ENSG00000031003

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000033079 ENSG00000031003 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM13B protein_coding protein_coding 9.351412 3.442021 14.67603 0.2902601 0.6588251 2.088931 2.9028261 1.5993871 4.9943550 0.29732170 0.3855283 1.636673 0.3807042 0.45796667 0.34120000 -0.116766667 0.55152196 0.01686178 FALSE TRUE
ENST00000513640 ENSG00000031003 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM13B protein_coding retained_intron 9.351412 3.442021 14.67603 0.2902601 0.6588251 2.088931 0.4337371 0.1412619 0.7153193 0.03058584 0.3612386 2.261568 0.0566750 0.04293333 0.04676667 0.003833333 0.99488018 0.01686178   FALSE
ENST00000689681 ENSG00000031003 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM13B protein_coding protein_coding 9.351412 3.442021 14.67603 0.2902601 0.6588251 2.088931 3.5727667 1.1676525 4.6855567 0.17431710 0.2432535 1.995382 0.3608417 0.33983333 0.32000000 -0.019833333 0.95165155 0.01686178 FALSE TRUE
MSTRG.26988.3 ENSG00000031003 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM13B protein_coding   9.351412 3.442021 14.67603 0.2902601 0.6588251 2.088931 2.1607525 0.3447594 3.8721494 0.09766772 0.2761743 3.451943 0.1665125 0.09746667 0.26340000 0.165933333 0.01686178 0.01686178 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000031003 E001 337.7919236 0.0020457715 3.725918e-09 1.921490e-07 5 137937960 137939841 1882 - 2.399 2.590 0.636
ENSG00000031003 E002 76.4863262 1.2576279813 4.172852e-01 6.415976e-01 5 137939842 137940150 309 - 1.741 1.990 0.841
ENSG00000031003 E003 31.8319786 0.7501366732 4.070666e-01 6.337826e-01 5 137940151 137940171 21 - 1.392 1.570 0.613
ENSG00000031003 E004 28.6287265 0.7233845179 4.239960e-01 6.465375e-01 5 137940172 137940180 9 - 1.351 1.518 0.577
ENSG00000031003 E005 62.9091504 0.9704975131 4.996443e-01 7.005009e-01 5 137940181 137940348 168 - 1.695 1.821 0.426
ENSG00000031003 E006 51.8373624 0.0667081264 7.322120e-01 8.555673e-01 5 137941944 137942045 102 - 1.634 1.684 0.170
ENSG00000031003 E007 72.0978663 0.0006512881 8.963227e-01 9.499620e-01 5 137942875 137943038 164 - 1.778 1.816 0.128
ENSG00000031003 E008 50.3961321 0.0030634823 6.794988e-01 8.224196e-01 5 137943133 137943194 62 - 1.618 1.678 0.202
ENSG00000031003 E009 34.2717334 0.0139644053 4.814850e-01 6.880825e-01 5 137943195 137943216 22 - 1.473 1.447 -0.090
ENSG00000031003 E010 56.5475747 0.0047243163 7.626076e-01 8.741462e-01 5 137945902 137945997 96 - 1.677 1.694 0.059
ENSG00000031003 E011 4.5198212 0.0063819381 4.949141e-01 6.973590e-01 5 137945998 137946227 230 - 0.643 0.772 0.535
ENSG00000031003 E012 23.0834833 0.0015232926 7.466201e-01 8.647332e-01 5 137946228 137946311 84 - 1.293 1.352 0.203
ENSG00000031003 E013 1.8474031 0.3759296076 4.368670e-01 6.563518e-01 5 137946312 137946395 84 - 0.450 0.209 -1.552
ENSG00000031003 E014 84.5360702 0.0182274849 1.125739e-01 3.034503e-01 5 137948955 137949184 230 - 1.869 1.781 -0.297
ENSG00000031003 E015 50.5217476 0.0216287860 3.808540e-01 6.129084e-01 5 137952628 137952709 82 - 1.641 1.597 -0.149
