ENSG00000038532

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261657 ENSG00000038532 HEK293_OSMI2_6hA HEK293_TMG_6hB CLEC16A protein_coding protein_coding 9.291369 14.49372 6.790336 1.791226 0.7748007 -1.092745 1.5178999 2.5823647 0.3215186 0.4217533 0.06828210 -2.9671068 0.13794583 0.17710000 0.04630000 -0.13080000 3.430637e-05 3.430637e-05 FALSE FALSE
ENST00000494853 ENSG00000038532 HEK293_OSMI2_6hA HEK293_TMG_6hB CLEC16A protein_coding retained_intron 9.291369 14.49372 6.790336 1.791226 0.7748007 -1.092745 0.1770121 0.0000000 0.8505895 0.0000000 0.46252525 6.4272534 0.02397083 0.00000000 0.11246667 0.11246667 1.530863e-01 3.430637e-05 FALSE TRUE
MSTRG.12041.1 ENSG00000038532 HEK293_OSMI2_6hA HEK293_TMG_6hB CLEC16A protein_coding   9.291369 14.49372 6.790336 1.791226 0.7748007 -1.092745 4.7965050 6.9241416 3.6397714 0.9819758 0.29223022 -0.9259112 0.54022500 0.47520000 0.54393333 0.06873333 7.628289e-01 3.430637e-05 FALSE TRUE
MSTRG.12041.2 ENSG00000038532 HEK293_OSMI2_6hA HEK293_TMG_6hB CLEC16A protein_coding   9.291369 14.49372 6.790336 1.791226 0.7748007 -1.092745 1.1926001 3.7317375 1.0759464 0.4482413 0.09010109 -1.7847554 0.13834167 0.26366667 0.16243333 -0.10123333 4.248953e-01 3.430637e-05 FALSE TRUE
MSTRG.12041.4 ENSG00000038532 HEK293_OSMI2_6hA HEK293_TMG_6hB CLEC16A protein_coding   9.291369 14.49372 6.790336 1.791226 0.7748007 -1.092745 1.0472890 0.3873801 0.5481658 0.3873801 0.27541006 0.4901742 0.09994167 0.02333333 0.08283333 0.05950000 6.642471e-01 3.430637e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

No results under this category.

Splicing

All exons whithin this gene region are shown and numbering below.

No results under this category.

Transcripts

All isoforms whithin this gene region are shown below.

