ENSG00000011021

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000346436 ENSG00000011021 HEK293_OSMI2_6hA HEK293_TMG_6hB CLCN6 protein_coding protein_coding 8.340678 9.780795 7.638826 0.9361264 0.6880783 -0.3561878 3.91865760 4.9033201 3.7795874 0.59993484 0.24853743 -0.374657450 0.475391667 0.5070 0.50873333 0.001733333 1.000000000 0.001161767 FALSE TRUE
ENST00000376497 ENSG00000011021 HEK293_OSMI2_6hA HEK293_TMG_6hB CLCN6 protein_coding processed_transcript 8.340678 9.780795 7.638826 0.9361264 0.6880783 -0.3561878 0.53284869 0.2677185 1.0196736 0.04080897 0.08827802 1.890492140 0.066895833 0.0280 0.13786667 0.109866667 0.001161767 0.001161767 FALSE TRUE
ENST00000494028 ENSG00000011021 HEK293_OSMI2_6hA HEK293_TMG_6hB CLCN6 protein_coding processed_transcript 8.340678 9.780795 7.638826 0.9361264 0.6880783 -0.3561878 0.42678889 0.6213235 0.6233287 0.26840506 0.22059697 0.004575091 0.050900000 0.0628 0.08023333 0.017433333 0.919209066 0.001161767 FALSE FALSE
ENST00000617059 ENSG00000011021 HEK293_OSMI2_6hA HEK293_TMG_6hB CLCN6 protein_coding misc_RNA 8.340678 9.780795 7.638826 0.9361264 0.6880783 -0.3561878 0.07694905 0.0000000 0.6155924 0.00000000 0.61559240 5.967151091 0.008741667 0.0000 0.06993333 0.069933333 0.854515694 0.001161767   FALSE
MSTRG.323.18 ENSG00000011021 HEK293_OSMI2_6hA HEK293_TMG_6hB CLCN6 protein_coding   8.340678 9.780795 7.638826 0.9361264 0.6880783 -0.3561878 1.52298250 2.2826548 0.1427892 1.21280851 0.14278918 -3.907404875 0.172012500 0.2278 0.01623333 -0.211566667 0.143871646 0.001161767 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000011021 E001 0.7272023 0.1229953090 3.858941e-01   1 11806096 11806190 95 + 0.347 0.176 -1.287
ENSG00000011021 E002 0.8580705 0.3230861478 6.093034e-01   1 11806191 11806212 22 + 0.346 0.237 -0.747
ENSG00000011021 E003 0.9819241 0.3786632869 4.694192e-01   1 11806213 11806230 18 + 0.414 0.236 -1.142
ENSG00000011021 E004 0.9819241 0.3786632869 4.694192e-01   1 11806231 11806233 3 + 0.414 0.236 -1.142
ENSG00000011021 E005 0.9819241 0.3786632869 4.694192e-01   1 11806234 11806236 3 + 0.414 0.236 -1.142
ENSG00000011021 E006 2.1368875 0.0289002477 4.209762e-01 0.6444549962 1 11806237 11806243 7 + 0.586 0.444 -0.681
ENSG00000011021 E007 6.3947375 0.2832466321 2.813758e-01 0.5216643026 1 11806244 11806257 14 + 1.063 0.676 -1.497
ENSG00000011021 E008 9.0329926 0.4179465334 5.367779e-01 0.7268815482 1 11806258 11806259 2 + 1.165 0.845 -1.183
ENSG00000011021 E009 10.3599551 0.3648571749 7.398869e-01 0.8603473590 1 11806260 11806262 3 + 1.176 0.946 -0.840
ENSG00000011021 E010 21.9990421 0.4412563516 5.141560e-01 0.7110843058 1 11806263 11806349 87 + 1.311 1.373 0.215
ENSG00000011021 E011 28.7586873 0.0676081422 8.086597e-01 0.9013870417 1 11807131 11807190 60 + 1.468 1.462 -0.022
ENSG00000011021 E012 32.6599278 0.0224217368 8.979598e-01 0.9508005929 1 11815846 11815911 66 + 1.524 1.514 -0.032
ENSG00000011021 E013 32.5973616 0.0102165973 1.005673e-01 0.2828199607 1 11816615 11816680 66 + 1.598 1.458 -0.479
ENSG00000011021 E014 4.0477168 0.1449157096 3.054580e-02 0.1289783112 1 11817973 11818037 65 + 0.348 0.826 2.214
ENSG00000011021 E015 31.4195837 0.0015075204 1.945299e-02 0.0940222169 1 11819488 11819554 67 + 1.582 1.428 -0.530
ENSG00000011021 E016 7.0339312 0.0072162384 5.650420e-04 0.0062651562 1 11820362 11820779 418 + 1.109 0.683 -1.636
ENSG00000011021 E017 35.7775731 0.0011820928 9.269934e-02 0.2687824216 1 11822695 11822801 107 + 1.613 1.507 -0.364
ENSG00000011021 E018 32.5403382 0.0013747800 8.574589e-02 0.2559385618 1 11823707 11823833 127 + 1.577 1.463 -0.392
ENSG00000011021 E019 24.5466359 0.0015949078 2.564118e-03 0.0207454157 1 11824486 11824553 68 + 1.512 1.292 -0.758
ENSG00000011021 E020 23.2720177 0.0155298808 8.018448e-04 0.0082980919 1 11826156 11826214 59 + 1.528 1.224 -1.057
ENSG00000011021 E021 1.1440048 0.3045270562 4.145742e-01   1 11826215 11826224 10 + 0.420 0.250 -1.065
