ENSG00000038219

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000040738 ENSG00000038219 HEK293_OSMI2_6hA HEK293_TMG_6hB BOD1L1 protein_coding protein_coding 9.452199 8.910958 12.65208 2.008009 0.6901641 0.5052445 3.6887897 2.6219131 5.832246 0.4425779 0.2281933 1.1504112 0.37377500 0.30563333 0.46546667 0.15983333 2.033326e-01 8.995491e-11 FALSE TRUE
ENST00000507943 ENSG00000038219 HEK293_OSMI2_6hA HEK293_TMG_6hB BOD1L1 protein_coding protein_coding 9.452199 8.910958 12.65208 2.008009 0.6901641 0.5052445 0.6673579 1.7891019 0.000000 0.7270089 0.0000000 -7.4911331 0.09937500 0.18666667 0.00000000 -0.18666667 8.995491e-11 8.995491e-11 FALSE TRUE
ENST00000509897 ENSG00000038219 HEK293_OSMI2_6hA HEK293_TMG_6hB BOD1L1 protein_coding retained_intron 9.452199 8.910958 12.65208 2.008009 0.6901641 0.5052445 0.5699547 0.0000000 0.289757 0.0000000 0.2897570 4.9057215 0.05667083 0.00000000 0.02066667 0.02066667 9.123924e-01 8.995491e-11   FALSE
MSTRG.24637.2 ENSG00000038219 HEK293_OSMI2_6hA HEK293_TMG_6hB BOD1L1 protein_coding   9.452199 8.910958 12.65208 2.008009 0.6901641 0.5052445 1.2242824 0.5253365 2.320071 0.1975690 0.1234811 2.1218562 0.10561667 0.05753333 0.18526667 0.12773333 9.542142e-03 8.995491e-11 FALSE TRUE
MSTRG.24637.4 ENSG00000038219 HEK293_OSMI2_6hA HEK293_TMG_6hB BOD1L1 protein_coding   9.452199 8.910958 12.65208 2.008009 0.6901641 0.5052445 1.3177407 1.8282035 1.420058 1.0277320 0.3568675 -0.3622225 0.13931667 0.18320000 0.11016667 -0.07303333 8.711862e-01 8.995491e-11 FALSE TRUE
MSTRG.24637.8 ENSG00000038219 HEK293_OSMI2_6hA HEK293_TMG_6hB BOD1L1 protein_coding   9.452199 8.910958 12.65208 2.008009 0.6901641 0.5052445 1.2447069 1.6684853 2.074609 0.6043980 0.4765293 0.3126172 0.13960000 0.20373333 0.16106667 -0.04266667 9.558675e-01 8.995491e-11 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000038219 E001 109.1033068 0.696142197 1.172519e-01 0.3112308444 4 13568738 13569505 768 - 1.789 2.256 1.567
ENSG00000038219 E002 50.6139208 0.477153305 1.178346e-01 0.3122770209 4 13569506 13569785 280 - 1.498 1.905 1.380
ENSG00000038219 E003 26.5934589 0.315033877 2.049711e-01 0.4358783063 4 13569786 13569838 53 - 1.320 1.564 0.841
ENSG00000038219 E004 18.5077966 0.208470921 1.576548e-01 0.3731954879 4 13569839 13569855 17 - 1.154 1.427 0.957
ENSG00000038219 E005 15.1881019 0.151209447 1.003648e-01 0.2824458960 4 13569856 13569856 1 - 1.045 1.369 1.148
ENSG00000038219 E006 27.3354125 0.316440778 1.744073e-01 0.3964036914 4 13569857 13569889 33 - 1.311 1.592 0.968
ENSG00000038219 E007 80.4548494 0.637053884 1.638331e-01 0.3823837143 4 13569890 13570128 239 - 1.712 2.092 1.281
ENSG00000038219 E008 18.9290575 0.002076104 7.130014e-03 0.0452346388 4 13572702 13572842 141 - 1.165 1.437 0.950
ENSG00000038219 E009 92.7363947 0.036591747 3.978703e-01 0.6266813529 4 13576838 13576991 154 - 1.878 2.067 0.633
ENSG00000038219 E010 74.7699959 0.066906966 9.602302e-01 0.9819599356 4 13577403 13577487 85 - 1.827 1.927 0.334
ENSG00000038219 E011 0.0000000       4 13577581 13577581 1 -      
ENSG00000038219 E012 54.5298555 0.058027873 6.400565e-01 0.7969270886 4 13577582 13577631 50 - 1.719 1.754 0.118
ENSG00000038219 E013 1.7908512 0.073585988 1.373885e-01 0.3435169459 4 13577632 13578201 570 - 0.516 0.262 -1.461
ENSG00000038219 E014 49.2393388 0.049675179 5.300435e-01 0.7221167841 4 13579928 13579969 42 - 1.682 1.703 0.071
ENSG00000038219 E015 32.1955097 0.038447792 7.890659e-01 0.8899117712 4 13579970 13579973 4 - 1.483 1.560 0.262
ENSG00000038219 E016 1.6232785 0.138064331 1.943392e-01 0.4225661364 4 13579974 13580066 93 - 0.483 0.260 -1.316
