ENSG00000016864

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000266014 ENSG00000016864 HEK293_OSMI2_6hA HEK293_TMG_6hB GLT8D1 protein_coding protein_coding 39.62055 25.18066 54.68455 1.644758 0.9752182 1.118508 6.862801 3.9182444 5.324304 0.60957738 0.4701175 0.4414154 0.17430417 0.15473333 0.09716667 -0.05756667 0.3092884281 0.0006433371 FALSE TRUE
ENST00000394783 ENSG00000016864 HEK293_OSMI2_6hA HEK293_TMG_6hB GLT8D1 protein_coding protein_coding 39.62055 25.18066 54.68455 1.644758 0.9752182 1.118508 13.408259 8.5373247 19.634427 0.26961984 1.0718386 1.2005753 0.33696667 0.34173333 0.35933333 0.01760000 0.9443832441 0.0006433371 FALSE TRUE
ENST00000481643 ENSG00000016864 HEK293_OSMI2_6hA HEK293_TMG_6hB GLT8D1 protein_coding nonsense_mediated_decay 39.62055 25.18066 54.68455 1.644758 0.9752182 1.118508 4.213042 3.2769607 5.819428 0.90052771 0.7761293 0.8266000 0.11155417 0.12676667 0.10596667 -0.02080000 0.9214199187 0.0006433371 FALSE TRUE
MSTRG.23064.24 ENSG00000016864 HEK293_OSMI2_6hA HEK293_TMG_6hB GLT8D1 protein_coding   39.62055 25.18066 54.68455 1.644758 0.9752182 1.118508 2.647700 2.7839552 2.592327 0.05401604 0.2467614 -0.1025067 0.07924167 0.11126667 0.04743333 -0.06383333 0.0006433371 0.0006433371   FALSE
MSTRG.23064.5 ENSG00000016864 HEK293_OSMI2_6hA HEK293_TMG_6hB GLT8D1 protein_coding   39.62055 25.18066 54.68455 1.644758 0.9752182 1.118508 3.699790 1.5671021 6.296758 0.23724986 0.6952977 1.9996225 0.07842917 0.06163333 0.11486667 0.05323333 0.0901374756 0.0006433371 FALSE TRUE
MSTRG.23064.7 ENSG00000016864 HEK293_OSMI2_6hA HEK293_TMG_6hB GLT8D1 protein_coding   39.62055 25.18066 54.68455 1.644758 0.9752182 1.118508 1.754261 0.7700831 4.673228 0.39361542 1.3152369 2.5858036 0.04212083 0.03026667 0.08513333 0.05486667 0.6255476055 0.0006433371 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000016864 E001 2.078506 0.0847028518 8.004090e-01 8.965610e-01 3 52694486 52694488 3 - 0.464 0.502 0.189
ENSG00000016864 E002 2.369982 0.0120482713 1.780324e-01 4.011893e-01 3 52694489 52694491 3 - 0.429 0.648 1.031
ENSG00000016864 E003 2.767526 0.1400494847 5.046810e-01 7.040819e-01 3 52694492 52694502 11 - 0.527 0.647 0.542
ENSG00000016864 E004 139.705815 0.0003020413 2.215265e-01 4.553082e-01 3 52694503 52694671 169 - 2.119 2.155 0.121
ENSG00000016864 E005 245.397020 0.0001988088 3.732496e-01 6.067074e-01 3 52694672 52694801 130 - 2.370 2.389 0.064
ENSG00000016864 E006 290.407353 0.0003262944 3.035493e-01 5.441172e-01 3 52694802 52694898 97 - 2.443 2.464 0.071
ENSG00000016864 E007 301.490302 0.0018748254 8.514696e-01 9.258669e-01 3 52694899 52695006 108 - 2.469 2.462 -0.025
ENSG00000016864 E008 188.878655 0.0013393238 8.341634e-01 9.161109e-01 3 52695007 52695035 29 - 2.262 2.267 0.014
ENSG00000016864 E009 38.027863 0.0937353013 9.072342e-01 9.557467e-01 3 52695036 52695189 154 - 1.600 1.521 -0.270
ENSG00000016864 E010 208.280420 0.0002519027 1.426150e-01 3.513457e-01 3 52695190 52695239 50 - 2.294 2.329 0.119
ENSG00000016864 E011 161.186598 0.0003083875 3.430943e-01 5.807563e-01 3 52695240 52695273 34 - 2.187 2.213 0.087
ENSG00000016864 E012 149.473262 0.0004980648 6.638826e-01 8.123305e-01 3 52695274 52695302 29 - 2.161 2.173 0.041
ENSG00000016864 E013 26.254757 0.1142754217 8.948681e-01 9.491799e-01 3 52695303 52695420 118 - 1.420 1.418 -0.008
