ENSG00000015133

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389857 ENSG00000015133 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC88C protein_coding protein_coding 3.707187 5.212161 3.182878 0.5658455 0.1319515 -0.7097896 2.2184847 3.595154 2.2511245 0.4976403 0.01547306 -0.6730203 0.6031167 0.6858 0.7100667 0.02426667 0.95736403 0.00581216 FALSE TRUE
ENST00000556726 ENSG00000015133 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC88C protein_coding protein_coding 3.707187 5.212161 3.182878 0.5658455 0.1319515 -0.7097896 0.7912547 1.223772 0.2143707 0.1998129 0.05790298 -2.4591196 0.1958292 0.2342 0.0661000 -0.16810000 0.00581216 0.00581216 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000015133 E001 199.7117929 1.147175457 0.2629845800 0.502192593 14 91271323 91273468 2146 - 1.974 2.379 1.355
ENSG00000015133 E002 34.1545722 0.367189153 0.3354280976 0.573950163 14 91273469 91273653 185 - 1.381 1.582 0.690
ENSG00000015133 E003 37.9369865 0.004500449 0.2962312190 0.536778857 14 91277922 91278140 219 - 1.488 1.615 0.431
ENSG00000015133 E004 23.2225781 0.004878063 0.3744138535 0.607691950 14 91278141 91278211 71 - 1.284 1.412 0.446
ENSG00000015133 E005 24.1904594 0.001591316 0.0444565169 0.166253530 14 91279238 91279306 69 - 1.231 1.441 0.733
ENSG00000015133 E006 2.0443036 0.055188678 0.9397454746 0.972099487 14 91279307 91279977 671 - 0.444 0.461 0.086
ENSG00000015133 E007 0.7912460 0.018091730 0.7008929394   14 91281162 91281308 147 - 0.276 0.231 -0.342
ENSG00000015133 E008 26.7645237 0.002089829 0.0388287194 0.151693563 14 91281457 91281525 69 - 1.274 1.483 0.725
ENSG00000015133 E009 37.7296771 0.001065790 0.1545310249 0.368792735 14 91283329 91283517 189 - 1.470 1.612 0.487
ENSG00000015133 E010 1.7772088 0.432519905 0.3042448429 0.544806056 14 91283518 91283623 106 - 0.162 0.521 2.360
ENSG00000015133 E011 8.5260699 0.077164760 0.8501879560 0.925095272 14 91285395 91285836 442 - 0.951 0.965 0.054
ENSG00000015133 E012 0.8565226 0.460445738 0.6526580069   14 91288732 91289104 373 - 0.280 0.235 -0.333
ENSG00000015133 E013 33.4697680 0.001307196 0.8451110862 0.922194991 14 91289105 91289343 239 - 1.489 1.531 0.143
ENSG00000015133 E014 24.8121882 0.004180520 0.6896835982 0.828816033 14 91290995 91291084 90 - 1.375 1.395 0.072
ENSG00000015133 E015 31.6793429 0.007990974 0.7731581215 0.880552284 14 91294173 91294318 146 - 1.470 1.502 0.109
ENSG00000015133 E016 30.1196290 0.001154679 0.3211033579 0.560639719 14 91297305 91297491 187 - 1.391 1.512 0.418
ENSG00000015133 E017 29.9503138 0.001549195 0.0089637666 0.053651490 14 91299927 91300070 144 - 1.304 1.545 0.831
ENSG00000015133 E018 40.6901539 0.001040383 0.7678992781 0.877351932 14 91303701 91303978 278 - 1.553 1.624 0.243
ENSG00000015133 E019 23.1959378 0.025971162 0.6681049846 0.814969870 14 91305765 91305926 162 - 1.353 1.370 0.062
ENSG00000015133 E020 32.6767313 0.056229449 0.2669694041 0.506559090 14 91307038 91307226 189 - 1.566 1.465 -0.346
