ENSG00000028203

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000436874 ENSG00000028203 HEK293_OSMI2_6hA HEK293_TMG_6hB VEZT protein_coding protein_coding 20.08176 4.310383 36.21961 0.5493795 2.124669 3.067938 3.9389555 1.0807044 7.32848157 0.30590619 0.29975999 2.750221 0.23977500 0.23923333 0.20280000 -0.03643333 8.810691e-01 3.194715e-06 FALSE TRUE
ENST00000546398 ENSG00000028203 HEK293_OSMI2_6hA HEK293_TMG_6hB VEZT protein_coding processed_transcript 20.08176 4.310383 36.21961 0.5493795 2.124669 3.067938 0.4044789 0.3531829 0.85066854 0.09004168 0.11081870 1.244762 0.03434167 0.09120000 0.02343333 -0.06776667 1.126699e-01 3.194715e-06 FALSE TRUE
ENST00000547611 ENSG00000028203 HEK293_OSMI2_6hA HEK293_TMG_6hB VEZT protein_coding nonsense_mediated_decay 20.08176 4.310383 36.21961 0.5493795 2.124669 3.067938 1.5886609 0.0000000 2.67746539 0.00000000 0.22449011 8.070102 0.04681250 0.00000000 0.07513333 0.07513333 3.194715e-06 3.194715e-06 TRUE TRUE
ENST00000549192 ENSG00000028203 HEK293_OSMI2_6hA HEK293_TMG_6hB VEZT protein_coding retained_intron 20.08176 4.310383 36.21961 0.5493795 2.124669 3.067938 1.7422298 0.2762081 2.92634299 0.14684518 0.31169550 3.358884 0.07081250 0.06693333 0.08150000 0.01456667 8.940473e-01 3.194715e-06 FALSE TRUE
ENST00000549589 ENSG00000028203 HEK293_OSMI2_6hA HEK293_TMG_6hB VEZT protein_coding processed_transcript 20.08176 4.310383 36.21961 0.5493795 2.124669 3.067938 0.1515460 0.2370807 0.07675075 0.16296923 0.07675075 -1.510034 0.02631667 0.05306667 0.00190000 -0.05116667 3.118092e-01 3.194715e-06   FALSE
ENST00000552660 ENSG00000028203 HEK293_OSMI2_6hA HEK293_TMG_6hB VEZT protein_coding nonsense_mediated_decay 20.08176 4.310383 36.21961 0.5493795 2.124669 3.067938 3.1296346 1.0397642 6.36134637 0.28219032 0.92226919 2.601533 0.16174167 0.23136667 0.17390000 -0.05746667 7.847798e-01 3.194715e-06 FALSE TRUE
ENST00000552821 ENSG00000028203 HEK293_OSMI2_6hA HEK293_TMG_6hB VEZT protein_coding protein_coding 20.08176 4.310383 36.21961 0.5493795 2.124669 3.067938 1.1121782 0.0000000 3.74337936 0.00000000 1.91182118 8.552046 0.02953750 0.00000000 0.09983333 0.09983333 5.348754e-01 3.194715e-06 FALSE FALSE
MSTRG.7816.9 ENSG00000028203 HEK293_OSMI2_6hA HEK293_TMG_6hB VEZT protein_coding   20.08176 4.310383 36.21961 0.5493795 2.124669 3.067938 0.6228228 0.1620598 1.31682944 0.16205981 1.31682944 2.947001 0.05569583 0.05013333 0.04006667 -0.01006667 8.926835e-01 3.194715e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000028203 E001 0.1779838 0.0360639135 1.000000e+00   12 95217746 95217752 7 + 0.055 0.000 -8.840
ENSG00000028203 E002 0.1779838 0.0360639135 1.000000e+00   12 95217753 95217757 5 + 0.055 0.000 -10.678
ENSG00000028203 E003 0.1779838 0.0360639135 1.000000e+00   12 95217758 95217760 3 + 0.055 0.000 -10.678
ENSG00000028203 E004 0.1779838 0.0360639135 1.000000e+00   12 95217761 95217761 1 + 0.055 0.000 -10.678
ENSG00000028203 E005 0.1779838 0.0360639135 1.000000e+00   12 95217762 95217762 1 + 0.055 0.000 -10.678
ENSG00000028203 E006 0.1779838 0.0360639135 1.000000e+00   12 95217763 95217763 1 + 0.055 0.000 -10.678
ENSG00000028203 E007 1.1176617 0.0148345585 1.000000e+00   12 95217764 95217770 7 + 0.256 0.250 -0.051