ENSG00000016864 E014 289.413198 0.0002284847 6.946899e-01 8.320942e-01 3 52695421 52695587 167 - 2.451 2.441 -0.033
ENSG00000016864 E015 49.932496 0.1724334768 4.360706e-01 6.558631e-01 3 52695588 52695927 340 - 1.748 1.564 -0.623
ENSG00000016864 E016 228.471762 0.0004181545 9.682109e-01 9.859652e-01 3 52695928 52696040 113 - 2.345 2.342 -0.011
ENSG00000016864 E017 2.882767 0.0117025910 4.800123e-01 6.870965e-01 3 52696197 52696233 37 - 0.617 0.499 -0.544
ENSG00000016864 E018 94.547267 0.0056839065 5.378724e-01 7.275379e-01 3 52696234 52696242 9 - 1.954 1.980 0.089
ENSG00000016864 E019 174.857453 0.0017097344 8.237037e-01 9.101036e-01 3 52696243 52696318 76 - 2.228 2.233 0.015
ENSG00000016864 E020 5.786841 0.0083736739 5.111087e-02 1.823320e-01 3 52696319 52696541 223 - 0.890 0.605 -1.163
ENSG00000016864 E021 231.884746 0.0040515124 7.247516e-01 8.509485e-01 3 52696542 52696659 118 - 2.349 2.358 0.030
ENSG00000016864 E022 5.790811 0.0940536613 5.283250e-01 7.208691e-01 3 52697505 52697720 216 - 0.773 0.873 0.394
ENSG00000016864 E023 181.385521 0.0008736363 5.166779e-01 7.128194e-01 3 52697721 52697781 61 - 2.241 2.258 0.058
ENSG00000016864 E024 179.761166 0.0003082394 9.228282e-01 9.637243e-01 3 52697782 52697859 78 - 2.244 2.240 -0.014
ENSG00000016864 E025 97.715662 0.0005509252 1.825153e-01 4.072755e-01 3 52697860 52697862 3 - 1.997 1.945 -0.176
ENSG00000016864 E026 190.604919 0.0017883583 2.304552e-02 1.060986e-01 3 52697863 52697934 72 - 2.292 2.215 -0.260
ENSG00000016864 E027 17.132359 0.0036771745 5.258908e-12 4.770745e-10 3 52698414 52698678 265 - 0.928 1.523 2.111
ENSG00000016864 E028 139.315145 0.0004421771 1.677675e-01 3.876383e-01 3 52700262 52700284 23 - 2.146 2.100 -0.154
ENSG00000016864 E029 187.571063 0.0002810882 2.615222e-02 1.157872e-01 3 52700285 52700360 76 - 2.281 2.218 -0.209
ENSG00000016864 E030 134.693327 0.0005354219 9.791665e-03 5.722323e-02 3 52700445 52700496 52 - 2.146 2.058 -0.293
ENSG00000016864 E031 8.926723 0.1009405798 7.350916e-01 8.573040e-01 3 52700497 52700697 201 - 0.947 1.015 0.254
ENSG00000016864 E032 6.136368 0.0917610906 6.881671e-01 8.279544e-01 3 52701209 52701343 135 - 0.806 0.876 0.269
ENSG00000016864 E033 6.156765 0.0645510183 5.504830e-01 7.366856e-01 3 52702064 52702144 81 - 0.867 0.763 -0.407
ENSG00000016864 E034 1.568340 0.0230276855 7.934765e-01 8.923781e-01 3 52703087 52703255 169 - 0.389 0.435 0.248
ENSG00000016864 E035 14.131876 0.0388758220 5.378225e-01 7.275202e-01 3 52703504 52703698 195 - 1.131 1.219 0.315
ENSG00000016864 E036 10.632711 0.0029228501 1.875450e-01 4.138229e-01 3 52703799 52703928 130 - 0.997 1.130 0.484
ENSG00000016864 E037 90.695977 0.0004477380 6.385710e-02 2.113672e-01 3 52704724 52704812 89 - 1.974 1.900 -0.250
ENSG00000016864 E038 106.381188 0.0023075736 6.831414e-02 2.213146e-01 3 52704813 52704948 136 - 2.043 1.963 -0.267
ENSG00000016864 E039 35.880824 0.0011697226 5.458581e-01 7.333369e-01 3 52704949 52704952 4 - 1.562 1.523 -0.134
ENSG00000016864 E040 151.150957 0.0002783017 5.858361e-01 7.608536e-01 3 52705447 52705698 252 - 2.160 2.175 0.049
ENSG00000016864 E041 23.348321 0.0015127832 5.637289e-05 9.239854e-04 3 52705699 52705702 4 - 1.247 1.534 0.993
ENSG00000016864 E042 34.330351 0.0013034070 1.892800e-05 3.646522e-04 3 52705703 52706032 330 - 1.429 1.684 0.874