ENSG00000024048

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372899 ENSG00000024048 HEK293_OSMI2_6hA HEK293_TMG_6hB UBR2 protein_coding protein_coding 6.493115 2.958272 10.56644 0.4431923 0.2431525 1.833158 1.0039933 0.3367585 1.721340236 0.04279273 0.077454625 2.319886 0.1308917 0.1243000 0.1632000 0.0389000 7.635530e-01 1.26126e-12 FALSE TRUE
ENST00000372901 ENSG00000024048 HEK293_OSMI2_6hA HEK293_TMG_6hB UBR2 protein_coding protein_coding 6.493115 2.958272 10.56644 0.4431923 0.2431525 1.833158 4.8632275 1.8154811 8.705770551 0.30019269 0.277910277 2.255352 0.6645417 0.6120667 0.8235667 0.2115000 9.797357e-03 1.26126e-12 FALSE TRUE
MSTRG.28294.4 ENSG00000024048 HEK293_OSMI2_6hA HEK293_TMG_6hB UBR2 protein_coding   6.493115 2.958272 10.56644 0.4431923 0.2431525 1.833158 0.5645126 0.7687322 0.009692433 0.24940378 0.009692433 -5.305414 0.1921958 0.2479667 0.0009000 -0.2470667 1.261260e-12 1.26126e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000024048 E001 18.4960887 0.0023555986 3.795122e-02 1.494973e-01 6 42564029 42564061 33 + 1.256 1.056 -0.718
ENSG00000024048 E002 59.2495843 0.0009285976 9.415949e-03 5.560541e-02 6 42564062 42564397 336 + 1.729 1.589 -0.475
ENSG00000024048 E003 73.0909109 0.0005814131 2.601965e-03 2.097567e-02 6 42573734 42573993 260 + 1.821 1.675 -0.492
ENSG00000024048 E004 44.5516999 0.0008825287 1.395746e-03 1.286528e-02 6 42592151 42592229 79 + 1.621 1.415 -0.706
ENSG00000024048 E005 50.4718003 0.0008120049 1.144285e-05 2.354039e-04 6 42594191 42594304 114 + 1.685 1.405 -0.960
ENSG00000024048 E006 47.0773927 0.0008885270 2.575902e-05 4.732743e-04 6 42603588 42603718 131 + 1.652 1.372 -0.958
ENSG00000024048 E007 52.2141294 0.0007264244 7.167690e-04 7.585932e-03 6 42605721 42605859 139 + 1.684 1.481 -0.690
ENSG00000024048 E008 40.9523637 0.0011609247 3.669203e-04 4.406755e-03 6 42606589 42606651 63 + 1.586 1.337 -0.857
ENSG00000024048 E009 50.5370904 0.0039560588 8.593351e-03 5.201742e-02 6 42612171 42612291 121 + 1.663 1.491 -0.587
ENSG00000024048 E010 44.0069230 0.0011146783 7.224680e-03 4.569523e-02 6 42615071 42615178 108 + 1.607 1.435 -0.588
ENSG00000024048 E011 39.3081651 0.0252070436 6.249431e-03 4.095300e-02 6 42616002 42616090 89 + 1.577 1.286 -1.002
ENSG00000024048 E012 8.0013619 0.0038016403 1.420367e-01 3.504801e-01 6 42617240 42617338 99 + 0.921 0.722 -0.782
ENSG00000024048 E013 33.6115366 0.0053136149 3.333556e-05 5.906871e-04 6 42617409 42617507 99 + 1.524 1.158 -1.274
ENSG00000024048 E014 0.1723744 0.0410618423 1.269559e-01   6 42619468 42620351 884 + 0.000 0.207 10.280
ENSG00000024048 E015 52.4737137 0.0010466856 2.045414e-03 1.736705e-02 6 42632552 42632715 164 + 1.682 1.498 -0.627
ENSG00000024048 E016 44.2895705 0.0009316428 2.543130e-02 1.135396e-01 6 42632805 42632904 100 + 1.608 1.472 -0.466
ENSG00000024048 E017 59.3903869 0.0006111512 2.155086e-02 1.011281e-01 6 42635418 42635546 129 + 1.727 1.609 -0.402
ENSG00000024048 E018 56.8535097 0.0006668043 2.892085e-01 5.297393e-01 6 42637011 42637194 184 + 1.694 1.646 -0.162
ENSG00000024048 E019 36.3494038 0.0016145747 4.271117e-01 6.487954e-01 6 42640209 42640270 62 + 1.508 1.463 -0.153
ENSG00000024048 E020 56.3070479 0.0031746701 6.142720e-02 2.059738e-01 6 42641582 42641692 111 + 1.704 1.596 -0.366
ENSG00000024048 E021 47.4417651 0.0007432160 6.066109e-03 4.005929e-02 6 42642416 42642481 66 + 1.638 1.472 -0.568
