ENSG00000011485

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000012443 ENSG00000011485 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP5C protein_coding protein_coding 150.0185 191.9883 108.8297 24.24485 4.499649 -0.8188882 56.14695 78.25980 26.06972 16.464493 1.324364 -1.5855272 0.3412542 0.3974667 0.2394000 -0.15806667 0.05786850 0.00262588 FALSE TRUE
MSTRG.17355.3 ENSG00000011485 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP5C protein_coding   150.0185 191.9883 108.8297 24.24485 4.499649 -0.8188882 34.32937 43.20046 21.77376 6.901761 1.578347 -0.9881272 0.2213583 0.2233000 0.2016333 -0.02166667 0.87631578 0.00262588 TRUE TRUE
MSTRG.17355.4 ENSG00000011485 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP5C protein_coding   150.0185 191.9883 108.8297 24.24485 4.499649 -0.8188882 31.97984 39.07299 34.31622 6.868231 2.640316 -0.1872296 0.2350417 0.2005667 0.3146000 0.11403333 0.01351017 0.00262588 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000011485 E001 7.4086504 2.099056e-02 1.385700e-01 3.453381e-01 19 46347000 46347033 34 + 0.731 0.957 0.877
ENSG00000011485 E002 12.4482066 6.425683e-03 2.882549e-01 5.290025e-01 19 46347034 46347039 6 + 1.011 1.139 0.465
ENSG00000011485 E003 57.7263552 2.484808e-03 5.341268e-03 3.639344e-02 19 46347040 46347086 47 + 1.611 1.785 0.589
ENSG00000011485 E004 147.5981927 8.176692e-04 3.217639e-04 3.951614e-03 19 46347087 46347100 14 + 2.211 2.105 -0.354
ENSG00000011485 E005 286.2807757 9.462046e-04 2.143235e-08 9.342161e-07 19 46347101 46347107 7 + 2.513 2.380 -0.444
ENSG00000011485 E006 760.2275084 3.552440e-04 6.980579e-03 4.454823e-02 19 46347108 46347217 110 + 2.868 2.837 -0.104
ENSG00000011485 E007 1347.4878323 9.776901e-05 8.134639e-06 1.753998e-04 19 46353748 46353989 242 + 3.120 3.083 -0.122
ENSG00000011485 E008 499.6740622 1.369219e-04 8.028851e-01 8.979771e-01 19 46375604 46375626 23 + 2.659 2.667 0.025
ENSG00000011485 E009 994.2918934 1.363252e-04 2.074762e-02 9.849393e-02 19 46375627 46375751 125 + 2.975 2.957 -0.060
ENSG00000011485 E010 1115.7100835 1.466850e-04 7.746325e-03 4.811470e-02 19 46376453 46376574 122 + 3.027 3.006 -0.070
ENSG00000011485 E011 14.8461160 4.339287e-01 1.807223e-01 4.049355e-01 19 46376575 46376703 129 + 1.309 1.081 -0.811
ENSG00000011485 E012 22.6929501 3.201394e-01 3.396841e-01 5.777167e-01 19 46381511 46381725 215 + 1.413 1.301 -0.390
ENSG00000011485 E013 87.5613919 3.034293e-01 2.180739e-01 4.511222e-01 19 46381726 46382771 1046 + 2.025 1.849 -0.589
ENSG00000011485 E014 26.9944507 6.280171e-01 7.281161e-01 8.531116e-01 19 46382772 46383155 384 + 1.393 1.418 0.089
ENSG00000011485 E015 19.5817185 2.429491e-01 7.701437e-01 8.787322e-01 19 46383156 46383322 167 + 1.142 1.324 0.640
ENSG00000011485 E016 23.2949835 2.779125e-01 8.697847e-01 9.357193e-01 19 46383323 46383410 88 + 1.288 1.372 0.294
ENSG00000011485 E017 747.0860878 2.479553e-04 7.565967e-02 2.361209e-01 19 46383411 46383462 52 + 2.850 2.834 -0.052
ENSG00000011485 E018 672.2414080 2.275484e-04 5.954136e-02 2.017594e-01 19 46383463 46383476 14 + 2.805 2.787 -0.060
