ENSG00000017797

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000019317 ENSG00000017797 HEK293_OSMI2_6hA HEK293_TMG_6hB RALBP1 protein_coding protein_coding 17.26698 12.15775 24.52216 3.112818 0.832787 1.011612 2.581362 1.8560664 3.522033 0.8857741 0.6805226 0.9204987 0.1559875 0.14156667 0.1424333 0.0008666667 1.0000000 0.0131684 FALSE TRUE
ENST00000383432 ENSG00000017797 HEK293_OSMI2_6hA HEK293_TMG_6hB RALBP1 protein_coding protein_coding 17.26698 12.15775 24.52216 3.112818 0.832787 1.011612 10.390294 9.6248688 11.785653 2.0450564 0.9815884 0.2919183 0.6507292 0.81406667 0.4803667 -0.3337000000 0.0131684 0.0131684 FALSE TRUE
MSTRG.15484.4 ENSG00000017797 HEK293_OSMI2_6hA HEK293_TMG_6hB RALBP1 protein_coding   17.26698 12.15775 24.52216 3.112818 0.832787 1.011612 3.809452 0.4668413 8.556078 0.4668413 0.5603234 4.1670536 0.1671792 0.02723333 0.3502667 0.3230333333 0.0525025 0.0131684 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000017797 E001 4.7102414 0.0063463794 2.928881e-01 5.335614e-01 18 9475009 9475176 168 + 0.804 0.652 -0.620
ENSG00000017797 E002 1.0301373 0.0162356785 7.140750e-01   18 9475454 9475512 59 + 0.316 0.250 -0.463
ENSG00000017797 E003 7.0516784 0.0047920824 7.848872e-03 4.862184e-02 18 9475513 9475619 107 + 0.745 1.059 1.197
ENSG00000017797 E004 13.2573852 0.0143573963 1.187196e-01 3.137605e-01 18 9475620 9475669 50 + 1.071 1.236 0.591
ENSG00000017797 E005 16.7499387 0.0023055136 9.724538e-01 9.882162e-01 18 9475670 9475691 22 + 1.246 1.247 0.003
ENSG00000017797 E006 0.0000000       18 9476127 9476134 8 +      
ENSG00000017797 E007 0.1308682 0.0308546605 3.373632e-01   18 9476135 9476286 152 + 0.000 0.142 9.308
ENSG00000017797 E008 0.0000000       18 9476969 9477253 285 +      
ENSG00000017797 E009 0.1779838 0.0356623796 7.018566e-01   18 9479344 9479437 94 + 0.103 0.000 -9.422
ENSG00000017797 E010 53.1503858 0.0035472694 1.241751e-01 3.223421e-01 18 9512991 9513074 84 + 1.765 1.677 -0.300
ENSG00000017797 E011 129.5289849 0.0003806422 2.710443e-03 2.162738e-02 18 9513075 9513289 215 + 2.147 2.049 -0.329
ENSG00000017797 E012 268.4415048 0.0002485035 3.487843e-03 2.626538e-02 18 9516845 9517303 459 + 2.448 2.382 -0.220
ENSG00000017797 E013 22.0796944 0.0660344620 9.272557e-03 5.498423e-02 18 9517304 9520199 2896 + 1.484 1.100 -1.348
ENSG00000017797 E014 278.6896324 0.0008018249 5.655159e-04 6.269592e-03 18 9522160 9522509 350 + 2.469 2.386 -0.275
ENSG00000017797 E015 168.4959132 0.0003993625 3.399543e-04 4.139092e-03 18 9524594 9524755 162 + 2.261 2.158 -0.344
ENSG00000017797 E016 156.0419336 0.0003419459 1.034301e-03 1.016836e-02 18 9525720 9525851 132 + 2.224 2.126 -0.327
ENSG00000017797 E017 134.4387611 0.0003663499 3.266052e-01 5.657911e-01 18 9530834 9530941 108 + 2.135 2.102 -0.111
ENSG00000017797 E018 133.8850558 0.0004499269 4.591431e-02 1.698390e-01 18 9533335 9533456 122 + 2.093 2.152 0.199
ENSG00000017797 E019 144.0781649 0.0003502599 4.843284e-04 5.533139e-03 18 9533703 9533826 124 + 2.108 2.208 0.335
ENSG00000017797 E020 629.6585014 0.0001432007 5.898751e-19 1.495140e-16 18 9535671 9538114 2444 + 2.743 2.852 0.361