ENSG00000047315

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314595 ENSG00000047315 HEK293_OSMI2_6hA HEK293_TMG_6hB POLR2B protein_coding protein_coding 68.73538 16.3529 124.0176 1.063814 3.473395 2.92216 48.964167 10.2099518 89.090664 1.40380174 3.0654231 3.124048 0.68345417 0.62003333 0.71810000 0.09806667 5.926132e-01 5.153438e-15 FALSE  
ENST00000431623 ENSG00000047315 HEK293_OSMI2_6hA HEK293_TMG_6hB POLR2B protein_coding protein_coding 68.73538 16.3529 124.0176 1.063814 3.473395 2.92216 3.693226 0.8938923 7.703878 0.07718189 1.0402385 3.093234 0.05674167 0.05566667 0.06186667 0.00620000 9.400944e-01 5.153438e-15 FALSE  
ENST00000450656 ENSG00000047315 HEK293_OSMI2_6hA HEK293_TMG_6hB POLR2B protein_coding protein_coding 68.73538 16.3529 124.0176 1.063814 3.473395 2.92216 3.675336 0.0000000 6.232749 0.00000000 0.2716757 9.286038 0.03190833 0.00000000 0.05020000 0.05020000 5.153438e-15 5.153438e-15    
ENST00000484821 ENSG00000047315 HEK293_OSMI2_6hA HEK293_TMG_6hB POLR2B protein_coding retained_intron 68.73538 16.3529 124.0176 1.063814 3.473395 2.92216 7.853947 3.1457589 13.569969 0.71151774 0.7564664 2.105421 0.14199583 0.19220000 0.10980000 -0.08240000 4.863806e-01 5.153438e-15    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000047315 E001 1.0725712 0.0153833765 6.220534e-02   4 56976440 56977566 1127 + 0.177 0.541 2.294
ENSG00000047315 E002 1.3034679 0.0135882285 2.740333e-01   4 56977672 56977721 50 + 0.303 0.000 -10.839
ENSG00000047315 E003 1.7689339 0.0115895420 1.512268e-01 3.641138e-01 4 56977722 56977741 20 + 0.378 0.000 -11.298
ENSG00000047315 E004 5.0101417 0.0245082316 2.118173e-01 4.438853e-01 4 56977742 56977781 40 + 0.670 0.422 -1.162
ENSG00000047315 E005 4.9935736 0.0150866866 2.068004e-01 4.379076e-01 4 56977782 56977791 10 + 0.669 0.423 -1.157
ENSG00000047315 E006 2.5236630 0.0085591698 5.778359e-01 7.556936e-01 4 56977792 56977808 17 + 0.422 0.541 0.592
ENSG00000047315 E007 1.6174814 0.0120284398 4.263648e-02 1.616293e-01 4 56977809 56978000 192 + 0.245 0.633 2.123
ENSG00000047315 E008 14.3652825 0.0030660553 8.764233e-01 9.394205e-01 4 56978640 56978863 224 + 1.035 1.068 0.121
ENSG00000047315 E009 6.2081643 0.0148875572 5.047256e-01 7.041235e-01 4 56978864 56978868 5 + 0.712 0.830 0.476
ENSG00000047315 E010 41.5710342 0.0045027019 5.626036e-01 7.450969e-01 4 56978869 56978895 27 + 1.476 1.438 -0.130
ENSG00000047315 E011 49.4482220 0.0039657608 6.807736e-01 8.231863e-01 4 56978896 56978903 8 + 1.539 1.581 0.145
ENSG00000047315 E012 293.7401635 0.0011027548 2.445491e-03 1.998018e-02 4 56978904 56979004 101 + 2.317 2.226 -0.305
ENSG00000047315 E013 0.7625515 0.0671998667 1.669082e-01   4 56985260 56985279 20 + 0.140 0.421 2.106
ENSG00000047315 E014 2.6776162 0.0087782382 2.653686e-02 1.168837e-01 4 56985280 56985457 178 + 0.378 0.775 1.836
ENSG00000047315 E015 323.1402585 0.0023551592 1.198692e-03 1.142343e-02 4 56986354 56986426 73 + 2.360 2.252 -0.363
ENSG00000047315 E016 0.0000000       4 56986427 56986803 377 +      
ENSG00000047315 E017 372.1477570 0.0009732286 4.878160e-02 1.767621e-01 4 56990748 56990898 151 + 2.413 2.367 -0.155
ENSG00000047315 E018 0.3040503 0.0244411696 1.000000e+00   4 56990899 56990906 8 + 0.098 0.000 -8.837
ENSG00000047315 E019 300.0612840 0.0001777871 7.677759e-03 4.784632e-02 4 56994404 56994516 113 + 2.325 2.257 -0.227
