ENSG00000012983

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000013125 ENSG00000012983 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP4K5 protein_coding protein_coding 12.42552 5.161089 21.40882 0.5918384 0.2605381 2.050339 1.2440685 0.6837658 1.142650 0.2799144 0.4839747 0.7324343 0.10925833 0.1311667 0.05296667 -0.07820000 4.916218e-01 8.278754e-09 FALSE TRUE
ENST00000682126 ENSG00000012983 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP4K5 protein_coding protein_coding 12.42552 5.161089 21.40882 0.5918384 0.2605381 2.050339 4.9011916 2.7304408 7.783783 0.8229412 0.3950767 1.5079158 0.44922083 0.5035667 0.36393333 -0.13963333 7.309446e-01 8.278754e-09 FALSE TRUE
MSTRG.9520.1 ENSG00000012983 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP4K5 protein_coding   12.42552 5.161089 21.40882 0.5918384 0.2605381 2.050339 1.4771383 0.4446681 3.671020 0.3394870 0.2989821 3.0172196 0.14022083 0.1043333 0.17146667 0.06713333 6.528398e-01 8.278754e-09 FALSE TRUE
MSTRG.9520.5 ENSG00000012983 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP4K5 protein_coding   12.42552 5.161089 21.40882 0.5918384 0.2605381 2.050339 0.8277695 0.8273048 1.398845 0.1709884 1.0116187 0.7506886 0.07729167 0.1604667 0.06653333 -0.09393333 6.371007e-01 8.278754e-09 FALSE TRUE
MSTRG.9520.9 ENSG00000012983 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP4K5 protein_coding   12.42552 5.161089 21.40882 0.5918384 0.2605381 2.050339 2.2555018 0.0000000 5.825724 0.0000000 1.3443191 9.1887678 0.10839583 0.0000000 0.27066667 0.27066667 8.278754e-09 8.278754e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000012983 E001 1.5228404 0.0121989077 2.925033e-01 5.331694e-01 14 50418501 50418520 20 - 0.409 0.203 -1.394
ENSG00000012983 E002 1.9577589 0.0110330377 4.979730e-01 6.994699e-01 14 50418521 50418524 4 - 0.465 0.341 -0.684
ENSG00000012983 E003 223.5695304 0.0042913236 2.074413e-04 2.756087e-03 14 50418525 50419559 1035 - 2.235 2.391 0.520
ENSG00000012983 E004 40.7837232 0.0251998272 2.356346e-01 4.715774e-01 14 50419560 50419679 120 - 1.512 1.645 0.454
ENSG00000012983 E005 21.8142954 0.0667100092 5.063223e-01 7.051547e-01 14 50419680 50419680 1 - 1.254 1.362 0.378
ENSG00000012983 E006 49.4310754 0.0133372024 1.280205e-01 3.286552e-01 14 50419681 50419739 59 - 1.594 1.721 0.429
ENSG00000012983 E007 170.9337871 0.0004040697 2.297594e-04 2.999110e-03 14 50419740 50420106 367 - 2.131 2.255 0.415
ENSG00000012983 E008 75.5758512 0.0005872450 6.010365e-02 2.030634e-01 14 50423121 50423176 56 - 1.788 1.885 0.329
ENSG00000012983 E009 91.9865744 0.0023084561 7.455928e-01 8.640495e-01 14 50425907 50425977 71 - 1.890 1.917 0.090
ENSG00000012983 E010 89.9481577 0.0005508250 2.133046e-01 4.456100e-01 14 50428662 50428754 93 - 1.872 1.936 0.217
ENSG00000012983 E011 83.0657243 0.0006517607 4.172097e-01 6.415544e-01 14 50429192 50429256 65 - 1.841 1.889 0.160
ENSG00000012983 E012 51.8216832 0.0007089022 3.480430e-01 5.855096e-01 14 50429257 50429260 4 - 1.635 1.698 0.214
ENSG00000012983 E013 124.9229012 0.0005994957 2.710622e-01 5.110418e-01 14 50434394 50434571 178 - 2.013 2.065 0.174
ENSG00000012983 E014 48.6381680 0.0007497434 8.216192e-01 9.089102e-01 14 50434962 50434963 2 - 1.619 1.643 0.082
ENSG00000012983 E015 90.0132153 0.0010276798 6.189959e-01 7.830975e-01 14 50434964 50435065 102 - 1.880 1.914 0.116
ENSG00000012983 E016 69.7606132 0.0044512628 8.951060e-01 9.492768e-01 14 50437476 50437534 59 - 1.777 1.785 0.027
ENSG00000012983 E017 87.7363988 0.0081986400 5.845672e-01 7.600483e-01 14 50437894 50438008 115 - 1.878 1.860 -0.062
ENSG00000012983 E018 30.5395909 0.0014332040 8.944389e-01 9.489320e-01 14 50438092 50438094 3 - 1.425 1.426 0.002
ENSG00000012983 E019 9.9671397 0.0342191521 8.069982e-01 9.003158e-01 14 50438095 50438401 307 - 0.958 0.999 0.151
ENSG00000012983 E020 52.8575110 0.0007764090 1.070119e-01 2.939821e-01 14 50440013 50440073 61 - 1.677 1.593 -0.285
