ENSG00000008441

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360105 ENSG00000008441 HEK293_OSMI2_6hA HEK293_TMG_6hB NFIX protein_coding protein_coding 5.411643 7.464782 3.792405 1.287146 0.2049618 -0.9751193 0.5165679 0.7584640 0.2686227 0.18140971 0.10535045 -1.4636650 0.09272917 0.10160000 0.07303333 -0.02856667 0.8282656517 2.30807e-05 FALSE TRUE
ENST00000397661 ENSG00000008441 HEK293_OSMI2_6hA HEK293_TMG_6hB NFIX protein_coding protein_coding 5.411643 7.464782 3.792405 1.287146 0.2049618 -0.9751193 1.4638330 1.7285998 1.2182884 0.62813518 0.13602024 -0.5012765 0.28281667 0.21186667 0.32100000 0.10913333 0.6924568416 2.30807e-05 FALSE TRUE
ENST00000585382 ENSG00000008441 HEK293_OSMI2_6hA HEK293_TMG_6hB NFIX protein_coding nonsense_mediated_decay 5.411643 7.464782 3.792405 1.287146 0.2049618 -0.9751193 0.3393428 0.0000000 0.1203528 0.00000000 0.12035278 3.7043495 0.06020417 0.00000000 0.02876667 0.02876667 0.7485251936 2.30807e-05 TRUE FALSE
ENST00000587760 ENSG00000008441 HEK293_OSMI2_6hA HEK293_TMG_6hB NFIX protein_coding protein_coding 5.411643 7.464782 3.792405 1.287146 0.2049618 -0.9751193 2.5758072 4.4090923 1.9962859 0.58025824 0.09307551 -1.1392229 0.47120417 0.60856667 0.52730000 -0.08126667 0.7779260326 2.30807e-05 FALSE TRUE
ENST00000592199 ENSG00000008441 HEK293_OSMI2_6hA HEK293_TMG_6hB NFIX protein_coding protein_coding 5.411643 7.464782 3.792405 1.287146 0.2049618 -0.9751193 0.3038140 0.4707783 0.0000000 0.05693863 0.00000000 -5.5873000 0.05122083 0.06643333 0.00000000 -0.06643333 0.0002018765 2.30807e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000008441 E001 1.5825418 0.0118114332 0.141328695 0.34947418 19 12995475 12995607 133 + 0.173 0.465 1.974
ENSG00000008441 E002 9.9871735 0.0033046448 0.647448962 0.80179480 19 12995608 12995864 257 + 1.032 0.998 -0.124
ENSG00000008441 E003 0.0000000       19 13012188 13012206 19 +      
ENSG00000008441 E004 0.0000000       19 13012207 13012266 60 +      
ENSG00000008441 E005 1.0045791 0.0153787590 0.303232898   19 13023991 13024031 41 + 0.392 0.215 -1.193
ENSG00000008441 E006 1.0045791 0.0153787590 0.303232898   19 13024032 13024034 3 + 0.392 0.215 -1.193
ENSG00000008441 E007 0.0000000       19 13024580 13024580 1 +      
ENSG00000008441 E008 0.0000000       19 13024581 13024584 4 +      
ENSG00000008441 E009 0.1723744 0.0470417415 1.000000000   19 13024585 13024612 28 + 0.000 0.084 10.730
ENSG00000008441 E010 0.3751086 0.0308454922 0.552649292   19 13024613 13024626 14 + 0.000 0.155 11.830
ENSG00000008441 E011 0.3751086 0.0308454922 0.552649292   19 13024627 13024680 54 + 0.000 0.155 11.830
ENSG00000008441 E012 0.2027342 0.0364401519 1.000000000   19 13024681 13024682 2 + 0.000 0.084 10.802
ENSG00000008441 E013 0.2027342 0.0364401519 1.000000000   19 13024683 13024684 2 + 0.000 0.084 10.802
ENSG00000008441 E014 0.2027342 0.0364401519 1.000000000   19 13024685 13024719 35 + 0.000 0.084 10.802
ENSG00000008441 E015 0.2027342 0.0364401519 1.000000000   19 13024720 13024723 4 + 0.000 0.084 10.802
ENSG00000008441 E016 0.0000000       19 13024888 13024938 51 +      
ENSG00000008441 E017 0.1614157 0.0359657438 0.204620615   19 13024939 13025020 82 + 0.173 0.000 -12.972
ENSG00000008441 E018 36.7429654 0.0011719179 0.098157437 0.27856613 19 13025021 13025175 155 + 1.597 1.513 -0.287
ENSG00000008441 E019 54.3747004 0.0013501581 0.109805284 0.29871902 19 13025176 13025368 193 + 1.753 1.689 -0.216
ENSG00000008441 E020 73.6621856 0.0006938969 0.035062426 0.14174723 19 13025369 13025552 184 + 1.887 1.814 -0.247
ENSG00000008441 E021 0.0000000       19 13070003 13070069 67 +      
ENSG00000008441 E022 57.0943751 0.0007772404 0.202081477 0.43220134 19 13073047 13073109 63 + 1.760 1.715 -0.152
ENSG00000008441 E023 55.0045983 0.0006787324 0.438335395 0.65749341 19 13073422 13073496 75 + 1.730 1.708 -0.073
ENSG00000008441 E024 61.0736977 0.0012785830 0.031682686 0.13228227 19 13073906 13074026 121 + 1.822 1.736 -0.291
ENSG00000008441 E025 57.8025907 0.0178912040 0.794884272 0.89326119 19 13075535 13075671 137 + 1.744 1.731 -0.042
ENSG00000008441 E026 43.6929150 0.0091093749 0.547625559 0.73456353 19 13078613 13078735 123 + 1.580 1.635 0.189
ENSG00000008441 E027 74.0550576 0.0009286666 0.532207511 0.72362751 19 13081680 13081855 176 + 1.850 1.839 -0.037
ENSG00000008441 E028 4.2734316 0.0063554173 0.761580138 0.87357026 19 13087989 13088136 148 + 0.645 0.704 0.249
ENSG00000008441 E029 55.8280282 0.0007526684 0.819443802 0.90777704 19 13090299 13090390 92 + 1.701 1.730 0.096
ENSG00000008441 E030 553.5163475 0.0019846062 0.001484895 0.01350811 19 13094635 13098796 4162 + 2.657 2.726 0.231