ENSG00000021826

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000430249 ENSG00000021826 HEK293_OSMI2_6hA HEK293_TMG_6hB CPS1 protein_coding protein_coding 9.182359 4.812082 12.24984 1.626314 0.4173747 1.346212 2.1143209 0.3520393 4.20724527 0.3520393 0.55389849 3.542083 0.19842083 0.0720000 0.345600000 0.27360000 2.154144e-01 2.933894e-22 FALSE TRUE
ENST00000645825 ENSG00000021826 HEK293_OSMI2_6hA HEK293_TMG_6hB CPS1 protein_coding processed_transcript 9.182359 4.812082 12.24984 1.626314 0.4173747 1.346212 0.8212156 0.4812023 0.04147953 0.4812023 0.02129082 -3.254246 0.12210833 0.0634000 0.003433333 -0.05996667 9.369802e-01 2.933894e-22 FALSE TRUE
ENST00000673510 ENSG00000021826 HEK293_OSMI2_6hA HEK293_TMG_6hB CPS1 protein_coding protein_coding 9.182359 4.812082 12.24984 1.626314 0.4173747 1.346212 3.4338803 0.9885167 5.30525788 0.4409686 0.48095568 2.412281 0.34314583 0.2259333 0.432200000 0.20626667 3.692694e-01 2.933894e-22 FALSE TRUE
ENST00000673630 ENSG00000021826 HEK293_OSMI2_6hA HEK293_TMG_6hB CPS1 protein_coding protein_coding 9.182359 4.812082 12.24984 1.626314 0.4173747 1.346212 1.5463038 0.8351306 2.14314231 0.4246765 0.10874578 1.349197 0.16237917 0.1906667 0.174766667 -0.01590000 1.000000e+00 2.933894e-22 FALSE TRUE
ENST00000673698 ENSG00000021826 HEK293_OSMI2_6hA HEK293_TMG_6hB CPS1 protein_coding nonsense_mediated_decay 9.182359 4.812082 12.24984 1.626314 0.4173747 1.346212 0.1794528 0.4629945 0.00000000 0.4629945 0.00000000 -5.563751 0.02616250 0.0610000 0.000000000 -0.06100000 7.401016e-01 2.933894e-22 TRUE TRUE
ENST00000673711 ENSG00000021826 HEK293_OSMI2_6hA HEK293_TMG_6hB CPS1 protein_coding protein_coding 9.182359 4.812082 12.24984 1.626314 0.4173747 1.346212 0.5424725 1.4199069 0.00000000 0.4920965 0.00000000 -7.159777 0.07612083 0.3014667 0.000000000 -0.30146667 2.933894e-22 2.933894e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000021826 E001 7.6090041 0.0088413884 6.926564e-03 4.429970e-02 2 210477682 210477708 27 + 0.991 0.607 -1.529
ENSG00000021826 E002 26.7644842 0.0014721780 2.859184e-02 1.231307e-01 2 210477709 210477766 58 + 1.447 1.286 -0.560
ENSG00000021826 E003 29.7307316 0.0017148015 2.653788e-02 1.168843e-01 2 210519551 210519670 120 + 1.487 1.329 -0.544
ENSG00000021826 E004 11.3090347 0.0031888922 9.986616e-01 1.000000e+00 2 210519671 210519784 114 + 1.058 1.067 0.031
ENSG00000021826 E005 1.9723355 0.2515529213 5.311191e-01 7.228619e-01 2 210549967 210550021 55 + 0.418 0.541 0.613
ENSG00000021826 E006 0.1779838 0.0392535613 1.000000e+00   2 210556599 210556718 120 + 0.081 0.000 -10.216
ENSG00000021826 E007 56.5792918 0.0006931191 4.594785e-04 5.307082e-03 2 210556719 210556859 141 + 1.764 1.581 -0.621
