ENSG00000031698

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000234677 ENSG00000031698 HEK293_OSMI2_6hA HEK293_TMG_6hB SARS1 protein_coding protein_coding 205.7743 192.371 171.478 32.62988 5.984644 -0.1658588 155.23521 159.92777 108.82126 28.766550 7.822987 -0.5554177 0.7483250 0.82760000 0.6329333 -0.1946667 0.001297493 1.626748e-07 FALSE TRUE
MSTRG.1740.5 ENSG00000031698 HEK293_OSMI2_6hA HEK293_TMG_6hB SARS1 protein_coding   205.7743 192.371 171.478 32.62988 5.984644 -0.1658588 30.68326 17.28437 40.70905 4.977681 1.865969 1.2354015 0.1520208 0.08896667 0.2387667 0.1498000 0.004994940 1.626748e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000031698 E001 1.7852760 1.111441e-02 2.118748e-02 9.995891e-02 1 109213865 109213883 19 + 0.145 0.561 2.738
ENSG00000031698 E002 2.3934787 9.676551e-03 5.150927e-03 3.541315e-02 1 109213884 109213886 3 + 0.145 0.647 3.120
ENSG00000031698 E003 2.7140972 8.907120e-03 6.740122e-02 2.192269e-01 1 109213887 109213891 5 + 0.339 0.647 1.536
ENSG00000031698 E004 25.6301714 7.090155e-03 7.609111e-01 8.731272e-01 1 109213892 109213917 26 + 1.407 1.423 0.057
ENSG00000031698 E005 101.8335371 6.433796e-03 6.224196e-01 7.854855e-01 1 109213918 109213931 14 + 2.020 1.986 -0.117
ENSG00000031698 E006 322.1317267 3.935585e-03 9.399141e-01 9.721960e-01 1 109213932 109213967 36 + 2.502 2.496 -0.019
ENSG00000031698 E007 511.4696022 2.777607e-03 3.773517e-01 6.101457e-01 1 109213968 109213981 14 + 2.720 2.685 -0.116
ENSG00000031698 E008 1250.2187647 7.758766e-04 3.567954e-02 1.433928e-01 1 109213982 109214128 147 + 3.110 3.069 -0.137
ENSG00000031698 E009 82.3608333 1.036153e-03 1.849853e-30 1.539939e-27 1 109214547 109214975 429 + 2.139 1.646 -1.658
ENSG00000031698 E010 38.3755052 1.111801e-03 2.292140e-31 2.070521e-28 1 109214976 109215153 178 + 1.881 1.160 -2.480
ENSG00000031698 E011 0.4952057 2.527376e-01 4.534258e-01   1 109221080 109221086 7 + 0.253 0.102 -1.575
ENSG00000031698 E012 22.6889019 1.804729e-01 7.664288e-01 8.764696e-01 1 109221087 109221203 117 + 1.379 1.353 -0.091
ENSG00000031698 E013 731.6460710 2.099299e-04 6.676752e-01 8.147148e-01 1 109223978 109223981 4 + 2.861 2.846 -0.049
ENSG00000031698 E014 1132.4727515 9.583731e-05 6.193060e-01 7.833604e-01 1 109223982 109224048 67 + 3.049 3.035 -0.047
ENSG00000031698 E015 1156.9373949 8.094783e-04 8.178204e-01 9.068642e-01 1 109228352 109228432 81 + 3.055 3.048 -0.023
ENSG00000031698 E016 1787.7463545 1.114109e-03 1.733906e-03 1.525534e-02 1 109229414 109229572 159 + 3.273 3.218 -0.181
ENSG00000031698 E017 1639.0935853 1.223539e-03 5.830231e-03 3.890225e-02 1 109230878 109231021 144 + 3.233 3.183 -0.167
ENSG00000031698 E018 42.7960548 5.616585e-02 2.666595e-02 1.172637e-01 1 109231158 109231630 473 + 1.781 1.494 -0.977
ENSG00000031698 E019 1001.0880147 3.235174e-04 2.185392e-01 4.516884e-01 1 109231631 109231732 102 + 3.003 2.978 -0.083
ENSG00000031698 E020 765.5012428 8.448184e-04 2.092659e-01 4.409913e-01 1 109231733 109231786 54 + 2.861 2.879 0.059
ENSG00000031698 E021 1440.9791093 3.756247e-04 3.528933e-03 2.651543e-02 1 109235210 109235431 222 + 3.127 3.159 0.106
ENSG00000031698 E022 580.3498979 1.096504e-04 1.109726e-01 3.005599e-01 1 109235977 109235985 9 + 2.741 2.757 0.053
ENSG00000031698 E023 1167.2095499 3.703725e-04 4.822714e-03 3.365970e-02 1 109235986 109236106 121 + 3.034 3.067 0.110
ENSG00000031698 E024 21.8154205 8.361958e-02 1.066123e-01 2.933451e-01 1 109236231 109236390 160 + 1.480 1.235 -0.850
ENSG00000031698 E025 1537.4908752 9.409889e-05 9.445763e-02 2.720090e-01 1 109236391 109236548 158 + 3.168 3.176 0.029
ENSG00000031698 E026 26.6845101 9.551802e-02 6.678964e-01 8.148734e-01 1 109236549 109236804 256 + 1.468 1.407 -0.210
ENSG00000031698 E027 16.6560073 9.596766e-02 4.580172e-01 6.717585e-01 1 109236805 109236870 66 + 1.299 1.190 -0.383
ENSG00000031698 E028 36.1205829 1.116496e-01 2.526345e-01 4.907642e-01 1 109236871 109237243 373 + 1.651 1.487 -0.559
ENSG00000031698 E029 1318.1469885 4.442387e-04 6.479123e-03 4.209112e-02 1 109237244 109237373 130 + 3.089 3.120 0.102
ENSG00000031698 E030 1340.4606278 3.343848e-04 3.198407e-07 1.043669e-05 1 109237731 109237873 143 + 3.079 3.137 0.193
ENSG00000031698 E031 1038.3650075 2.851169e-04 1.314944e-06 3.603482e-05 1 109237874 109238182 309 + 2.969 3.027 0.193
ENSG00000031698 E032 4.3285573 6.587171e-03 8.270266e-01 9.121114e-01 1 109238213 109238253 41 + 0.694 0.718 0.098