ENSG00000011485 E019 42.3221123 2.329753e-01 3.568770e-01 5.931932e-01 19 46383477 46383779 303 + 1.678 1.561 -0.400
ENSG00000011485 E020 553.0479289 1.979605e-04 1.054290e-02 6.042614e-02 19 46383780 46383783 4 + 2.730 2.698 -0.106
ENSG00000011485 E021 588.2972465 4.154705e-04 3.121215e-01 5.524679e-01 19 46383784 46383793 10 + 2.738 2.732 -0.021
ENSG00000011485 E022 1053.6546322 7.362810e-04 2.391037e-01 4.755764e-01 19 46383794 46383878 85 + 2.992 2.984 -0.025
ENSG00000011485 E023 8.7549799 3.557968e-02 7.362824e-01 8.581515e-01 19 46383879 46383998 120 + 0.989 0.947 -0.156
ENSG00000011485 E024 23.4037415 8.260059e-02 6.956690e-01 8.327032e-01 19 46384377 46384803 427 + 1.378 1.338 -0.137
ENSG00000011485 E025 1278.8318794 1.194667e-04 1.320443e-01 3.350238e-01 19 46384804 46384909 106 + 3.075 3.070 -0.018
ENSG00000011485 E026 3.1205741 3.620087e-01 4.421808e-01 6.602057e-01 19 46384910 46384943 34 + 0.724 0.509 -0.947
ENSG00000011485 E027 10.6348741 1.000262e-01 4.835819e-01 6.894863e-01 19 46386718 46387092 375 + 0.923 1.063 0.516
ENSG00000011485 E028 1579.1430516 5.520168e-04 8.978603e-01 9.507490e-01 19 46387093 46387235 143 + 3.155 3.164 0.029
ENSG00000011485 E029 1038.7476526 3.315700e-04 7.941708e-02 2.436516e-01 19 46387366 46387453 88 + 2.954 2.990 0.121
ENSG00000011485 E030 17.3516613 1.965038e-01 6.882911e-01 8.279898e-01 19 46387454 46387925 472 + 1.238 1.222 -0.057
ENSG00000011485 E031 15.1461100 1.540176e-01 7.127859e-01 8.434833e-01 19 46387926 46388407 482 + 1.198 1.156 -0.150
ENSG00000011485 E032 868.0245381 1.328212e-04 4.364616e-01 6.561142e-01 19 46388408 46388448 41 + 2.888 2.910 0.075
ENSG00000011485 E033 3.8408640 2.067944e-01 6.795692e-01 8.224513e-01 19 46388449 46388552 104 + 0.724 0.616 -0.457
ENSG00000011485 E034 1644.7134066 1.022617e-04 1.488613e-01 3.606801e-01 19 46388553 46388731 179 + 3.163 3.189 0.086
ENSG00000011485 E035 1060.8288080 3.272321e-04 1.039898e-02 5.986107e-02 19 46390051 46390132 82 + 2.957 3.005 0.161
ENSG00000011485 E036 26.3149670 1.248870e-01 7.755983e-01 8.821106e-01 19 46390133 46390283 151 + 1.409 1.394 -0.053
ENSG00000011485 E037 1183.7158195 1.835172e-03 2.922123e-09 1.544007e-07 19 46390284 46390568 285 + 2.929 3.077 0.491
ENSG00000011485 E038 286.3714465 3.455479e-01 8.245663e-02 2.496440e-01 19 46390569 46390775 207 + 2.113 2.506 1.315
ENSG00000011485 E039 101.5237939 5.968587e-01 1.460054e-01 3.563842e-01 19 46390776 46390975 200 + 1.641 2.063 1.424
ENSG00000011485 E040 15.0538460 1.008740e-01 8.032910e-01 8.982480e-01 19 46391151 46391155 5 + 1.133 1.195 0.220
ENSG00000011485 E041 33.2371624 1.144636e-02 5.640446e-01 7.461499e-01 19 46391156 46391258 103 + 1.527 1.484 -0.145
ENSG00000011485 E042 33.4033822 7.597157e-03 7.592462e-01 8.720922e-01 19 46392637 46392803 167 + 1.513 1.498 -0.053
ENSG00000011485 E043 13.6857417 2.447378e-02 6.226052e-01 7.855782e-01 19 46392804 46392981 178 + 1.177 1.128 -0.177
ENSG00000011485 E044 0.3032425 2.744240e-02 5.476577e-01   19 46393174 46393296 123 + 0.001 0.154 7.923