ENSG00000039523

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000042381 ENSG00000039523 HEK293_OSMI2_6hA HEK293_TMG_6hB RIPOR1 protein_coding protein_coding 12.78075 16.48086 8.486274 2.362054 0.2873807 -0.9567648 9.233552 14.39727 5.577804 2.526118 0.5257404 -1.366444 0.7126375 0.8642333 0.6560333 -0.2082000 5.755279e-02 6.641891e-24 FALSE TRUE
ENST00000566522 ENSG00000039523 HEK293_OSMI2_6hA HEK293_TMG_6hB RIPOR1 protein_coding processed_transcript 12.78075 16.48086 8.486274 2.362054 0.2873807 -0.9567648 1.192408 0.00000 1.763144 0.000000 0.1593914 7.470166 0.1086375 0.0000000 0.2072667 0.2072667 6.641891e-24 6.641891e-24 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000039523 E001 0.0000000       16 67518418 67518613 196 +      
ENSG00000039523 E002 0.0000000       16 67528288 67528513 226 +      
ENSG00000039523 E003 0.5059767 0.0218125160 0.5195657873   16 67528817 67528828 12 + 0.000 0.183 9.749
ENSG00000039523 E004 11.0794311 0.0502638636 0.8186970989 0.90726352 16 67528829 67528866 38 + 1.025 1.009 -0.058
ENSG00000039523 E005 15.5727126 0.0025507271 0.9494715106 0.97677784 16 67528867 67528880 14 + 1.151 1.148 -0.011
ENSG00000039523 E006 21.3885694 0.0019963044 0.2261641755 0.46080238 16 67528881 67528914 34 + 1.186 1.300 0.403
ENSG00000039523 E007 0.8565226 0.5599584300 0.4182597918   16 67529347 67529636 290 + 0.346 0.187 -1.180
ENSG00000039523 E008 1.0288969 0.7208698843 0.4866126999   16 67529637 67529726 90 + 0.347 0.236 -0.759
ENSG00000039523 E009 0.6785387 0.7746991699 0.7920560648   16 67529727 67529790 64 + 0.204 0.187 -0.153
ENSG00000039523 E010 0.8509131 0.9590929028 0.8416064730   16 67529791 67529859 69 + 0.204 0.237 0.271
ENSG00000039523 E011 1.5954914 0.0806260846 0.0238463695 0.10862827 16 67529860 67530087 228 + 0.661 0.230 -2.361
ENSG00000039523 E012 1.3381088 0.2786386037 0.5579850080   16 67531548 67531630 83 + 0.202 0.352 1.075
ENSG00000039523 E013 0.7310763 0.3343720875 0.3427812031   16 67537454 67537472 19 + 0.346 0.133 -1.767
ENSG00000039523 E014 0.7145081 0.0214232764 0.2340859266   16 67537473 67537597 125 + 0.342 0.130 -1.777
ENSG00000039523 E015 0.7733225 0.0229947789 0.9440780582   16 67538078 67538423 346 + 0.204 0.229 0.216
ENSG00000039523 E016 25.3184200 0.0017994497 0.4188109632 0.64271145 16 67538424 67538463 40 + 1.290 1.360 0.244
ENSG00000039523 E017 39.1740138 0.0012113460 0.0162034518 0.08253696 16 67538464 67538550 87 + 1.386 1.560 0.601
ENSG00000039523 E018 0.2027342 0.0390368222 1.0000000000   16 67538660 67538671 12 + 0.000 0.070 8.163
ENSG00000039523 E019 54.7875538 0.0932899239 0.1086521188 0.29684760 16 67538672 67538824 153 + 1.493 1.708 0.731
ENSG00000039523 E020 0.3337900 0.0345812451 0.3687085510   16 67538965 67538989 25 + 0.203 0.070 -1.777
ENSG00000039523 E021 56.0199029 0.1140822279 0.6779911886 0.82143339 16 67538990 67539068 79 + 1.675 1.679 0.013
ENSG00000039523 E022 41.9582474 0.0513213989 0.4578284661 0.67162788 16 67539728 67539751 24 + 1.512 1.569 0.196
ENSG00000039523 E023 34.9262749 0.0316246252 0.7593088107 0.87213129 16 67539846 67539849 4 + 1.474 1.483 0.030
ENSG00000039523 E024 38.3859075 0.0380484716 0.5629713958 0.74540882 16 67539850 67539864 15 + 1.490 1.528 0.131
ENSG00000039523 E025 47.5817627 0.0675085770 0.3360151503 0.57446267 16 67539865 67539899 35 + 1.534 1.628 0.321
