ENSG00000011405

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265970 ENSG00000011405 HEK293_OSMI2_6hA HEK293_TMG_6hB PIK3C2A protein_coding protein_coding 8.188698 2.006272 15.35607 0.1485179 0.2944702 2.929986 0.7333359 1.17104237 0.000000 0.23899498 0.0000000 -6.883917 0.37973750 0.597933333 0.0000000 -0.5979333 1.627183e-10 1.627183e-10 FALSE TRUE
ENST00000691414 ENSG00000011405 HEK293_OSMI2_6hA HEK293_TMG_6hB PIK3C2A protein_coding protein_coding 8.188698 2.006272 15.35607 0.1485179 0.2944702 2.929986 5.7752113 0.69072450 11.881423 0.28281809 0.1650234 4.084930 0.49063333 0.331200000 0.7739333 0.4427333 1.033273e-02 1.627183e-10 FALSE TRUE
MSTRG.5224.5 ENSG00000011405 HEK293_OSMI2_6hA HEK293_TMG_6hB PIK3C2A protein_coding   8.188698 2.006272 15.35607 0.1485179 0.2944702 2.929986 1.0293979 0.01984263 2.519796 0.01094257 0.1545431 6.405503 0.07097083 0.009466667 0.1641667 0.1547000 6.014466e-06 1.627183e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000011405 E001 0.1614157 0.0328764853 1.000000000   11 17077730 17077922 193 - 0.048 0.000 -6.955
ENSG00000011405 E002 0.4054685 0.6485148155 0.049018755   11 17086572 17086574 3 - 0.000 0.464 13.867
ENSG00000011405 E003 337.0359168 1.7780715647 0.303301793 0.543863608 11 17086575 17089297 2723 - 2.235 2.756 1.739
ENSG00000011405 E004 131.3327774 1.4819278350 0.377681612 0.610329959 11 17089298 17089920 623 - 1.860 2.270 1.375
ENSG00000011405 E005 62.9473296 0.0575224232 0.452605717 0.667584435 11 17091334 17091459 126 - 1.595 1.774 0.605
ENSG00000011405 E006 63.3761017 0.0007383225 0.328236909 0.567260222 11 17091547 17091656 110 - 1.601 1.776 0.594
ENSG00000011405 E007 48.6004017 0.0010962223 0.363302527 0.598390124 11 17091996 17092068 73 - 1.488 1.666 0.608
ENSG00000011405 E008 63.3588959 0.0253958312 0.790058211 0.890580699 11 17092159 17092276 118 - 1.611 1.700 0.304
ENSG00000011405 E009 70.0341212 0.0499871565 0.747895658 0.865443450 11 17094261 17094385 125 - 1.655 1.727 0.243
ENSG00000011405 E010 92.3993872 0.0248083370 0.197540523 0.426545166 11 17097057 17097264 208 - 1.783 1.782 -0.006
ENSG00000011405 E011 64.5273834 0.0150618392 0.289608465 0.530151756 11 17099860 17099969 110 - 1.627 1.657 0.100
ENSG00000011405 E012 67.3696323 0.0020257957 0.087542476 0.259161052 11 17101278 17101434 157 - 1.650 1.658 0.026
ENSG00000011405 E013 60.0785288 0.0030334975 0.332780657 0.571438416 11 17102662 17102831 170 - 1.600 1.649 0.169
ENSG00000011405 E014 60.3873224 0.0008386160 0.213808670 0.446124536 11 17105169 17105305 137 - 1.605 1.641 0.123
ENSG00000011405 E015 63.5109155 0.0015768062 0.045240547 0.168215036 11 17110432 17110561 130 - 1.628 1.613 -0.051
ENSG00000011405 E016 56.4003296 0.0008873350 0.010607545 0.060708558 11 17112574 17112666 93 - 1.583 1.519 -0.219
ENSG00000011405 E017 47.8480495 0.0205227961 0.155553807 0.370233184 11 17114361 17114465 105 - 1.506 1.481 -0.085
