000047849 E006 1182.6695602 0.0008105023 3.862039e-08 1.583445e-06 3 47851868 47852144 277 - 2.980 3.080 0.332
ENSG00000047849 E007 1355.6098654 0.0005087876 5.413565e-10 3.315355e-08 3 47852145 47852619 475 - 3.045 3.137 0.305
ENSG00000047849 E008 741.0410211 0.0002555997 3.341944e-23 1.425977e-20 3 47852620 47852854 235 - 2.733 2.896 0.543
ENSG00000047849 E009 550.1679028 0.0001282735 5.064303e-22 1.881915e-19 3 47852855 47852938 84 - 2.599 2.769 0.566
ENSG00000047849 E010 457.3871332 0.0001262117 1.633125e-14 2.322798e-12 3 47852939 47853039 101 - 2.536 2.682 0.487
ENSG00000047849 E011 695.8310432 0.0010076143 1.914493e-05 3.685388e-04 3 47853163 47853352 190 - 2.754 2.848 0.311
ENSG00000047849 E012 23.3587732 0.1279191637 4.918113e-01 6.952063e-01 3 47855125 47855247 123 - 1.435 1.319 -0.402
ENSG00000047849 E013 668.2657662 0.0006334625 3.056971e-01 5.463456e-01 3 47855248 47855360 113 - 2.787 2.808 0.072
ENSG00000047849 E014 665.4022020 0.0006560776 9.436692e-01 9.741808e-01 3 47857431 47857512 82 - 2.797 2.800 0.008
ENSG00000047849 E015 615.1839210 0.0002995504 4.237147e-01 6.463862e-01 3 47867246 47867338 93 - 2.755 2.770 0.050
ENSG00000047849 E016 2.7484191 0.0239519261 6.156532e-01 7.807774e-01 3 47869212 47869213 2 - 0.511 0.601 0.417
ENSG00000047849 E017 642.9755521 0.0001124056 1.079011e-01 2.955556e-01 3 47869214 47869327 114 - 2.767 2.795 0.093
ENSG00000047849 E018 386.8272269 0.0003172755 2.754331e-01 5.154939e-01 3 47870813 47870857 45 - 2.549 2.575 0.088
ENSG00000047849 E019 836.5156003 0.0005433630 4.640030e-03 3.268921e-02 3 47870858 47871105 248 - 2.866 2.917 0.172
ENSG00000047849 E020 299.5478419 0.0004381137 1.065577e-01 2.932466e-01 3 47871227 47871247 21 - 2.429 2.471 0.141
ENSG00000047849 E021 396.8302063 0.0001419531 7.730592e-01 8.805282e-01 3 47871248 47871286 39 - 2.572 2.581 0.030
ENSG00000047849 E022 745.9347279 0.0001279554 5.183937e-01 7.139569e-01 3 47871917 47872100 184 - 2.844 2.856 0.041
ENSG00000047849 E023 874.4678446 0.0001406621 6.965975e-01 8.333858e-01 3 47875685 47875900 216 - 2.914 2.922 0.027
ENSG00000047849 E024 6.6593996 0.0117928812 1.834161e-02 9.015457e-02 3 47876920 47877326 407 - 1.037 0.733 -1.164
ENSG00000047849 E025 3.3731557 0.0120743235 3.835148e-02 1.505012e-01 3 47877327 47877416 90 - 0.805 0.489 -1.368
ENSG00000047849 E026 578.7292095 0.0001218895 3.976276e-01 6.264850e-01 3 47877417 47877523 107 - 2.748 2.737 -0.035
ENSG00000047849 E027 1.1140774 0.0153787590 2.183936e-01   3 47877524 47877765 242 - 0.447 0.229 -1.370
ENSG00000047849 E028 1.1555836 0.0967647291 2.885523e-01   3 47891024 47892835 1812 - 0.445 0.231 -1.347
