ENSG00000011275

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389902 ENSG00000011275 HEK293_OSMI2_6hA HEK293_TMG_6hB RNF216 protein_coding protein_coding 17.8405 20.93876 19.43837 4.440721 0.6876872 -0.1072153 5.974230 7.1615532 4.596562 1.7622244 0.9633849 -0.6385951 0.33582083 0.33896667 0.2382000 -0.1007667 5.899573e-01 1.4549e-16 FALSE TRUE
ENST00000425013 ENSG00000011275 HEK293_OSMI2_6hA HEK293_TMG_6hB RNF216 protein_coding protein_coding 17.8405 20.93876 19.43837 4.440721 0.6876872 -0.1072153 8.394806 12.6002911 7.147060 2.8008741 0.9393872 -0.8171626 0.47645417 0.59786667 0.3661333 -0.2317333 1.480812e-02 1.4549e-16 FALSE TRUE
MSTRG.29444.6 ENSG00000011275 HEK293_OSMI2_6hA HEK293_TMG_6hB RNF216 protein_coding   17.8405 20.93876 19.43837 4.440721 0.6876872 -0.1072153 1.336313 0.2519624 3.731718 0.1093267 0.2842354 3.8362690 0.06857083 0.01126667 0.1914667 0.1802000 1.454900e-16 1.4549e-16 FALSE TRUE
MSTRG.29444.8 ENSG00000011275 HEK293_OSMI2_6hA HEK293_TMG_6hB RNF216 protein_coding   17.8405 20.93876 19.43837 4.440721 0.6876872 -0.1072153 1.282817 0.4800023 2.879478 0.2514669 0.7243807 2.5599484 0.07077917 0.03230000 0.1484333 0.1161333 2.371979e-01 1.4549e-16 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000011275 E001 0.8917543 0.1021001290 7.907283e-01   7 5616167 5616208 42 - 0.239 0.326 0.604
ENSG00000011275 E002 0.9596762 0.0165391031 8.091214e-01   7 5619215 5619271 57 - 0.241 0.327 0.604
ENSG00000011275 E003 0.9105353 0.0184721428 8.058879e-01   7 5619868 5619907 40 - 0.240 0.327 0.604
ENSG00000011275 E004 2.6218568 0.0122537017 6.731573e-01 8.183370e-01 7 5619908 5620046 139 - 0.555 0.549 -0.028
ENSG00000011275 E005 912.1816673 1.7229439453 3.761763e-01 6.091492e-01 7 5620047 5622694 2648 - 2.693 3.082 1.292
ENSG00000011275 E006 142.5057994 1.0952011588 3.838279e-01 6.154286e-01 7 5622695 5622835 141 - 1.952 2.257 1.023
ENSG00000011275 E007 135.4977627 1.0370965156 3.189801e-01 5.587003e-01 7 5622836 5622926 91 - 1.891 2.249 1.202
ENSG00000011275 E008 200.9660722 1.2149011419 3.819307e-01 6.138557e-01 7 5622927 5623179 253 - 2.088 2.410 1.079
ENSG00000011275 E009 133.9888390 0.0052326097 2.403520e-01 4.769657e-01 7 5624056 5624125 70 - 2.045 2.184 0.465
ENSG00000011275 E010 211.5972637 0.0003283988 1.763381e-01 3.988845e-01 7 5641154 5641347 194 - 2.253 2.379 0.422
ENSG00000011275 E011 86.3183087 0.0120354927 8.870699e-01 9.451574e-01 7 5641348 5641376 29 - 1.868 1.987 0.398
ENSG00000011275 E012 0.5059767 0.0221211584 1.893828e-01   7 5649640 5650015 376 - 0.000 0.266 11.511
ENSG00000011275 E013 138.2172492 0.0071713203 7.827448e-01 8.862564e-01 7 5652413 5652510 98 - 2.071 2.188 0.391
ENSG00000011275 E014 115.4366562 0.0026300998 4.691036e-01 6.794671e-01 7 5711761 5711839 79 - 1.989 2.114 0.418
