ENSG00000009413

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358835 ENSG00000009413 HEK293_OSMI2_6hA HEK293_TMG_6hB REV3L protein_coding protein_coding 4.836816 3.128441 8.258317 0.5432593 0.2669093 1.397545 0.2734080 0.05998665 0.7659205 0.05998665 0.5298616 3.4707572 0.0629000 0.01540000 0.0970000 0.08160000 0.594963505 0.001068131 FALSE TRUE
ENST00000368802 ENSG00000009413 HEK293_OSMI2_6hA HEK293_TMG_6hB REV3L protein_coding protein_coding 4.836816 3.128441 8.258317 0.5432593 0.2669093 1.397545 1.4877942 0.65836621 3.3461885 0.13113042 0.5093878 2.3281130 0.2354167 0.21006667 0.4022667 0.19220000 0.100936704 0.001068131 FALSE TRUE
ENST00000413831 ENSG00000009413 HEK293_OSMI2_6hA HEK293_TMG_6hB REV3L protein_coding nonsense_mediated_decay 4.836816 3.128441 8.258317 0.5432593 0.2669093 1.397545 0.1624950 0.00000000 0.4821010 0.00000000 0.3306999 5.6208824 0.0262625 0.00000000 0.0561000 0.05610000 0.511955454 0.001068131 TRUE TRUE
ENST00000462119 ENSG00000009413 HEK293_OSMI2_6hA HEK293_TMG_6hB REV3L protein_coding processed_transcript 4.836816 3.128441 8.258317 0.5432593 0.2669093 1.397545 1.0417412 1.28083189 0.9881118 0.20486788 0.2230532 -0.3710278 0.3060292 0.41353333 0.1188667 -0.29466667 0.001068131 0.001068131 TRUE TRUE
MSTRG.28807.8 ENSG00000009413 HEK293_OSMI2_6hA HEK293_TMG_6hB REV3L protein_coding   4.836816 3.128441 8.258317 0.5432593 0.2669093 1.397545 0.6253875 0.15999416 1.1130692 0.09680291 0.2091753 2.7238897 0.1045792 0.06606667 0.1347000 0.06863333 0.598058459 0.001068131 TRUE TRUE
MSTRG.28807.9 ENSG00000009413 HEK293_OSMI2_6hA HEK293_TMG_6hB REV3L protein_coding   4.836816 3.128441 8.258317 0.5432593 0.2669093 1.397545 0.9684574 0.87978707 1.4216724 0.24779533 0.2119320 0.6861693 0.2154708 0.26870000 0.1742000 -0.09450000 0.518295413 0.001068131 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000009413 E001 0.0000000       6 111299028 111299030 3 -      
ENSG00000009413 E002 0.0000000       6 111299031 111299032 2 -      
ENSG00000009413 E003 0.0000000       6 111299033 111299051 19 -      
ENSG00000009413 E004 16.8891163 0.4183369026 7.256015e-02 2.298898e-01 6 111299052 111299353 302 - 0.987 1.528 1.909
ENSG00000009413 E005 21.7902055 0.4829573937 9.015960e-02 2.640859e-01 6 111299354 111299460 107 - 1.107 1.617 1.776
ENSG00000009413 E006 43.6124975 0.7512549518 1.765966e-01 3.992007e-01 6 111299461 111299759 299 - 1.432 1.870 1.490
ENSG00000009413 E007 67.4563936 0.8948775550 2.280742e-01 4.630658e-01 6 111299760 111300156 397 - 1.628 2.042 1.394
ENSG00000009413 E008 51.8108250 0.0538852488 7.398006e-03 4.653498e-02 6 111307361 111307570 210 - 1.543 1.903 1.220
ENSG00000009413 E009 0.0000000       6 111307731 111307735 5 -      
ENSG00000009413 E010 2.7921063 0.0105330074 7.233975e-01 8.501580e-01 6 111308014 111308245 232 - 0.526 0.518 -0.039
ENSG00000009413 E011 43.7521338 0.7335021450 1.625313e-01 3.805295e-01 6 111309853 111310099 247 - 1.421 1.885 1.579
ENSG00000009413 E012 33.2402371 0.6789412399 1.848713e-01 4.103170e-01 6 111311069 111311259 191 - 1.312 1.762 1.540
ENSG00000009413 E013 33.1925706 0.6935518733 2.672606e-01 5.068851e-01 6 111313352 111313489 138 - 1.367 1.691 1.112
ENSG00000009413 E014 34.9246955 0.0812790712 2.278525e-01 4.628424e-01 6 111315267 111315381 115 - 1.435 1.637 0.692
ENSG00000009413 E015 3.0723634 0.0084137091 6.923279e-02 2.232462e-01 6 111315382 111315637 256 - 0.449 0.790 1.509
ENSG00000009413 E016 43.5833808 0.0016292702 3.861595e-01 6.174359e-01 6 111322569 111322678 110 - 1.558 1.681 0.420
ENSG00000009413 E017 55.6733975 0.0006518524 6.850453e-01 8.259247e-01 6 111329532 111329738 207 - 1.667 1.762 0.320
ENSG00000009413 E018 35.3446571 0.0060041292 5.966184e-01 7.680559e-01 6 111331676 111331784 109 - 1.467 1.582 0.391
ENSG00000009413 E019 51.3295565 0.0015018972 1.046695e-01 2.900524e-01 6 111333123 111333367 245 - 1.615 1.778 0.551
ENSG00000009413 E020 42.6894450 0.0083783555 9.313824e-02 2.695791e-01 6 111335469 111335610 142 - 1.523 1.722 0.675
ENSG00000009413 E021 28.2053930 0.0050113192 4.747522e-01 6.833927e-01 6 111343925 111343949 25 - 1.368 1.496 0.442
