ENSG00000033867

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000419036 ENSG00000033867 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC4A7 protein_coding protein_coding 5.84139 0.643267 10.67756 0.08015099 0.7276509 4.032115 1.6309609 0.35910001 2.091750 0.02017833 0.1783719 2.509507 0.48190000 0.5766667 0.2001333 -0.37653333 0.01030448 0.01030448 FALSE TRUE
ENST00000428386 ENSG00000033867 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC4A7 protein_coding protein_coding 5.84139 0.643267 10.67756 0.08015099 0.7276509 4.032115 1.2321730 0.14356919 2.819591 0.07192513 0.3809479 4.203633 0.16913750 0.1984667 0.2692333 0.07076667 0.89764478 0.01030448 FALSE TRUE
ENST00000455077 ENSG00000033867 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC4A7 protein_coding protein_coding 5.84139 0.643267 10.67756 0.08015099 0.7276509 4.032115 1.0379563 0.00000000 1.678107 0.00000000 0.9887103 7.399262 0.09254167 0.0000000 0.1558000 0.15580000 0.69496472 0.01030448 FALSE TRUE
ENST00000457377 ENSG00000033867 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC4A7 protein_coding nonsense_mediated_decay 5.84139 0.643267 10.67756 0.08015099 0.7276509 4.032115 0.7859361 0.08418411 1.626739 0.04225627 0.2618277 4.119197 0.09325417 0.1467000 0.1558000 0.00910000 0.94891776 0.01030448 TRUE TRUE
ENST00000465487 ENSG00000033867 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC4A7 protein_coding retained_intron 5.84139 0.643267 10.67756 0.08015099 0.7276509 4.032115 0.4374417 0.00000000 1.794523 0.00000000 0.9357202 7.495474 0.03772500 0.0000000 0.1570333 0.15703333 0.68345454 0.01030448 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000033867 E001 0.0000000       3 27372721 27372722 2 -      
ENSG00000033867 E002 191.4106136 1.251433965 0.204794220 0.43567267 3 27372723 27376450 3728 - 1.883 2.456 1.919
ENSG00000033867 E003 19.2747121 0.665299880 0.331737407 0.57059587 3 27376451 27376605 155 - 0.958 1.331 1.336
ENSG00000033867 E004 18.4276003 0.659090408 0.362320760 0.59757745 3 27376606 27376728 123 - 0.944 1.287 1.239
ENSG00000033867 E005 10.4633093 0.488922134 0.411414163 0.63712919 3 27376729 27376763 35 - 0.739 1.023 1.088
ENSG00000033867 E006 20.0363849 0.671540812 0.296435709 0.53696563 3 27376764 27376845 82 - 0.971 1.360 1.392
ENSG00000033867 E007 30.5501013 0.001550177 0.084938680 0.25448187 3 27379249 27379356 108 - 1.147 1.491 1.202
ENSG00000033867 E008 29.1578851 0.005941818 0.684148751 0.82537408 3 27383153 27383250 98 - 1.145 1.272 0.451
ENSG00000033867 E009 30.4952224 0.038044202 0.638868006 0.79620796 3 27385892 27386023 132 - 1.162 1.273 0.391
ENSG00000033867 E010 33.9168757 0.015588019 0.154231670 0.36832159 3 27389931 27390104 174 - 1.212 1.205 -0.024
ENSG00000033867 E011 0.0000000       3 27390311 27390312 2 -      
ENSG00000033867 E012 0.0000000       3 27391736 27391739 4 -      
ENSG00000033867 E013 21.6893742 0.120432608 0.531669331 0.72321423 3 27391740 27391808 69 - 1.027 1.095 0.247
ENSG00000033867 E014 0.1723744 0.036814247 0.021887403   3 27391809 27391845 37 - 0.000 0.374 16.768
ENSG00000033867 E015 50.9551304 0.019368646 0.029993024 0.12731853 3 27394518 27394769 252 - 1.384 1.304 -0.279
ENSG00000033867 E016 37.9372186 0.027613701 0.084929959 0.25447370 3 27394954 27395115 162 - 1.262 1.203 -0.209