ENSG00000039523 E026 65.1006259 0.2327775777 0.5365040990 0.72668838 16 67540053 67540124 72 + 1.719 1.748 0.099
ENSG00000039523 E027 84.2425928 0.0007021695 0.0486200319 0.17641603 16 67540125 67540205 81 + 1.921 1.836 -0.287
ENSG00000039523 E028 1.3569625 0.0152347807 0.3414258604   16 67540206 67540299 94 + 0.446 0.272 -1.042
ENSG00000039523 E029 77.5112004 0.0005317630 0.0064514659 0.04193563 16 67540300 67540352 53 + 1.912 1.792 -0.405
ENSG00000039523 E030 53.9569738 0.0008436345 0.0015870996 0.01423127 16 67540353 67540363 11 + 1.792 1.626 -0.563
ENSG00000039523 E031 67.3736171 0.0005504150 0.0000878521 0.00134070 16 67540458 67540501 44 + 1.896 1.713 -0.616
ENSG00000039523 E032 0.9686097 0.1804340930 0.5936631625   16 67540502 67540551 50 + 0.342 0.230 -0.777
ENSG00000039523 E033 0.9873907 0.2232880927 0.5725499173   16 67540552 67540578 27 + 0.343 0.230 -0.789
ENSG00000039523 E034 94.2425906 0.0005239510 0.0159161138 0.08148204 16 67540579 67540704 126 + 1.977 1.880 -0.326
ENSG00000039523 E035 1.0526225 0.0584625097 0.0536435234   16 67541347 67541429 83 + 0.531 0.181 -2.214
ENSG00000039523 E036 94.4844495 0.0268807984 0.0349850659 0.14154978 16 67541430 67541578 149 + 2.034 1.853 -0.608
ENSG00000039523 E037 97.8013188 0.0130875850 0.0171636378 0.08604264 16 67541653 67541782 130 + 2.030 1.876 -0.515
ENSG00000039523 E038 296.9279151 0.0836242800 0.6410409516 0.79754062 16 67541867 67542998 1132 + 2.387 2.396 0.033
ENSG00000039523 E039 135.0521526 0.0003336246 0.0024673199 0.02012042 16 67542999 67543264 266 + 1.968 2.085 0.390
ENSG00000039523 E040 43.8560719 0.0010212117 0.9925388889 0.99793863 16 67543348 67543350 3 + 1.573 1.577 0.010
ENSG00000039523 E041 101.4900993 0.0006149692 0.9477420109 0.97618618 16 67543351 67543469 119 + 1.931 1.937 0.022
ENSG00000039523 E042 3.4312071 0.1231192043 0.3830682146 0.61478341 16 67543470 67543826 357 + 0.715 0.538 -0.771
ENSG00000039523 E043 83.8553478 0.0007353142 0.3586265124 0.59466904 16 67544299 67544393 95 + 1.820 1.867 0.158
ENSG00000039523 E044 64.4736899 0.0082538944 0.2568533025 0.49564019 16 67544394 67544431 38 + 1.672 1.762 0.308
ENSG00000039523 E045 98.1504483 0.0005607860 0.1895475089 0.41636661 16 67544695 67544830 136 + 1.876 1.936 0.204
ENSG00000039523 E046 99.8155485 0.0005140582 0.0385138056 0.15090861 16 67544956 67545117 162 + 1.858 1.951 0.313
ENSG00000039523 E047 0.1723744 0.0461010880 1.0000000000   16 67545372 67545375 4 + 0.000 0.070 8.161
ENSG00000039523 E048 135.1537179 0.0143006411 0.5104478613 0.70829421 16 67545376 67545534 159 + 2.013 2.066 0.180
ENSG00000039523 E049 0.3150090 0.0285178002 0.3699977113   16 67545537 67545663 127 + 0.203 0.070 -1.776
ENSG00000039523 E050 151.6187031 0.0056059225 0.1430250451 0.35201725 16 67545664 67545860 197 + 2.042 2.122 0.267
ENSG00000039523 E051 90.4985777 0.0004800741 0.3538349198 0.59067966 16 67545949 67546032 84 + 1.851 1.895 0.148
ENSG00000039523 E052 3.2840605 0.2091945242 0.9537183742 0.97878407 16 67546033 67546140 108 + 0.533 0.570 0.175
ENSG00000039523 E053 105.9969786 0.0237413356 0.7975306396 0.89492633 16 67546141 67546231 91 + 1.932 1.955 0.076
ENSG00000039523 E054 139.1642067 0.0116821343 0.8568963051 0.92875811 16 67546366 67546788 423 + 2.053 2.073 0.070