ENSG00000038219 E017 45.1978518 0.029675741 6.157312e-01 0.7808043646 4 13581020 13581051 32 - 1.637 1.685 0.164
ENSG00000038219 E018 26.5560529 0.001547669 5.730113e-01 0.7523271395 4 13581052 13581054 3 - 1.423 1.444 0.070
ENSG00000038219 E019 5.9142101 0.144628769 2.697008e-02 0.1182276596 4 13581128 13581131 4 - 0.947 0.539 -1.674
ENSG00000038219 E020 54.9709228 0.034791100 9.743976e-01 0.9890751714 4 13581132 13581207 76 - 1.698 1.796 0.334
ENSG00000038219 E021 0.0000000       4 13582230 13582236 7 -      
ENSG00000038219 E022 53.3203984 0.040721563 5.639724e-01 0.7460991339 4 13582237 13582310 74 - 1.656 1.817 0.545
ENSG00000038219 E023 57.7938733 0.034399375 8.183152e-01 0.9070771777 4 13582652 13582736 85 - 1.714 1.823 0.369
ENSG00000038219 E024 61.5043944 0.046024282 6.586249e-01 0.8091178417 4 13586396 13586475 80 - 1.769 1.809 0.133
ENSG00000038219 E025 55.8527283 0.040157491 6.591590e-01 0.8094967229 4 13587699 13587771 73 - 1.732 1.765 0.110
ENSG00000038219 E026 52.5651972 0.053745968 7.244416e-01 0.8507963151 4 13588722 13588792 71 - 1.702 1.743 0.141
ENSG00000038219 E027 42.6383570 0.050854411 7.927913e-01 0.8920536958 4 13590386 13590446 61 - 1.580 1.696 0.395
ENSG00000038219 E028 40.2050401 0.041225443 7.432364e-01 0.8625144346 4 13591923 13591966 44 - 1.584 1.632 0.163
ENSG00000038219 E029 8.6530731 0.104698424 2.764331e-01 0.5164156363 4 13591967 13593520 1554 - 1.018 0.884 -0.503
ENSG00000038219 E030 50.7558945 0.005231425 7.625283e-01 0.8741029008 4 13595860 13595944 85 - 1.673 1.757 0.285
ENSG00000038219 E031 40.1615672 0.001050991 9.318547e-01 0.9680515410 4 13597104 13597168 65 - 1.587 1.650 0.215
ENSG00000038219 E032 159.9486419 0.869785750 4.120904e-01 0.6376589437 4 13598946 13599966 1021 - 2.123 2.290 0.559
ENSG00000038219 E033 205.1470454 1.350552085 5.423734e-01 0.7307855095 4 13599967 13601540 1574 - 2.254 2.371 0.391
ENSG00000038219 E034 46.0798471 0.627459634 6.176868e-01 0.7822359409 4 13601541 13601831 291 - 1.669 1.650 -0.067
ENSG00000038219 E035 32.2707085 0.529797718 6.378962e-01 0.7956624981 4 13601832 13601933 102 - 1.519 1.500 -0.064
ENSG00000038219 E036 304.8641551 0.277900047 8.545618e-01 0.9273470745 4 13601934 13605084 3151 - 2.501 2.429 -0.240
ENSG00000038219 E037 16.3479753 0.074950251 6.112408e-04 0.0066786714 4 13607117 13607121 5 - 1.361 0.876 -1.750
ENSG00000038219 E038 24.9960999 0.061882618 1.976349e-04 0.0026483825 4 13607122 13607189 68 - 1.532 1.076 -1.597
ENSG00000038219 E039 31.6712845 0.042993337 7.153407e-04 0.0075727035 4 13608530 13608668 139 - 1.607 1.275 -1.146
ENSG00000038219 E040 31.1372468 0.017854626 6.822607e-05 0.0010858815 4 13609295 13609406 112 - 1.593 1.289 -1.050
ENSG00000038219 E041 40.1933769 0.043228264 1.616250e-03 0.0144362526 4 13610934 13611100 167 - 1.695 1.414 -0.961
ENSG00000038219 E042 0.3040503 0.024441170 3.200808e-01   4 13613506 13613511 6 - 0.178 0.000 -8.997
ENSG00000038219 E043 29.4319468 0.036693493 5.766228e-04 0.0063677866 4 13613512 13613661 150 - 1.572 1.256 -1.092
ENSG00000038219 E044 63.8915557 0.087234348 1.085044e-03 0.0105650737 4 13614196 13614810 615 - 1.920 1.499 -1.430
ENSG00000038219 E045 34.2057612 0.045918365 1.773509e-05 0.0003451949 4 13615312 13615502 191 - 1.663 1.220 -1.531
ENSG00000038219 E046 20.5681768 0.050998590 6.454496e-04 0.0069656956 4 13619943 13620067 125 - 1.436 1.061 -1.323
ENSG00000038219 E047 22.5429985 0.049385627 9.631539e-06 0.0002028848 4 13623390 13626312 2923 - 1.029 1.631 2.107
ENSG00000038219 E048 14.0629588 0.041732638 6.069487e-02 0.2043791471 4 13627345 13627725 381 - 1.229 1.062 -0.595