ENSG00000033867 E017 29.7735817 0.023620667 0.074617632 0.23400083 3 27397684 27397797 114 - 1.165 1.075 -0.323
ENSG00000033867 E018 0.5173834 0.151755546 1.000000000   3 27397865 27398191 327 - 0.090 0.000 -10.094
ENSG00000033867 E019 38.1277910 0.043860492 0.153634140 0.36749927 3 27398192 27398353 162 - 1.264 1.235 -0.103
ENSG00000033867 E020 36.4195763 0.031371228 0.039806591 0.15424804 3 27400764 27400869 106 - 1.249 1.122 -0.452
ENSG00000033867 E021 0.3337900 0.030225366 0.079042593   3 27400870 27401044 175 - 0.032 0.374 4.158
ENSG00000033867 E022 38.6000877 0.015932922 0.014685861 0.07691587 3 27403139 27403384 246 - 1.274 1.122 -0.539
ENSG00000033867 E023 21.1609649 0.003366857 0.051221870 0.18263735 3 27404830 27404963 134 - 1.032 0.893 -0.520
ENSG00000033867 E024 24.2219424 0.034681195 0.004447821 0.03165195 3 27409356 27409530 175 - 1.093 0.705 -1.484
ENSG00000033867 E025 18.8858488 0.004451099 0.876422041 0.93942047 3 27411642 27411748 107 - 0.976 1.123 0.536
ENSG00000033867 E026 20.9622136 0.001904079 0.627663552 0.78897793 3 27418486 27418632 147 - 1.019 1.123 0.375
ENSG00000033867 E027 19.8712727 0.001713513 0.169979198 0.39041328 3 27420700 27420787 88 - 1.004 0.963 -0.151
ENSG00000033867 E028 17.6430459 0.002897559 0.154137924 0.36823284 3 27421622 27421671 50 - 0.959 0.893 -0.247
ENSG00000033867 E029 21.0211118 0.007236723 0.129031758 0.33025712 3 27421672 27421779 108 - 1.028 0.963 -0.242
ENSG00000033867 E030 0.0000000       3 27422781 27422840 60 -      
ENSG00000033867 E031 0.1426347 0.031349639 0.510501115   3 27423641 27424036 396 - 0.032 0.000 -8.490
ENSG00000033867 E032 26.8461703 0.021641809 0.029652642 0.12629912 3 27424037 27424152 116 - 1.129 0.960 -0.615
ENSG00000033867 E033 0.6129023 0.019391069 0.265518728   3 27424153 27424502 350 - 0.090 0.373 2.570
ENSG00000033867 E034 0.0000000       3 27428268 27428286 19 -      
ENSG00000033867 E035 0.1426347 0.031349639 0.510501115   3 27431298 27431313 16 - 0.032 0.000 -8.490
ENSG00000033867 E036 0.3206185 0.027442404 1.000000000   3 27431314 27431669 356 - 0.062 0.000 -9.491
ENSG00000033867 E037 0.1308682 0.031081500 0.021924778   3 27433167 27433191 25 - 0.000 0.373 16.764
ENSG00000033867 E038 19.3385159 0.018686633 0.014493213 0.07621481 3 27433916 27433954 39 - 1.001 0.706 -1.147
ENSG00000033867 E039 15.6318420 0.005978687 0.001850176 0.01605890 3 27433955 27433976 22 - 0.925 0.373 -2.442
ENSG00000033867 E040 38.4891148 0.025835403 0.043097107 0.16282327 3 27433977 27434104 128 - 1.270 1.165 -0.370
ENSG00000033867 E041 44.8310642 0.026262504 0.039661407 0.15386803 3 27436388 27436548 161 - 1.332 1.240 -0.323
ENSG00000033867 E042 34.7982561 0.021598704 0.447649945 0.66402532 3 27437388 27437526 139 - 1.219 1.303 0.294
ENSG00000033867 E043 25.1304093 0.001426678 0.639574213 0.79664549 3 27448651 27448797 147 - 1.090 1.204 0.408
ENSG00000033867 E044 14.4316248 0.042860677 0.232979455 0.46858295 3 27452417 27452498 82 - 0.878 0.810 -0.264
ENSG00000033867 E045 0.0000000       3 27456651 27456754 104 -      
ENSG00000033867 E046 0.9239672 0.225564532 0.122653547   3 27483519 27483627 109 - 0.117 0.563 3.104
ENSG00000033867 E047 0.7695163 0.022612603 1.000000000   3 27484067 27484078 12 - 0.140 0.000 -10.811
ENSG00000033867 E048 9.3935945 0.019729074 0.725842030 0.85163396 3 27484079 27484420 342 - 0.716 0.809 0.371