ENSG00000011405 E018 73.0285363 0.0128102388 0.127025686 0.327064755 11 17117491 17117671 181 - 1.683 1.682 -0.005
ENSG00000011405 E019 55.1453372 0.0028010111 0.818626766 0.907232935 11 17118645 17118739 95 - 1.553 1.657 0.356
ENSG00000011405 E020 49.3489075 0.0074265275 0.294739470 0.535291487 11 17119220 17119313 94 - 1.515 1.551 0.126
ENSG00000011405 E021 63.9651326 0.0071100126 0.246096521 0.483747130 11 17119786 17119974 189 - 1.623 1.658 0.119
ENSG00000011405 E022 61.3356748 0.0149806465 0.047368866 0.173439007 11 17122188 17122333 146 - 1.614 1.554 -0.205
ENSG00000011405 E023 56.8529499 0.0110458197 0.154821094 0.369121883 11 17122702 17122813 112 - 1.576 1.575 -0.004
ENSG00000011405 E024 56.4333897 0.0038708005 0.187880018 0.414255181 11 17129300 17129467 168 - 1.572 1.594 0.074
ENSG00000011405 E025 45.4671330 0.0067660926 0.025169620 0.112718031 11 17131916 17132038 123 - 1.492 1.413 -0.273
ENSG00000011405 E026 63.5042158 0.0099731626 0.056450575 0.194703293 11 17134819 17135029 211 - 1.627 1.593 -0.116
ENSG00000011405 E027 36.9951264 0.0014301544 0.164306435 0.383135769 11 17135111 17135159 49 - 1.399 1.398 -0.003
ENSG00000011405 E028 63.0080512 0.0093741357 0.029310847 0.125318589 11 17136482 17136625 144 - 1.627 1.573 -0.186
ENSG00000011405 E029 0.0000000       11 17141322 17141381 60 -      
ENSG00000011405 E030 44.2468329 0.0053672858 0.048787389 0.176770659 11 17145668 17145731 64 - 1.477 1.428 -0.170
ENSG00000011405 E031 47.6164632 0.0010380529 0.005866869 0.039085965 11 17145863 17145942 80 - 1.514 1.414 -0.345
ENSG00000011405 E032 52.8072486 0.0069409710 0.023510515 0.107578391 11 17147517 17147628 112 - 1.555 1.483 -0.246
ENSG00000011405 E033 2.3913898 0.0092899147 0.057801661 0.197893353 11 17148239 17148666 428 - 0.440 0.000 -10.848
ENSG00000011405 E034 51.3390857 0.0088776416 0.052277392 0.185014142 11 17148667 17148787 121 - 1.540 1.494 -0.157
ENSG00000011405 E035 62.6199445 0.0176352301 0.020846258 0.098832332 11 17150498 17150655 158 - 1.630 1.538 -0.314
ENSG00000011405 E036 48.6163251 0.0133453138 0.019601853 0.094555453 11 17155526 17155629 104 - 1.522 1.415 -0.368
ENSG00000011405 E037 141.1175326 0.0057054517 0.000169950 0.002333856 11 17168677 17169351 675 - 1.976 1.882 -0.316
ENSG00000011405 E038 104.6972353 0.0349862370 0.003864401 0.028387585 11 17169352 17169806 455 - 1.855 1.691 -0.555
ENSG00000011405 E039 0.4929928 0.0214469820 0.389088816   11 17194389 17194393 5 - 0.091 0.277 1.930
ENSG00000011405 E040 0.3503582 0.0327482892 0.204115544   11 17194394 17194414 21 - 0.048 0.277 2.929
ENSG00000011405 E041 1.4922929 0.0374920895 0.668931523 0.815511655 11 17204307 17204375 69 - 0.286 0.443 0.926
ENSG00000011405 E042 29.6107268 0.0090476677 0.004949059 0.034359348 11 17207848 17208014 167 - 1.325 1.128 -0.697