ENSG00000024048 E022 60.3134141 0.0007727225 1.034095e-01 2.879234e-01 6 42644214 42644336 123 + 1.725 1.646 -0.266
ENSG00000024048 E023 41.3203540 0.0010293274 3.737175e-01 6.071193e-01 6 42644473 42644536 64 + 1.560 1.514 -0.157
ENSG00000024048 E024 55.4201498 0.0015506496 1.006269e-01 2.829173e-01 6 42645466 42645590 125 + 1.694 1.609 -0.290
ENSG00000024048 E025 37.0421419 0.0135960348 2.199516e-01 4.534361e-01 6 42648118 42648170 53 + 1.527 1.425 -0.351
ENSG00000024048 E026 45.7309283 0.0082784635 5.495069e-01 7.359420e-01 6 42650284 42650386 103 + 1.603 1.567 -0.120
ENSG00000024048 E027 37.3548605 0.0011582995 9.165018e-01 9.604219e-01 6 42652023 42652071 49 + 1.503 1.523 0.066
ENSG00000024048 E028 34.2322769 0.0058795555 6.005804e-01 7.705956e-01 6 42652491 42652539 49 + 1.461 1.514 0.182
ENSG00000024048 E029 51.6247306 0.0020678226 4.175045e-01 6.417293e-01 6 42652540 42652645 106 + 1.653 1.615 -0.128
ENSG00000024048 E030 56.2801516 0.0007080629 2.984832e-01 5.389216e-01 6 42655621 42655723 103 + 1.693 1.646 -0.158
ENSG00000024048 E031 54.3515583 0.0007456494 8.039557e-01 8.986061e-01 6 42658024 42658133 110 + 1.660 1.686 0.089
ENSG00000024048 E032 53.6377655 0.0018061209 3.936146e-01 6.232227e-01 6 42658240 42658320 81 + 1.645 1.707 0.210
ENSG00000024048 E033 74.7047254 0.0005612418 3.685634e-01 6.028771e-01 6 42658646 42658824 179 + 1.789 1.845 0.186
ENSG00000024048 E034 70.2667180 0.0007045039 1.097519e-01 2.986299e-01 6 42659656 42659855 200 + 1.754 1.844 0.305
ENSG00000024048 E035 47.1749882 0.0008919972 5.606383e-01 7.437412e-01 6 42662184 42662277 94 + 1.612 1.589 -0.078
ENSG00000024048 E036 61.9795361 0.0008182725 3.546496e-01 5.914113e-01 6 42663258 42663419 162 + 1.729 1.692 -0.126
ENSG00000024048 E037 52.4436126 0.0023639561 7.323586e-01 8.556386e-01 6 42665409 42665512 104 + 1.641 1.675 0.117
ENSG00000024048 E038 51.3260339 0.0007493067 3.852132e-01 6.166629e-01 6 42666167 42666245 79 + 1.625 1.686 0.210
ENSG00000024048 E039 73.3447598 0.0007026311 4.593908e-01 6.727404e-01 6 42670092 42670240 149 + 1.781 1.829 0.163
ENSG00000024048 E040 45.6827855 0.0111495867 8.654308e-01 9.333744e-01 6 42670660 42670715 56 + 1.591 1.595 0.015
ENSG00000024048 E041 48.9184003 0.0096218647 3.205573e-01 5.602040e-01 6 42673791 42673887 97 + 1.600 1.691 0.308
ENSG00000024048 E042 43.4978000 0.0010314221 2.163547e-01 4.491221e-01 6 42674126 42674193 68 + 1.546 1.634 0.302
ENSG00000024048 E043 59.9184696 0.0007081552 2.102994e-02 9.944221e-02 6 42676056 42676191 136 + 1.670 1.801 0.444
ENSG00000024048 E044 55.4667408 0.0008160040 1.907566e-03 1.645607e-02 6 42676783 42676873 91 + 1.625 1.801 0.598
ENSG00000024048 E045 67.3888469 0.0015730891 1.770813e-02 8.803951e-02 6 42678539 42678669 131 + 1.722 1.855 0.450
ENSG00000024048 E046 71.1301636 0.0025416826 3.444417e-02 1.400772e-01 6 42679724 42679832 109 + 1.747 1.870 0.414
ENSG00000024048 E047 57.4738742 0.0031151615 1.697097e-01 3.901127e-01 6 42683055 42683111 57 + 1.664 1.756 0.312
ENSG00000024048 E048 58.2034750 0.0011548454 7.746177e-03 4.811470e-02 6 42684794 42684871 78 + 1.652 1.805 0.518
ENSG00000024048 E049 94.9424445 0.0013456024 4.469389e-05 7.562865e-04 6 42688216 42688386 171 + 1.852 2.037 0.625
ENSG00000024048 E050 74.6750368 0.0006800954 5.464568e-04 6.096901e-03 6 42689569 42689670 102 + 1.753 1.924 0.577
ENSG00000024048 E051 230.3562787 0.0043049998 5.855484e-14 7.625735e-12 6 42691032 42693505 2474 + 2.198 2.492 0.982