ENSG00000021826 E008 47.6634486 0.0007368557 1.220439e-02 6.726467e-02 2 210573298 210573407 110 + 1.682 1.545 -0.466
ENSG00000021826 E009 55.5646115 0.0009225343 2.582394e-03 2.085949e-02 2 210576346 210576490 145 + 1.755 1.598 -0.532
ENSG00000021826 E010 0.3228314 0.4749393033 7.645145e-01   2 210577155 210577420 266 + 0.150 0.000 -11.221
ENSG00000021826 E011 44.0730335 0.0182833989 9.906700e-02 2.801315e-01 2 210577421 210577510 90 + 1.654 1.518 -0.462
ENSG00000021826 E012 36.3031255 0.0330423885 4.548980e-01 6.694061e-01 2 210579714 210579770 57 + 1.554 1.492 -0.213
ENSG00000021826 E013 0.1723744 0.1233850622 1.955419e-01   2 210579771 210579800 30 + 0.000 0.179 12.810
ENSG00000021826 E014 43.6971636 0.0009793898 8.786541e-01 9.405970e-01 2 210582617 210582709 93 + 1.614 1.614 0.002
ENSG00000021826 E015 44.6723304 0.0008721102 1.681528e-01 3.881046e-01 2 210588058 210588147 90 + 1.641 1.569 -0.244
ENSG00000021826 E016 52.8838061 0.0009046501 1.041540e-01 2.890911e-01 2 210590106 210590234 129 + 1.715 1.636 -0.271
ENSG00000021826 E017 39.7968178 0.0021110213 2.233030e-01 4.573267e-01 2 210590800 210590906 107 + 1.589 1.520 -0.237
ENSG00000021826 E018 52.1737041 0.0007871512 8.197468e-02 2.487036e-01 2 210591831 210591969 139 + 1.707 1.620 -0.294
ENSG00000021826 E019 40.6312599 0.0008575535 1.844032e-01 4.097116e-01 2 210592879 210592956 78 + 1.599 1.526 -0.249
ENSG00000021826 E020 0.0000000       2 210593355 210593365 11 +      
ENSG00000021826 E021 0.0000000       2 210593366 210593674 309 +      
ENSG00000021826 E022 45.3529755 0.0010876691 2.101953e-01 4.420776e-01 2 210594508 210594606 99 + 1.645 1.581 -0.219
ENSG00000021826 E023 39.8600058 0.0014363849 6.566224e-02 2.154218e-01 2 210595487 210595582 96 + 1.605 1.498 -0.366
ENSG00000021826 E024 61.9408441 0.0114954406 2.975311e-02 1.265976e-01 2 210599372 210599532 161 + 1.800 1.654 -0.492
ENSG00000021826 E025 30.2242771 0.0014249694 7.482540e-03 4.694674e-02 2 210599533 210599561 29 + 1.507 1.318 -0.651
ENSG00000021826 E026 63.0253773 0.0010064838 5.688693e-04 6.298358e-03 2 210600555 210600712 158 + 1.809 1.636 -0.587
ENSG00000021826 E027 55.6092219 0.0165834425 9.080090e-01 9.561655e-01 2 210602202 210602330 129 + 1.714 1.698 -0.056
ENSG00000021826 E028 0.0000000       2 210604965 210605101 137 +      
ENSG00000021826 E029 60.9396817 0.0007628505 7.056830e-01 8.391360e-01 2 210605102 210605246 145 + 1.750 1.740 -0.034
ENSG00000021826 E030 78.7094326 0.0028067050 7.792352e-01 8.843105e-01 2 210606731 210606941 211 + 1.850 1.874 0.082
ENSG00000021826 E031 76.0111111 0.0010208119 8.789363e-01 9.407345e-01 2 210608361 210608559 199 + 1.844 1.846 0.007
ENSG00000021826 E032 65.7530103 0.0005926807 4.712823e-01 6.810943e-01 2 210612117 210612293 177 + 1.792 1.767 -0.086
