ENSG00000036549

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000458763 ENSG00000036549 HEK293_OSMI2_6hA HEK293_TMG_6hB ZZZ3 protein_coding processed_transcript 27.1952 10.34276 47.92443 1.412984 2.134442 2.211047 2.491831 3.209377 1.668245 0.3646263 0.2299899 -0.9398278 0.1952458 0.31830000 0.0346000 -0.2837 1.517259e-13 1.517259e-13   FALSE
ENST00000481346 ENSG00000036549 HEK293_OSMI2_6hA HEK293_TMG_6hB ZZZ3 protein_coding processed_transcript 27.1952 10.34276 47.92443 1.412984 2.134442 2.211047 3.202766 1.719658 6.569428 0.3599295 0.9246595 1.9274757 0.1566042 0.16273333 0.1372333 -0.0255 8.416472e-01 1.517259e-13 FALSE TRUE
MSTRG.1444.13 ENSG00000036549 HEK293_OSMI2_6hA HEK293_TMG_6hB ZZZ3 protein_coding   27.1952 10.34276 47.92443 1.412984 2.134442 2.211047 5.115398 0.372086 11.439013 0.3720860 0.8579274 4.9051820 0.1164583 0.03366667 0.2383667 0.2047 1.339611e-01 1.517259e-13 FALSE TRUE
MSTRG.1444.4 ENSG00000036549 HEK293_OSMI2_6hA HEK293_TMG_6hB ZZZ3 protein_coding   27.1952 10.34276 47.92443 1.412984 2.134442 2.211047 10.879219 3.169872 21.107286 0.5549655 0.5284126 2.7313839 0.3595667 0.31010000 0.4412000 0.1311 3.107341e-01 1.517259e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000036549 E001 221.423313 0.0003362118 1.163786e-04 1.695878e-03 1 77562416 77564505 2090 - 2.203 2.304 0.338
ENSG00000036549 E002 155.283299 0.0016626032 2.448267e-05 4.539988e-04 1 77564506 77564887 382 - 2.041 2.189 0.497
ENSG00000036549 E003 286.411304 0.0002129975 6.683602e-07 2.001609e-05 1 77564888 77565264 377 - 2.313 2.427 0.381
ENSG00000036549 E004 77.302353 0.0032650435 1.635785e-03 1.457012e-02 1 77565265 77565273 9 - 1.742 1.898 0.528
ENSG00000036549 E005 78.105438 0.0030855424 5.452811e-03 3.698425e-02 1 77565274 77565290 17 - 1.751 1.887 0.458
ENSG00000036549 E006 92.611272 0.0016173059 2.769000e-02 1.203706e-01 1 77565291 77565299 9 - 1.834 1.925 0.308
ENSG00000036549 E007 481.899325 0.0001406532 1.793368e-03 1.565514e-02 1 77565300 77565784 485 - 2.551 2.599 0.160
ENSG00000036549 E008 184.837943 0.0003696837 4.783196e-01 6.859661e-01 1 77566081 77566181 101 - 2.143 2.153 0.031
ENSG00000036549 E009 184.901431 0.0013432665 9.524559e-02 2.733912e-01 1 77568332 77568466 135 - 2.136 2.182 0.156
ENSG00000036549 E010 184.896543 0.0054019300 4.652023e-01 6.767002e-01 1 77576068 77576220 153 - 2.141 2.167 0.088
ENSG00000036549 E011 155.079218 0.0010580881 1.700670e-02 8.548265e-02 1 77578774 77578869 96 - 2.056 2.134 0.263
ENSG00000036549 E012 173.538792 0.0002581031 2.579172e-01 4.966652e-01 1 77579527 77579628 102 - 2.115 2.139 0.081
ENSG00000036549 E013 3.902753 0.0066797838 9.368235e-01 9.706398e-01 1 77579629 77580997 1369 - 0.588 0.591 0.011
ENSG00000036549 E014 106.431929 0.0003884373 4.220953e-01 6.452328e-01 1 77580998 77581017 20 - 1.918 1.865 -0.177
ENSG00000036549 E015 140.566510 0.0003996467 7.780556e-01 8.835406e-01 1 77581018 77581069 52 - 2.030 2.004 -0.089
ENSG00000036549 E016 133.682678 0.0004318855 2.848010e-01 5.253550e-01 1 77581776 77581817 42 - 2.015 1.954 -0.203
ENSG00000036549 E017 128.571765 0.0003574642 2.569309e-01 4.957257e-01 1 77581818 77581888 71 - 2.000 1.936 -0.214
ENSG00000036549 E018 41.639113 0.0009609114 7.242873e-01 8.507151e-01 1 77581889 77581891 3 - 1.517 1.476 -0.140
ENSG00000036549 E019 180.711094 0.0005309857 2.624462e-01 5.016422e-01 1 77581979 77582126 148 - 2.145 2.088 -0.191
ENSG00000036549 E020 205.590265 0.0009636940 3.117516e-02 1.308646e-01 1 77584517 77584655 139 - 2.207 2.113 -0.316
ENSG00000036549 E021 2.764075 0.0824539490 9.936684e-03 5.787754e-02 1 77584767 77584829 63 - 0.362 0.831 2.151
ENSG00000036549 E022 1.500145 0.0486234503 1.153120e-03 1.107148e-02 1 77584830 77584908 79 - 0.155 0.730 3.347
ENSG00000036549 E023 1.738228 0.0287255819 2.315983e-04 3.018938e-03 1 77584909 77585059 151 - 0.156 0.785 3.563
ENSG00000036549 E024 8.322772 0.0038839765 3.649277e-01 5.998812e-01 1 77631835 77631849 15 - 0.881 0.728 -0.605
ENSG00000036549 E025 835.587662 0.0096162977 4.920692e-04 5.601224e-03 1 77631850 77633114 1265 - 2.823 2.650 -0.577
ENSG00000036549 E026 145.934587 0.0003548836 1.904352e-06 4.998498e-05 1 77633115 77633181 67 - 2.073 1.848 -0.756
ENSG00000036549 E027 114.237717 0.0005062517 2.588967e-04 3.312735e-03 1 77633182 77633245 64 - 1.965 1.770 -0.656
ENSG00000036549 E028 104.129484 0.0005512651 6.663972e-05 1.064224e-03 1 77633246 77633311 66 - 1.929 1.707 -0.751
ENSG00000036549 E029 106.109245 0.0004689537 9.146315e-06 1.942297e-04 1 77633312 77633405 94 - 1.941 1.694 -0.831
ENSG00000036549 E030 126.943928 0.0003615441 4.704563e-05 7.891575e-04 1 77639449 77639602 154 - 2.011 1.806 -0.689
ENSG00000036549 E031 1.392570 0.0136968632 4.842963e-02 1.760034e-01 1 77640954 77641383 430 - 0.235 0.590 2.008
ENSG00000036549 E032 66.982311 0.0006122711 7.133278e-02 2.274407e-01 1 77641384 77641446 63 - 1.728 1.603 -0.426
ENSG00000036549 E033 101.043103 0.0004742206 1.851660e-02 9.078046e-02 1 77641522 77641655 134 - 1.908 1.775 -0.448
ENSG00000036549 E034 18.584578 0.0061449253 1.173181e-32 1.185911e-29 1 77676982 77677310 329 - 0.759 1.771 3.613
ENSG00000036549 E035 14.286065 0.0022604227 9.406920e-11 6.709414e-09 1 77682585 77682675 91 - 0.898 1.487 2.105
ENSG00000036549 E036 48.628719 0.0009041242 9.167237e-01 9.605122e-01 1 77683262 77683553 292 - 1.578 1.570 -0.026