ENSG00000015475

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342111 ENSG00000015475 HEK293_OSMI2_6hA HEK293_TMG_6hB BID protein_coding protein_coding 62.88984 75.45657 32.54332 14.08114 1.925932 -1.213033 10.834761 17.8448582 1.498619 2.93511024 0.79681420 -3.5650162 0.15082083 0.23920000 0.0473000 -0.19190000 4.079124e-01 3.92809e-16 FALSE TRUE
ENST00000399765 ENSG00000015475 HEK293_OSMI2_6hA HEK293_TMG_6hB BID protein_coding protein_coding 62.88984 75.45657 32.54332 14.08114 1.925932 -1.213033 6.257098 5.7915759 3.978950 1.00264936 0.07977552 -0.5404358 0.11054167 0.07743333 0.1228333 0.04540000 3.277956e-02 3.92809e-16 FALSE FALSE
ENST00000399767 ENSG00000015475 HEK293_OSMI2_6hA HEK293_TMG_6hB BID protein_coding protein_coding 62.88984 75.45657 32.54332 14.08114 1.925932 -1.213033 29.990453 35.6851818 13.566821 7.84438005 1.26235918 -1.3945836 0.45404167 0.46540000 0.4153000 -0.05010000 7.268086e-01 3.92809e-16 FALSE TRUE
ENST00000551952 ENSG00000015475 HEK293_OSMI2_6hA HEK293_TMG_6hB BID protein_coding protein_coding 62.88984 75.45657 32.54332 14.08114 1.925932 -1.213033 11.533971 14.3748502 7.415314 2.45187927 0.58235642 -0.9540263 0.19146250 0.19316667 0.2273333 0.03416667 6.366601e-01 3.92809e-16 FALSE TRUE
ENST00000622694 ENSG00000015475 HEK293_OSMI2_6hA HEK293_TMG_6hB BID protein_coding protein_coding 62.88984 75.45657 32.54332 14.08114 1.925932 -1.213033 3.224738 0.8207065 5.350119 0.08800925 0.62635783 2.6898545 0.07414167 0.01166667 0.1644333 0.15276667 3.928090e-16 3.92809e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000015475 E001 1.2187199 0.1238229073 6.374698e-03   22 17734138 17734141 4 - 0.615 0.081 -3.930
ENSG00000015475 E002 4.0215973 0.0820228787 1.010566e-03 9.989954e-03 22 17734142 17734174 33 - 0.993 0.385 -2.630
ENSG00000015475 E003 130.2387591 0.0064170945 2.895605e-37 4.132272e-34 22 17734175 17735221 1047 - 2.426 1.776 -2.175
ENSG00000015475 E004 40.0709581 0.0015659189 1.709398e-21 5.973151e-19 22 17735222 17735363 142 - 1.889 1.324 -1.930
ENSG00000015475 E005 215.6780605 0.0047600049 8.088144e-02 2.465753e-01 22 17735364 17735498 135 - 2.351 2.262 -0.297
ENSG00000015475 E006 244.8849855 0.0035959071 6.747996e-01 8.194067e-01 22 17735499 17735551 53 - 2.368 2.333 -0.115
ENSG00000015475 E007 257.0411596 0.0019856876 3.410133e-01 5.789569e-01 22 17735552 17735591 40 - 2.400 2.352 -0.160
ENSG00000015475 E008 278.8270635 0.0002635697 7.497761e-01 8.666510e-01 22 17738017 17738057 41 - 2.420 2.392 -0.091
ENSG00000015475 E009 487.4711775 0.0001476884 3.562774e-04 4.299245e-03 22 17738058 17738229 172 - 2.614 2.654 0.136
ENSG00000015475 E010 395.6459556 0.0002368642 2.414316e-03 1.977364e-02 22 17739349 17739447 99 - 2.525 2.565 0.131
ENSG00000015475 E011 286.6218583 0.0005634198 5.911061e-03 3.930599e-02 22 17739448 17739488 41 - 2.381 2.427 0.156
ENSG00000015475 E012 4.6138609 0.0056688410 1.728077e-01 3.942280e-01 22 17739489 17740081 593 - 0.552 0.753 0.861
ENSG00000015475 E013 2.2168090 0.4774569000 9.000454e-01 9.518995e-01 22 17740082 17740176 95 - 0.492 0.460 -0.156
ENSG00000015475 E014 6.5190551 0.1097153719 2.935957e-01 5.342603e-01 22 17740177 17741194 1018 - 0.706 0.877 0.676
ENSG00000015475 E015 378.3611198 0.0001743120 5.033471e-04 5.707794e-03 22 17743803 17744013 211 - 2.499 2.547 0.161
ENSG00000015475 E016 187.4069919 0.0003445187 1.481957e-05 2.951106e-04 22 17750105 17750174 70 - 2.151 2.259 0.362
ENSG00000015475 E017 1.0108560 0.0507913238 3.807153e-01   22 17773610 17774016 407 - 0.180 0.343 1.232
ENSG00000015475 E018 221.8569087 0.0003447108 4.541743e-09 2.301678e-07 22 17774381 17774495 115 - 2.198 2.340 0.475
ENSG00000015475 E019 0.9596762 0.0175214340 8.292410e-01   22 17774640 17774665 26 - 0.307 0.258 -0.342
ENSG00000015475 E020 0.6376527 0.0194268530 3.897753e-01   22 17774693 17774770 78 - 0.307 0.148 -1.340