ENSG00000018869

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000586929 ENSG00000018869 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF582 protein_coding protein_coding 2.684106 1.836103 2.276478 0.2713332 0.2194461 0.308644 0.6098658 0.1957338 1.05034885 0.10437003 0.009472041 2.365689 0.2329000 0.09326667 0.47030000 0.3770333 0.08231675 0.01207387 FALSE TRUE
ENST00000587778 ENSG00000018869 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF582 protein_coding non_stop_decay 2.684106 1.836103 2.276478 0.2713332 0.2194461 0.308644 0.2766407 0.1963097 0.00000000 0.19630969 0.000000000 -4.366740 0.1031792 0.10616667 0.00000000 -0.1061667 0.87437967 0.01207387 FALSE FALSE
ENST00000589143 ENSG00000018869 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF582 protein_coding protein_coding 2.684106 1.836103 2.276478 0.2713332 0.2194461 0.308644 0.3924602 0.3201639 0.04505389 0.04544193 0.045053890 -2.584266 0.1517125 0.17476667 0.02033333 -0.1544333 0.01207387 0.01207387 FALSE TRUE
ENST00000593145 ENSG00000018869 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF582 protein_coding non_stop_decay 2.684106 1.836103 2.276478 0.2713332 0.2194461 0.308644 0.5554029 0.0000000 0.68623101 0.00000000 0.353761501 6.121494 0.1829000 0.00000000 0.29833333 0.2983333 0.30785192 0.01207387 FALSE FALSE
MSTRG.17764.2 ENSG00000018869 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF582 protein_coding   2.684106 1.836103 2.276478 0.2713332 0.2194461 0.308644 0.7329655 1.0227273 0.49484398 0.20828064 0.292709693 -1.032550 0.2792250 0.56396667 0.21100000 -0.3529667 0.45848275 0.01207387 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000018869 E001 1.3264150 0.015481150 0.0733137412   19 56375846 56376001 156 - 0.200 0.496 1.867
ENSG00000018869 E002 3.0976096 0.075608129 0.0576260283 0.197454495 19 56376002 56376118 117 - 0.441 0.769 1.467
ENSG00000018869 E003 2.8909835 0.009777148 0.0146524654 0.076784607 19 56376119 56376121 3 - 0.391 0.750 1.660
ENSG00000018869 E004 0.1426347 0.031251969 0.6302721801   19 56382751 56382751 1 - 0.111 0.001 -7.958
ENSG00000018869 E005 28.5663842 0.033260957 0.0005352939 0.005995200 19 56382752 56384872 2121 - 1.599 1.253 -1.196
ENSG00000018869 E006 1.7061735 0.014836149 0.2876407664 0.528378002 19 56384873 56384881 9 - 0.523 0.315 -1.129
ENSG00000018869 E007 9.6943324 0.003907735 0.0008856254 0.008978542 19 56384882 56385184 303 - 1.168 0.777 -1.461
ENSG00000018869 E008 12.0017096 0.003679654 0.5002124015 0.700898272 19 56390001 56390096 96 - 1.159 1.067 -0.332
ENSG00000018869 E009 14.4035016 0.002504870 0.2596177433 0.498587263 19 56390375 56390501 127 - 1.160 1.222 0.221
ENSG00000018869 E010 12.6119736 0.003791474 0.0230897512 0.106236001 19 56391744 56391832 89 - 1.050 1.222 0.614
ENSG00000018869 E011 7.9066083 0.005068011 0.0261453700 0.115774616 19 56393220 56393236 17 - 0.836 1.054 0.818
ENSG00000018869 E012 11.5236942 0.027933841 0.0725541764 0.229889134 19 56393237 56393441 205 - 1.005 1.181 0.636
ENSG00000018869 E013 6.0086250 0.007782557 0.3350413034 0.573600412 19 56393442 56393538 97 - 0.797 0.890 0.360