ENSG00000011275 E015 155.7359990 0.0204978280 5.975115e-01 7.686424e-01 7 5712715 5712863 149 - 2.156 2.216 0.199
ENSG00000011275 E016 0.0000000       7 5713305 5713441 137 -      
ENSG00000011275 E017 179.7250546 0.0095380365 1.948224e-01 4.231129e-01 7 5715053 5715190 138 - 2.240 2.263 0.077
ENSG00000011275 E018 126.2152760 0.0158669756 1.290827e-01 3.303377e-01 7 5716716 5716766 51 - 2.106 2.095 -0.034
ENSG00000011275 E019 189.2898089 0.0057648129 1.824268e-02 8.982912e-02 7 5721033 5721172 140 - 2.283 2.270 -0.041
ENSG00000011275 E020 170.4764312 0.0052237825 4.620972e-04 5.329715e-03 7 5725324 5725438 115 - 2.266 2.202 -0.212
ENSG00000011275 E021 153.2101233 0.0051610082 2.778624e-03 2.205226e-02 7 5729432 5729529 98 - 2.211 2.167 -0.144
ENSG00000011275 E022 107.4223097 0.0013455183 1.126626e-02 6.346677e-02 7 5729530 5729596 67 - 2.037 2.032 -0.018
ENSG00000011275 E023 100.7243016 0.0039345664 9.443696e-03 5.571655e-02 7 5730715 5730817 103 - 2.020 1.990 -0.100
ENSG00000011275 E024 0.3503582 0.0786101398 7.343808e-01   7 5732970 5733162 193 - 0.137 0.108 -0.396
ENSG00000011275 E025 88.9857615 0.0134183032 1.189127e-01 3.140643e-01 7 5739276 5739352 77 - 1.953 1.945 -0.028
ENSG00000011275 E026 10.0748642 0.1150701050 8.423607e-02 2.532346e-01 7 5739353 5739621 269 - 1.161 0.911 -0.917
ENSG00000011275 E027 3.3970435 0.2389406029 2.464664e-01 4.841211e-01 7 5739622 5739625 4 - 0.743 0.521 -0.967
ENSG00000011275 E028 433.0057917 0.0108614292 1.199264e-04 1.737210e-03 7 5740973 5741578 606 - 2.687 2.588 -0.331
ENSG00000011275 E029 130.0562066 0.0066505656 1.053853e-07 3.885551e-06 7 5741579 5741644 66 - 2.204 2.033 -0.572
ENSG00000011275 E030 78.0760930 0.0167054351 4.681561e-03 3.290988e-02 7 5741645 5741815 171 - 1.959 1.840 -0.401
ENSG00000011275 E031 179.0148614 0.0094270574 1.127810e-03 1.087437e-02 7 5752846 5752979 134 - 2.298 2.213 -0.284
ENSG00000011275 E032 0.0000000       7 5760391 5760511 121 -      
ENSG00000011275 E033 89.4028844 0.0109345043 1.083158e-02 6.165905e-02 7 5761003 5761010 8 - 1.993 1.920 -0.244
ENSG00000011275 E034 124.5278061 0.0029905293 6.011885e-05 9.753117e-04 7 5761011 5761087 77 - 2.137 2.062 -0.250
ENSG00000011275 E035 85.2992088 0.0023164534 6.470243e-05 1.038461e-03 7 5761088 5761138 51 - 1.981 1.893 -0.294
ENSG00000011275 E036 0.4702677 0.0216987280 3.236329e-01   7 5766895 5766939 45 - 0.241 0.108 -1.398
ENSG00000011275 E037 0.6486114 0.0193874923 5.842510e-01   7 5775005 5775179 175 - 0.137 0.266 1.192
ENSG00000011275 E038 5.5836878 0.3639924520 4.356421e-01 6.554699e-01 7 5777487 5777628 142 - 0.886 0.741 -0.567
ENSG00000011275 E039 0.0000000       7 5779985 5780292 308 -      
ENSG00000011275 E040 70.9689843 0.0124918864 2.620183e-02 1.159312e-01 7 5781541 5781696 156 - 1.891 1.824 -0.226