ENSG00000009335

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348165 ENSG00000009335 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE3C protein_coding protein_coding 39.38252 26.66905 47.16075 3.816679 1.940452 0.8221854 14.623163 8.270618 19.0858699 1.229607 0.6241908 1.2054502 0.3518125 0.3142000 0.40710000 0.09290000 0.56332916 0.03393202 FALSE TRUE
ENST00000474153 ENSG00000009335 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE3C protein_coding retained_intron 39.38252 26.66905 47.16075 3.816679 1.940452 0.8221854 3.353157 2.485933 0.5402908 0.738889 0.2156457 -2.1813134 0.1038667 0.1047667 0.01116667 -0.09360000 0.03393202 0.03393202 FALSE TRUE
MSTRG.30997.9 ENSG00000009335 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE3C protein_coding   39.38252 26.66905 47.16075 3.816679 1.940452 0.8221854 14.879979 11.357770 18.8952378 1.786576 2.0508605 0.7338367 0.3864958 0.4237667 0.39860000 -0.02516667 0.90597210 0.03393202 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000009335 E001 0.2617363 0.1457054393 1.244636e-01   7 157138916 157138925 10 + 0.000 0.260 11.058
ENSG00000009335 E002 12.1758264 0.0448271925 3.989192e-02 1.544272e-01 7 157138926 157138986 61 + 0.968 1.277 1.113
ENSG00000009335 E003 13.9208991 0.0636317734 3.833405e-02 1.504698e-01 7 157138987 157138999 13 + 1.003 1.348 1.230
ENSG00000009335 E004 16.6538064 0.0653582727 2.986684e-02 1.269511e-01 7 157139000 157139081 82 + 1.074 1.420 1.218
ENSG00000009335 E005 12.8329884 0.0960079336 3.454523e-02 1.403352e-01 7 157139082 157139141 60 + 0.950 1.324 1.347
ENSG00000009335 E006 6.0490680 0.0384103905 2.431608e-03 1.989224e-02 7 157139142 157139170 29 + 0.603 1.070 1.838
ENSG00000009335 E007 5.5628677 0.0250754257 5.151206e-02 1.833179e-01 7 157139171 157139194 24 + 0.677 0.968 1.144
ENSG00000009335 E008 8.9582164 0.0394689533 6.155522e-01 7.806881e-01 7 157139195 157139209 15 + 0.956 1.038 0.306
ENSG00000009335 E009 10.1272319 0.0150345074 8.470075e-01 9.233126e-01 7 157139210 157139211 2 + 1.021 1.057 0.132
ENSG00000009335 E010 42.0398790 0.0021589030 1.132804e-01 3.046149e-01 7 157139212 157139278 67 + 1.647 1.568 -0.271
ENSG00000009335 E011 72.6655927 0.0005308654 2.862094e-03 2.257292e-02 7 157139279 157139338 60 + 1.893 1.778 -0.390
ENSG00000009335 E012 103.1771262 0.0004221732 6.824023e-07 2.038839e-05 7 157163810 157163863 54 + 2.061 1.889 -0.576
ENSG00000009335 E013 0.6151152 0.4750808600 7.869992e-01   7 157164419 157164530 112 + 0.243 0.148 -0.888
ENSG00000009335 E014 1.0408063 0.0284650613 1.752563e-01   7 157167238 157167361 124 + 0.396 0.151 -1.837
ENSG00000009335 E015 70.0878169 0.0008205367 4.193647e-05 7.163324e-04 7 157169048 157169051 4 + 1.896 1.723 -0.585
ENSG00000009335 E016 129.1572015 0.0004100801 9.880017e-05 1.479635e-03 7 157169052 157169122 71 + 2.140 2.025 -0.384
ENSG00000009335 E017 205.6449588 0.0014477850 5.403296e-07 1.658420e-05 7 157170304 157170450 147 + 2.351 2.209 -0.476
ENSG00000009335 E018 189.4092661 0.0005775431 1.476516e-06 3.990871e-05 7 157174919 157175034 116 + 2.311 2.188 -0.411
ENSG00000009335 E019 216.2721797 0.0003155105 8.617239e-05 1.319810e-03 7 157178690 157178847 158 + 2.355 2.269 -0.287