ENSG00000047849 E029 0.3447487 0.7924136129 6.361041e-01   3 47902950 47903000 51 - 0.000 0.169 9.787
ENSG00000047849 E030 97.2666571 0.0181234805 1.885616e-02 9.196730e-02 3 47909038 47912421 3384 - 2.063 1.910 -0.513
ENSG00000047849 E031 590.0788652 0.0001388330 1.479385e-06 3.997989e-05 3 47914817 47914939 123 - 2.796 2.723 -0.243
ENSG00000047849 E032 1451.1645846 0.0005043209 1.540848e-10 1.050467e-08 3 47915951 47916541 591 - 3.196 3.107 -0.295
ENSG00000047849 E033 498.7541531 0.0008629962 4.590396e-03 3.242066e-02 3 47916542 47916672 131 - 2.715 2.654 -0.202
ENSG00000047849 E034 298.8404674 0.0004974085 2.546409e-05 4.686667e-04 3 47916673 47916682 10 - 2.517 2.420 -0.324
ENSG00000047849 E035 689.0941484 0.0027670990 1.563690e-02 8.049178e-02 3 47916683 47916861 179 - 2.863 2.788 -0.250
ENSG00000047849 E036 912.5948924 0.0017246110 2.890436e-08 1.220444e-06 3 47916862 47917174 313 - 3.020 2.887 -0.441
ENSG00000047849 E037 539.3392452 0.0001626857 5.415519e-26 3.005489e-23 3 47918719 47918841 123 - 2.815 2.645 -0.566
ENSG00000047849 E038 610.8878185 0.0003374302 6.333729e-25 3.191729e-22 3 47921765 47921878 114 - 2.870 2.697 -0.574
ENSG00000047849 E039 456.7523238 0.0020333325 3.740364e-11 2.893849e-09 3 47928228 47928272 45 - 2.751 2.564 -0.623
ENSG00000047849 E040 516.1012485 0.0010743683 6.545839e-15 9.863354e-13 3 47928273 47928350 78 - 2.797 2.622 -0.585
ENSG00000047849 E041 5.6090472 0.0151783173 1.497844e-01 3.619778e-01 3 47940499 47940534 36 - 0.913 0.715 -0.777
ENSG00000047849 E042 0.1723744 0.0648271108 8.844356e-01   3 47973084 47973085 2 - 0.000 0.091 8.750
ENSG00000047849 E043 1.2892282 0.2728486576 5.061849e-01   3 47973086 47975465 2380 - 0.447 0.285 -0.955
ENSG00000047849 E044 391.9259022 0.0003758745 5.087716e-14 6.697761e-12 3 47977865 47977928 64 - 2.665 2.515 -0.500
ENSG00000047849 E045 231.8423445 0.0013484338 2.685167e-10 1.737817e-08 3 47977929 47977933 5 - 2.459 2.273 -0.621
ENSG00000047849 E046 1.6256636 0.0112375430 3.032564e-01 5.438626e-01 3 47987383 47987433 51 - 0.511 0.334 -0.956
ENSG00000047849 E047 682.5518591 0.0026114585 2.517276e-09 1.354536e-07 3 47998638 47998879 242 - 2.917 2.744 -0.577
ENSG00000047849 E048 0.8403870 0.0176616108 7.774540e-01   3 48013475 48013517 43 - 0.278 0.229 -0.369
ENSG00000047849 E049 0.1779838 0.0376966978 2.565907e-01   3 48016334 48016420 87 - 0.161 0.000 -10.697
ENSG00000047849 E050 1.7917635 0.1430338753 6.347210e-01 7.933914e-01 3 48087910 48088066 157 - 0.507 0.413 -0.478
ENSG00000047849 E051 273.0013851 0.0058831089 1.952881e-03 1.675282e-02 3 48088773 48088963 191 - 2.502 2.360 -0.476
ENSG00000047849 E052 24.8908773 0.0013849194 3.631797e-02 1.450967e-01 3 48088964 48089272 309 - 1.278 1.441 0.566