ENSG00000015133 E021 33.1682558 0.004810986 0.0154794506 0.079876064 14 91308351 91308492 142 - 1.580 1.470 -0.377
ENSG00000015133 E022 26.3432971 0.024514720 0.0668169624 0.217902543 14 91309859 91309986 128 - 1.491 1.375 -0.402
ENSG00000015133 E023 86.9353866 0.022697044 0.7091180123 0.841192398 14 91313080 91313942 863 - 1.903 1.929 0.088
ENSG00000015133 E024 33.5755564 0.017535551 0.3446805211 0.582219678 14 91313943 91314150 208 - 1.533 1.514 -0.066
ENSG00000015133 E025 23.1219507 0.013568522 0.0481089024 0.175243232 14 91315650 91315787 138 - 1.443 1.324 -0.413
ENSG00000015133 E026 0.2617363 0.095522221 0.5417135350   14 91315788 91315870 83 - 0.000 0.165 14.121
ENSG00000015133 E027 25.4986524 0.021238292 0.0072618946 0.045887878 14 91321120 91321304 185 - 1.527 1.321 -0.711
ENSG00000015133 E028 19.2237773 0.002424810 0.0398208252 0.154284233 14 91324779 91324923 145 - 1.358 1.245 -0.396
ENSG00000015133 E029 17.3836659 0.001921224 0.3298804471 0.568842208 14 91325910 91326056 147 - 1.264 1.234 -0.107
ENSG00000015133 E030 9.4617955 0.003783711 0.9114558033 0.957912972 14 91338005 91338053 49 - 0.976 1.014 0.142
ENSG00000015133 E031 13.7404589 0.003091726 0.4693279638 0.679593134 14 91338054 91338163 110 - 1.067 1.190 0.439
ENSG00000015133 E032 16.2815246 0.002203961 0.8123649714 0.903646292 14 91338489 91338570 82 - 1.170 1.245 0.263
ENSG00000015133 E033 0.6731895 0.045937835 0.0841210804   14 91338571 91338856 286 - 0.369 0.091 -2.516
ENSG00000015133 E034 0.4654660 0.024305900 0.0175998135   14 91338862 91339277 416 - 0.368 0.000 -16.615
ENSG00000015133 E035 26.4124028 0.001442093 0.0994849857 0.280838640 14 91339278 91339462 185 - 1.456 1.395 -0.212
ENSG00000015133 E036 23.0337525 0.003276115 0.0050481454 0.034888946 14 91339884 91340024 141 - 1.456 1.295 -0.559
ENSG00000015133 E037 0.0000000       14 91342143 91342379 237 -      
ENSG00000015133 E038 20.0369022 0.023498016 0.0505090104 0.180851202 14 91342380 91342463 84 - 1.397 1.242 -0.542
ENSG00000015133 E039 15.9657275 0.020338940 0.0057020410 0.038248652 14 91343599 91343657 59 - 1.356 1.111 -0.865
ENSG00000015133 E040 17.0744693 0.047604720 0.0117535567 0.065456295 14 91359642 91359711 70 - 1.402 1.124 -0.977
ENSG00000015133 E041 0.2027342 0.039763853 1.0000000000   14 91378641 91378658 18 - 0.000 0.091 13.142
ENSG00000015133 E042 3.7613362 0.007276961 0.0002665483 0.003391223 14 91378659 91379885 1227 - 0.910 0.421 -2.123
ENSG00000015133 E043 0.8676241 0.107263509 0.1088083337   14 91384390 91384551 162 - 0.442 0.165 -1.941
ENSG00000015133 E044 0.0000000       14 91408130 91408658 529 -      
ENSG00000015133 E045 20.7597195 0.017465373 0.0020962690 0.017711179 14 91408659 91408767 109 - 1.467 1.220 -0.860
ENSG00000015133 E046 14.7857085 0.010499391 0.0025341306 0.020554696 14 91416738 91416838 101 - 1.330 1.086 -0.867
ENSG00000015133 E047 0.2027342 0.039763853 1.0000000000   14 91417161 91417346 186 - 0.000 0.091 13.142
ENSG00000015133 E048 6.4980590 0.010344248 0.0189408602 0.092245425 14 91417631 91417844 214 - 1.014 0.770 -0.934