ENSG00000032219

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355431 ENSG00000032219 HEK293_OSMI2_6hA HEK293_TMG_6hB ARID4A protein_coding protein_coding 3.384068 1.067298 7.323723 0.0494251 0.4326786 2.767128 2.2319136 0.81296814 4.21071919 0.10559781 0.05687143 2.358580 0.73276667 0.7612667 0.579366667 -0.181900000 0.49386039 0.02261433 FALSE TRUE
ENST00000417477 ENSG00000032219 HEK293_OSMI2_6hA HEK293_TMG_6hB ARID4A protein_coding protein_coding 3.384068 1.067298 7.323723 0.0494251 0.4326786 2.767128 0.2635081 0.07636654 0.95470533 0.07636654 0.12063757 3.481544 0.04632500 0.0719000 0.129566667 0.057666667 0.67884747 0.02261433 FALSE TRUE
ENST00000445108 ENSG00000032219 HEK293_OSMI2_6hA HEK293_TMG_6hB ARID4A protein_coding protein_coding 3.384068 1.067298 7.323723 0.0494251 0.4326786 2.767128 0.2061179 0.00000000 0.94663801 0.00000000 0.39760569 6.579901 0.02895417 0.0000000 0.124066667 0.124066667 0.02261433 0.02261433 FALSE TRUE
ENST00000466065 ENSG00000032219 HEK293_OSMI2_6hA HEK293_TMG_6hB ARID4A protein_coding retained_intron 3.384068 1.067298 7.323723 0.0494251 0.4326786 2.767128 0.0569414 0.00000000 0.04270006 0.00000000 0.04270006 2.397805 0.05155417 0.0000000 0.005233333 0.005233333 1.00000000 0.02261433 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000032219 E001 0.9584589 0.0157524278 1.000000000   14 58298504 58298554 51 + 0.235 0.237 0.015
ENSG00000032219 E002 0.7970432 0.0173544112 0.853981896   14 58298555 58298555 1 + 0.197 0.237 0.337
ENSG00000032219 E003 0.7970432 0.0173544112 0.853981896   14 58298556 58298558 3 + 0.197 0.237 0.337
ENSG00000032219 E004 3.8370444 0.0067741506 0.983436770 0.99352276 14 58298559 58298587 29 + 0.588 0.591 0.015
ENSG00000032219 E005 9.8505529 0.0248114087 0.295624122 0.53612455 14 58298588 58298700 113 + 0.947 0.785 -0.626
ENSG00000032219 E006 0.4349185 0.0232200002 0.462079420   14 58299331 58299536 206 + 0.110 0.236 1.334
ENSG00000032219 E007 1.1716042 0.0158238120 0.445752315   14 58299537 58299691 155 + 0.235 0.389 1.012
ENSG00000032219 E008 0.1308682 0.0326491905 0.079585897   14 58299692 58299797 106 + 0.000 0.236 11.297
ENSG00000032219 E009 13.4998901 0.0028580632 0.024966536 0.11212196 14 58299798 58299860 63 + 1.081 0.784 -1.124
ENSG00000032219 E010 22.7013083 0.0021530377 0.022631162 0.10470473 14 58301580 58301690 111 + 1.281 1.047 -0.834
ENSG00000032219 E011 0.7555370 0.0174961056 0.856261916   14 58303538 58303761 224 + 0.197 0.237 0.335
ENSG00000032219 E012 19.8924302 0.0019398631 0.026065038 0.11552165 14 58304944 58305009 66 + 1.229 0.987 -0.873
ENSG00000032219 E013 24.1508405 0.0016630375 0.009426271 0.05564508 14 58306022 58306112 91 + 1.310 1.047 -0.934
ENSG00000032219 E014 22.0562128 0.0016280364 0.001016797 0.01003637 14 58318542 58318621 80 + 1.284 0.916 -1.332
ENSG00000032219 E015 22.3247804 0.0016948642 0.004714627 0.03308368 14 58318711 58318805 95 + 1.287 0.987 -1.079
ENSG00000032219 E016 26.1406769 0.0016690450 0.154854142 0.36917994 14 58323485 58323617 133 + 1.333 1.210 -0.432
ENSG00000032219 E017 18.4221974 0.0081689988 0.382104348 0.61393870 14 58328237 58328316 80 + 1.189 1.100 -0.321
ENSG00000032219 E018 21.1882109 0.0016130148 0.010518955 0.06034186 14 58329528 58329604 77 + 1.261 0.987 -0.987
ENSG00000032219 E019 25.8703687 0.0061181037 0.103812248 0.28855610 14 58330003 58330169 167 + 1.326 1.170 -0.550
ENSG00000032219 E020 0.3206185 0.0274424043 1.000000000   14 58331287 58331518 232 + 0.110 0.000 -9.965
ENSG00000032219 E021 13.3045545 0.0051710755 0.854137974 0.92715373 14 58344695 58344767 73 + 1.033 1.018 -0.053
ENSG00000032219 E022 19.3704236 0.0020157823 0.243102928 0.48013736 14 58346411 58346505 95 + 1.162 1.282 0.424
ENSG00000032219 E023 20.6150777 0.0047993094 0.282511399 0.52290936 14 58347020 58347117 98 + 1.187 1.298 0.391
ENSG00000032219 E024 33.1796430 0.0014073902 0.950298378 0.97718753 14 58347647 58347878 232 + 1.405 1.409 0.014
ENSG00000032219 E025 26.3408000 0.0014455196 0.804075858 0.89863691 14 58351073 58351296 224 + 1.312 1.343 0.106
ENSG00000032219 E026 11.2277666 0.0027485701 0.709343891 0.84136831 14 58351297 58351323 27 + 0.963 1.018 0.202
ENSG00000032219 E027 3.1058979 0.0073854658 0.440585060 0.65913876 14 58351324 58351676 353 + 0.537 0.389 -0.751
ENSG00000032219 E028 0.8274031 0.0172218944 0.851332120   14 58353454 58353657 204 + 0.197 0.237 0.338
ENSG00000032219 E029 30.4133222 0.0132107769 0.730475655 0.85450853 14 58353658 58353855 198 + 1.366 1.410 0.153
ENSG00000032219 E030 22.6549545 0.0020550799 0.893338111 0.94830203 14 58359132 58359216 85 + 1.251 1.247 -0.012
ENSG00000032219 E031 24.5556192 0.0013869080 0.962432146 0.98319028 14 58360901 58361042 142 + 1.284 1.298 0.047
ENSG00000032219 E032 118.6475948 0.0005198083 0.002620214 0.02109275 14 58364170 58365300 1131 + 1.932 2.054 0.411
ENSG00000032219 E033 0.4466850 0.0243508287 0.808990899   14 58365475 58365517 43 + 0.155 0.000 -10.514
ENSG00000032219 E034 28.0233607 0.0019107141 0.003054454 0.02374206 14 58365518 58365622 105 + 1.291 1.527 0.817
ENSG00000032219 E035 17.7669599 0.0023700168 0.632717953 0.79213586 14 58366024 58366068 45 + 1.166 1.124 -0.147
ENSG00000032219 E036 29.6798819 0.0036998602 0.380741391 0.61280845 14 58366069 58366230 162 + 1.380 1.313 -0.233
ENSG00000032219 E037 26.1021274 0.0091613548 0.629669659 0.79027734 14 58366883 58367029 147 + 1.302 1.356 0.188
ENSG00000032219 E038 85.6821856 0.0075707650 0.001125543 0.01085978 14 58371886 58373887 2002 + 1.777 1.969 0.648