ENSG00000047621

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261250 ENSG00000047621 HEK293_OSMI2_6hA HEK293_TMG_6hB C12orf4 protein_coding protein_coding 6.426886 1.925393 10.87307 0.08840895 0.1548154 2.491388 4.0955156 1.2516292 6.0330792 0.18412799 0.3034352 2.2599959 0.70311250 0.6586000 0.5558333 -0.10276667 8.018266e-01 9.728636e-10 FALSE TRUE
ENST00000509318 ENSG00000047621 HEK293_OSMI2_6hA HEK293_TMG_6hB C12orf4 protein_coding processed_transcript 6.426886 1.925393 10.87307 0.08840895 0.1548154 2.491388 0.2822083 0.3957237 0.3399879 0.07588089 0.0881315 -0.2131925 0.07655000 0.2026667 0.0315000 -0.17116667 1.871957e-04 9.728636e-10   FALSE
MSTRG.6652.4 ENSG00000047621 HEK293_OSMI2_6hA HEK293_TMG_6hB C12orf4 protein_coding   6.426886 1.925393 10.87307 0.08840895 0.1548154 2.491388 1.3966722 0.0000000 2.3728841 0.00000000 0.1191193 7.8965650 0.13794583 0.0000000 0.2181667 0.21816667 9.728636e-10 9.728636e-10 FALSE TRUE
MSTRG.6652.5 ENSG00000047621 HEK293_OSMI2_6hA HEK293_TMG_6hB C12orf4 protein_coding   6.426886 1.925393 10.87307 0.08840895 0.1548154 2.491388 0.4760925 0.1488009 1.4124026 0.14880090 0.1659086 3.1630388 0.05441667 0.0727000 0.1295667 0.05686667 5.908173e-01 9.728636e-10 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000047621 E001 108.1374470 1.431417946 0.41729593 0.64160130 12 4487735 4489414 1680 - 1.843 2.139 0.993
ENSG00000047621 E002 9.5123770 0.501805070 0.88130833 0.94199975 12 4489415 4489426 12 - 0.912 0.878 -0.130
ENSG00000047621 E003 17.0099436 0.684374849 0.55880720 0.74240229 12 4489427 4489560 134 - 1.106 1.251 0.516
ENSG00000047621 E004 14.2587707 0.428838628 0.15348736 0.36731388 12 4489561 4489616 56 - 0.977 1.348 1.330
ENSG00000047621 E005 34.7597761 0.762268981 0.31382226 0.55403799 12 4489617 4489794 178 - 1.366 1.646 0.960
ENSG00000047621 E006 35.7730901 0.790858241 0.32157114 0.56109995 12 4489795 4489899 105 - 1.375 1.665 0.994
ENSG00000047621 E007 38.1262654 0.009791849 0.11094214 0.30049167 12 4490522 4490589 68 - 1.430 1.622 0.657
ENSG00000047621 E008 34.7749872 0.001295465 0.36863642 0.60294274 12 4491177 4491234 58 - 1.400 1.537 0.472
ENSG00000047621 E009 58.7147324 0.008774624 0.62684862 0.78842474 12 4500138 4500314 177 - 1.626 1.736 0.375
ENSG00000047621 E010 26.3671523 0.032561843 0.70345628 0.83782302 12 4500315 4500340 26 - 1.289 1.414 0.436
ENSG00000047621 E011 0.6072928 0.019561798 0.15348111   12 4502311 4502482 172 - 0.107 0.395 2.405
ENSG00000047621 E012 37.6093991 0.033141262 0.88640622 0.94479637 12 4505306 4505380 75 - 1.442 1.534 0.318
ENSG00000047621 E013 1.7766116 0.403541252 0.13873701 0.34558752 12 4508878 4509350 473 - 0.229 0.741 2.697
ENSG00000047621 E014 23.3310026 0.071277300 0.13226934 0.33536946 12 4517061 4517091 31 - 1.279 1.115 -0.582
ENSG00000047621 E015 19.7701672 0.129305539 0.20199853 0.43207290 12 4517092 4517105 14 - 1.213 1.035 -0.641
ENSG00000047621 E016 28.6793966 0.049314950 0.01041473 0.05991807 12 4517106 4517189 84 - 1.379 1.085 -1.041
ENSG00000047621 E017 42.4059001 0.010005553 0.02791011 0.12102162 12 4518058 4518255 198 - 1.527 1.417 -0.376
ENSG00000047621 E018 30.7000863 0.029663386 0.21594609 0.44856023 12 4518774 4518880 107 - 1.385 1.331 -0.187
ENSG00000047621 E019 1.3745261 0.029225056 0.64929447   12 4524935 4525253 319 - 0.266 0.396 0.821
ENSG00000047621 E020 36.6958075 0.038809569 0.22010453 0.45364286 12 4525254 4525375 122 - 1.461 1.398 -0.215
ENSG00000047621 E021 20.8322421 0.050025597 0.51164460 0.70925181 12 4525484 4525516 33 - 1.219 1.197 -0.078
ENSG00000047621 E022 31.8574030 0.014352861 0.07388622 0.23254345 12 4525517 4525583 67 - 1.405 1.306 -0.344
ENSG00000047621 E023 44.3854208 0.016453593 0.06656752 0.21733112 12 4529869 4530050 182 - 1.544 1.460 -0.287
ENSG00000047621 E024 0.1779838 0.046285315 1.00000000   12 4534045 4534156 112 - 0.057 0.000 -7.104
ENSG00000047621 E025 33.7763745 0.019254614 0.28133270 0.52162964 12 4534157 4534302 146 - 1.418 1.391 -0.096
ENSG00000047621 E026 18.2432148 0.013485579 0.05977803 0.20228122 12 4536017 4536082 66 - 1.182 1.026 -0.560
ENSG00000047621 E027 24.7694155 0.040706204 0.09075308 0.26513231 12 4536083 4536211 129 - 1.306 1.155 -0.532
ENSG00000047621 E028 11.7164759 0.003737037 0.15292637 0.36650535 12 4536212 4536219 8 - 1.005 0.885 -0.448
ENSG00000047621 E029 17.5599900 0.012371592 0.07971432 0.24425023 12 4538409 4538564 156 - 1.165 1.026 -0.500