ENSG00000011332

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355526 ENSG00000011332 HEK293_OSMI2_6hA HEK293_TMG_6hB DPF1 protein_coding protein_coding 16.60048 26.98499 8.414538 4.110098 0.3040509 -1.680022 2.7227144 4.133031 0.0000000 1.0117846 0.0000000 -8.694543 0.13626250 0.14833333 0.00000000 -0.14833333 7.655641e-14 7.655641e-14 FALSE TRUE
ENST00000456296 ENSG00000011332 HEK293_OSMI2_6hA HEK293_TMG_6hB DPF1 protein_coding protein_coding 16.60048 26.98499 8.414538 4.110098 0.3040509 -1.680022 1.0944483 2.531199 0.0000000 0.4409074 0.0000000 -7.989365 0.05749583 0.09590000 0.00000000 -0.09590000 2.562604e-09 7.655641e-14 FALSE TRUE
ENST00000475938 ENSG00000011332 HEK293_OSMI2_6hA HEK293_TMG_6hB DPF1 protein_coding retained_intron 16.60048 26.98499 8.414538 4.110098 0.3040509 -1.680022 0.7476096 1.047107 0.4898613 0.4467655 0.2627011 -1.080522 0.05377083 0.04186667 0.05790000 0.01603333 1.000000e+00 7.655641e-14 FALSE TRUE
ENST00000494031 ENSG00000011332 HEK293_OSMI2_6hA HEK293_TMG_6hB DPF1 protein_coding retained_intron 16.60048 26.98499 8.414538 4.110098 0.3040509 -1.680022 0.7743077 1.289953 0.5518628 0.6802182 0.2759451 -1.210170 0.05058333 0.04940000 0.06350000 0.01410000 9.929396e-01 7.655641e-14   FALSE
ENST00000614244 ENSG00000011332 HEK293_OSMI2_6hA HEK293_TMG_6hB DPF1 protein_coding protein_coding 16.60048 26.98499 8.414538 4.110098 0.3040509 -1.680022 3.1318737 6.191482 2.3442130 0.8352464 0.4367054 -1.397368 0.19233750 0.23220000 0.28166667 0.04946667 8.823801e-01 7.655641e-14 FALSE TRUE
MSTRG.17085.12 ENSG00000011332 HEK293_OSMI2_6hA HEK293_TMG_6hB DPF1 protein_coding   16.60048 26.98499 8.414538 4.110098 0.3040509 -1.680022 4.4745915 8.395017 3.1160624 1.5309351 0.7219552 -1.426904 0.27044583 0.30836667 0.36536667 0.05700000 8.824188e-01 7.655641e-14 FALSE TRUE
MSTRG.17085.13 ENSG00000011332 HEK293_OSMI2_6hA HEK293_TMG_6hB DPF1 protein_coding   16.60048 26.98499 8.414538 4.110098 0.3040509 -1.680022 1.1453564 1.623340 0.6910762 0.4837067 0.6910762 -1.220182 0.07683750 0.05763333 0.08803333 0.03040000 6.225502e-01 7.655641e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000011332 E001 1.160317 0.0515975006 0.1604590160   19 38211006 38211008 3 - 0.001 0.348 9.520
ENSG00000011332 E002 12.635593 0.0878859381 0.7157225370 0.845391399 19 38211009 38211042 34 - 1.108 1.020 -0.322
ENSG00000011332 E003 120.063988 0.0013008739 0.0034734706 0.026184091 19 38211043 38211699 657 - 1.868 2.002 0.450
ENSG00000011332 E004 6.788786 0.0508838369 0.4488739444 0.664900094 19 38211700 38211701 2 - 0.697 0.821 0.499
ENSG00000011332 E005 7.918744 0.0400136404 0.2413312548 0.478082213 19 38211702 38211716 15 - 0.698 0.892 0.773
ENSG00000011332 E006 11.888602 0.0219780493 0.1624190508 0.380360333 19 38211717 38211754 38 - 0.845 1.041 0.736
ENSG00000011332 E007 47.125777 0.0038322331 0.5519904463 0.737691512 19 38211755 38211961 207 - 1.544 1.583 0.131
ENSG00000011332 E008 26.335344 0.0026662258 0.7795251911 0.884456691 19 38211962 38211973 12 - 1.349 1.325 -0.085
ENSG00000011332 E009 81.439967 0.0031231606 0.5104017185 0.708284681 19 38211974 38212064 91 - 1.781 1.814 0.110
ENSG00000011332 E010 58.173914 0.0009917931 0.6743593537 0.819112297 19 38212065 38212071 7 - 1.685 1.660 -0.083