ENSG00000009413 E022 44.4516173 0.0086729146 6.048106e-01 7.733625e-01 6 111343950 111344043 94 - 1.564 1.675 0.376
ENSG00000009413 E023 0.0000000       6 111348953 111349217 265 -      
ENSG00000009413 E024 47.4803417 0.0026228297 6.642076e-01 8.125166e-01 6 111349218 111349336 119 - 1.612 1.660 0.164
ENSG00000009413 E025 38.9218208 0.0009730763 8.763855e-01 9.394081e-01 6 111351676 111351791 116 - 1.520 1.602 0.282
ENSG00000009413 E026 0.1308682 0.0326491905 1.757595e-01   6 111356668 111357013 346 - 0.000 0.197 14.481
ENSG00000009413 E027 25.4159980 0.0016500900 2.614468e-01 5.005318e-01 6 111357014 111357080 67 - 1.317 1.473 0.537
ENSG00000009413 E028 21.3534581 0.0036818330 2.734748e-01 5.133222e-01 6 111357081 111357125 45 - 1.247 1.409 0.563
ENSG00000009413 E029 40.3135275 0.0125589838 9.574272e-01 9.805681e-01 6 111358822 111359014 193 - 1.533 1.616 0.281
ENSG00000009413 E030 39.4394847 0.0021880579 4.641312e-01 6.759471e-01 6 111363853 111363978 126 - 1.541 1.569 0.097
ENSG00000009413 E031 3.2748917 0.1242637504 3.084914e-01 5.490755e-01 6 111364944 111365042 99 - 0.615 0.434 -0.862
ENSG00000009413 E032 30.8496297 0.0055422834 6.222075e-01 7.853380e-01 6 111365265 111365344 80 - 1.433 1.471 0.132
ENSG00000009413 E033 72.4577592 0.0068196091 2.140906e-01 4.464660e-01 6 111367115 111367625 511 - 1.804 1.802 -0.007
ENSG00000009413 E034 69.6601504 0.0018125984 2.984606e-01 5.389205e-01 6 111367626 111368028 403 - 1.779 1.799 0.069
ENSG00000009413 E035 31.7079844 0.0172421121 2.957062e-01 5.361912e-01 6 111372596 111372694 99 - 1.454 1.423 -0.110
ENSG00000009413 E036 305.2673229 0.0085043191 1.637727e-06 4.379901e-05 6 111372695 111376529 3835 - 2.453 2.308 -0.482
ENSG00000009413 E037 25.2286113 0.0349486929 2.671664e-04 3.397390e-03 6 111376530 111376757 228 - 1.427 1.045 -1.350
ENSG00000009413 E038 21.8680558 0.0263761434 3.211103e-04 3.945298e-03 6 111377701 111377843 143 - 1.363 0.981 -1.366
ENSG00000009413 E039 29.8679755 0.0250113990 1.294745e-04 1.854567e-03 6 111379982 111380219 238 - 1.491 1.116 -1.313
ENSG00000009413 E040 18.4979889 0.0021945032 1.172240e-04 1.705709e-03 6 111381325 111381444 120 - 1.286 0.956 -1.188
ENSG00000009413 E041 0.0000000       6 111387746 111387764 19 -      
ENSG00000009413 E042 22.3533843 0.0125169925 1.166128e-04 1.698562e-03 6 111387765 111387902 138 - 1.365 1.009 -1.269
ENSG00000009413 E043 11.6769565 0.0488988463 1.909089e-01 4.180333e-01 6 111387903 111387913 11 - 1.066 0.930 -0.502
ENSG00000009413 E044 17.4191564 0.0161824723 4.114083e-02 1.577124e-01 6 111388001 111388085 85 - 1.236 1.075 -0.575
ENSG00000009413 E045 23.4597797 0.0016220208 9.259819e-05 1.402417e-03 6 111389106 111389210 105 - 1.381 1.096 -1.004
ENSG00000009413 E046 20.3140521 0.0048647062 2.233377e-05 4.200208e-04 6 111390086 111390180 95 - 1.332 0.956 -1.351
ENSG00000009413 E047 0.0000000       6 111392695 111392875 181 -      
ENSG00000009413 E048 19.6756481 0.0019701285 7.734348e-06 1.679415e-04 6 111392876 111392972 97 - 1.321 0.927 -1.419
ENSG00000009413 E049 0.1779838 0.0425388864 1.000000e+00   6 111405427 111405469 43 - 0.072 0.000 -11.894
ENSG00000009413 E050 22.2963825 0.0017951794 1.636761e-06 4.378007e-05 6 111405470 111405630 161 - 1.380 0.983 -1.418
ENSG00000009413 E051 0.0000000       6 111405631 111405632 2 -      
ENSG00000009413 E052 12.6619194 0.0025906303 2.282832e-02 1.054159e-01 6 111411480 111411554 75 - 1.119 0.927 -0.702
ENSG00000009413 E053 0.0000000       6 111411555 111411556 2 -      
ENSG00000009413 E054 17.7600162 0.0030020941 1.091852e-02 6.202344e-02 6 111416283 111416472 190 - 1.256 1.075 -0.645
ENSG00000009413 E055 0.0000000       6 111460300 111460406 107 -      
ENSG00000009413 E056 3.2193901 0.0073484108 8.190591e-01 9.074929e-01 6 111472013 111472140 128 - 0.571 0.588 0.077
ENSG00000009413 E057 12.6858804 0.0049785712 4.031309e-01 6.308275e-01 6 111482750 111483229 480 - 1.094 1.074 -0.069
ENSG00000009413 E058 1.2457534 0.0153786544 8.899843e-01   6 111483599 111483715 117 - 0.319 0.332 0.080