ENSG00000047578

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261588 ENSG00000047578 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNIP protein_coding protein_coding 6.486699 8.872705 4.957435 0.6494545 0.2881894 -0.838498 1.2858220 2.0493099 1.5444709 0.06086849 0.2088466 -0.4057373 0.21193750 0.23443333 0.31656667 0.08213333 0.716523089 0.005457581 FALSE TRUE
ENST00000568258 ENSG00000047578 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNIP protein_coding protein_coding 6.486699 8.872705 4.957435 0.6494545 0.2881894 -0.838498 0.1805509 0.0000000 0.4400305 0.00000000 0.2216611 5.4919509 0.03031667 0.00000000 0.08903333 0.08903333 0.217372783 0.005457581 FALSE TRUE
ENST00000568622 ENSG00000047578 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNIP protein_coding retained_intron 6.486699 8.872705 4.957435 0.6494545 0.2881894 -0.838498 2.1484456 3.6480617 0.9595667 0.35121880 0.1626498 -1.9156674 0.28970000 0.41053333 0.19256667 -0.21796667 0.005457581 0.005457581 FALSE TRUE
ENST00000618117 ENSG00000047578 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNIP protein_coding protein_coding 6.486699 8.872705 4.957435 0.6494545 0.2881894 -0.838498 0.6386231 0.5300129 0.1945166 0.09636237 0.1001145 -1.4007761 0.08601250 0.05890000 0.03743333 -0.02146667 0.802664462 0.005457581 FALSE FALSE
MSTRG.12333.1 ENSG00000047578 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNIP protein_coding   6.486699 8.872705 4.957435 0.6494545 0.2881894 -0.838498 0.3794485 0.3448497 0.0000000 0.34484967 0.0000000 -5.1491361 0.07162083 0.03953333 0.00000000 -0.03953333 0.960592216 0.005457581 FALSE TRUE
MSTRG.12333.5 ENSG00000047578 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNIP protein_coding   6.486699 8.872705 4.957435 0.6494545 0.2881894 -0.838498 0.4363660 0.7001486 0.8081768 0.35996541 0.1501920 0.2042916 0.07404167 0.07813333 0.16183333 0.08370000 0.722210551 0.005457581 FALSE TRUE
MSTRG.12333.6 ENSG00000047578 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNIP protein_coding   6.486699 8.872705 4.957435 0.6494545 0.2881894 -0.838498 0.6187917 0.7548133 0.8940360 0.55132892 0.2480046 0.2412725 0.10845833 0.07913333 0.18010000 0.10096667 0.669970446 0.005457581 FALSE TRUE
MSTRG.12333.7 ENSG00000047578 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNIP protein_coding   6.486699 8.872705 4.957435 0.6494545 0.2881894 -0.838498 0.3602748 0.5600043 0.0000000 0.56000430 0.0000000 -5.8329009 0.05372500 0.06420000 0.00000000 -0.06420000 0.964497117 0.005457581 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000047578 E001 0.2027342 0.0381480146 8.757939e-01   16 27550105 27550132 28 + 0.000 0.092 8.586
ENSG00000047578 E002 0.2027342 0.0381480146 8.757939e-01   16 27550133 27550143 11 + 0.000 0.092 10.820
ENSG00000047578 E003 0.3336024 0.0274424043 4.306556e-01   16 27550144 27550148 5 + 0.000 0.167 11.882
ENSG00000047578 E004 4.6218526 0.0269684573 6.643850e-02 2.170527e-01 16 27550149 27550157 9 + 0.885 0.608 -1.127
ENSG00000047578 E005 15.5954776 0.0356142080 1.714281e-01 3.924276e-01 16 27550158 27550177 20 + 1.293 1.124 -0.599
ENSG00000047578 E006 16.7121616 0.0024309392 2.402217e-02 1.091539e-01 16 27573901 27573906 6 + 1.339 1.144 -0.685
ENSG00000047578 E007 19.0790230 0.0020087319 2.752272e-03 2.188399e-02 16 27573907 27573921 15 + 1.419 1.179 -0.839
ENSG00000047578 E008 21.7654913 0.0019691998 1.652277e-03 1.468774e-02 16 27573922 27573956 35 + 1.474 1.236 -0.827
ENSG00000047578 E009 0.0000000       16 27573957 27574295 339 +      
ENSG00000047578 E010 21.2848802 0.0029611900 4.398515e-04 5.127113e-03 16 27618425 27618469 45 + 1.480 1.206 -0.954
ENSG00000047578 E011 23.2454923 0.0155052902 5.233216e-03 3.584707e-02 16 27618470 27618501 32 + 1.506 1.248 -0.897