ENSG00000028203 E008 1.2602963 0.0141448434 8.897335e-01   12 95217771 95217771 1 + 0.287 0.250 -0.272
ENSG00000028203 E009 1.5996958 0.0116513120 6.723173e-01 8.177842e-01 12 95217772 95217779 8 + 0.344 0.250 -0.636
ENSG00000028203 E010 1.7776797 0.0113797640 5.869222e-01 7.615581e-01 12 95217780 95217798 19 + 0.369 0.250 -0.789
ENSG00000028203 E011 1.9203143 0.0110303575 5.134009e-01 7.105141e-01 12 95217799 95217806 8 + 0.394 0.250 -0.926
ENSG00000028203 E012 1.9203143 0.0110303575 5.134009e-01 7.105141e-01 12 95217807 95217807 1 + 0.394 0.250 -0.926
ENSG00000028203 E013 1.7423305 0.0115464193 5.884507e-01 7.626490e-01 12 95217808 95217809 2 + 0.369 0.250 -0.787
ENSG00000028203 E014 2.0463808 0.0103194673 4.487338e-01 6.648280e-01 12 95217810 95217810 1 + 0.416 0.250 -1.050
ENSG00000028203 E015 2.0463808 0.0103194673 4.487338e-01 6.648280e-01 12 95217811 95217811 1 + 0.416 0.250 -1.050
ENSG00000028203 E016 5.9370079 0.0047215558 4.864247e-01 6.915246e-01 12 95217812 95217817 6 + 0.735 0.613 -0.512
ENSG00000028203 E017 15.3245786 0.0020639974 4.325690e-01 6.531650e-01 12 95217818 95217823 6 + 1.064 1.152 0.316
ENSG00000028203 E018 17.7387433 0.0019438168 3.547839e-01 5.915550e-01 12 95217824 95217825 2 + 1.121 1.218 0.346
ENSG00000028203 E019 33.6859704 0.0012443194 2.183795e-01 4.514692e-01 12 95217826 95217841 16 + 1.386 1.484 0.336
ENSG00000028203 E020 59.1358264 0.0007560845 1.653232e-01 3.843772e-01 12 95217842 95217886 45 + 1.626 1.711 0.287
ENSG00000028203 E021 0.0000000       12 95218065 95218115 51 +      
ENSG00000028203 E022 0.0000000       12 95218116 95218128 13 +      
ENSG00000028203 E023 0.0000000       12 95218129 95218228 100 +      
ENSG00000028203 E024 0.0000000       12 95218229 95218229 1 +      
ENSG00000028203 E025 0.1426347 0.0320015520 1.000000e+00   12 95218230 95218253 24 + 0.055 0.000 -10.713
ENSG00000028203 E026 0.1426347 0.0320015520 1.000000e+00   12 95218254 95218254 1 + 0.055 0.000 -10.713
ENSG00000028203 E027 0.1426347 0.0320015520 1.000000e+00   12 95218255 95218260 6 + 0.055 0.000 -10.713
ENSG00000028203 E028 0.1426347 0.0320015520 1.000000e+00   12 95218261 95218277 17 + 0.055 0.000 -10.713
ENSG00000028203 E029 0.0000000       12 95218278 95218309 32 +      
ENSG00000028203 E030 0.0000000       12 95218310 95218345 36 +      
ENSG00000028203 E031 0.1779838 0.0360639135 1.000000e+00   12 95218346 95218613 268 + 0.055 0.000 -10.678
ENSG00000028203 E032 2.4116804 0.0597784243 1.009398e-03 9.984220e-03 12 95224180 95224236 57 + 0.287 0.896 2.875
ENSG00000028203 E033 0.0000000       12 95231412 95231545 134 +      
ENSG00000028203 E034 3.2444823 0.0169824604 3.223943e-08 1.345208e-06 12 95242164 95242264 101 + 0.257 1.099 3.844
ENSG00000028203 E035 1.2736898 0.0130603224 8.495044e-08   12 95242265 95242314 50 + 0.000 0.858 16.139
ENSG00000028203 E036 0.7673035 0.0172671820 5.023999e-01   12 95243941 95244009 69 + 0.223 0.000 -13.140
ENSG00000028203 E037 57.5571586 0.0006906777 7.120625e-01 8.431383e-01 12 95251940 95251944 5 + 1.624 1.648 0.082
ENSG00000028203 E038 66.7332156 0.0006009554 8.945902e-01 9.490202e-01 12 95251945 95251966 22 + 1.689 1.698 0.030
ENSG00000028203 E039 113.8422164 0.0004797570 2.268424e-01 4.615577e-01 12 95251967 95252071 105 + 1.925 1.869 -0.189
