ENSG00000023287

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000025008 ENSG00000023287 HEK293_OSMI2_6hA HEK293_TMG_6hB RB1CC1 protein_coding protein_coding 11.56065 1.944346 24.80661 0.2562334 1.083114 3.666548 5.425760 0.84281095 12.139677 0.12159717 0.7831113 3.832548 0.47257500 0.46646667 0.48900000 0.02253333 9.898936e-01 6.887583e-06 FALSE TRUE
ENST00000435644 ENSG00000023287 HEK293_OSMI2_6hA HEK293_TMG_6hB RB1CC1 protein_coding protein_coding 11.56065 1.944346 24.80661 0.2562334 1.083114 3.666548 1.613369 0.90301475 3.200697 0.29611466 0.3822357 1.814176 0.25849167 0.43706667 0.13090000 -0.30616667 6.870529e-02 6.887583e-06 FALSE TRUE
MSTRG.31498.4 ENSG00000023287 HEK293_OSMI2_6hA HEK293_TMG_6hB RB1CC1 protein_coding   11.56065 1.944346 24.80661 0.2562334 1.083114 3.666548 1.252896 0.00000000 2.364883 0.00000000 0.4149175 7.891713 0.06144167 0.00000000 0.09613333 0.09613333 9.433698e-04 6.887583e-06 FALSE TRUE
MSTRG.31498.5 ENSG00000023287 HEK293_OSMI2_6hA HEK293_TMG_6hB RB1CC1 protein_coding   11.56065 1.944346 24.80661 0.2562334 1.083114 3.666548 2.740805 0.03375479 6.466532 0.03375479 0.8096655 7.209637 0.13085833 0.01573333 0.25873333 0.24300000 6.887583e-06 6.887583e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000023287 E001 0.0000000       8 52622458 52622458 1 -      
ENSG00000023287 E002 94.8879503 1.2477178577 0.2078410330 0.439214899 8 52622459 52623328 870 - 1.647 2.194 1.840
ENSG00000023287 E003 55.8739842 0.8231568030 0.1376781557 0.343958418 8 52623329 52623471 143 - 1.427 1.956 1.797
ENSG00000023287 E004 42.4973814 0.7591269683 0.1990806955 0.428563172 8 52623472 52623490 19 - 1.337 1.753 1.422
ENSG00000023287 E005 59.1010307 0.8590358525 0.1870693523 0.413122129 8 52623491 52623583 93 - 1.466 1.928 1.569
ENSG00000023287 E006 71.2346852 0.9437170896 0.2596443879 0.498593207 8 52623584 52623713 130 - 1.558 1.954 1.340
ENSG00000023287 E007 43.9467083 0.7841701830 0.2790999079 0.519209356 8 52623714 52623727 14 - 1.369 1.682 1.070
ENSG00000023287 E008 70.8980665 0.9256393647 0.2673396255 0.506967016 8 52623728 52623859 132 - 1.562 1.928 1.240
ENSG00000023287 E009 53.6590866 0.0826705693 0.0208922870 0.098990356 8 52624717 52624787 71 - 1.442 1.829 1.318
ENSG00000023287 E010 17.3630943 0.0097380268 0.0609499408 0.204929054 8 52628032 52628040 9 - 1.002 1.307 1.091
ENSG00000023287 E011 84.3662586 0.0006006412 0.0041936090 0.030230548 8 52628041 52628168 128 - 1.658 1.911 0.854
ENSG00000023287 E012 71.1011665 0.0250877738 0.8388726073 0.918773235 8 52630470 52630528 59 - 1.600 1.691 0.308
ENSG00000023287 E013 81.1879396 0.0355452204 0.9742645137 0.989029279 8 52634921 52634968 48 - 1.655 1.761 0.361
ENSG00000023287 E014 76.3844397 0.0334869306 0.5809073358 0.757784570 8 52636015 52636069 55 - 1.621 1.789 0.567
ENSG00000023287 E015 154.5860713 0.0311038630 0.5047276227 0.704123477 8 52642351 52642591 241 - 1.922 2.097 0.588