ENSG00000011021 E022 16.8280018 0.0023233625 5.254203e-05 0.0008682344 1 11827089 11827114 26 + 1.414 1.069 -1.219
ENSG00000011021 E023 32.0518421 0.0284326059 1.447290e-02 0.0761433609 1 11827115 11827221 107 + 1.633 1.403 -0.789
ENSG00000011021 E024 33.5856302 0.0320671217 3.141626e-01 0.5543955901 1 11828106 11828219 114 + 1.582 1.487 -0.325
ENSG00000011021 E025 21.3846870 0.0016900237 5.176618e-01 0.7133943649 1 11828458 11828624 167 + 1.371 1.314 -0.196
ENSG00000011021 E026 36.5255231 0.0053654922 4.498791e-01 0.6656103660 1 11829196 11829322 127 + 1.596 1.539 -0.193
ENSG00000011021 E027 10.0274604 0.1323211549 3.073642e-01 0.5479697425 1 11829849 11830270 422 + 1.100 0.974 -0.460
ENSG00000011021 E028 39.8562974 0.0236239695 2.942372e-01 0.5348200612 1 11833515 11833638 124 + 1.670 1.557 -0.385
ENSG00000011021 E029 25.1985399 0.0753320046 5.117024e-01 0.7092914555 1 11833877 11833886 10 + 1.478 1.365 -0.391
ENSG00000011021 E030 48.1129751 0.0043860167 2.048997e-01 0.4357811229 1 11833887 11834030 144 + 1.732 1.651 -0.277
ENSG00000011021 E031 44.1936373 0.0019992649 9.858048e-01 0.9947415846 1 11834236 11834395 160 + 1.639 1.633 -0.021
ENSG00000011021 E032 40.9183668 0.0095044666 6.305984e-01 0.7908133386 1 11834484 11834590 107 + 1.623 1.592 -0.103
ENSG00000011021 E033 54.8517586 0.0017321109 5.004970e-01 0.7010954496 1 11835967 11836153 187 + 1.753 1.714 -0.130
ENSG00000011021 E034 46.5713956 0.0009941862 8.401783e-01 0.9195238940 1 11836999 11837156 158 + 1.674 1.656 -0.059
ENSG00000011021 E035 19.8203512 0.0047601698 3.563871e-01 0.5928607861 1 11837343 11837376 34 + 1.249 1.322 0.253
ENSG00000011021 E036 35.4208974 0.0011568537 4.196517e-01 0.6434130601 1 11837377 11837499 123 + 1.517 1.559 0.143
ENSG00000011021 E037 41.9305645 0.0101347594 9.400837e-02 0.2711632551 1 11838335 11838442 108 + 1.538 1.655 0.398
ENSG00000011021 E038 50.4245454 0.0008646725 9.085208e-03 0.0542041136 1 11838535 11838660 126 + 1.609 1.739 0.440
ENSG00000011021 E039 1.4099749 0.1660314293 1.754491e-01 0.3977440810 1 11838661 11839050 390 + 0.148 0.454 2.183
ENSG00000011021 E040 60.8761264 0.0013395840 3.311385e-01 0.5700103167 1 11840143 11840371 229 + 1.756 1.797 0.138
ENSG00000011021 E041 15.0869118 0.0024349438 3.579237e-01 0.5940953887 1 11840372 11840378 7 + 1.148 1.225 0.271
ENSG00000011021 E042 136.2946151 0.0042491244 7.266130e-01 0.8521761529 1 11840379 11841016 638 + 2.113 2.131 0.057
ENSG00000011021 E043 28.9234328 0.0187104523 8.700412e-01 0.9358978638 1 11841017 11841028 12 + 1.443 1.465 0.077
ENSG00000011021 E044 36.7702876 0.0128798371 1.231219e-01 0.3206990100 1 11841029 11841057 29 + 1.473 1.603 0.445
ENSG00000011021 E045 61.0651093 0.0009353715 1.096636e-01 0.2984759230 1 11841058 11841207 150 + 1.730 1.801 0.239
ENSG00000011021 E046 30.7783856 0.0024563032 4.780127e-01 0.6858107870 1 11841208 11841322 115 + 1.465 1.503 0.131
ENSG00000011021 E047 204.6478792 0.0012760564 3.793860e-04 0.0045333853 1 11841323 11842649 1327 + 2.236 2.331 0.315
ENSG00000011021 E048 83.2975131 0.0041925226 9.345315e-04 0.0093747382 1 11842650 11843143 494 + 1.806 1.963 0.528
ENSG00000011021 E049 2.1283748 0.1032742156 7.396079e-01 0.8601668595 1 11843704 11843733 30 + 0.422 0.519 0.487
ENSG00000011021 E050 4.9094114 0.0093752801 8.842483e-02 0.2608628629 1 11843734 11843811 78 + 0.587 0.837 1.034
ENSG00000011021 E051 12.4406070 0.0715534029 1.215282e-01 0.3182755662 1 11843812 11844073 262 + 0.942 1.195 0.920
ENSG00000011021 E052 4.5832064 0.0061915029 4.771335e-01 0.6850718106 1 11845547 11845548 2 + 0.670 0.767 0.399
ENSG00000011021 E053 13.0917421 0.0230612782 1.128409e-02 0.0635419274 1 11845549 11845766 218 + 0.920 1.229 1.126
ENSG00000011021 E054 1.9755739 0.0109645323 9.909941e-02 0.2801749325 1 11847434 11847441 8 + 0.259 0.550 1.643
ENSG00000011021 E055 4.2826229 0.0372654641 5.845475e-01 0.7600402309 1 11847442 11847576 135 + 0.668 0.748 0.330
ENSG00000011021 E056 9.4250264 0.0063909514 4.742958e-01 0.6830457935 1 11847577 11848079 503 + 0.962 1.039 0.284