ENSG00000028203 E040 1.3551249 0.3622770786 2.850867e-01   12 95252072 95252440 369 + 0.226 0.529 1.799
ENSG00000028203 E041 44.1097845 0.0053124619 7.105586e-01 8.421738e-01 12 95256550 95256622 73 + 1.510 1.536 0.090
ENSG00000028203 E042 58.4352949 0.0152173758 5.422236e-01 7.306458e-01 12 95257150 95257153 4 + 1.638 1.577 -0.209
ENSG00000028203 E043 103.4255036 0.0086391685 2.131207e-01 4.454004e-01 12 95257154 95257239 86 + 1.887 1.800 -0.293
ENSG00000028203 E044 1.8670416 0.0111918261 8.601939e-01 9.304504e-01 12 95258245 95258282 38 + 0.369 0.407 0.209
ENSG00000028203 E045 0.7791197 0.0743501712 1.993208e-01   12 95258283 95258287 5 + 0.148 0.404 1.926
ENSG00000028203 E046 1.4438896 0.0153054345 1.946511e-01 4.228881e-01 12 95262304 95262412 109 + 0.344 0.000 -13.957
ENSG00000028203 E047 153.1561719 0.0026790920 1.172911e-01 3.112739e-01 12 95262906 95263081 176 + 2.054 1.980 -0.250
ENSG00000028203 E048 0.7013366 0.0367768922 5.715840e-01   12 95263746 95263797 52 + 0.147 0.250 0.950
ENSG00000028203 E049 210.4459097 0.0002534622 9.442229e-01 9.744627e-01 12 95266357 95266632 276 + 2.180 2.183 0.009
ENSG00000028203 E050 0.0000000       12 95266633 95266633 1 +      
ENSG00000028203 E051 1.1118645 0.0174202261 7.632149e-02   12 95269824 95270038 215 + 0.186 0.522 2.121
ENSG00000028203 E052 30.9528386 0.0055312907 9.238582e-01 9.643106e-01 12 95270039 95270050 12 + 1.364 1.371 0.027
ENSG00000028203 E053 133.1257253 0.0051625156 6.592277e-01 8.095161e-01 12 95270051 95270188 138 + 1.988 1.962 -0.087
ENSG00000028203 E054 64.6020041 0.0007782003 3.399936e-02 1.388633e-01 12 95274742 95274745 4 + 1.693 1.555 -0.467
ENSG00000028203 E055 142.1122306 0.0005707811 2.893098e-02 1.241571e-01 12 95274746 95274889 144 + 2.027 1.932 -0.317
ENSG00000028203 E056 0.0000000       12 95274890 95274891 2 +      
ENSG00000028203 E057 88.9649002 0.0005163833 2.432300e-02 1.100945e-01 12 95282313 95282359 47 + 1.828 1.705 -0.418
ENSG00000028203 E058 205.8850746 0.0003199067 1.550584e-02 7.998204e-02 12 95282360 95282644 285 + 2.185 2.100 -0.284
ENSG00000028203 E059 165.8186216 0.0004593994 3.425766e-01 5.802652e-01 12 95287664 95287857 194 + 2.083 2.046 -0.123
ENSG00000028203 E060 0.0000000       12 95287858 95287864 7 +      
ENSG00000028203 E061 0.8455639 0.3160322390 2.499903e-01   12 95293684 95294271 588 + 0.148 0.411 1.951
ENSG00000028203 E062 138.9330898 0.0003307927 1.047279e-01 2.901576e-01 12 95294272 95294372 101 + 2.013 1.944 -0.231
ENSG00000028203 E063 77.5636826 0.0004801482 8.803643e-01 9.414331e-01 12 95296051 95296068 18 + 1.752 1.761 0.029
ENSG00000028203 E064 171.1788433 0.0002737656 8.068768e-01 9.002423e-01 12 95296069 95296258 190 + 2.095 2.086 -0.029
ENSG00000028203 E065 5.8261854 0.0099287013 2.637354e-02 1.163998e-01 12 95296259 95296956 698 + 0.652 0.978 1.287
ENSG00000028203 E066 14.0313343 0.0022923988 1.580014e-01 3.737455e-01 12 95298862 95298943 82 + 1.017 1.175 0.573
ENSG00000028203 E067 11.9020836 0.0101575551 7.944791e-06 1.719179e-04 12 95299094 95300164 1071 + 0.863 1.356 1.786
ENSG00000028203 E068 516.9603578 0.0001996243 1.065389e-06 3.004942e-05 12 95300165 95302799 2635 + 2.555 2.649 0.313