ENSG00000015676

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000460110 ENSG00000015676 HEK293_OSMI2_6hA HEK293_TMG_6hB NUDCD3 protein_coding processed_transcript 68.05402 110.0863 43.29673 14.58656 1.275804 -1.346103 37.967120 62.29085 20.695061 9.410072 0.4850608 -1.5892684 0.53869167 0.5625667 0.4782 -0.08436667 0.16934874 0.0004416958 FALSE FALSE
ENST00000464812 ENSG00000015676 HEK293_OSMI2_6hA HEK293_TMG_6hB NUDCD3 protein_coding retained_intron 68.05402 110.0863 43.29673 14.58656 1.275804 -1.346103 6.173676 10.78565 2.966036 2.439908 0.2044127 -1.8589858 0.08435417 0.0970000 0.0689 -0.02810000 0.59241826 0.0004416958 FALSE FALSE
MSTRG.29805.4 ENSG00000015676 HEK293_OSMI2_6hA HEK293_TMG_6hB NUDCD3 protein_coding   68.05402 110.0863 43.29673 14.58656 1.275804 -1.346103 19.158531 30.08208 16.353619 3.321491 1.2028728 -0.8788921 0.30267500 0.2751667 0.3767 0.10153333 0.04533144 0.0004416958 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000015676 E001 76.0607699 0.0033109502 9.726278e-01 9.882499e-01 7 44379119 44383590 4472 - 1.807 1.826 0.063
ENSG00000015676 E002 295.1440565 0.0008061923 1.136014e-09 6.566419e-08 7 44383591 44383756 166 - 2.253 2.452 0.665
ENSG00000015676 E003 3130.5459098 0.0009236965 7.801872e-09 3.756556e-07 7 44383757 44385350 1594 - 3.364 3.454 0.300
ENSG00000015676 E004 1066.7338600 0.0002660671 9.118697e-01 9.581029e-01 7 44385351 44385813 463 - 2.951 2.971 0.066
ENSG00000015676 E005 353.0688922 0.0002486292 3.814735e-01 6.134578e-01 7 44385814 44385892 79 - 2.455 2.497 0.140
ENSG00000015676 E006 625.5170687 0.0007180470 7.185993e-01 8.473549e-01 7 44385893 44386121 229 - 2.714 2.742 0.092
ENSG00000015676 E007 464.1952845 0.0002060779 1.721754e-02 8.624667e-02 7 44392297 44392384 88 - 2.624 2.600 -0.079
ENSG00000015676 E008 504.4532559 0.0001322877 4.702525e-08 1.887936e-06 7 44392385 44392485 101 - 2.697 2.623 -0.247
ENSG00000015676 E009 9.4222092 0.1551702069 8.409507e-01 9.199867e-01 7 44392486 44392508 23 - 0.910 0.976 0.249
ENSG00000015676 E010 4.9920918 0.0057427881 3.589581e-02 1.439265e-01 7 44402642 44402923 282 - 0.914 0.642 -1.089
ENSG00000015676 E011 366.2786098 0.0001566840 1.367110e-05 2.748511e-04 7 44404440 44404512 73 - 2.554 2.486 -0.227
ENSG00000015676 E012 328.2346052 0.0002201907 5.410552e-03 3.674904e-02 7 44404513 44404583 71 - 2.488 2.448 -0.132
ENSG00000015676 E013 1.8865921 0.0102419874 9.567090e-01 9.802243e-01 7 44413191 44413283 93 - 0.425 0.430 0.027
ENSG00000015676 E014 2.1173011 0.0205692900 9.784178e-02 2.780187e-01 7 44425900 44425909 10 - 0.636 0.364 -1.340
ENSG00000015676 E015 3.9342924 0.0064423264 3.338658e-01 5.724537e-01 7 44425910 44426153 244 - 0.735 0.603 -0.556
ENSG00000015676 E016 1.3465513 0.0156066290 4.233312e-01   7 44426154 44426279 126 - 0.425 0.288 -0.816
ENSG00000015676 E017 380.6868006 0.0001669344 2.531681e-02 1.131772e-01 7 44427571 44427703 133 - 2.540 2.516 -0.079
ENSG00000015676 E018 0.3040503 0.0274424043 3.372227e-02   7 44467852 44468345 494 - 0.323 0.000 -11.317
ENSG00000015676 E019 0.0000000       7 44471769 44471960 192 -      
ENSG00000015676 E020 4.2714536 0.1054207105 3.272750e-01 5.663910e-01 7 44481292 44481461 170 - 0.504 0.724 0.971
ENSG00000015676 E021 0.0000000       7 44481462 44481462 1 -      
ENSG00000015676 E022 0.5421338 0.0222210471 1.258634e-01   7 44484444 44484624 181 - 0.324 0.075 -2.555
ENSG00000015676 E023 381.7067934 0.0002228574 3.461739e-04 4.200663e-03 7 44484968 44485068 101 - 2.562 2.510 -0.174
ENSG00000015676 E024 504.8958627 0.0003012949 4.192851e-08 1.701416e-06 7 44485069 44485284 216 - 2.703 2.624 -0.265
ENSG00000015676 E025 5.2455962 0.0054404844 1.092059e-03 1.061633e-02 7 44485531 44485622 92 - 1.017 0.603 -1.645
ENSG00000015676 E026 13.5553201 0.0028263724 6.683340e-01 8.151168e-01 7 44489823 44490408 586 - 1.120 1.096 -0.084
ENSG00000015676 E027 336.5738424 0.0009681799 1.657094e-02 8.386608e-02 7 44490409 44490658 250 - 2.499 2.459 -0.133