ENSG00000023287 E016 118.8731310 0.0191871274 0.8498556733 0.924896693 8 52642704 52642812 109 - 1.819 1.912 0.315
ENSG00000023287 E017 0.4466850 0.0217681645 1.0000000000   8 52642813 52643243 431 - 0.111 0.001 -7.636
ENSG00000023287 E018 118.7805362 0.0013469281 0.8358295504 0.917075306 8 52645702 52645867 166 - 1.822 1.928 0.354
ENSG00000023287 E019 487.8260761 1.8795192657 0.6474154679 0.801767847 8 52656008 52657884 1877 - 2.424 2.546 0.407
ENSG00000023287 E020 43.4884242 0.2377486495 0.6341921269 0.793069392 8 52657885 52657908 24 - 1.395 1.488 0.321
ENSG00000023287 E021 73.0956522 0.0099968075 0.4714271991 0.681169224 8 52657998 52658124 127 - 1.623 1.643 0.068
ENSG00000023287 E022 62.6639352 0.0094014393 0.1113122134 0.301162599 8 52658873 52658976 104 - 1.560 1.520 -0.138
ENSG00000023287 E023 44.3751379 0.0138529016 0.7489650466 0.866120251 8 52660596 52660657 62 - 1.405 1.476 0.244
ENSG00000023287 E024 67.2014515 0.0556170901 0.4555938526 0.669965665 8 52660926 52661007 82 - 1.584 1.611 0.091
ENSG00000023287 E025 99.5734839 0.0593876674 0.0075248060 0.047142256 8 52661095 52661281 187 - 1.769 1.514 -0.867
ENSG00000023287 E026 102.0253002 0.0465488080 0.0073038994 0.046088140 8 52661535 52661719 185 - 1.778 1.556 -0.753
ENSG00000023287 E027 106.9167790 0.0178477577 0.0097046685 0.056845325 8 52668021 52668191 171 - 1.792 1.664 -0.433
ENSG00000023287 E028 196.3882161 0.0269820412 0.0008490747 0.008681871 8 52673845 52674274 430 - 2.057 1.856 -0.674
ENSG00000023287 E029 93.4744366 0.0411348032 0.0126922900 0.069215592 8 52676369 52676571 203 - 1.739 1.545 -0.658
ENSG00000023287 E030 52.3599075 0.0525051833 0.0291479719 0.124795059 8 52683549 52683603 55 - 1.494 1.281 -0.738
ENSG00000023287 E031 46.0489587 0.0466879556 0.0036426937 0.027160747 8 52683604 52683634 31 - 1.446 1.106 -1.196
ENSG00000023287 E032 43.3431285 0.0382351974 0.0042624184 0.030618700 8 52683635 52683687 53 - 1.420 1.107 -1.102
ENSG00000023287 E033 31.2415567 0.0615751804 0.0303802768 0.128487069 8 52683688 52683719 32 - 1.283 1.023 -0.932
ENSG00000023287 E034 56.8486013 0.0435295365 0.0030290353 0.023586586 8 52683887 52683949 63 - 1.534 1.229 -1.056
ENSG00000023287 E035 60.0065171 0.0402649782 0.0014113806 0.012979092 8 52683950 52684013 64 - 1.558 1.229 -1.139
ENSG00000023287 E036 40.8275954 0.0440706776 0.0020170506 0.017177994 8 52685399 52685423 25 - 1.398 1.023 -1.332
ENSG00000023287 E037 58.5786120 0.0466091107 0.0003966959 0.004699553 8 52685424 52685520 97 - 1.551 1.136 -1.449
ENSG00000023287 E038 0.9231097 0.0161115784 0.6009115211   8 52685937 52686156 220 - 0.172 0.317 1.147
ENSG00000023287 E039 49.0515975 0.0136968972 0.0051675082 0.035497199 8 52686853 52686945 93 - 1.469 1.258 -0.731
ENSG00000023287 E040 19.9638412 0.0020820115 0.2436524337 0.480667572 8 52686946 52686967 22 - 1.095 1.027 -0.245
ENSG00000023287 E041 41.6634986 0.0411097039 0.8793240596 0.940953817 8 52714075 52714466 392 - 1.375 1.463 0.303
ENSG00000023287 E042 0.0000000       8 52745549 52745843 295 -