ENSG00000021826 E033 58.0035773 0.0006611658 1.867603e-01 4.127447e-01 2 210616423 210616541 119 + 1.747 1.688 -0.198
ENSG00000021826 E034 0.0000000       2 210631228 210631286 59 +      
ENSG00000021826 E035 59.7113581 0.0006107958 8.538396e-01 9.270313e-01 2 210637702 210637843 142 + 1.737 1.755 0.061
ENSG00000021826 E036 39.0722807 0.0009212463 7.578295e-01 8.712866e-01 2 210639150 210639215 66 + 1.554 1.581 0.094
ENSG00000021826 E037 38.9107092 0.0009261311 3.303186e-01 5.692644e-01 2 210639996 210640059 64 + 1.536 1.604 0.232
ENSG00000021826 E038 68.7119443 0.0006569015 1.750300e-02 8.729806e-02 2 210642484 210642665 182 + 1.760 1.877 0.396
ENSG00000021826 E039 77.5194358 0.0006215817 4.413448e-03 3.145084e-02 2 210647863 210648057 195 + 1.810 1.942 0.442
ENSG00000021826 E040 55.2066238 0.0013208812 7.175177e-01 8.466108e-01 2 210648473 210648540 68 + 1.701 1.731 0.101
ENSG00000021826 E041 53.3297656 0.0008492178 4.594392e-01 6.727404e-01 2 210650363 210650438 76 + 1.678 1.727 0.167
ENSG00000021826 E042 0.0000000       2 210653737 210653879 143 +      
ENSG00000021826 E043 58.7218769 0.0007297901 9.814636e-01 9.925198e-01 2 210654025 210654102 78 + 1.732 1.744 0.038
ENSG00000021826 E044 69.2693918 0.0007658170 7.394090e-01 8.600492e-01 2 210656525 210656632 108 + 1.802 1.827 0.083
ENSG00000021826 E045 0.5233527 0.0217681645 8.840415e-01   2 210657360 210657655 296 + 0.149 0.179 0.316
ENSG00000021826 E046 0.2027342 0.0314465225 1.917638e-01   2 210658194 210658228 35 + 0.000 0.179 12.809
ENSG00000021826 E047 0.7249894 0.0376164690 6.192390e-01   2 210658383 210658598 216 + 0.208 0.304 0.723
ENSG00000021826 E048 63.3386499 0.0008105091 6.562817e-01 8.075335e-01 2 210658599 210658688 90 + 1.758 1.789 0.106
ENSG00000021826 E049 89.2728079 0.0004403886 9.471156e-01 9.758706e-01 2 210660485 210660655 171 + 1.912 1.919 0.023
ENSG00000021826 E050 63.1083687 0.0043268872 8.375067e-01 9.180495e-01 2 210663123 210663197 75 + 1.763 1.760 -0.011
ENSG00000021826 E051 0.0000000       2 210665538 210665687 150 +      
ENSG00000021826 E052 55.4368093 0.0007418592 2.378876e-01 4.741362e-01 2 210668186 210668284 99 + 1.686 1.756 0.237
ENSG00000021826 E053 0.3040503 0.0274424043 6.104103e-01   2 210671615 210674901 3287 + 0.149 0.000 -11.213
ENSG00000021826 E054 51.1495030 0.0053024198 1.758272e-02 8.757735e-02 2 210674902 210674961 60 + 1.617 1.774 0.534
ENSG00000021826 E055 68.3689899 0.0007665582 1.510714e-03 1.368799e-02 2 210675728 210675840 113 + 1.744 1.897 0.517
ENSG00000021826 E056 65.9069713 0.0060531930 2.067854e-02 9.826485e-02 2 210677007 210677136 130 + 1.731 1.875 0.486
ENSG00000021826 E057 245.7005784 0.0047499212 1.374623e-06 3.747073e-05 2 210677887 210679107 1221 + 2.280 2.478 0.661