ENSG00000047315 E020 433.4018775 0.0004952445 2.065005e-06 5.368118e-05 4 56994647 56994866 220 + 2.490 2.371 -0.396
ENSG00000047315 E021 370.2007325 0.0001696715 1.961297e-09 1.083165e-07 4 56995251 56995409 159 + 2.425 2.263 -0.540
ENSG00000047315 E022 393.1056184 0.0002292582 4.876024e-06 1.126767e-04 4 56999617 56999781 165 + 2.446 2.332 -0.380
ENSG00000047315 E023 451.8012209 0.0001985032 3.859547e-01 6.172797e-01 4 57005246 57005442 197 + 2.493 2.486 -0.024
ENSG00000047315 E024 349.2085204 0.0003721296 9.548896e-01 9.793410e-01 4 57005600 57005719 120 + 2.379 2.395 0.054
ENSG00000047315 E025 460.0837330 0.0005524135 4.346242e-01 6.547082e-01 4 57006816 57007002 187 + 2.501 2.496 -0.019
ENSG00000047315 E026 19.6622624 0.3235039951 9.559618e-01 9.798903e-01 4 57009559 57010172 614 + 1.121 1.347 0.797
ENSG00000047315 E027 5.4449174 0.1436806440 8.828177e-01 9.427850e-01 4 57010173 57010200 28 + 0.663 0.711 0.200
ENSG00000047315 E028 11.8869719 0.2401399684 9.446786e-01 9.746835e-01 4 57010201 57010360 160 + 0.936 1.082 0.536
ENSG00000047315 E029 429.2027899 0.0005659304 9.264436e-01 9.653182e-01 4 57010361 57010504 144 + 2.468 2.485 0.056
ENSG00000047315 E030 373.3078305 0.0001753272 7.770624e-01 8.829678e-01 4 57010748 57010887 140 + 2.409 2.416 0.023
ENSG00000047315 E031 438.3024455 0.0010646532 1.847080e-02 9.060301e-02 4 57010989 57011100 112 + 2.486 2.433 -0.179
ENSG00000047315 E032 543.4744171 0.0015659269 4.788488e-02 1.747395e-01 4 57015502 57015656 155 + 2.577 2.534 -0.143
ENSG00000047315 E033 0.0000000       4 57015657 57015658 2 +      
ENSG00000047315 E034 588.3027522 0.0007258016 8.961136e-01 9.498587e-01 4 57017043 57017241 199 + 2.605 2.616 0.038
ENSG00000047315 E035 529.9956299 0.0001197444 9.640479e-01 9.839063e-01 4 57017560 57017728 169 + 2.559 2.575 0.051
ENSG00000047315 E036 393.0664872 0.0007984119 6.864607e-01 8.267801e-01 4 57020899 57020995 97 + 2.428 2.454 0.086
ENSG00000047315 E037 247.8192225 0.0003976419 6.151241e-01 7.803594e-01 4 57022152 57022182 31 + 2.234 2.231 -0.010
ENSG00000047315 E038 359.4669071 0.0001461161 1.771497e-01 3.999906e-01 4 57022183 57022246 64 + 2.397 2.375 -0.075
ENSG00000047315 E039 3.1733719 0.0081215391 4.779466e-02 1.745305e-01 4 57023227 57023329 103 + 0.422 0.775 1.595
ENSG00000047315 E040 581.5134030 0.0001559160 3.053745e-01 5.459884e-01 4 57023330 57023490 161 + 2.603 2.595 -0.026
ENSG00000047315 E041 442.1050489 0.0001282244 1.117027e-01 3.019017e-01 4 57023491 57023580 90 + 2.476 2.528 0.173
ENSG00000047315 E042 36.7122548 0.0753591346 1.061891e-01 2.926875e-01 4 57023581 57023661 81 + 1.366 1.649 0.972
ENSG00000047315 E043 426.0107149 0.0001704905 1.973490e-02 9.500623e-02 4 57023662 57023751 90 + 2.458 2.528 0.234
ENSG00000047315 E044 469.3892613 0.0010391706 2.194590e-03 1.836644e-02 4 57024005 57024112 108 + 2.495 2.590 0.317
ENSG00000047315 E045 544.8246739 0.0009839509 1.250981e-03 1.179859e-02 4 57024886 57024999 114 + 2.559 2.653 0.313
ENSG00000047315 E046 598.3128926 0.0001552979 3.373045e-05 5.963776e-04 4 57025377 57025537 161 + 2.599 2.696 0.324
ENSG00000047315 E047 556.2734942 0.0104097451 3.923289e-03 2.872202e-02 4 57030204 57030399 196 + 2.558 2.714 0.520
ENSG00000047315 E048 221.6076052 1.7036403647 4.685088e-01 6.790294e-01 4 57030899 57031337 439 + 2.137 2.402 0.886