ENSG00000011332 E011 67.717437 0.0022060245 0.9095369109 0.956878496 19 38212072 38212133 62 - 1.735 1.728 -0.027
ENSG00000011332 E012 94.675488 0.0027224561 0.6621351949 0.811169847 19 38212280 38212361 82 - 1.856 1.881 0.083
ENSG00000011332 E013 24.475428 0.0025640964 0.9031685109 0.953439047 19 38212362 38212391 30 - 1.294 1.307 0.046
ENSG00000011332 E014 115.280720 0.0054374301 0.4597958149 0.672992068 19 38213644 38213756 113 - 1.924 1.968 0.150
ENSG00000011332 E015 2.373355 0.0597010054 0.9225510959 0.963582930 19 38213757 38213979 223 - 0.478 0.457 -0.107
ENSG00000011332 E016 117.766424 0.0098400587 0.9615417113 0.982794407 19 38216140 38216241 102 - 1.960 1.971 0.037
ENSG00000011332 E017 72.218884 0.0070763046 0.6716761014 0.817355527 19 38216242 38216259 18 - 1.735 1.766 0.105
ENSG00000011332 E018 68.181928 0.0012666820 0.7212238917 0.848909300 19 38216353 38216403 51 - 1.719 1.739 0.069
ENSG00000011332 E019 4.918913 0.4053310751 0.3744122881 0.607691950 19 38216404 38216510 107 - 0.855 0.635 -0.894
ENSG00000011332 E020 2.146303 0.0124035758 0.3854349114 0.616808452 19 38217391 38217459 69 - 0.565 0.407 -0.781
ENSG00000011332 E021 129.912126 0.0004182606 0.2176354961 0.450571913 19 38217460 38217591 132 - 2.048 2.002 -0.154
ENSG00000011332 E022 11.381380 0.0545367323 0.0004978307 0.005654679 19 38217592 38217797 206 - 1.352 0.852 -1.817
ENSG00000011332 E023 136.453637 0.0004281560 0.3225804773 0.561967402 19 38217798 38217876 79 - 2.061 2.025 -0.122
ENSG00000011332 E024 135.535862 0.0003839004 0.4714262616 0.681169224 19 38218573 38218627 55 - 2.051 2.025 -0.088
ENSG00000011332 E025 103.221337 0.0004141255 0.7486769160 0.865908176 19 38218628 38218656 29 - 1.923 1.910 -0.043
ENSG00000011332 E026 73.658721 0.0005512354 0.3144682155 0.554696246 19 38218657 38218662 6 - 1.809 1.760 -0.166
ENSG00000011332 E027 167.377873 0.0003668799 0.6889347224 0.828396772 19 38218931 38219028 98 - 2.109 2.123 0.048
ENSG00000011332 E028 95.734408 0.0004684051 0.8588693718 0.929781625 19 38219029 38219058 30 - 1.876 1.885 0.030
ENSG00000011332 E029 6.357727 0.0491693455 0.0891459872 0.262211427 19 38219059 38219939 881 - 0.988 0.703 -1.107
ENSG00000011332 E030 140.624662 0.0008024099 0.8507700868 0.925467783 19 38222357 38222464 108 - 2.051 2.043 -0.027
ENSG00000011332 E031 123.294642 0.0004506530 0.2365867518 0.472627885 19 38222548 38222703 156 - 2.027 1.982 -0.152
ENSG00000011332 E032 46.413900 0.0024982176 0.3186673292 0.558467881 19 38222704 38222708 5 - 1.519 1.591 0.244
ENSG00000011332 E033 1.701899 0.1743582455 0.2182902962 0.451381958 19 38222835 38223082 248 - 0.569 0.290 -1.510
ENSG00000011332 E034 1.706223 0.0208641935 0.0499993969 0.179674290 19 38223083 38223298 216 - 0.638 0.286 -1.844
ENSG00000011332 E035 2.158667 0.0395396531 0.2370125267 0.473102934 19 38223756 38224113 358 - 0.222 0.478 1.587
ENSG00000011332 E036 43.576663 0.0045600703 0.9327454856 0.968512617 19 38224114 38224250 137 - 1.545 1.555 0.035
ENSG00000011332 E037 0.000000       19 38227946 38228042 97 -      
ENSG00000011332 E038 0.000000       19 38228662 38228693 32 -      
ENSG00000011332 E039 5.968038 0.0078715565 0.0701901380 0.225141655 19 38229559 38229714 156 - 0.478 0.799 1.402