ENSG00000031003 E016 27.1048586 0.0015418126 6.063472e-01 7.744562e-01 5 137953336 137953345 10 - 1.372 1.363 -0.030
ENSG00000031003 E017 59.1611519 0.0043821494 3.121292e-01 5.524679e-01 5 137953346 137953465 120 - 1.709 1.682 -0.091
ENSG00000031003 E018 72.4424885 0.0102926869 5.056153e-01 7.046888e-01 5 137954166 137954376 211 - 1.791 1.786 -0.016
ENSG00000031003 E019 1.1905729 0.2281657793 6.402788e-01   5 137954377 137954624 248 - 0.309 0.209 -0.751
ENSG00000031003 E020 15.1773076 0.0077207151 8.154398e-01 9.054796e-01 5 137956477 137956542 66 - 1.121 1.179 0.205
ENSG00000031003 E021 58.8231178 0.0009844286 2.925689e-01 5.332603e-01 5 137959616 137959763 148 - 1.703 1.678 -0.087
ENSG00000031003 E022 37.8847770 0.0011019981 2.510904e-01 4.891416e-01 5 137960166 137960214 49 - 1.521 1.475 -0.160
ENSG00000031003 E023 44.7163201 0.0012743731 1.554103e-02 8.012819e-02 5 137962405 137962469 65 - 1.604 1.475 -0.441
ENSG00000031003 E024 57.2538662 0.0112556709 1.937942e-02 9.377342e-02 5 137985257 137985389 133 - 1.712 1.565 -0.501
ENSG00000031003 E025 64.6459308 0.0115372866 2.969742e-02 1.264240e-01 5 137987461 137987616 156 - 1.760 1.633 -0.432
ENSG00000031003 E026 40.4626437 0.0010211186 2.274113e-01 4.622690e-01 5 137988274 137988315 42 - 1.549 1.501 -0.165
ENSG00000031003 E027 64.9492834 0.0013387389 2.322644e-03 1.920249e-02 5 138006990 138007147 158 - 1.765 1.625 -0.473
ENSG00000031003 E028 51.4030431 0.0014126246 1.995835e-02 9.572801e-02 5 138011008 138011149 142 - 1.661 1.549 -0.381
ENSG00000031003 E029 35.9591346 0.0010556973 2.096059e-01 4.414283e-01 5 138011768 138011889 122 - 1.503 1.447 -0.193
ENSG00000031003 E030 21.1472682 0.0058000151 7.340863e-01 8.567022e-01 5 138011890 138011945 56 - 1.251 1.315 0.225
ENSG00000031003 E031 27.8981335 0.0086336161 4.928130e-01 6.958859e-01 5 138018302 138018385 84 - 1.390 1.363 -0.097
ENSG00000031003 E032 21.1499134 0.0015776127 1.162431e-01 3.095513e-01 5 138018386 138018408 23 - 1.293 1.179 -0.402
ENSG00000031003 E033 34.0450789 0.0012850637 6.164559e-02 2.064982e-01 5 138018409 138018478 70 - 1.491 1.386 -0.365
ENSG00000031003 E034 28.6944580 0.0017418341 3.424379e-02 1.395145e-01 5 138018479 138018514 36 - 1.428 1.288 -0.487
ENSG00000031003 E035 39.9241983 0.0082263662 1.849397e-02 9.069572e-02 5 138018955 138019146 192 - 1.564 1.407 -0.539
ENSG00000031003 E036 1.6713743 0.0502923544 8.375509e-01 9.180624e-01 5 138019881 138019977 97 - 0.372 0.350 -0.132
ENSG00000031003 E037 3.7931825 0.2444197637 9.114019e-01 9.579089e-01 5 138020763 138021030 268 - 0.590 0.682 0.396
ENSG00000031003 E038 37.3100098 0.0135185656 7.519901e-01 8.679452e-01 5 138021031 138021197 167 - 1.510 1.508 -0.008
ENSG00000031003 E039 31.6545986 0.3331212800 2.191641e-01 4.524128e-01 5 138032782 138033086 305 - 1.367 1.619 0.865
ENSG00000031003 E040 0.1779838 0.0424865941 1.000000e+00   5 138033773 138033869 97 - 0.068 0.001 -6.910
ENSG00000031003 E041 0.0000000       5 138034001 138034073 73 -      
ENSG00000031003 E042 0.0000000       5 138038566 138038606 41 -      
ENSG00000031003 E043 0.0000000       5 138051878 138051961 84 -