ENSG00000047578 E012 0.0000000       16 27628588 27628660 73 +      
ENSG00000047578 E013 38.1254950 0.0017924678 8.910528e-04 9.020642e-03 16 27628661 27628830 170 + 1.685 1.487 -0.677
ENSG00000047578 E014 25.5836998 0.0015220246 3.879145e-01 6.188638e-01 16 27631065 27631162 98 + 1.440 1.377 -0.220
ENSG00000047578 E015 1.6976496 0.0150137751 6.053864e-01 7.737745e-01 16 27631163 27631254 92 + 0.367 0.459 0.499
ENSG00000047578 E016 0.2027342 0.0381480146 8.757939e-01   16 27632464 27632603 140 + 0.000 0.092 10.820
ENSG00000047578 E017 21.4855594 0.0022817656 3.141356e-02 1.315305e-01 16 27648604 27648735 132 + 1.426 1.260 -0.581
ENSG00000047578 E018 11.3160149 0.0294336693 1.236387e-01 3.214732e-01 16 27654608 27654736 129 + 1.184 0.988 -0.709
ENSG00000047578 E019 45.6333071 0.0204939739 9.184492e-02 2.670967e-01 16 27677729 27677996 268 + 1.734 1.587 -0.500
ENSG00000047578 E020 31.5396903 0.0013780938 6.735819e-02 2.191416e-01 16 27681399 27681530 132 + 1.566 1.448 -0.407
ENSG00000047578 E021 30.8359675 0.0358364050 7.766602e-01 8.826998e-01 16 27698328 27698500 173 + 1.506 1.465 -0.140
ENSG00000047578 E022 15.9553301 0.0020427778 4.676321e-01 6.784622e-01 16 27699534 27699599 66 + 1.251 1.186 -0.231
ENSG00000047578 E023 0.0000000       16 27701434 27701588 155 +      
ENSG00000047578 E024 22.4681642 0.0101580336 5.909137e-01 7.643261e-01 16 27701589 27701695 107 + 1.380 1.328 -0.180
ENSG00000047578 E025 22.7914103 0.0554121978 7.870197e-01 8.887695e-01 16 27703896 27703998 103 + 1.349 1.359 0.033
ENSG00000047578 E026 15.2238781 0.3259310500 8.637936e-01 9.325087e-01 16 27708705 27708713 9 + 1.233 1.166 -0.236
ENSG00000047578 E027 33.7196429 0.4883846353 4.830291e-01 6.891725e-01 16 27708714 27708920 207 + 1.470 1.542 0.249
ENSG00000047578 E028 28.0414123 0.0041351737 4.323134e-01 6.529822e-01 16 27721558 27721695 138 + 1.411 1.465 0.187
ENSG00000047578 E029 1.5895066 0.0116162238 7.489423e-01 8.661116e-01 16 27727216 27727873 658 + 0.367 0.423 0.310
ENSG00000047578 E030 113.2402536 0.0005428487 4.628021e-01 6.750116e-01 16 27740041 27740920 880 + 2.055 2.027 -0.091
ENSG00000047578 E031 87.8899758 0.0051254382 1.060114e-01 2.923714e-01 16 27749584 27750306 723 + 1.977 1.894 -0.277
ENSG00000047578 E032 42.5475780 0.0097447773 8.662653e-01 9.339244e-01 16 27751719 27751924 206 + 1.622 1.609 -0.047
ENSG00000047578 E033 25.0398260 0.0017132077 5.234353e-01 7.174182e-01 16 27754173 27754251 79 + 1.364 1.409 0.156
ENSG00000047578 E034 0.6566214 0.4695968057 2.967795e-01   16 27754252 27755752 1501 + 0.368 0.093 -2.490
ENSG00000047578 E035 44.2103813 0.0009090075 1.029827e-01 2.871117e-01 16 27761413 27761590 178 + 1.572 1.662 0.306
ENSG00000047578 E036 38.6814256 0.0019952064 6.373449e-02 2.111053e-01 16 27766309 27766474 166 + 1.505 1.619 0.388
ENSG00000047578 E037 38.4721526 0.0109965349 6.714259e-01 8.172000e-01 16 27769861 27770018 158 + 1.556 1.592 0.121
ENSG00000047578 E038 30.3332089 0.0203111817 6.058374e-01 7.740962e-01 16 27771588 27771652 65 + 1.445 1.498 0.180
ENSG00000047578 E039 41.0967102 0.0366640838 7.904700e-01 8.908059e-01 16 27773099 27773209 111 + 1.577 1.616 0.131
ENSG00000047578 E040 46.6945195 0.0047384223 2.328237e-02 1.068299e-01 16 27774945 27775084 140 + 1.561 1.703 0.482
ENSG00000047578 E041 9.0929514 0.0344254160 5.735330e-01 7.526454e-01 16 27776866 27776927 62 + 0.932 1.014 0.306
ENSG00000047578 E042 42.1163707 0.0035781362 3.253851e-02 1.348180e-01 16 27776928 27777029 102 + 1.528 1.660 0.452
ENSG00000047578 E043 64.8822236 0.0089581361 2.332754e-01 4.689065e-01 16 27777610 27777770 161 + 1.752 1.824 0.245
ENSG00000047578 E044 56.6086910 0.0014715421 6.506173e-01 8.039304e-01 16 27777881 27777969 89 + 1.730 1.751 0.072
ENSG00000047578 E045 288.8728712 0.0002208709 5.174175e-10 3.181368e-08 16 27778574 27780344 1771 + 2.353 2.481 0.426