ENSG00000012983 E021 68.5902605 0.0005586078 9.456383e-01 9.751649e-01 14 50440362 50440441 80 - 1.767 1.775 0.024
ENSG00000012983 E022 84.4393509 0.0014233324 8.536340e-01 9.268974e-01 14 50442732 50442816 85 - 1.856 1.858 0.006
ENSG00000012983 E023 69.6608519 0.0006180815 6.533003e-01 8.056180e-01 14 50443729 50443770 42 - 1.767 1.800 0.110
ENSG00000012983 E024 95.2278987 0.0005916631 2.263151e-01 4.610213e-01 14 50443939 50444036 98 - 1.918 1.875 -0.143
ENSG00000012983 E025 108.7883019 0.0004167009 2.628441e-02 1.161605e-01 14 50445041 50445194 154 - 1.986 1.905 -0.272
ENSG00000012983 E026 63.2026844 0.0085386455 2.641885e-01 5.034255e-01 14 50446079 50446121 43 - 1.754 1.681 -0.245
ENSG00000012983 E027 58.1949703 0.0284187031 5.532314e-01 7.385387e-01 14 50447414 50447481 68 - 1.716 1.659 -0.195
ENSG00000012983 E028 51.1263440 0.1225593269 5.932759e-01 7.658255e-01 14 50448774 50448832 59 - 1.632 1.692 0.202
ENSG00000012983 E029 8.3300900 0.0592324609 6.280098e-01 7.892379e-01 14 50448833 50450600 1768 - 0.919 0.846 -0.282
ENSG00000012983 E030 62.7880310 1.0098256009 5.402179e-01 7.291446e-01 14 50456516 50456594 79 - 1.709 1.801 0.311
ENSG00000012983 E031 56.2316713 0.1534574352 5.079391e-01 7.063784e-01 14 50462665 50462692 28 - 1.666 1.747 0.274
ENSG00000012983 E032 75.3975797 0.0504393019 6.839270e-01 8.252384e-01 14 50462693 50462781 89 - 1.803 1.840 0.123
ENSG00000012983 E033 55.4663770 0.0033379383 4.049603e-02 1.560154e-01 14 50464052 50464077 26 - 1.708 1.586 -0.414
ENSG00000012983 E034 67.5809509 0.0045462560 7.039566e-02 2.255027e-01 14 50464078 50464133 56 - 1.789 1.687 -0.345
ENSG00000012983 E035 73.7102321 0.0008449758 1.679050e-01 3.877892e-01 14 50466583 50466645 63 - 1.815 1.757 -0.197
ENSG00000012983 E036 64.5577699 0.0010982521 8.091105e-02 2.466399e-01 14 50468651 50468689 39 - 1.761 1.677 -0.284
ENSG00000012983 E037 80.8148302 0.0006285793 2.493754e-02 1.120334e-01 14 50468690 50468782 93 - 1.862 1.765 -0.327
ENSG00000012983 E038 45.7187828 0.0015012790 8.999252e-03 5.381457e-02 14 50475077 50475091 15 - 1.634 1.472 -0.554
ENSG00000012983 E039 54.9099934 0.0026127963 1.017021e-02 5.885040e-02 14 50475092 50475149 58 - 1.705 1.552 -0.522
ENSG00000012983 E040 56.3353231 0.0009041729 4.872222e-02 1.766336e-01 14 50476128 50476170 43 - 1.705 1.600 -0.356
ENSG00000012983 E041 49.8988578 0.0031268123 1.046323e-01 2.899998e-01 14 50476259 50476306 48 - 1.651 1.553 -0.333
ENSG00000012983 E042 59.9219560 0.0007321055 6.350446e-04 6.883588e-03 14 50482361 50482416 56 - 1.748 1.559 -0.641
ENSG00000012983 E043 2.5881865 0.0101588501 9.300301e-03 5.508527e-02 14 50482652 50483149 498 - 0.379 0.804 1.945
ENSG00000012983 E044 57.1295874 0.0059245343 8.436333e-03 5.131939e-02 14 50485578 50485642 65 - 1.723 1.552 -0.584
ENSG00000012983 E045 0.1779838 0.0389941704 1.000000e+00   14 50485929 50486103 175 - 0.070 0.000 -8.052
ENSG00000012983 E046 50.2355756 0.0180125696 4.901885e-02 1.772690e-01 14 50486104 50486194 91 - 1.670 1.508 -0.551
ENSG00000012983 E047 38.2979009 0.0010369676 2.185017e-02 1.020730e-01 14 50504800 50504857 58 - 1.557 1.406 -0.518
ENSG00000012983 E048 0.0000000       14 50504858 50505128 271 -      
ENSG00000012983 E049 43.2285580 0.0008044970 8.133707e-01 9.042683e-01 14 50531942 50532158 217 - 1.577 1.573 -0.015
ENSG00000012983 E050 3.1440623 0.1507904009 2.580188e-01 4.967468e-01 14 50532400 50532447 48 - 0.506 0.720 0.945
ENSG00000012983 E051 9.4232644 0.0033575921 1.152327e-01 3.078546e-01 14 50532448 50532461 14 - 0.901 1.091 0.703
ENSG00000012983 E052 9.9999937 0.0407707254 4.695592e-02 1.724565e-01 14 50532462 50532619 158 - 0.897 1.170 1.000
ENSG00000012983 E053 0.1614157 0.0338167975 1.000000e+00   14 50542499 50542584 86 - 0.070 0.000 -8.051
ENSG00000012983 E054 3.3439951 0.0682837355 6.832441e-07 2.040705e-05 14 50561040 50561126 87 - 0.183 1.080 4.390