ENSG00000008735

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000329492 ENSG00000008735 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPK8IP2 protein_coding protein_coding 19.1946 22.89856 8.570781 2.539661 0.2015628 -1.416706 4.4550958 3.6709163 2.5375308 0.3751920 0.2255891 -0.5309654 0.24468750 0.16596667 0.29546667 0.12950000 1.893950e-01 5.17362e-19 FALSE TRUE
MSTRG.22391.3 ENSG00000008735 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPK8IP2 protein_coding   19.1946 22.89856 8.570781 2.539661 0.2015628 -1.416706 1.5812458 2.5379444 0.7710566 0.5028651 0.1208114 -1.7058347 0.07962500 0.10850000 0.08983333 -0.01866667 8.437756e-01 5.17362e-19 TRUE TRUE
MSTRG.22391.5 ENSG00000008735 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPK8IP2 protein_coding   19.1946 22.89856 8.570781 2.539661 0.2015628 -1.416706 0.9821427 0.8128168 0.5352346 0.4916437 0.2989368 -0.5936941 0.05058333 0.03446667 0.06346667 0.02900000 9.607057e-01 5.17362e-19 TRUE TRUE
MSTRG.22391.7 ENSG00000008735 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPK8IP2 protein_coding   19.1946 22.89856 8.570781 2.539661 0.2015628 -1.416706 0.4099405 0.0000000 0.5697128 0.0000000 0.5697128 5.8572665 0.02331250 0.00000000 0.06606667 0.06606667 7.871619e-01 5.17362e-19 TRUE TRUE
MSTRG.22391.8 ENSG00000008735 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPK8IP2 protein_coding   19.1946 22.89856 8.570781 2.539661 0.2015628 -1.416706 6.0061324 7.3696888 3.5267437 0.7496858 0.5707606 -1.0611383 0.32828333 0.32540000 0.41046667 0.08506667 7.503210e-01 5.17362e-19 TRUE TRUE
MSTRG.22391.9 ENSG00000008735 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPK8IP2 protein_coding   19.1946 22.89856 8.570781 2.539661 0.2015628 -1.416706 4.0069480 7.3587852 0.0000000 1.5889217 0.0000000 -9.5252830 0.17495000 0.31360000 0.00000000 -0.31360000 5.173620e-19 5.17362e-19 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000008735 E001 0.5059767 0.0215562070 4.768171e-01   22 50600651 50600668 18 + 0.001 0.184 8.840
ENSG00000008735 E002 4.4460279 0.0058840433 4.733938e-03 3.318329e-02 22 50600669 50600727 59 + 0.202 0.747 2.954
ENSG00000008735 E003 6.9162600 0.0042685744 1.489788e-01 3.608054e-01 22 50600728 50600741 14 + 0.658 0.866 0.838
ENSG00000008735 E004 16.5567515 0.0019914025 5.119214e-01 7.094144e-01 22 50600742 50600792 51 + 1.128 1.184 0.200
ENSG00000008735 E005 86.7386829 0.0004747870 4.595984e-01 6.728335e-01 22 50600793 50600883 91 + 1.901 1.859 -0.141
ENSG00000008735 E006 149.4680285 0.0004000771 3.408210e-04 4.147860e-03 22 50601789 50601894 106 + 2.198 2.071 -0.423
ENSG00000008735 E007 2.5402606 0.0556056166 8.133090e-02 2.474933e-01 22 50603133 50603222 90 + 0.712 0.385 -1.542
ENSG00000008735 E008 240.7206902 0.0002539307 2.764165e-01 5.164097e-01 22 50603223 50603498 276 + 2.338 2.300 -0.128
ENSG00000008735 E009 110.4609346 0.0016862991 2.303838e-02 1.060715e-01 22 50603626 50603719 94 + 1.898 1.988 0.304
ENSG00000008735 E010 5.8395251 0.0048850061 2.988416e-01 5.392989e-01 22 50603838 50603840 3 + 0.658 0.810 0.620
ENSG00000008735 E011 110.6467835 0.0004438405 2.282011e-03 1.893569e-02 22 50603841 50603972 132 + 1.881 1.999 0.395
ENSG00000008735 E012 112.5853740 0.0005983349 5.878668e-08 2.307751e-06 22 50603973 50604196 224 + 1.796 2.024 0.769
ENSG00000008735 E013 149.3616722 0.0020094141 4.742619e-04 5.443035e-03 22 50604197 50604739 543 + 1.997 2.131 0.449
ENSG00000008735 E014 221.3473054 0.0019453619 1.091923e-01 2.977611e-01 22 50604740 50605064 325 + 2.239 2.283 0.147
ENSG00000008735 E015 156.4481213 0.0003903035 7.143691e-01 8.445637e-01 22 50605368 50605443 76 + 2.123 2.126 0.009
ENSG00000008735 E016 227.1424442 0.0002648754 2.034704e-01 4.338957e-01 22 50605562 50605734 173 + 2.264 2.289 0.084
ENSG00000008735 E017 159.2056672 0.0003278085 9.844177e-02 2.790512e-01 22 50605825 50605934 110 + 2.093 2.139 0.152
ENSG00000008735 E018 157.6220269 0.0012295188 1.716601e-02 8.605198e-02 22 50606658 50606765 108 + 2.063 2.141 0.262
ENSG00000008735 E019 142.6631506 0.0070281081 3.740568e-01 6.074140e-01 22 50606921 50606991 71 + 2.053 2.089 0.119
ENSG00000008735 E020 176.1602380 0.0065562464 9.967530e-01 1.000000e+00 22 50610212 50610310 99 + 2.179 2.169 -0.031
ENSG00000008735 E021 545.1756359 0.0001340201 1.468084e-01 3.576965e-01 22 50610707 50611846 1140 + 2.688 2.655 -0.112
ENSG00000008735 E022 62.8320186 0.0286652651 3.205129e-03 2.463251e-02 22 50611847 50612278 432 + 1.929 1.646 -0.957
ENSG00000008735 E023 46.8589194 0.0236301003 7.987062e-04 8.272165e-03 22 50612279 50612499 221 + 1.828 1.504 -1.100
ENSG00000008735 E024 37.7218527 0.0296561119 2.923725e-04 3.652731e-03 22 50612500 50612825 326 + 1.778 1.384 -1.343
ENSG00000008735 E025 50.3091075 0.0204758512 1.139009e-02 6.395461e-02 22 50612826 50613354 529 + 1.803 1.574 -0.777
ENSG00000008735 E026 62.8519239 0.0054750548 2.123085e-03 1.789146e-02 22 50613355 50613981 627 + 1.871 1.677 -0.656