ENSG00000009335 E020 236.4455421 0.0021205754 8.775986e-03 5.283426e-02 7 157181518 157181671 154 + 2.387 2.319 -0.228
ENSG00000009335 E021 260.2949376 0.0004217563 6.218609e-02 2.077106e-01 7 157182108 157182328 221 + 2.416 2.387 -0.095
ENSG00000009335 E022 237.9153002 0.0003114568 1.398436e-01 3.472305e-01 7 157183878 157184029 152 + 2.374 2.354 -0.067
ENSG00000009335 E023 285.3880601 0.0006584692 1.079178e-01 2.955814e-01 7 157186834 157187021 188 + 2.454 2.430 -0.077
ENSG00000009335 E024 1.3431708 0.1705117037 2.292943e-01   7 157188949 157189296 348 + 0.245 0.490 1.458
ENSG00000009335 E025 235.3829581 0.0002572262 1.102354e-04 1.621785e-03 7 157201721 157201807 87 + 2.387 2.307 -0.266
ENSG00000009335 E026 302.6120983 0.0006228937 3.415902e-05 6.026374e-04 7 157207398 157207512 115 + 2.496 2.413 -0.276
ENSG00000009335 E027 238.6760084 0.0002407219 4.026237e-06 9.549549e-05 7 157207513 157207555 43 + 2.399 2.302 -0.324
ENSG00000009335 E028 477.1326693 0.0002324135 1.915153e-06 5.023743e-05 7 157207703 157207935 233 + 2.689 2.621 -0.227
ENSG00000009335 E029 257.5459070 0.0001919431 1.804039e-01 4.045214e-01 7 157216867 157216971 105 + 2.404 2.389 -0.050
ENSG00000009335 E030 6.8738007 0.0041472263 5.241092e-01 7.178987e-01 7 157216972 157217245 274 + 0.902 0.836 -0.253
ENSG00000009335 E031 4.2470585 0.0088960016 6.111453e-01 7.777078e-01 7 157220668 157220688 21 + 0.739 0.677 -0.254
ENSG00000009335 E032 203.5497323 0.0002397143 1.511592e-01 3.640198e-01 7 157220689 157220776 88 + 2.275 2.328 0.176
ENSG00000009335 E033 28.0057538 0.1589572529 5.975798e-01 7.686751e-01 7 157220777 157223253 2477 + 1.371 1.550 0.614
ENSG00000009335 E034 188.2625253 0.0002768192 1.664633e-01 3.858156e-01 7 157223254 157223351 98 + 2.242 2.295 0.176
ENSG00000009335 E035 226.6691994 0.0003381968 4.425268e-01 6.604088e-01 7 157225407 157225499 93 + 2.330 2.365 0.116
ENSG00000009335 E036 111.7078402 0.0004718029 6.537325e-01 8.059331e-01 7 157225500 157225501 2 + 2.027 2.058 0.105
ENSG00000009335 E037 154.9976308 0.0003132805 8.845652e-01 9.437085e-01 7 157225502 157225539 38 + 2.176 2.187 0.039
ENSG00000009335 E038 363.1134064 0.0045376952 2.070674e-01 4.382751e-01 7 157231080 157231327 248 + 2.520 2.589 0.230
ENSG00000009335 E039 5.8685337 0.0051145642 5.492677e-01 7.358103e-01 7 157231328 157231815 488 + 0.795 0.885 0.352
ENSG00000009335 E040 329.7501682 0.0030525231 1.207185e-01 3.169921e-01 7 157248368 157248580 213 + 2.477 2.546 0.231
ENSG00000009335 E041 1.2992634 0.2720588983 9.419221e-01   7 157248581 157248624 44 + 0.354 0.352 -0.012
ENSG00000009335 E042 300.4447803 0.0002214137 3.514524e-05 6.174066e-04 7 157253954 157254142 189 + 2.421 2.525 0.346
ENSG00000009335 E043 162.2517416 0.0002964146 1.362281e-02 7.286970e-02 7 157254244 157254310 67 + 2.166 2.252 0.289
ENSG00000009335 E044 7.7359571 0.1668000834 3.055945e-01 5.462264e-01 7 157256687 157256913 227 + 0.817 1.069 0.945
ENSG00000009335 E045 196.9461740 0.0002443534 5.541886e-03 3.742999e-02 7 157256914 157257044 131 + 2.249 2.337 0.293
ENSG00000009335 E046 1511.2160234 0.0006781494 2.340972e-17 4.836386e-15 7 157267585 157269370 1786 + 3.113 3.240 0.423