No results under this category.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000038532 E001 0.9271035 0.0180086189 6.720113e-01   16 10944562 10944563 2 + 0.298 0.266 -0.221
ENSG00000038532 E002 4.1885816 0.0063000106 3.143437e-01 0.554551482 16 10944564 10944579 16 + 0.735 0.662 -0.301
ENSG00000038532 E003 7.3944019 0.0199642720 6.280845e-02 0.209065615 16 10944580 10944580 1 + 0.995 0.839 -0.589
ENSG00000038532 E004 52.7302271 0.0137329567 2.716239e-03 0.021665831 16 10944581 10944797 217 + 1.775 1.655 -0.405
ENSG00000038532 E005 61.1840896 0.0072645346 9.246710e-04 0.009296691 16 10957782 10957910 129 + 1.828 1.722 -0.357
ENSG00000038532 E006 57.7015824 0.0117464609 2.360554e-03 0.019447745 16 10962455 10962588 134 + 1.805 1.694 -0.374
ENSG00000038532 E007 73.1425955 0.0006435260 3.940442e-07 0.000012562 16 10969161 10969309 149 + 1.918 1.791 -0.425
ENSG00000038532 E008 69.7882751 0.0198404433 2.386696e-03 0.019602982 16 10971125 10971230 106 + 1.904 1.762 -0.478
ENSG00000038532 E009 0.2617363 0.1375015912 7.813278e-01   16 10972481 10972553 73 + 0.000 0.151 34.388
ENSG00000038532 E010 0.0000000       16 10972554 10972559 6 +      
ENSG00000038532 E011 76.4821389 0.0187260643 1.359563e-02 0.072758684 16 10972938 10973061 124 + 1.908 1.820 -0.297
ENSG00000038532 E012 89.9958672 0.0028381972 1.166410e-02 0.065093907 16 10977225 10977399 175 + 1.935 1.913 -0.073
ENSG00000038532 E013 51.4694764 0.0013683415 2.013338e-01 0.431378991 16 10979329 10979382 54 + 1.661 1.685 0.082
ENSG00000038532 E014 75.4373502 0.0006437743 1.780204e-02 0.088366513 16 10982878 10982991 114 + 1.851 1.841 -0.033
ENSG00000038532 E015 97.3803575 0.0005421825 3.155808e-04 0.003887768 16 11003074 11003257 184 + 1.984 1.941 -0.146
ENSG00000038532 E016 34.7851104 0.0012418143 4.546151e-03 0.032181781 16 11003258 11003305 48 + 1.579 1.494 -0.289
ENSG00000038532 E017 67.5643370 0.0007097163 6.135632e-02 0.205834852 16 11020193 11020325 133 + 1.793 1.800 0.026
ENSG00000038532 E018 0.0000000       16 11024153 11024261 109 +      
ENSG00000038532 E019 0.0000000       16 11024473 11024479 7 +      
ENSG00000038532 E020 0.0000000       16 11024480 11024507 28 +      
ENSG00000038532 E021 0.0000000       16 11024508 11024526 19 +      
ENSG00000038532 E022 0.0000000       16 11024527 11024571 45 +      
ENSG00000038532 E023 0.0000000       16 11024818 11024820 3 +      
ENSG00000038532 E024 42.9491715 0.0009744912 2.820566e-01 0.522409208 16 11024821 11024866 46 + 1.584 1.617 0.109
ENSG00000038532 E025 43.0266767 0.0010595679 2.892555e-01 0.529773715 16 11024867 11024921 55 + 1.579 1.610 0.108
ENSG00000038532 E026 0.3088520 0.0327352530 4.288096e-01   16 11036047 11036092 46 + 0.174 0.083 -1.224
ENSG00000038532 E027 61.0299212 0.0017527921 1.422129e-01 0.350736559 16 11039754 11039876 123 + 1.737 1.757 0.066
ENSG00000038532 E028 0.9936204 0.0156695918 3.665862e-02   16 11039877 11042253 2377 + 0.473 0.153 -2.220
ENSG00000038532 E029 65.2831372 0.0448703259 4.290384e-01 0.650338523 16 11042254 11042363 110 + 1.766 1.786 0.069
ENSG00000038532 E030 49.3189382 0.0349026125 4.766195e-01 0.684722383 16 11044028 11044072 45 + 1.638 1.670 0.109
ENSG00000038532 E031 1.5049463 0.0121989077 8.173029e-01 0.906566061 16 11044073 11044105 33 + 0.298 0.395 0.590
ENSG00000038532 E032 0.4873834 0.3460173858 7.816407e-01   16 11044106 11044222 117 + 0.172 0.155 -0.181
ENSG00000038532 E033 50.3568071 0.0266725053 6.485463e-01 0.802580193 16 11047292 11047342 51 + 1.624 1.688 0.217
ENSG00000038532 E034 2.8871047 0.0604555296 3.157610e-01 0.555770143 16 11047343 11048318 976 + 0.646 0.523 -0.550
ENSG00000038532 E035 1.2039167 0.0258305258 8.691170e-01   16 11048319 11048518 200 + 0.298 0.314 0.107
ENSG00000038532 E036 72.2974767 0.0423955126 5.465767e-01 0.733863835 16 11051513 11051641 129 + 1.794 1.837 0.144
ENSG00000038532 E037 66.4586847 0.0407301916 6.968596e-01 0.833535943 16 11060902 11061022 121 + 1.742 1.808 0.224
ENSG00000038532 E038 73.0372787 0.0042825267 1.907848e-01 0.417876602 16 11120615 11120766 152 + 1.809 1.841 0.106
ENSG00000038532 E039 29.7963076 0.0106806372 3.119583e-01 0.552305503 16 11123742 11123742 1 + 1.440 1.453 0.045
ENSG00000038532 E040 72.9212002 0.0014613210 1.447281e-01 0.354535444 16 11123743 11123894 152 + 1.813 1.841 0.096
ENSG00000038532 E041 32.6677014 0.0013994578 5.316816e-01 0.723225071 16 11123895 11123899 5 + 1.456 1.509 0.182
ENSG00000038532 E042 43.8620293 0.0009582256 4.482290e-01 0.664422739 16 11123900 11123946 47 + 1.579 1.630 0.174
ENSG00000038532 E043 42.8876669 0.0009456951 1.398842e-01 0.347299756 16 11125979 11126009 31 + 1.601 1.610 0.031
ENSG00000038532 E044 61.8357021 0.0009272729 5.734119e-01 0.752568338 16 11126010 11126146 137 + 1.713 1.782 0.232
ENSG00000038532 E045 2.5490973 0.0238224790 7.089905e-03 0.045028941 16 11126147 11126787 641 + 0.000 0.621 37.325
ENSG00000038532 E046 0.7143205 0.0454700605 1.000000e+00   16 11136069 11136283 215 + 0.174 0.214 0.369
ENSG00000038532 E047 1.3937869 0.0145827598 8.222208e-01 0.909252120 16 11149886 11150317 432 + 0.298 0.394 0.585
ENSG00000038532 E048 0.1308682 0.0311423172 1.000000e+00   16 11156574 11156682 109 + 0.000 0.083 33.410
ENSG00000038532 E049 0.3032425 0.0274424043 7.193030e-01   16 11157077 11157233 157 + 0.000 0.153 34.411
ENSG00000038532 E050 64.1197889 0.0006026092 1.218195e-03 0.011568391 16 11166388 11166552 165 + 1.573 1.842 0.911
ENSG00000038532 E051 10.3594624 0.0033662686 2.274009e-01 0.462269008 16 11174154 11174277 124 + 0.839 1.072 0.871
ENSG00000038532 E052 38.0820512 0.1464824575 1.005749e-01 0.282832918 16 11178335 11178384 50 + 1.291 1.631 1.170
ENSG00000038532 E053 126.4890133 0.6181296480 2.820702e-01 0.522423024 16 11178385 11178896 512 + 1.842 2.134 0.981
ENSG00000038532 E054 824.9408579 1.5841574954 3.943659e-01 0.623891116 16 11178897 11182186 3290 + 2.619 2.952 1.110